SRC is a membrane-associated non-receptor protein tyrosine kinase with SH3, SH2, and catalytic kinase domains. It is recruited to activated receptors, adhesion complexes, and cytoskeletal scaffolds where it phosphorylates tyrosine residues to regulate intracellular signaling, adhesion, migration, osteoclast function, epithelial responses, and cell growth contexts.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: plasma membrane localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005102 signaling receptor binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: signaling receptor binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0030154 cell differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: cell differentiation pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. Supporting Evidence: file:mouse/Src/Src-bioreason-rl-predictions.md A cytoplasmic non-receptor tyrosine kinase that uses an SH3-SH2-kinase architecture to assemble with proline-rich and phosphotyrosine-containing partners file:mouse/Src/Src-deep-research-falcon.md Falcon synthesis supports Src as a membrane-associated non-receptor tyrosine kinase with SH3, SH2, and catalytic kinase domains. |
| GO:0007155 cell adhesion | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: cell adhesion pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: epidermal growth factor receptor signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0050847 progesterone receptor signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: progesterone receptor signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:2001237 negative regulation of extrinsic apoptotic signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: negative regulation of extrinsic apoptotic signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2001243 negative regulation of intrinsic apoptotic signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: negative regulation of intrinsic apoptotic signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000120 | MARK AS OVER ANNOTATED | Summary: protein kinase activity is less specific than SRC tyrosine kinase activity Reason: The annotation is directionally correct but over-broad because more specific SRC tyrosine kinase terms are present. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. Supporting Evidence: file:mouse/Src/Src-bioreason-rl-predictions.md A cytoplasmic non-receptor tyrosine kinase that uses an SH3-SH2-kinase architecture to assemble with proline-rich and phosphotyrosine-containing partners |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: ATP binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: nucleus pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005743 mitochondrial inner membrane | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: mitochondrial inner membrane pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005856 cytoskeleton | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: cytoskeleton pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: plasma membrane localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005925 focal adhesion | IEA GO_REF:0000044 | ACCEPT | Summary: focal adhesion localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0007155 cell adhesion | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: cell adhesion pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0007276 gamete generation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: gamete generation pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0010628 positive regulation of gene expression | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: positive regulation of gene expression pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0036120 cellular response to platelet-derived growth factor stimulus | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: cellular response to platelet-derived growth factor stimulus pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: perinuclear region of cytoplasm pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0070161 anchoring junction | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: anchoring junction pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0070301 cellular response to hydrogen peroxide | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: cellular response to hydrogen peroxide pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: positive regulation of ERK1 and ERK2 cascade pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:1903829 positive regulation of protein localization | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: positive regulation of protein localization pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:1904385 cellular response to angiotensin | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: cellular response to angiotensin pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0005515 protein binding | IPI PMID:10220404 Identification of profilin and src homology 3 domains as bin... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:16267818 A proteomics strategy for the enrichment of receptor-associa... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:16298995 EphB receptors regulate dendritic spine morphogenesis throug... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:16407161 Role of Src in C3 transient receptor potential channel funct... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:16990796 PSD-95 is a negative regulator of the tyrosine kinase Src in... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:18289379 Dramatic inhibition of osteoclast sealing ring formation and... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:18560762 Mobility of TOAC spin-labelled peptides binding to the Src S... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:19122674 Deficiency of a beta-arrestin-2 signal complex contributes t... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:21199370 Roles of the SH2 and SH3 domains in the regulation of neuron... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:21266176 Linker length dependent binding of a focal adhesion kinase d... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:21282606 NΞ΅-lysine acetylation determines dissociation from GAP junct... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:22439932 NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR ... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:28054552 c-Src phosphorylation and activation of hexokinase promotes ... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:7518772 Phosphorylation of receptor protein-tyrosine phosphatase alp... