Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005886 plasma membrane	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0030154 cell differentiation	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0007155 cell adhesion	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0007173 epidermal growth factor receptor signaling pathway	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0050847 progesterone receptor signaling pathway	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0005524 ATP binding	IEA GO_REF:0000002	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005743 mitochondrial inner membrane	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0005856 cytoskeleton	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0005925 focal adhesion	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0007155 cell adhesion	IEA GO_REF:0000117	PENDING	Summary: TODO: Review this GOA annotation
GO:0007276 gamete generation	IEA GO_REF:0000117	PENDING	Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression	IEA GO_REF:0000117	PENDING	Summary: TODO: Review this GOA annotation
GO:0036120 cellular response to platelet-derived growth factor stimulus	IEA GO_REF:0000117	PENDING	Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0070161 anchoring junction	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0070301 cellular response to hydrogen peroxide	IEA GO_REF:0000117	PENDING	Summary: TODO: Review this GOA annotation
GO:0070374 positive regulation of ERK1 and ERK2 cascade	IEA GO_REF:0000117	PENDING	Summary: TODO: Review this GOA annotation
GO:1903829 positive regulation of protein localization	IEA GO_REF:0000117	PENDING	Summary: TODO: Review this GOA annotation
GO:1904385 cellular response to angiotensin	IEA GO_REF:0000117	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:10220404 Identification of profilin and src homology 3 domains as bin...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:16267818 A proteomics strategy for the enrichment of receptor-associa...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:16298995 EphB receptors regulate dendritic spine morphogenesis throug...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:16407161 Role of Src in C3 transient receptor potential channel funct...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:16990796 PSD-95 is a negative regulator of the tyrosine kinase Src in...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:18289379 Dramatic inhibition of osteoclast sealing ring formation and...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:18560762 Mobility of TOAC spin-labelled peptides binding to the Src S...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:19122674 Deficiency of a beta-arrestin-2 signal complex contributes t...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:21199370 Roles of the SH2 and SH3 domains in the regulation of neuron...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:21266176 Linker length dependent binding of a focal adhesion kinase d...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:21282606 Nε-lysine acetylation determines dissociation from GAP junct...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:22439932 NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:28054552 c-Src phosphorylation and activation of hexokinase promotes ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:7518772 Phosphorylation of receptor protein-tyrosine phosphatase alp...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005178 integrin binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005764 lysosome	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005770 late endosome	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005901 caveola	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0005911 cell-cell junction	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0007179 transforming growth factor beta receptor signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0007229 integrin-mediated signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0010632 regulation of epithelial cell migration	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0010634 positive regulation of epithelial cell migration	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0016004 phospholipase activator activity	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0019899 enzyme binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0020037 heme binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0022407 regulation of cell-cell adhesion	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0030054 cell junction	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0031333 negative regulation of protein-containing complex assembly	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0034139 regulation of toll-like receptor 3 signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0034614 cellular response to reactive oxygen species	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0035306 positive regulation of dephosphorylation	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0035331 negative regulation of hippo signaling	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0042169 SH2 domain binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0043066 negative regulation of apoptotic process	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0043149 stress fiber assembly	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0043274 phospholipase binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0044325 transmembrane transporter binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0045747 positive regulation of Notch signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0046875 ephrin receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0048041 focal adhesion assembly	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0051057 positive regulation of small GTPase mediated signal transduction	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0051219 phosphoprotein binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0051902 negative regulation of mitochondrial depolarization	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0060576 intestinal epithelial cell development	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0070102 interleukin-6-mediated signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0070555 response to interleukin-1	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0070700 BMP receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0097110 scaffold protein binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:1902564 negative regulation of neutrophil activation	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:1904263 positive regulation of TORC1 signaling	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:2000394 positive regulation of lamellipodium morphogenesis	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:2000641 regulation of early endosome to late endosome transport	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:2000811 negative regulation of anoikis	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:2001286 regulation of caveolin-mediated endocytosis	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0001545 primary ovarian follicle growth	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0001819 positive regulation of cytokine production	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0004715 non-membrane spanning protein tyrosine kinase activity	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005178 integrin binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005743 mitochondrial inner membrane	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005764 lysosome	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005770 late endosome	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005901 caveola	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005911 cell-cell junction	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0007179 transforming growth factor beta receptor signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0007229 integrin-mediated signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0010629 negative regulation of gene expression	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0010632 regulation of epithelial cell migration	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0010634 positive regulation of epithelial cell migration	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0010907 positive regulation of glucose metabolic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0014911 positive regulation of smooth muscle cell migration	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0016004 phospholipase activator activity	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0019899 enzyme binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0020037 heme binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0022407 regulation of cell-cell adhesion	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0030054 cell junction	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0030335 positive regulation of cell migration	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0031333 negative regulation of protein-containing complex assembly	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0032205 negative regulation of telomere maintenance	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0034139 regulation of toll-like receptor 3 signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0034614 cellular response to reactive oxygen species	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0035306 positive regulation of dephosphorylation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0035331 negative regulation of hippo signaling	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0038083 peptidyl-tyrosine autophosphorylation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0042169 SH2 domain binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0042311 vasodilation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0043065 positive regulation of apoptotic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0043066 negative regulation of apoptotic process	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0043149 stress fiber assembly	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0043274 phospholipase binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0043406 positive regulation of MAP kinase activity	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0044325 transmembrane transporter binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0045056 transcytosis	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0045747 positive regulation of Notch signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0045780 positive regulation of bone resorption	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0045785 positive regulation of cell adhesion	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0045793 positive regulation of cell size	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0046579 positive regulation of Ras protein signal transduction	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0046628 positive regulation of insulin receptor signaling pathway	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0046875 ephrin receptor binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0048011 neurotrophin TRK receptor signaling pathway	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0048041 focal adhesion assembly	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0050839 cell adhesion molecule binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0050847 progesterone receptor signaling pathway	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0051057 positive regulation of small GTPase mediated signal transduction	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0051219 phosphoprotein binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0051222 positive regulation of protein transport	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0051895 negative regulation of focal adhesion assembly	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0051902 negative regulation of mitochondrial depolarization	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0060576 intestinal epithelial cell development	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0070102 interleukin-6-mediated signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0070555 response to interleukin-1	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0070700 BMP receptor binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0097110 scaffold protein binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:1902564 negative regulation of neutrophil activation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:1904263 positive regulation of TORC1 signaling	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:2000394 positive regulation of lamellipodium morphogenesis	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:2000641 regulation of early endosome to late endosome transport	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:2000811 negative regulation of anoikis	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:2001286 regulation of caveolin-mediated endocytosis	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0030331 nuclear estrogen receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0030546 signaling receptor activator activity	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0035255 ionotropic glutamate receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0044325 transmembrane transporter binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005080 protein kinase C binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005158 insulin receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005901 caveola	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0016020 membrane	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0016579 protein deubiquitination	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0019899 enzyme binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0030424 axon	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0031669 cellular response to nutrient levels	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0034138 toll-like receptor 3 signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0038202 TORC1 signaling	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0043025 neuronal cell body	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0044294 dendritic growth cone	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0044877 protein-containing complex binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0070374 positive regulation of ERK1 and ERK2 cascade	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0071393 cellular response to progesterone stimulus	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0071897 DNA biosynthetic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0090303 positive regulation of wound healing	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0097060 synaptic membrane	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0098978 glutamatergic synapse	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0098984 neuron to neuron synapse	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0099073 mitochondrion-derived vesicle	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0099091 postsynaptic specialization, intracellular component	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1902533 positive regulation of intracellular signal transduction	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1902737 dendritic filopodium	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1904262 negative regulation of TORC1 signaling	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:2000179 positive regulation of neural precursor cell proliferation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:2000256 positive regulation of male germ cell proliferation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:2000386 positive regulation of ovarian follicle development	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:18044967 Laminin-induced activation of Rac1 and JNKp46 is initiated b...	PENDING	Summary: TODO: Review this GOA annotation