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of transcription by RNA polymerase II pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0005102 signaling receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: signaling receptor binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0005178 integrin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: integrin binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: cytoplasm localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005739 mitochondrion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: mitochondrion pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005764 lysosome | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: lysosome pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005770 late endosome | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: late endosome pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005829 cytosol | IEA GO_REF:0000107 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005901 caveola | IEA GO_REF:0000120 | ACCEPT | Summary: caveola localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005911 cell-cell junction | IEA GO_REF:0000107 | ACCEPT | Summary: cell-cell junction localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0007179 transforming growth factor beta receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: transforming growth factor beta receptor signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0007229 integrin-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: integrin-mediated signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0010632 regulation of epithelial cell migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of epithelial cell migration pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0010634 positive regulation of epithelial cell migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of epithelial cell migration pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0016004 phospholipase activator activity | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: phospholipase activator activity pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0019899 enzyme binding | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Generic enzyme binding annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0020037 heme binding | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Generic heme binding annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0022407 regulation of cell-cell adhesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of cell-cell adhesion pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0030054 cell junction | IEA GO_REF:0000107 | ACCEPT | Summary: cell junction localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0031333 negative regulation of protein-containing complex assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of protein-containing complex assembly pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0034139 regulation of toll-like receptor 3 signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of toll-like receptor 3 signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0034614 cellular response to reactive oxygen species | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cellular response to reactive oxygen species pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0035306 positive regulation of dephosphorylation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of dephosphorylation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0035331 negative regulation of hippo signaling | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of hippo signaling pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0035556 intracellular signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: SRC intracellular signaling function Reason: SRC acts near activated receptors and adhesion complexes to propagate tyrosine-phosphorylation-dependent intracellular signaling. |
| GO:0042169 SH2 domain binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: SH2 domain binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0043066 negative regulation of apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of apoptotic process pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0043149 stress fiber assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: stress fiber assembly pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0043274 phospholipase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: phospholipase binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0044325 transmembrane transporter binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: transmembrane transporter binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0045747 positive regulation of Notch signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of Notch signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0046875 ephrin receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ephrin receptor binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0048041 focal adhesion assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: focal adhesion assembly pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0051057 positive regulation of small GTPase mediated signal transduction | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: positive regulation of small GTPase mediated signal transduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0051219 phosphoprotein binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: phosphoprotein binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0051902 negative regulation of mitochondrial depolarization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of mitochondrial depolarization pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0060576 intestinal epithelial cell development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: intestinal epithelial cell development pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0070102 interleukin-6-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: interleukin-6-mediated signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0070555 response to interleukin-1 | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: response to interleukin-1 pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0070700 BMP receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: BMP receptor binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0097110 scaffold protein binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: scaffold protein binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:1902564 negative regulation of neutrophil activation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of neutrophil activation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:1904263 positive regulation of TORC1 signaling | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of TORC1 signaling pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000394 positive regulation of lamellipodium morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of lamellipodium morphogenesis pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000641 regulation of early endosome to late endosome transport | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of early endosome to late endosome transport pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000811 negative regulation of anoikis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of anoikis pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2001237 negative regulation of extrinsic apoptotic signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of extrinsic apoptotic signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2001243 negative regulation of intrinsic apoptotic signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of intrinsic apoptotic signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2001286 regulation of caveolin-mediated endocytosis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of caveolin-mediated endocytosis pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of transcription by RNA polymerase II pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0001545 primary ovarian follicle growth | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: primary ovarian follicle growth pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0001819 positive regulation of cytokine production | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of cytokine production pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0004672 protein kinase activity | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: protein kinase activity is less specific than SRC tyrosine kinase activity Reason: The annotation is directionally correct but over-broad because more specific SRC tyrosine kinase terms are present. |
| GO:0004713 protein tyrosine kinase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. Supporting Evidence: file:mouse/Src/Src-bioreason-rl-predictions.md A cytoplasmic non-receptor tyrosine kinase that uses an SH3-SH2-kinase architecture to assemble with proline-rich and phosphotyrosine-containing partners |
| GO:0005102 signaling receptor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: signaling receptor binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0005178 integrin binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: integrin binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005737 cytoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: cytoplasm localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005739 mitochondrion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: mitochondrion pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005743 mitochondrial inner membrane | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: mitochondrial inner membrane pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005764 lysosome | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: lysosome pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005770 late endosome | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: late endosome pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005829 cytosol | ISO GO_REF:0000119 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005886 plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: plasma membrane localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005901 caveola | ISO GO_REF:0000119 | ACCEPT | Summary: caveola localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005911 cell-cell junction | ISO GO_REF:0000119 | ACCEPT | Summary: cell-cell junction localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0007179 transforming growth factor beta receptor signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: transforming growth factor beta receptor signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0007229 integrin-mediated signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: integrin-mediated signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0008284 positive regulation of cell population proliferation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of cell population proliferation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0010628 positive regulation of gene expression | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of gene expression pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0010629 negative regulation of gene expression | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of gene expression pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0010632 regulation of epithelial cell migration | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: regulation of epithelial cell migration pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0010634 positive regulation of epithelial cell migration | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of epithelial cell migration pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0010907 positive regulation of glucose metabolic process | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of glucose metabolic process pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0014911 positive regulation of smooth muscle cell migration | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of smooth muscle cell migration pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0016004 phospholipase activator activity | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phospholipase activator activity pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0019899 enzyme binding | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Generic enzyme binding annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0020037 heme binding | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Generic heme binding annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0022407 regulation of cell-cell adhesion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: regulation of cell-cell adhesion pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0030054 cell junction | ISO GO_REF:0000119 | ACCEPT | Summary: cell junction localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0030335 positive regulation of cell migration | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of cell migration pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0031333 negative regulation of protein-containing complex assembly | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of protein-containing complex assembly pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0032205 negative regulation of telomere maintenance | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of telomere maintenance pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0034139 regulation of toll-like receptor 3 signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: regulation of toll-like receptor 3 signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0034614 cellular response to reactive oxygen species | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to reactive oxygen species pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0035306 positive regulation of dephosphorylation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of dephosphorylation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0035331 negative regulation of hippo signaling | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of hippo signaling pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0035556 intracellular signal transduction | ISO GO_REF:0000119 | ACCEPT | Summary: SRC intracellular signaling function Reason: SRC acts near activated receptors and adhesion complexes to propagate tyrosine-phosphorylation-dependent intracellular signaling. |
| GO:0038083 peptidyl-tyrosine autophosphorylation | ISO GO_REF:0000096 | ACCEPT | Summary: Direct SRC tyrosine phosphorylation activity Reason: This term directly describes the catalytic output of SRC kinase activity on protein tyrosine residues. |