GO:0035022 positive regulation of Rac protein signal transduction	IMP PMID:18044967 Laminin-induced activation of Rac1 and JNKp46 is initiated b...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:25043309 Actin filament-associated protein 1 is required for cSrc act...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	IDA PMID:25043309 Actin filament-associated protein 1 is required for cSrc act...	PENDING	Summary: TODO: Review this GOA annotation
GO:0007595 lactation	IDA PMID:25043309 Actin filament-associated protein 1 is required for cSrc act...	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	IMP PMID:12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Ph...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	EXP PMID:22759635 A Src family kinase-Shp2 axis controls RUNX1 activity in meg...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-3928622	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-418870	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-420382	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-9011252	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-9763891	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-NUL-9726861	PENDING	Summary: TODO: Review this GOA annotation
GO:0005911 cell-cell junction	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0038166 angiotensin-activated signaling pathway	IGI PMID:25017399 Caveolin-1 modulates cardiac gap junction homeostasis and ar...	PENDING	Summary: TODO: Review this GOA annotation
GO:0086091 regulation of heart rate by cardiac conduction	IGI PMID:25017399 Caveolin-1 modulates cardiac gap junction homeostasis and ar...	PENDING	Summary: TODO: Review this GOA annotation
GO:0045821 positive regulation of glycolytic process	IDA PMID:35263589 Nociceptor-derived Reg3γ prevents endotoxic death by targeti...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IMP PMID:27505886 Tensin 3 is a new partner of Dock5 that controls osteoclast ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IMP PMID:27505886 Tensin 3 is a new partner of Dock5 that controls osteoclast ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0045747 positive regulation of Notch signaling pathway	IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege...	PENDING	Summary: TODO: Review this GOA annotation
GO:0060576 intestinal epithelial cell development	IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege...	PENDING	Summary: TODO: Review this GOA annotation
GO:0070102 interleukin-6-mediated signaling pathway	IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:11274221 Src and Pyk2 mediate G-protein-coupled receptor activation o...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005743 mitochondrial inner membrane	IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste...	PENDING	Summary: TODO: Review this GOA annotation
GO:0030054 cell junction	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0005925 focal adhesion	IMP PMID:22801373 Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:8910389 Bombesin, bradykinin, vasopressin, and phorbol esters rapidl...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion	IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005856 cytoskeleton	IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste...	PENDING	Summary: TODO: Review this GOA annotation
GO:0016020 membrane	IMP PMID:22801373 Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:18691334 Palmitoylation-dependent endosomal localization of AATYK1A a...	PENDING	Summary: TODO: Review this GOA annotation
GO:0045453 bone resorption	IMP PMID:19448635 Impaired gastric acidification negatively affects calcium ho...	PENDING	Summary: TODO: Review this GOA annotation
GO:0042476 odontogenesis	IMP PMID:23174213 Osteopetrosis, osteopetrorickets and hypophosphatemic ricket...	PENDING	Summary: TODO: Review this GOA annotation
GO:0070301 cellular response to hydrogen peroxide	IMP PMID:23651497 A signaling cascade mediated by ceramide, src and PDGFRβ coo...	PENDING	Summary: TODO: Review this GOA annotation
GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP PMID:23651497 A signaling cascade mediated by ceramide, src and PDGFRβ coo...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	IDA PMID:27994061 Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Pr...	PENDING	Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation	IDA PMID:27994061 Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Pr...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	TAS Reactome:R-MMU-9011252	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	TAS Reactome:R-NUL-9726861	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-NUL-9700655	PENDING	Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm	IDA PMID:14699011 Regulation of connexin43 protein complexes by intracellular ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071253 connexin binding	IPI PMID:14699011 Regulation of connexin43 protein complexes by intracellular ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm	TAS Reactome:R-MMU-8937703	PENDING	Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm	TAS Reactome:R-MMU-8937738	PENDING	Summary: TODO: Review this GOA annotation
GO:0002102 podosome	IDA PMID:17893324 Src-dependent phosphorylation of ASAP1 regulates podosomes.	PENDING	Summary: TODO: Review this GOA annotation
GO:0010954 positive regulation of protein processing	IGI PMID:17344476 The transcriptional repressor Glis2 is a novel binding partn...	PENDING	Summary: TODO: Review this GOA annotation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation	IGI PMID:17344476 The transcriptional repressor Glis2 is a novel binding partn...	PENDING	Summary: TODO: Review this GOA annotation
GO:1900182 positive regulation of protein localization to nucleus	IGI PMID:17344476 The transcriptional repressor Glis2 is a novel binding partn...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:20847314 CXCR4-mediated bone marrow progenitor cell maintenance and m...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071803 positive regulation of podosome assembly	IDA PMID:24127566 Phosphorylation of moesin by Jun N-terminal kinase is import...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	IDA PMID:24190966 A reactive oxygen species-mediated, self-perpetuating loop p...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:24190966 A reactive oxygen species-mediated, self-perpetuating loop p...	PENDING	Summary: TODO: Review this GOA annotation
GO:0034614 cellular response to reactive oxygen species	IDA PMID:24190966 A reactive oxygen species-mediated, self-perpetuating loop p...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:24841674 Mechanical loading in osteocytes induces formation of a Src/...	PENDING	Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm	IDA PMID:24841674 Mechanical loading in osteocytes induces formation of a Src/...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071498 cellular response to fluid shear stress	IMP PMID:24841674 Mechanical loading in osteocytes induces formation of a Src/...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IMP PMID:12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Ph...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005901 caveola	IDA PMID:12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Ph...	PENDING	Summary: TODO: Review this GOA annotation
GO:0097110 scaffold protein binding	IPI PMID:12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Ph...	PENDING	Summary: TODO: Review this GOA annotation
GO:0031648 protein destabilization	IMP PMID:25259869 Genetic disruption of the sh3pxd2a gene reveals an essential...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071375 cellular response to peptide hormone stimulus	IGI PMID:25017399 Caveolin-1 modulates cardiac gap junction homeostasis and ar...	PENDING	Summary: TODO: Review this GOA annotation
GO:0097110 scaffold protein binding	IPI PMID:25017399 Caveolin-1 modulates cardiac gap junction homeostasis and ar...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071560 cellular response to transforming growth factor beta stimulus	IGI PMID:21829547 Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005884 actin filament	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	PENDING	Summary: TODO: Review this GOA annotation
GO:0032587 ruffle membrane	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	PENDING	Summary: TODO: Review this GOA annotation
GO:0036120 cellular response to platelet-derived growth factor stimulus	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	PENDING	Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	IMP PMID:23100514 Abl family kinases regulate FcγR-mediated phagocytosis in mu...	PENDING	Summary: TODO: Review this GOA annotation
GO:0034446 substrate adhesion-dependent cell spreading	IDA PMID:11864995 Modulation of the F-actin cytoskeleton by c-Abl tyrosine kin...	PENDING	Summary: TODO: Review this GOA annotation
GO:0060491 regulation of cell projection assembly	IGI PMID:11864995 Modulation of the F-actin cytoskeleton by c-Abl tyrosine kin...	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	IGI PMID:23526378 Targeted disruption of leucine-rich repeat kinase 1 but not ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0036035 osteoclast development	IGI PMID:23526378 Targeted disruption of leucine-rich repeat kinase 1 but not ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	ISO PMID:22732588 Interchangeability of Themis1 and Themis2 in thymocyte devel...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:11826110 Delphilin: a novel PDZ and formin homology domain-containing...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:8861907 Mena, a relative of VASP and Drosophila Enabled, is implicat...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:21525037 The guanine nucleotide exchange factor Arhgef5 plays crucial...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	IDA PMID:21525037 The guanine nucleotide exchange factor Arhgef5 plays crucial...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071803 positive regulation of podosome assembly	IDA PMID:21525037 The guanine nucleotide exchange factor Arhgef5 plays crucial...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071803 positive regulation of podosome assembly	IGI PMID:21525037 The guanine nucleotide exchange factor Arhgef5 plays crucial...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:14600260 A caveolin-3 mutant that causes limb girdle muscular dystrop...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:17000758 Ccpg1, a novel scaffold protein that regulates the activity ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0046875 ephrin receptor binding	IPI PMID:12925710 EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and pro...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:14739300 Src kinase activity is essential for osteoclast function.	PENDING	Summary: TODO: Review this GOA annotation
GO:0020037 heme binding	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0045453 bone resorption	IMP PMID:14739300 Src kinase activity is essential for osteoclast function.	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	IDA PMID:19920076 Dishevelled-2 docks and activates Src in a Wnt-dependent man...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:19920076 Dishevelled-2 docks and activates Src in a Wnt-dependent man...	PENDING	Summary: TODO: Review this GOA annotation
GO:0090263 positive regulation of canonical Wnt signaling pathway	IGI PMID:19920076 Dishevelled-2 docks and activates Src in a Wnt-dependent man...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-1433273	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-3928622	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-418870	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-420382	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-5218834	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-8964229	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9680646	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9680706	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9682158	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9682182	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9682572	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9763891	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9763892	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9763903	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9764150	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9817994	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9818009	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-NUL-9700661	PENDING	Summary: TODO: Review this GOA annotation
GO:0070374 positive regulation of ERK1 and ERK2 cascade	IMP PMID:17045821 CD44 is the signaling component of the macrophage migration ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0033146 regulation of intracellular estrogen receptor signaling pathway	IMP PMID:16007215 c-Src-null mice exhibit defects in normal mammary gland deve...	PENDING	Summary: TODO: Review this GOA annotation
GO:0048477 oogenesis	IMP PMID:16007215 c-Src-null mice exhibit defects in normal mammary gland deve...	PENDING	Summary: TODO: Review this GOA annotation
GO:0060065 uterus development	IMP PMID:16007215 c-Src-null mice exhibit defects in normal mammary gland deve...	PENDING	Summary: TODO: Review this GOA annotation
GO:0060444 branching involved in mammary gland duct morphogenesis	IMP PMID:16007215 c-Src-null mice exhibit defects in normal mammary gland deve...	PENDING	Summary: TODO: Review this GOA annotation
GO:0019904 protein domain specific binding	IPI PMID:8438166 Identification of a ten-amino acid proline-rich SH3 binding ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation	IDA PMID:15937334 A role for mitogen-activated protein kinase(Erk1/2) activati...	PENDING	Summary: TODO: Review this GOA annotation
GO:0016477 cell migration	IMP PMID:15292044 Alterations in cell-adhesive and migratory properties of pro...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:12526740 Reelin activates SRC family tyrosine kinases in neurons.	PENDING	Summary: TODO: Review this GOA annotation
GO:0030900 forebrain development	IGI PMID:16162939 Absence of Fyn and Src causes a reeler-like phenotype.	PENDING	Summary: TODO: Review this GOA annotation
GO:0016301 kinase activity	IMP PMID:12808090 Gab1 is an integrator of cell death versus cell survival sig...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IMP PMID:14636584 Phosphorylation-dependent paxillin-ERK association mediates ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	IDA PMID:11274221 Src and Pyk2 mediate G-protein-coupled receptor activation o...	PENDING	Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation	IDA PMID:11274221 Src and Pyk2 mediate G-protein-coupled receptor activation o...	PENDING	Summary: TODO: Review this GOA annotation