| GO:0042169 SH2 domain binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: SH2 domain binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0042311 vasodilation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: vasodilation pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0043065 positive regulation of apoptotic process | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of apoptotic process pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0043066 negative regulation of apoptotic process | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of apoptotic process pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0043149 stress fiber assembly | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: stress fiber assembly pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0043274 phospholipase binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phospholipase binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0043406 positive regulation of MAP kinase activity | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of MAP kinase activity pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0044325 transmembrane transporter binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: transmembrane transporter binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0045056 transcytosis | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: transcytosis pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0045747 positive regulation of Notch signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of Notch signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0045780 positive regulation of bone resorption | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of bone resorption pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0045785 positive regulation of cell adhesion | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of cell adhesion pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0045793 positive regulation of cell size | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of cell size pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0046579 positive regulation of Ras protein signal transduction | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of Ras protein signal transduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0046628 positive regulation of insulin receptor signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of insulin receptor signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0046875 ephrin receptor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: ephrin receptor binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0048011 neurotrophin TRK receptor signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: neurotrophin TRK receptor signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0048041 focal adhesion assembly | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: focal adhesion assembly pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0048471 perinuclear region of cytoplasm | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: perinuclear region of cytoplasm pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of peptidyl-tyrosine phosphorylation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0050839 cell adhesion molecule binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: cell adhesion molecule binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0050847 progesterone receptor signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: progesterone receptor signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0051057 positive regulation of small GTPase mediated signal transduction | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of small GTPase mediated signal transduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0051219 phosphoprotein binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phosphoprotein binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0051222 positive regulation of protein transport | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of protein transport pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0051895 negative regulation of focal adhesion assembly | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of focal adhesion assembly pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0051902 negative regulation of mitochondrial depolarization | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of mitochondrial depolarization pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0060576 intestinal epithelial cell development | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: intestinal epithelial cell development pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0070102 interleukin-6-mediated signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: interleukin-6-mediated signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0070555 response to interleukin-1 | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: response to interleukin-1 pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0070700 BMP receptor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: BMP receptor binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0097110 scaffold protein binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: scaffold protein binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:1902564 negative regulation of neutrophil activation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of neutrophil activation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:1904263 positive regulation of TORC1 signaling | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of TORC1 signaling pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000394 positive regulation of lamellipodium morphogenesis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of lamellipodium morphogenesis pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000641 regulation of early endosome to late endosome transport | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: regulation of early endosome to late endosome transport pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000811 negative regulation of anoikis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of anoikis pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2001237 negative regulation of extrinsic apoptotic signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of extrinsic apoptotic signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2001243 negative regulation of intrinsic apoptotic signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of intrinsic apoptotic signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2001286 regulation of caveolin-mediated endocytosis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: regulation of caveolin-mediated endocytosis pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0030331 nuclear estrogen receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: nuclear estrogen receptor binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0030546 signaling receptor activator activity | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: signaling receptor activator activity pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0035255 ionotropic glutamate receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: ionotropic glutamate receptor binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0044325 transmembrane transporter binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: transmembrane transporter binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0004713 protein tyrosine kinase activity | ISO GO_REF:0000096 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0005080 protein kinase C binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: protein kinase C binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005102 signaling receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: signaling receptor binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0005158 insulin receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: insulin receptor binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005737 cytoplasm | ISO GO_REF:0000096 | ACCEPT | Summary: cytoplasm localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005901 caveola | ISO GO_REF:0000096 | ACCEPT | Summary: caveola localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0016020 membrane | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: Generic membrane annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0016579 protein deubiquitination | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: protein deubiquitination pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0019899 enzyme binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: Generic enzyme binding annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0019901 protein kinase binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: Generic protein kinase binding annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0030424 axon | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: axon pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0031669 cellular response to nutrient levels | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to nutrient levels pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0034138 toll-like receptor 3 signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: toll-like receptor 3 signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0038202 TORC1 signaling | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: TORC1 signaling pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0043025 neuronal cell body | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: neuronal cell body pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: proteasome-mediated ubiquitin-dependent protein catabolic process pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0044294 dendritic growth cone | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic growth cone pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0044877 protein-containing complex binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: Generic protein-containing complex binding annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of ERK1 and ERK2 cascade pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0071393 cellular response to progesterone stimulus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: cellular response to progesterone stimulus pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0071897 DNA biosynthetic process | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: DNA biosynthetic process pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0090303 positive regulation of wound healing | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of wound healing pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0097060 synaptic membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: synaptic membrane pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0098978 glutamatergic synapse | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: glutamatergic synapse pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0098984 neuron to neuron synapse | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: neuron to neuron synapse pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0099073 mitochondrion-derived vesicle | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: mitochondrion-derived vesicle pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0099091 postsynaptic specialization, intracellular component | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: postsynaptic specialization, intracellular component pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:1902533 positive regulation of intracellular signal transduction | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of intracellular signal transduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:1902737 dendritic filopodium | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic filopodium pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:1904262 negative regulation of TORC1 signaling | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of TORC1 signaling pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of vascular associated smooth muscle cell proliferation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000179 positive regulation of neural precursor cell proliferation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of neural precursor cell proliferation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000256 positive regulation of male germ cell proliferation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of male germ cell proliferation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:2000386 positive regulation of ovarian follicle development | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of ovarian follicle development pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:18044967 Laminin-induced activation of Rac1 and JNKp46 is initiated b... | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0035022 positive regulation of Rac protein signal transduction | IMP PMID:18044967 Laminin-induced activation of Rac1 and JNKp46 is initiated b... | KEEP AS NON CORE | Summary: positive regulation of Rac protein signal transduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0005515 protein binding | IPI PMID:25043309 Actin filament-associated protein 1 is required for cSrc act... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005886 plasma membrane | IDA PMID:25043309 Actin filament-associated protein 1 is required for cSrc act... | ACCEPT | Summary: plasma membrane localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. Supporting Evidence: PMID:25043309 activating signals trigger the trafficking of cSrc to the plasma membrane and its concomitant activation |
| GO:0007595 lactation | IDA PMID:25043309 Actin filament-associated protein 1 is required for cSrc act... | KEEP AS NON CORE | Summary: lactation pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0035556 intracellular signal transduction | IMP PMID:12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Ph... | ACCEPT | Summary: SRC intracellular signaling function Reason: SRC acts near activated receptors and adhesion complexes to propagate tyrosine-phosphorylation-dependent intracellular signaling. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:22759635 A Src family kinase-Shp2 axis controls RUNX1 activity in meg... | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-MMU-3928622 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-MMU-418870 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-MMU-420382 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-MMU-9011252 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-MMU-9763891 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-NUL-9726861 | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0005911 cell-cell junction | ISS GO_REF:0000024 | ACCEPT | Summary: cell-cell junction localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0038166 angiotensin-activated signaling pathway | IGI PMID:25017399 Caveolin-1 modulates cardiac gap junction homeostasis and ar... | KEEP AS NON CORE | Summary: angiotensin-activated signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0086091 regulation of heart rate by cardiac conduction | IGI PMID:25017399 Caveolin-1 modulates cardiac gap junction homeostasis and ar... | KEEP AS NON CORE | Summary: regulation of heart rate by cardiac conduction pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0045821 positive regulation of glycolytic process | IDA PMID:35263589 Nociceptor-derived Reg3Ξ³ prevents endotoxic death by targeti... | KEEP AS NON CORE | Summary: positive regulation of glycolytic process pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:27505886 Tensin 3 is a new partner of Dock5 that controls osteoclast ... | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0018108 peptidyl-tyrosine phosphorylation | IMP PMID:27505886 Tensin 3 is a new partner of Dock5 that controls osteoclast ... | ACCEPT | Summary: Direct SRC tyrosine phosphorylation activity Reason: This term directly describes the catalytic output of SRC kinase activity on protein tyrosine residues. |