References

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000096

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000119

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10220404

Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled.

PMID:11274221

Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade.

PMID:11826110

Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit.

PMID:11864995

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension.

PMID:12091389

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

PMID:12526740

Reelin activates SRC family tyrosine kinases in neurons.

PMID:12615910

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.

PMID:12808090

Gab1 is an integrator of cell death versus cell survival signals in oxidative stress.

PMID:12925710

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PMID:14600260

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes.

PMID:14636584

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.

PMID:14699011

Regulation of connexin43 protein complexes by intracellular acidification.

PMID:14739300

Src kinase activity is essential for osteoclast function.

PMID:15292044

Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice.

PMID:15937334

A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death.

PMID:16007215

c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling.

PMID:16162939

Absence of Fyn and Src causes a reeler-like phenotype.

PMID:16267818

A proteomics strategy for the enrichment of receptor-associated complexes.

PMID:16298995

EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.

PMID:16407161

Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels.

PMID:16990796

PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex.

PMID:17000758

Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.

PMID:17045821

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.

PMID:17344476

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin.

PMID:17623777

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.

PMID:17893324

Src-dependent phosphorylation of ASAP1 regulates podosomes.

PMID:18044967

Laminin-induced activation of Rac1 and JNKp46 is initiated by Src family kinases and mimics the effects of skeletal muscle contraction.

PMID:18289379

Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid.

PMID:18560762

Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR.

PMID:18691334

Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src.

PMID:19122674

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

PMID:19448635

Impaired gastric acidification negatively affects calcium homeostasis and bone mass.

PMID:19920076

Dishevelled-2 docks and activates Src in a Wnt-dependent manner.

PMID:20847314

CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity.

PMID:21199370

Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions.

PMID:21266176

Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains.

PMID:21282606

Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.

PMID:21525037

The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.

PMID:21829547

Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.

PMID:22439932

NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.

PMID:22732588

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

PMID:22759635

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.

PMID:22801373

Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.

PMID:23100514

Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.

PMID:23174213

Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization.

PMID:23526378

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

PMID:23651497

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

PMID:24127566

Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts.

PMID:24190966

A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α.

PMID:24841674

Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression.

PMID:25017399

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase.

PMID:25043309

Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland.

PMID:25259869

Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.

PMID:25731159

A gp130-Src-YAP module links inflammation to epithelial regeneration.

PMID:27505886

Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.

PMID:27994061

Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth.

PMID:28054552

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.

PMID:35263589

Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.

PMID:7518772

Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.

PMID:8438166

Identification of a ten-amino acid proline-rich SH3 binding site.

PMID:8861907

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.

PMID:8910389

Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase.

Reactome:R-MMU-1433273

Interaction of Src kinases with c-Kit

Reactome:R-MMU-3928622

SFKs phosphorylate Git1

Reactome:R-MMU-418870

Phosphorylation of Unc5C

Reactome:R-MMU-420382

Phosphorylation of FAK by Src kinases

Reactome:R-MMU-5218834

Fak/Src phosphorylate p130Cas

Reactome:R-MMU-8937703

Runx1 binds Src

Reactome:R-MMU-8937738

Src phosphorylates Runx1

Reactome:R-MMU-8964229

G alpha (i):GTP binds Src

Reactome:R-MMU-9011252

Src phosphorylates Robo3.1 in response to Ntn1

Reactome:R-MMU-9680646

Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated

Reactome:R-MMU-9680706

Csf1r trans-autophosphorylates on multiple tyrosine residues

Reactome:R-MMU-9682158

Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

Reactome:R-MMU-9682182

Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate

Reactome:R-MMU-9682572

Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras

Reactome:R-MMU-9763891

Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl

Reactome:R-MMU-9763892

p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12

Reactome:R-MMU-9763903

Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1

Reactome:R-MMU-9764150

Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1

Reactome:R-MMU-9817994

Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl

Reactome:R-MMU-9818009

Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1

Reactome:R-NUL-9700655

Active ALK phosphorylates Src

Reactome:R-NUL-9700661

Active ALK binds Src

Reactome:R-NUL-9726861

Src phosphorylates RHOU

📚 Additional Documentation

Deep Research Bioreason

(Src-deep-research-bioreason.md)

BioReason Chat Export

Exported on March 22, 2026 at 01:27 AM

Organism: Mus musculus

Sequence:

MGSNKSKPKDASQRRRSLEPSENVHGAGGAFPASQTPSKPASADGHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

Thinking Trace

I begin by dissecting the InterPro domain architecture and its order along the sequence. The N-terminal third contains IPR036028 (SH3-like domain superfamily, residues 63–155) with a well-defined IPR001452 SH3 domain core from residues 83–144. Immediately downstream lies IPR036860 (SH2 domain superfamily, residues 140–289) and a precise IPR000980 SH2 domain from residues 148–247. This tandem SH3–SH2 arrangement is a hallmark of non-receptor tyrosine kinases that couple modular recognition of proline-rich ligands (via SH3) and phosphotyrosine motifs (via SH2) to regulate catalytic output. The C-terminal half is dominated by the kinase engine: IPR011009 (Protein kinase-like domain superfamily, residues 258–528) houses the bilobal catalytic core that is specifically annotated as a tyrosine kinase by IPR020635 (Tyrosine-protein kinase, catalytic domain, residues 269–518), IPR000719 (Protein kinase domain, residues 269–522), and IPR001245 (Serine-threonine/tyrosine-protein kinase, catalytic domain, residues 270–517). Within this core, IPR017441 marks the ATP-binding site (residues 275–297), and IPR008266 annotates the tyrosine-kinase active site (residues 384–396). The overall family classification IPR050198 (Non-receptor tyrosine kinases involved in cell signaling, residues 89–530) ties these modules together into a cytosolic signaling enzyme. The linear architecture—N-terminal SH3 followed by SH2 and then the C-terminal catalytic domain—creates a regulated switch: SH3/SH2 dictate docking and allosteric control, while the kinase core executes phosphorylation.

This modular layout dictates molecular function. The ATP-binding pocket (IPR017441) and active-site signature (IPR008266) specify phosphotransfer chemistry on tyrosine residues, establishing protein tyrosine kinase activity and ATP binding as core activities. The SH3 and SH2 domains cause high-affinity, context-dependent assembly with proline-rich and phosphotyrosine-containing partners, thereby gating catalytic access and substrate selection. Thus, the primary molecular functions are protein tyrosine kinase activity and ATP binding.

From function to process, tyrosine phosphorylation cascades propagate and modulate intracellular pathways. The presence of a non-receptor tyrosine kinase core (IPR050198) and the SH3–SH2 regulatory modules couple extracellular and intracellular cues to phosphorylation-dependent signaling hubs. This architecture drives intracellular signal transduction and supports cell survival and division programs; therefore, it feeds into broader cell signaling and cell proliferation pathways.

Cellular location follows from the absence of transmembrane segments and the canonical behavior of non-receptor tyrosine kinases. The SH3–SH2–kinase assembly is soluble and recruited to membranes and cytoskeletal scaffolds via domain-mediated interactions, but its basal compartment is the cytoplasm. This is consistent with a cytoplasmic localization where signaling complexes assemble and remodel.

Mechanistically, the SH3 domain (IPR001452, residues 83–144) binds proline-rich segments to position the enzyme near actin and adaptor scaffolds; the SH2 domain (IPR000980, residues 148–247) recognizes phosphotyrosine motifs on activated receptors or adaptors, stabilizing the active conformation of the catalytic core. The catalytic region (IPR020635/IPR000719/IPR001245; residues ~269–522) then transfers phosphate from ATP to tyrosine residues on local substrates, amplifying downstream signaling. I hypothesize that this kinase transiently assembles with cytoplasmic adaptors and actin-associated complexes, tuning phosphorylation flux that supports survival and proliferation signals emanating from growth factor and integrin pathways.

Functional Summary

A cytoplasmic non-receptor tyrosine kinase that uses an SH3–SH2–kinase architecture to assemble with proline-rich and phosphotyrosine-containing partners and phosphorylate tyrosine residues on nearby substrates. By coupling modular docking to catalysis, it propagates intracellular signaling pathways that promote survival and cell division. Its soluble nature and scaffold-directed recruitment position it within cytoplasmic signaling assemblies where ATP-fueled phosphorylation drives downstream pathway activation.

UniProt Summary

Tyrosine-protein kinase involved in the homing and function of B-cells and the regulation of cell survival and cell division.

InterPro Domains

SH3-like domain superfamily (IPR036028, homologous_superfamily) — residues 63-155
SH3 domain (IPR001452, domain) — residues 83-144
Non-receptor tyrosine kinases involved in cell signaling (IPR050198, family) — residues 89-530
SH2 domain superfamily (IPR036860, homologous_superfamily) — residues 140-289
SH2 domain (IPR000980, domain) — residues 148-247
Protein kinase-like domain superfamily (IPR011009, homologous_superfamily) — residues 258-528
Tyrosine-protein kinase, catalytic domain (IPR020635, domain) — residues 269-518
Protein kinase domain (IPR000719, domain) — residues 269-522
Serine-threonine/tyrosine-protein kinase, catalytic domain (IPR001245, domain) — residues 270-517
Protein kinase, ATP binding site (IPR017441, binding_site) — residues 275-297
Tyrosine-protein kinase, active site (IPR008266, active_site) — residues 384-396