| GO:0045747 positive regulation of Notch signaling pathway | IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege... | KEEP AS NON CORE | Summary: positive regulation of Notch signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0060576 intestinal epithelial cell development | IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege... | KEEP AS NON CORE | Summary: intestinal epithelial cell development pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege... | KEEP AS NON CORE | Summary: interleukin-6-mediated signaling pathway pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005515 protein binding | IPI PMID:11274221 Src and Pyk2 mediate G-protein-coupled receptor activation o... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005743 mitochondrial inner membrane | IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste... | KEEP AS NON CORE | Summary: mitochondrial inner membrane pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0030054 cell junction | ISS GO_REF:0000024 | ACCEPT | Summary: cell junction localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005925 focal adhesion | IMP PMID:22801373 Protein tyrosine phosphatase Ξ± phosphotyrosyl-789 binds BCAR... | ACCEPT | Summary: focal adhesion localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:8910389 Bombesin, bradykinin, vasopressin, and phorbol esters rapidl... | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0005634 nucleus | IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste... | KEEP AS NON CORE | Summary: nucleus pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005739 mitochondrion | IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste... | KEEP AS NON CORE | Summary: mitochondrion pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005856 cytoskeleton | IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste... | KEEP AS NON CORE | Summary: cytoskeleton pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005886 plasma membrane | IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste... | ACCEPT | Summary: plasma membrane localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. Supporting Evidence: PMID:12615910 c-Src as a plasma membrane-associated molecular effector of a variety of extracellular stimuli |
| GO:0016020 membrane | IMP PMID:22801373 Protein tyrosine phosphatase Ξ± phosphotyrosyl-789 binds BCAR... | MARK AS OVER ANNOTATED | Summary: Generic membrane annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0005515 protein binding | IPI PMID:18691334 Palmitoylation-dependent endosomal localization of AATYK1A a... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0045453 bone resorption | IMP PMID:19448635 Impaired gastric acidification negatively affects calcium ho... | KEEP AS NON CORE | Summary: bone resorption pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0042476 odontogenesis | IMP PMID:23174213 Osteopetrosis, osteopetrorickets and hypophosphatemic ricket... | KEEP AS NON CORE | Summary: odontogenesis pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0070301 cellular response to hydrogen peroxide | IMP PMID:23651497 A signaling cascade mediated by ceramide, src and PDGFRΞ² coo... | KEEP AS NON CORE | Summary: cellular response to hydrogen peroxide pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway | IMP PMID:23651497 A signaling cascade mediated by ceramide, src and PDGFRΞ² coo... | KEEP AS NON CORE | Summary: positive regulation of platelet-derived growth factor receptor-beta signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0004672 protein kinase activity | IDA PMID:27994061 Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Pr... | MARK AS OVER ANNOTATED | Summary: protein kinase activity is less specific than SRC tyrosine kinase activity Reason: The annotation is directionally correct but over-broad because more specific SRC tyrosine kinase terms are present. |
| GO:0006468 protein phosphorylation | IDA PMID:27994061 Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Pr... | UNDECIDED | Summary: PMID:27994061 supports FAK phosphorylation of Beclin1, but the cached abstract does not directly support Src-mediated protein phosphorylation. Reason: Full text or a direct Src-specific passage would be needed before accepting this evidence-specific annotation. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9011252 | ACCEPT | Summary: plasma membrane localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-9726861 | ACCEPT | Summary: plasma membrane localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-9700655 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005737 cytoplasm | IDA PMID:14699011 Regulation of connexin43 protein complexes by intracellular ... | ACCEPT | Summary: cytoplasm localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0071253 connexin binding | IPI PMID:14699011 Regulation of connexin43 protein complexes by intracellular ... | KEEP AS NON CORE | Summary: connexin binding pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-8937703 | KEEP AS NON CORE | Summary: nucleoplasm pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-8937738 | KEEP AS NON CORE | Summary: nucleoplasm pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0002102 podosome | IDA PMID:17893324 Src-dependent phosphorylation of ASAP1 regulates podosomes. | KEEP AS NON CORE | Summary: podosome pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0010954 positive regulation of protein processing | IGI PMID:17344476 The transcriptional repressor Glis2 is a novel binding partn... | KEEP AS NON CORE | Summary: positive regulation of protein processing pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation | IGI PMID:17344476 The transcriptional repressor Glis2 is a novel binding partn... | KEEP AS NON CORE | Summary: positive regulation of peptidyl-tyrosine phosphorylation pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:1900182 positive regulation of protein localization to nucleus | IGI PMID:17344476 The transcriptional repressor Glis2 is a novel binding partn... | KEEP AS NON CORE | Summary: positive regulation of protein localization to nucleus pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0005515 protein binding | IPI PMID:20847314 CXCR4-mediated bone marrow progenitor cell maintenance and m... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0071803 positive regulation of podosome assembly | IDA PMID:24127566 Phosphorylation of moesin by Jun N-terminal kinase is import... | KEEP AS NON CORE | Summary: positive regulation of podosome assembly pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0004672 protein kinase activity | IDA PMID:24190966 A reactive oxygen species-mediated, self-perpetuating loop p... | MARK AS OVER ANNOTATED | Summary: protein kinase activity is less specific than SRC tyrosine kinase activity Reason: The annotation is directionally correct but over-broad because more specific SRC tyrosine kinase terms are present. |