GO Terms

Molecular Function: molecular_function (GO:0003674), binding (GO:0005488), catalytic activity (GO:0003824), transferase activity (GO:0016740), catalytic activity, acting on a protein (GO:0140096), protein binding (GO:0005515), signaling receptor binding (GO:0005102), transferase activity, transferring phosphorus-containing groups (GO:0016772), protein kinase activity (GO:0004672), scaffold protein binding (GO:0097110), protein domain specific binding (GO:0019904), ephrin receptor binding (GO:0046875), kinase activity (GO:0016301), phosphotransferase activity, alcohol group as acceptor (GO:0016773), protein tyrosine kinase activity (GO:0004713)

Biological Process: biological_process (GO:0008150), positive regulation of biological process (GO:0048518), regulation of biological process (GO:0050789), signaling (GO:0023052), reproduction (GO:0000003), multicellular organismal process (GO:0032501), biological regulation (GO:0065007), response to stimulus (GO:0050896), developmental process (GO:0032502), cellular process (GO:0009987), metabolic process (GO:0008152), reproductive process (GO:0022414), homeostatic process (GO:0042592), sexual reproduction (GO:0019953), anatomical structure development (GO:0048856), anatomical structure morphogenesis (GO:0009653), response to chemical (GO:0042221), cell motility (GO:0048870), nitrogen compound metabolic process (GO:0006807), multicellular organism reproduction (GO:0032504), developmental process involved in reproduction (GO:0003006), multicellular organismal-level homeostasis (GO:0048871), regulation of biological quality (GO:0065008), cellular process involved in reproduction in multicellular organism (GO:0022412), response to endogenous stimulus (GO:0009719), regulation of cellular process (GO:0050794), regulation of response to stimulus (GO:0048583), cellular response to stimulus (GO:0051716), regulation of signaling (GO:0023051), signal transduction (GO:0007165), cellular developmental process (GO:0048869), positive regulation of signaling (GO:0023056), multicellular organism development (GO:0007275), positive regulation of response to stimulus (GO:0048584), regulation of metabolic process (GO:0019222), cell adhesion (GO:0007155), regulation of localization (GO:0032879), tissue remodeling (GO:0048771), organic substance metabolic process (GO:0071704), system process (GO:0003008), cellular metabolic process (GO:0044237), positive regulation of metabolic process (GO:0009893), regulation of molecular function (GO:0065009), response to stress (GO:0006950), morphogenesis of a branching structure (GO:0001763), multicellular organismal reproductive process (GO:0048609), cell communication (GO:0007154), primary metabolic process (GO:0044238), positive regulation of cellular process (GO:0048522), tissue morphogenesis (GO:0048729), cell development (GO:0048468), cell differentiation (GO:0030154), response to fluid shear stress (GO:0034405), system development (GO:0048731), animal organ development (GO:0048513), response to growth factor (GO:0070848), regulation of signal transduction (GO:0009966), cellular response to endogenous stimulus (GO:0071495), regulation of macromolecule metabolic process (GO:0060255), reproductive structure development (GO:0048608), regulation of binding (GO:0051098), positive regulation of cellular component biogenesis (GO:0044089), circulatory system process (GO:0003013), response to hormone (GO:0009725), regulation of cellular component biogenesis (GO:0044087), phosphorus metabolic process (GO:0006793), tube development (GO:0035295), response to inorganic substance (GO:0010035), animal organ morphogenesis (GO:0009887), forebrain development (GO:0030900), G protein-coupled receptor signaling pathway (GO:0007186), regulation of nitrogen compound metabolic process (GO:0051171), cell surface receptor signaling pathway (GO:0007166), regulation of cellular component organization (GO:0051128), cell-substrate adhesion (GO:0031589), cell migration (GO:0016477), positive regulation of nitrogen compound metabolic process (GO:0051173), tube morphogenesis (GO:0035239), positive regulation of signal transduction (GO:0009967), gamete generation (GO:0007276), germ cell development (GO:0007281), positive regulation of protein localization (GO:1903829), organonitrogen compound metabolic process (GO:1901564), intracellular signal transduction (GO:0035556), positive regulation of macromolecule metabolic process (GO:0010604), response to oxidative stress (GO:0006979), regulation of cellular localization (GO:0060341), protein metabolic process (GO:0019538), morphogenesis of a branching epithelium (GO:0061138), response to oxygen-containing compound (GO:1901700), positive regulation of cellular component organization (GO:0051130), regulation of protein stability (GO:0031647), macromolecule metabolic process (GO:0043170), response to organic substance (GO:0010033), anatomical structure homeostasis (GO:0060249), tissue development (GO:0009888), response to nitrogen compound (GO:1901698), regulation of cell communication (GO:0010646), positive regulation of cellular metabolic process (GO:0031325), head development (GO:0060322), cellular response to chemical stimulus (GO:0070887), cellular response to stress (GO:0033554), bone remodeling (GO:0046849), positive regulation of cell communication (GO:0010647), regulation of cellular metabolic process (GO:0031323), tissue homeostasis (GO:0001894), regulation of primary metabolic process (GO:0080090), regulation of intracellular steroid hormone receptor signaling pathway (GO:0033143), cellular response to oxidative stress (GO:0034599), response to peptide (GO:1901652), epithelial tube morphogenesis (GO:0060562), regulation of protein-containing complex assembly (GO:0043254), digestive system development (GO:0055123), regulation of protein metabolic process (GO:0051246), regulation of Notch signaling pathway (GO:0008593), odontogenesis (GO:0042476), gland development (GO:0048732), bone resorption (GO:0045453), morphogenesis of an epithelium (GO:0002009), regulation of protein binding (GO:0043393), hemopoiesis (GO:0030097), regulation of cell projection assembly (GO:0060491), regulation of gene expression (GO:0010468), substrate adhesion-dependent cell spreading (GO:0034446), branching morphogenesis of an epithelial tube (GO:0048754), brain development (GO:0007420), macromolecule modification (GO:0043412), nervous system development (GO:0007399), female gamete generation (GO:0007292), epithelial cell development (GO:0002064), skeletal system development (GO:0001501), positive regulation of organelle assembly (GO:1902117), heart process (GO:0003015), central nervous system development (GO:0007417), positive regulation of intracellular signal transduction (GO:1902533), cellular response to fluid shear stress (GO:0071498), positive regulation of protein localization to nucleus (GO:1900182), cellular response to oxygen-containing compound (GO:1901701), cytokine-mediated signaling pathway (GO:0019221), response to platelet-derived growth factor (GO:0036119), positive regulation of Notch signaling pathway (GO:0045747), cellular response to organonitrogen compound (GO:0071417), response to transforming growth factor beta (GO:0071559), reproductive system development (GO:0061458), response to cytokine (GO:0034097), positive regulation of phosphorus metabolic process (GO:0010562), leukocyte differentiation (GO:0002521), regulation of cell projection organization (GO:0031344), cellular response to organic substance (GO:0071310), bone cell development (GO:0098751), cellular response to chemical stress (GO:0062197), oogenesis (GO:0048477), cellular response to nitrogen compound (GO:1901699), positive regulation of gene expression (GO:0010628), phosphate-containing compound metabolic process (GO:0006796), regulation of Wnt signaling pathway (GO:0030111), regulation of protein localization (GO:0032880), positive regulation of Wnt signaling pathway (GO:0030177), myeloid cell differentiation (GO:0030099), regulation of organelle assembly (GO:1902115), epithelial cell differentiation (GO:0030855), protein modification process (GO:0036211), response to peptide hormone (GO:0043434), regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640), cellular response to hormone stimulus (GO:0032870), bone development (GO:0060348), response to organonitrogen compound (GO:0010243), uterus development (GO:0060065), positive regulation of protein metabolic process (GO:0051247), regulation of organelle organization (GO:0033043), response to hydrogen peroxide (GO:0042542), epithelium development (GO:0060429), protein destabilization (GO:0031648), positive regulation of organelle organization (GO:0010638), gland morphogenesis (GO:0022612), digestive tract development (GO:0048565), response to reactive oxygen species (GO:0000302), cellular response to growth factor stimulus (GO:0071363), regulation of phosphorus metabolic process (GO:0051174), regulation of intracellular signal transduction (GO:1902531), positive regulation of protein-containing complex assembly (GO:0031334), mammary gland development (GO:0030879), myeloid cell development (GO:0061515), cellular response to platelet-derived growth factor stimulus (GO:0036120), intestinal epithelial cell differentiation (GO:0060575), branching involved in mammary gland duct morphogenesis (GO:0060444), regulation of proteolysis (GO:0030162), columnar/cuboidal epithelial cell development (GO:0002066), positive regulation of phosphate metabolic process (GO:0045937), peptidyl-amino acid modification (GO:0018193), cellular response to cytokine stimulus (GO:0071345), phosphorylation (GO:0016310), mammary gland morphogenesis (GO:0060443), positive regulation of MAPK cascade (GO:0043410), myeloid leukocyte differentiation (GO:0002573), cellular response to reactive oxygen species (GO:0034614), regulation of protein localization to nucleus (GO:1900180), regulation of protein maturation (GO:1903317), regulation of canonical Wnt signaling pathway (GO:0060828), positive regulation of protein modification process (GO:0031401), mammary gland epithelium development (GO:0061180), regulation of MAPK cascade (GO:0043408), cellular response to transforming growth factor beta stimulus (GO:0071560), regulation of intracellular estrogen receptor signaling pathway (GO:0033146), regulation of protein modification process (GO:0031399), cellular response to peptide hormone stimulus (GO:0071375), protein phosphorylation (GO:0006468), interleukin-6-mediated signaling pathway (GO:0070102), columnar/cuboidal epithelial cell differentiation (GO:0002065), regulation of phosphate metabolic process (GO:0019220), mammary gland duct morphogenesis (GO:0060603), response to interleukin-6 (GO:0070741), cellular response to peptide (GO:1901653), positive regulation of proteolysis (GO:0045862), response to angiotensin (GO:1990776), cellular response to hydrogen peroxide (GO:0070301), positive regulation of protein maturation (GO:1903319), positive regulation of canonical Wnt signaling pathway (GO:0090263), regulation of protein phosphorylation (GO:0001932), positive regulation of ERK1 and ERK2 cascade (GO:0070374), osteoclast differentiation (GO:0030316), cellular response to angiotensin (GO:1904385), positive regulation of phosphorylation (GO:0042327), positive regulation of protein phosphorylation (GO:0001934), regulation of ERK1 and ERK2 cascade (GO:0070372), peptidyl-tyrosine modification (GO:0018212), regulation of phosphorylation (GO:0042325), peptidyl-tyrosine phosphorylation (GO:0018108), intestinal epithelial cell development (GO:0060576), positive regulation of protein processing (GO:0010954), regulation of protein processing (GO:0070613), cellular response to interleukin-6 (GO:0071354), regulation of peptidyl-tyrosine phosphorylation (GO:0050730), positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)