| GO:0005515 protein binding | IPI PMID:24190966 A reactive oxygen species-mediated, self-perpetuating loop p... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0034614 cellular response to reactive oxygen species | IDA PMID:24190966 A reactive oxygen species-mediated, self-perpetuating loop p... | KEEP AS NON CORE | Summary: cellular response to reactive oxygen species pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0005634 nucleus | IDA PMID:24841674 Mechanical loading in osteocytes induces formation of a Src/... | KEEP AS NON CORE | Summary: nucleus pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:24841674 Mechanical loading in osteocytes induces formation of a Src/... | KEEP AS NON CORE | Summary: perinuclear region of cytoplasm pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0071498 cellular response to fluid shear stress | IMP PMID:24841674 Mechanical loading in osteocytes induces formation of a Src/... | KEEP AS NON CORE | Summary: cellular response to fluid shear stress pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Ph... | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0005901 caveola | IDA PMID:12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Ph... | ACCEPT | Summary: caveola localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0097110 scaffold protein binding | IPI PMID:12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Ph... | KEEP AS NON CORE | Summary: scaffold protein binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0031648 protein destabilization | IMP PMID:25259869 Genetic disruption of the sh3pxd2a gene reveals an essential... | KEEP AS NON CORE | Summary: protein destabilization pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0071375 cellular response to peptide hormone stimulus | IGI PMID:25017399 Caveolin-1 modulates cardiac gap junction homeostasis and ar... | KEEP AS NON CORE | Summary: cellular response to peptide hormone stimulus pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0097110 scaffold protein binding | IPI PMID:25017399 Caveolin-1 modulates cardiac gap junction homeostasis and ar... | KEEP AS NON CORE | Summary: scaffold protein binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0071560 cellular response to transforming growth factor beta stimulus | IGI PMID:21829547 Redox-induced Src kinase and caveolin-1 signaling in TGF-Ξ²1-... | KEEP AS NON CORE | Summary: cellular response to transforming growth factor beta stimulus pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0005884 actin filament | IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an... | KEEP AS NON CORE | Summary: actin filament pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0032587 ruffle membrane | IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an... | KEEP AS NON CORE | Summary: ruffle membrane pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0036120 cellular response to platelet-derived growth factor stimulus | IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an... | KEEP AS NON CORE | Summary: cellular response to platelet-derived growth factor stimulus pathway context Reason: This term captures a stimulus or pathway context in which SRC can act, not the core SRC molecular activity. |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an... | KEEP AS NON CORE | Summary: perinuclear region of cytoplasm pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0004672 protein kinase activity | IMP PMID:23100514 Abl family kinases regulate FcΞ³R-mediated phagocytosis in mu... | MARK AS OVER ANNOTATED | Summary: protein kinase activity is less specific than SRC tyrosine kinase activity Reason: The annotation is directionally correct but over-broad because more specific SRC tyrosine kinase terms are present. |
| GO:0034446 substrate adhesion-dependent cell spreading | IDA PMID:11864995 Modulation of the F-actin cytoskeleton by c-Abl tyrosine kin... | KEEP AS NON CORE | Summary: substrate adhesion-dependent cell spreading pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0060491 regulation of cell projection assembly | IGI PMID:11864995 Modulation of the F-actin cytoskeleton by c-Abl tyrosine kin... | KEEP AS NON CORE | Summary: regulation of cell projection assembly pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0035556 intracellular signal transduction | IGI PMID:23526378 Targeted disruption of leucine-rich repeat kinase 1 but not ... | KEEP AS NON CORE | Summary: SRC intracellular signaling function Reason: This Lrrk1 osteoclast study supports Src pathway involvement, but intracellular signal transduction is broad relative to SRC tyrosine kinase activity. Supporting Evidence: PMID:23526378 Lrrk1 may function at least in part through modulating the c-Src signaling pathway. |
| GO:0036035 osteoclast development | IGI PMID:23526378 Targeted disruption of leucine-rich repeat kinase 1 but not ... | KEEP AS NON CORE | Summary: osteoclast development pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0018108 peptidyl-tyrosine phosphorylation | ISO PMID:22732588 Interchangeability of Themis1 and Themis2 in thymocyte devel... | UNDECIDED | Summary: PMID:22732588 supports tyrosine phosphorylation of Themis proteins after TCR engagement, but the cached text does not directly support Src as the kinase for this annotation. Reason: Full text or a direct Src-family kinase passage would be needed before accepting this ISO transfer as Src peptidyl-tyrosine phosphorylation evidence. |
| GO:0005515 protein binding | IPI PMID:11826110 Delphilin: a novel PDZ and formin homology domain-containing... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:8861907 Mena, a relative of VASP and Drosophila Enabled, is implicat... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:21525037 The guanine nucleotide exchange factor Arhgef5 plays crucial... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005886 plasma membrane | IDA PMID:21525037 The guanine nucleotide exchange factor Arhgef5 plays crucial... | ACCEPT | Summary: plasma membrane localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0071803 positive regulation of podosome assembly | IDA PMID:21525037 The guanine nucleotide exchange factor Arhgef5 plays crucial... | KEEP AS NON CORE | Summary: positive regulation of podosome assembly pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0071803 positive regulation of podosome assembly | IGI PMID:21525037 The guanine nucleotide exchange factor Arhgef5 plays crucial... | KEEP AS NON CORE | Summary: positive regulation of podosome assembly pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0005515 protein binding | IPI PMID:14600260 A caveolin-3 mutant that causes limb girdle muscular dystrop... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0005515 protein binding | IPI PMID:17000758 Ccpg1, a novel scaffold protein that regulates the activity ... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0046875 ephrin receptor binding | IPI PMID:12925710 EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and pro... | KEEP AS NON CORE | Summary: ephrin receptor binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0005515 protein binding | IPI PMID:14739300 Src kinase activity is essential for osteoclast function. | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0020037 heme binding | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: Generic heme binding annotation Reason: The term is too broad or peripheral to capture SRC function when more specific tyrosine kinase and signaling annotations are available. |
| GO:0045453 bone resorption | IMP PMID:14739300 Src kinase activity is essential for osteoclast function. | KEEP AS NON CORE | Summary: bone resorption pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0004672 protein kinase activity | IDA PMID:19920076 Dishevelled-2 docks and activates Src in a Wnt-dependent man... | MARK AS OVER ANNOTATED | Summary: protein kinase activity is less specific than SRC tyrosine kinase activity Reason: The annotation is directionally correct but over-broad because more specific SRC tyrosine kinase terms are present. |
| GO:0005515 protein binding | IPI PMID:19920076 Dishevelled-2 docks and activates Src in a Wnt-dependent man... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding does not identify a specific SRC substrate-recognition mode or catalytic activity and is less informative than SH2/SH3/domain-specific terms. |
| GO:0090263 positive regulation of canonical Wnt signaling pathway | IGI PMID:19920076 Dishevelled-2 docks and activates Src in a Wnt-dependent man... | KEEP AS NON CORE | Summary: positive regulation of canonical Wnt signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-1433273 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-3928622 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-418870 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-420382 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-5218834 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-8964229 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9680646 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9680706 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9682158 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9682182 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9682572 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9763891 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9763892 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9763903 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9764150 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9817994 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9818009 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-9700661 | ACCEPT | Summary: cytosol localization Reason: SRC is a soluble non-receptor kinase recruited to cytosolic, membrane, junctional, caveolar, and focal-adhesion signaling assemblies. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IMP PMID:17045821 CD44 is the signaling component of the macrophage migration ... | KEEP AS NON CORE | Summary: positive regulation of ERK1 and ERK2 cascade pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0033146 regulation of intracellular estrogen receptor signaling pathway | IMP PMID:16007215 c-Src-null mice exhibit defects in normal mammary gland deve... | KEEP AS NON CORE | Summary: regulation of intracellular estrogen receptor signaling pathway pathway context Reason: This regulatory term is a downstream or pathway-specific consequence of SRC signaling rather than SRC core molecular activity. |
| GO:0048477 oogenesis | IMP PMID:16007215 c-Src-null mice exhibit defects in normal mammary gland deve... | KEEP AS NON CORE | Summary: oogenesis pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0060065 uterus development | IMP PMID:16007215 c-Src-null mice exhibit defects in normal mammary gland deve... | KEEP AS NON CORE | Summary: uterus development pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0060444 branching involved in mammary gland duct morphogenesis | IMP PMID:16007215 c-Src-null mice exhibit defects in normal mammary gland deve... | KEEP AS NON CORE | Summary: branching involved in mammary gland duct morphogenesis pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0019904 protein domain specific binding | IPI PMID:8438166 Identification of a ten-amino acid proline-rich SH3 binding ... | KEEP AS NON CORE | Summary: protein domain specific binding supports SRC recruitment or substrate recognition Reason: This interaction is mechanistically relevant to SRC signaling but is accessory to the core tyrosine kinase activity. |
| GO:0006468 protein phosphorylation | IDA PMID:15937334 A role for mitogen-activated protein kinase(Erk1/2) activati... | UNDECIDED | Summary: PMID:15937334 supports chronological activation of Src-family tyrosine kinases in P2X7R-mediated thymocyte death, but does not identify Src specifically in the cached abstract. Reason: Full text would be needed to confirm this as a direct Src protein-phosphorylation annotation. |
| GO:0016477 cell migration | IMP PMID:15292044 Alterations in cell-adhesive and migratory properties of pro... | KEEP AS NON CORE | Summary: cell migration pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0018108 peptidyl-tyrosine phosphorylation | IDA PMID:12526740 Reelin activates SRC family tyrosine kinases in neurons. | ACCEPT | Summary: PMID:12526740 shows Reelin-dependent activation of Src-family non-receptor tyrosine kinases in neurons, with Dab1 tyrosine phosphorylation by SFKs. Reason: The current term is already the tyrosine-specific phosphorylation process supported by the Reelin/Src-family kinase study, so no replacement is needed. Supporting Evidence: PMID:12526740 Dab1 is tyrosine phosphorylated by SFKs |
| GO:0030900 forebrain development | IGI PMID:16162939 Absence of Fyn and Src causes a reeler-like phenotype. | KEEP AS NON CORE | Summary: forebrain development pathway context Reason: The annotation is compatible with SRC pathway biology but represents a context-specific process, location, or phenotype rather than the core kinase function. |
| GO:0016301 kinase activity | IMP PMID:12808090 Gab1 is an integrator of cell death versus cell survival sig... | MARK AS OVER ANNOTATED | Summary: kinase activity is less specific than SRC tyrosine kinase activity Reason: The annotation is directionally correct but over-broad because more specific SRC tyrosine kinase terms are present. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:14636584 Phosphorylation-dependent paxillin-ERK association mediates ... | ACCEPT | Summary: Core SRC non-receptor tyrosine kinase activity Reason: SRC is a non-receptor tyrosine kinase; tyrosine phosphorylation of protein substrates is its primary molecular activity. |
| GO:0004672 protein kinase activity | IDA PMID:11274221 Src and Pyk2 mediate G-protein-coupled receptor activation o... | MARK AS OVER ANNOTATED | Summary: protein kinase activity is less specific than SRC tyrosine kinase activity Reason: The annotation is directionally correct but over-broad because more specific SRC tyrosine kinase terms are present. |
| GO:0006468 protein phosphorylation | IDA PMID:11274221 Src and Pyk2 mediate G-protein-coupled receptor activation o... | ACCEPT | Summary: Direct SRC tyrosine phosphorylation activity Reason: This term directly describes the catalytic output of SRC kinase activity on protein tyrosine residues. |
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