Cellular Component: cellular_component (GO:0005575), cellular anatomical entity (GO:0110165), intracellular anatomical structure (GO:0005622), organelle (GO:0043226), cell projection (GO:0042995), membrane (GO:0016020), cytosol (GO:0005829), perinuclear region of cytoplasm (GO:0048471), cell periphery (GO:0071944), cell junction (GO:0030054), cell leading edge (GO:0031252), leading edge membrane (GO:0031256), envelope (GO:0031975), cytoplasm (GO:0005737), membrane-enclosed lumen (GO:0031974), nucleoplasm (GO:0005654), supramolecular complex (GO:0099080), organelle membrane (GO:0031090), organelle envelope (GO:0031967), plasma membrane bounded cell projection (GO:0120025), intracellular organelle (GO:0043229), ruffle (GO:0001726), non-membrane-bounded organelle (GO:0043228), supramolecular polymer (GO:0099081), mitochondrion (GO:0005739), plasma membrane region (GO:0098590), organelle lumen (GO:0043233), membrane microdomain (GO:0098857), ruffle membrane (GO:0032587), anchoring junction (GO:0070161), membrane-bounded organelle (GO:0043227), plasma membrane (GO:0005886), cell-substrate junction (GO:0030055), membrane raft (GO:0045121), cell projection membrane (GO:0031253), mitochondrial envelope (GO:0005740), intracellular membrane-bounded organelle (GO:0043231), intracellular non-membrane-bounded organelle (GO:0043232), organelle inner membrane (GO:0019866), supramolecular fiber (GO:0099512), plasma membrane raft (GO:0044853), intracellular organelle lumen (GO:0070013), mitochondrial membrane (GO:0031966), podosome (GO:0002102), focal adhesion (GO:0005925), polymeric cytoskeletal fiber (GO:0099513), caveola (GO:0005901), mitochondrial inner membrane (GO:0005743), nucleus (GO:0005634), cytoskeleton (GO:0005856), nuclear lumen (GO:0031981), actin cytoskeleton (GO:0015629), actin filament (GO:0005884)

Generated by BioReason

Deep Research Bioreason Rl

(Src-deep-research-bioreason-rl.md)

BioReason Chat Export

Exported on March 22, 2026 at 01:27 AM

Organism: Mus musculus

Sequence:

MGSNKSKPKDASQRRRSLEPSENVHGAGGAFPASQTPSKPASADGHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

Thinking Trace

Functional Summary

UniProt Summary

Tyrosine-protein kinase involved in the homing and function of B-cells and the regulation of cell survival and cell division.

InterPro Domains

SH3-like domain superfamily (IPR036028, homologous_superfamily) — residues 63-155
SH3 domain (IPR001452, domain) — residues 83-144
Non-receptor tyrosine kinases involved in cell signaling (IPR050198, family) — residues 89-530
SH2 domain superfamily (IPR036860, homologous_superfamily) — residues 140-289
SH2 domain (IPR000980, domain) — residues 148-247
Protein kinase-like domain superfamily (IPR011009, homologous_superfamily) — residues 258-528
Tyrosine-protein kinase, catalytic domain (IPR020635, domain) — residues 269-518
Protein kinase domain (IPR000719, domain) — residues 269-522
Serine-threonine/tyrosine-protein kinase, catalytic domain (IPR001245, domain) — residues 270-517
Protein kinase, ATP binding site (IPR017441, binding_site) — residues 275-297
Tyrosine-protein kinase, active site (IPR008266, active_site) — residues 384-396

GO Terms

Generated by BioReason

Bioreason Rl Review

(Src-bioreason-rl-review.md)

BioReason-Pro RL Review: Src (mouse)

Source: Src-deep-research-bioreason-rl.md

Correctness: 5/5
Completeness: 3/5

Functional Summary Review

The BioReason functional summary is accurate but generic:

A cytoplasmic non-receptor tyrosine kinase that uses an SH3-SH2-kinase architecture to assemble with proline-rich and phosphotyrosine-containing partners and phosphorylate tyrosine residues on nearby substrates. By coupling modular docking to catalysis, it propagates intracellular signaling pathways that promote survival and cell division. Its soluble nature and scaffold-directed recruitment position it within cytoplasmic signaling assemblies where ATP-fueled phosphorylation drives downstream pathway activation.

This correctly identifies: (1) the SH3-SH2-kinase modular architecture, (2) non-receptor tyrosine kinase identity (GO:0004713), (3) the mechanism of SH2/SH3-mediated substrate targeting, (4) ATP-dependent tyrosine phosphorylation, and (5) roles in survival and cell division. These map to curated annotations including GO:0005886 (plasma membrane) and GO:0005102 (signaling receptor binding).

However, like the Fyn review, this summary reads as a generic Src-family kinase description without Src-specific biology. Src has well-characterized roles in: (1) integrin-mediated focal adhesion signaling, (2) osteoclast function and bone resorption, (3) receptor tyrosine kinase signal amplification, (4) cell migration and invasion, and (5) regulation of cell-cell junctions. The UniProt summary for mouse Src specifically mentions "B-cells and the regulation of cell survival and cell division." None of these specific functions are captured.

The summary also omits the regulatory mechanism (C-terminal inhibitory phosphorylation by Csk, N-terminal myristoylation) that distinguishes the Src activation cycle.

Comparison with interpro2go:

The curated review has one GO_REF:0000002 annotation: GO:0005524 (ATP binding). BioReason's description of "ATP-fueled phosphorylation" is consistent with this. The summary essentially recapitulates what interpro2go would predict from the SH3-SH2-kinase domain architecture without significant added insight. The narrative framing adds readability but not biological specificity beyond domain-based inference.

Notes on thinking trace

The trace correctly identifies the domain architecture and the non-receptor tyrosine kinase family assignment (IPR050198). The reasoning is sound but formulaic -- the same SH3-SH2-kinase logic applied to Fyn produces an essentially interchangeable description, which highlights the limitation of purely domain-architecture-driven functional prediction for paralogous proteins.

📄 View Raw YAML

id: P05480
gene_symbol: Src
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Src'
alternative_products:
- name: 1 (c-Src {ECO:0000250|UniProtKB:Q9WUD9})
  id: P05480-2
- name: 2 (N1-Src {ECO:0000250|UniProtKB:Q9WUD9})
  id: P05480-1
  sequence_note: VSP_060883
existing_annotations:
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030154
    label: cell differentiation
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007155
    label: cell adhesion
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007173
    label: epidermal growth factor receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050847
    label: progesterone receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001237
    label: negative regulation of extrinsic apoptotic signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001243
    label: negative regulation of intrinsic apoptotic signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005856
    label: cytoskeleton
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007155
    label: cell adhesion
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007276
    label: gamete generation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010628
    label: positive regulation of gene expression
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036120
    label: cellular response to platelet-derived growth factor stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070161
    label: anchoring junction
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070301
    label: cellular response to hydrogen peroxide
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070374
    label: positive regulation of ERK1 and ERK2 cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1903829
    label: positive regulation of protein localization
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904385
    label: cellular response to angiotensin
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10220404
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16267818
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16298995
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16407161
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16990796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18289379
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18560762
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19122674
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21199370
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21266176
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21282606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22439932
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28054552
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:7518772
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000122
    label: negative regulation of transcription by RNA polymerase II
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005178
    label: integrin binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005764
    label: lysosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005770
    label: late endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005901
    label: caveola
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005911
    label: cell-cell junction
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007179
    label: transforming growth factor beta receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007229
    label: integrin-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010632
    label: regulation of epithelial cell migration
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010634
    label: positive regulation of epithelial cell migration
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016004
    label: phospholipase activator activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0020037
    label: heme binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0022407
    label: regulation of cell-cell adhesion
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030054
    label: cell junction
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031333
    label: negative regulation of protein-containing complex assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034139
    label: regulation of toll-like receptor 3 signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034614
    label: cellular response to reactive oxygen species
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035306
    label: positive regulation of dephosphorylation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035331
    label: negative regulation of hippo signaling
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042169
    label: SH2 domain binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043066
    label: negative regulation of apoptotic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043149
    label: stress fiber assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043274
    label: phospholipase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044325
    label: transmembrane transporter binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045747
    label: positive regulation of Notch signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046875
    label: ephrin receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048041
    label: focal adhesion assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051057
    label: positive regulation of small GTPase mediated signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051219
    label: phosphoprotein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051897
    label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal
      transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051902
    label: negative regulation of mitochondrial depolarization
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060576
    label: intestinal epithelial cell development
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070102
    label: interleukin-6-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070555
    label: response to interleukin-1
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070700
    label: BMP receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902564
    label: negative regulation of neutrophil activation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904263
    label: positive regulation of TORC1 signaling
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000394
    label: positive regulation of lamellipodium morphogenesis
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000641
    label: regulation of early endosome to late endosome transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000811
    label: negative regulation of anoikis
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001237
    label: negative regulation of extrinsic apoptotic signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001243
    label: negative regulation of intrinsic apoptotic signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001286
    label: regulation of caveolin-mediated endocytosis
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000122
    label: negative regulation of transcription by RNA polymerase II
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001545
    label: primary ovarian follicle growth
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001819
    label: positive regulation of cytokine production
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005178
    label: integrin binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005764
    label: lysosome
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005770
    label: late endosome
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005901
    label: caveola
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005911
    label: cell-cell junction
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007179
    label: transforming growth factor beta receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007229
    label: integrin-mediated signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008284
    label: positive regulation of cell population proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010628
    label: positive regulation of gene expression
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010629
    label: negative regulation of gene expression
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010632
    label: regulation of epithelial cell migration
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010634
    label: positive regulation of epithelial cell migration
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010907
    label: positive regulation of glucose metabolic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0014911
    label: positive regulation of smooth muscle cell migration
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016004
    label: phospholipase activator activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0020037
    label: heme binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0022407
    label: regulation of cell-cell adhesion
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030054
    label: cell junction
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030335
    label: positive regulation of cell migration
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031333
    label: negative regulation of protein-containing complex assembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032205
    label: negative regulation of telomere maintenance
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034139
    label: regulation of toll-like receptor 3 signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034614
    label: cellular response to reactive oxygen species
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035306
    label: positive regulation of dephosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035331
    label: negative regulation of hippo signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0038083
    label: peptidyl-tyrosine autophosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042169
    label: SH2 domain binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042311
    label: vasodilation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043065
    label: positive regulation of apoptotic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043066
    label: negative regulation of apoptotic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043149
    label: stress fiber assembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043274
    label: phospholipase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043406
    label: positive regulation of MAP kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044325
    label: transmembrane transporter binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045056
    label: transcytosis
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045747
    label: positive regulation of Notch signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045780
    label: positive regulation of bone resorption
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045785
    label: positive regulation of cell adhesion
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045793
    label: positive regulation of cell size
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046579
    label: positive regulation of Ras protein signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046628
    label: positive regulation of insulin receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046875
    label: ephrin receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048011
    label: neurotrophin TRK receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048041
    label: focal adhesion assembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050731
    label: positive regulation of peptidyl-tyrosine phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050839
    label: cell adhesion molecule binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050847
    label: progesterone receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051057
    label: positive regulation of small GTPase mediated signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051219
    label: phosphoprotein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051222
    label: positive regulation of protein transport
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051895
    label: negative regulation of focal adhesion assembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051897
    label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal
      transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051897
    label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal
      transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051902
    label: negative regulation of mitochondrial depolarization
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060576
    label: intestinal epithelial cell development
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070102
    label: interleukin-6-mediated signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070555
    label: response to interleukin-1
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070700
    label: BMP receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902564
    label: negative regulation of neutrophil activation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904263
    label: positive regulation of TORC1 signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000394
    label: positive regulation of lamellipodium morphogenesis
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000641
    label: regulation of early endosome to late endosome transport
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000811
    label: negative regulation of anoikis
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001237
    label: negative regulation of extrinsic apoptotic signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001243
    label: negative regulation of intrinsic apoptotic signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001286
    label: regulation of caveolin-mediated endocytosis
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030331
    label: nuclear estrogen receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030546
    label: signaling receptor activator activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035255
    label: ionotropic glutamate receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044325
    label: transmembrane transporter binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005080
    label: protein kinase C binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005158
    label: insulin receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005901
    label: caveola
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016020
    label: membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016579
    label: protein deubiquitination
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019901
    label: protein kinase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030424
    label: axon
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031669
    label: cellular response to nutrient levels
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034138
    label: toll-like receptor 3 signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0038202
    label: TORC1 signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043025
    label: neuronal cell body
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044294
    label: dendritic growth cone
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070374
    label: positive regulation of ERK1 and ERK2 cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071393
    label: cellular response to progesterone stimulus
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071897
    label: DNA biosynthetic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090303
    label: positive regulation of wound healing
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097060
    label: synaptic membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098984
    label: neuron to neuron synapse
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0099073
    label: mitochondrion-derived vesicle
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0099091
    label: postsynaptic specialization, intracellular component
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902533
    label: positive regulation of intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902737
    label: dendritic filopodium
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904262
    label: negative regulation of TORC1 signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904707
    label: positive regulation of vascular associated smooth muscle cell proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000179
    label: positive regulation of neural precursor cell proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000256
    label: positive regulation of male germ cell proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000386
    label: positive regulation of ovarian follicle development
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:18044967
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035022
    label: positive regulation of Rac protein signal transduction
  evidence_type: IMP
  original_reference_id: PMID:18044967
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25043309
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:25043309
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007595
    label: lactation
  evidence_type: IDA
  original_reference_id: PMID:25043309
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IMP
  original_reference_id: PMID:12091389
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:22759635
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-3928622
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-418870
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-420382
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9011252
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763891
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9726861
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005911
    label: cell-cell junction
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0038166
    label: angiotensin-activated signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:25017399
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0086091
    label: regulation of heart rate by cardiac conduction
  evidence_type: IGI
  original_reference_id: PMID:25017399
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045821
    label: positive regulation of glycolytic process
  evidence_type: IDA
  original_reference_id: PMID:35263589
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IMP
  original_reference_id: PMID:27505886
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:27505886
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045747
    label: positive regulation of Notch signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:25731159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060576
    label: intestinal epithelial cell development
  evidence_type: IDA
  original_reference_id: PMID:25731159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070102
    label: interleukin-6-mediated signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:25731159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11274221
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IDA
  original_reference_id: PMID:12615910
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030054
    label: cell junction
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: IMP
  original_reference_id: PMID:22801373
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8910389
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:12615910
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IDA
  original_reference_id: PMID:12615910
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005856
    label: cytoskeleton
  evidence_type: IDA
  original_reference_id: PMID:12615910
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:12615910
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016020
    label: membrane
  evidence_type: IMP
  original_reference_id: PMID:22801373
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18691334
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045453
    label: bone resorption
  evidence_type: IMP
  original_reference_id: PMID:19448635
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042476
    label: odontogenesis
  evidence_type: IMP
  original_reference_id: PMID:23174213
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070301
    label: cellular response to hydrogen peroxide
  evidence_type: IMP
  original_reference_id: PMID:23651497
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000588
    label: positive regulation of platelet-derived growth factor receptor-beta signaling
      pathway
  evidence_type: IMP
  original_reference_id: PMID:23651497
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:27994061
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:27994061
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9011252
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9726861
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9700655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:14699011
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071253
    label: connexin binding
  evidence_type: IPI
  original_reference_id: PMID:14699011
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-8937703
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-8937738
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0002102
    label: podosome
  evidence_type: IDA
  original_reference_id: PMID:17893324
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010954
    label: positive regulation of protein processing
  evidence_type: IGI
  original_reference_id: PMID:17344476
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050731
    label: positive regulation of peptidyl-tyrosine phosphorylation
  evidence_type: IGI
  original_reference_id: PMID:17344476
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1900182
    label: positive regulation of protein localization to nucleus
  evidence_type: IGI
  original_reference_id: PMID:17344476
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20847314
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071803
    label: positive regulation of podosome assembly
  evidence_type: IDA
  original_reference_id: PMID:24127566
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:24190966
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24190966
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034614
    label: cellular response to reactive oxygen species
  evidence_type: IDA
  original_reference_id: PMID:24190966
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:24841674
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:24841674
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071498
    label: cellular response to fluid shear stress
  evidence_type: IMP
  original_reference_id: PMID:24841674
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IMP
  original_reference_id: PMID:12091389
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005901
    label: caveola
  evidence_type: IDA
  original_reference_id: PMID:12091389
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: IPI
  original_reference_id: PMID:12091389
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031648
    label: protein destabilization
  evidence_type: IMP
  original_reference_id: PMID:25259869
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071375
    label: cellular response to peptide hormone stimulus
  evidence_type: IGI
  original_reference_id: PMID:25017399
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: IPI
  original_reference_id: PMID:25017399
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071560
    label: cellular response to transforming growth factor beta stimulus
  evidence_type: IGI
  original_reference_id: PMID:21829547
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005884
    label: actin filament
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032587
    label: ruffle membrane
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036120
    label: cellular response to platelet-derived growth factor stimulus
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IMP
  original_reference_id: PMID:23100514
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034446
    label: substrate adhesion-dependent cell spreading
  evidence_type: IDA
  original_reference_id: PMID:11864995
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060491
    label: regulation of cell projection assembly
  evidence_type: IGI
  original_reference_id: PMID:11864995
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IGI
  original_reference_id: PMID:23526378
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036035
    label: osteoclast development
  evidence_type: IGI
  original_reference_id: PMID:23526378
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: ISO
  original_reference_id: PMID:22732588
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11826110
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8861907
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21525037
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:21525037
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071803
    label: positive regulation of podosome assembly
  evidence_type: IDA
  original_reference_id: PMID:21525037
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071803
    label: positive regulation of podosome assembly
  evidence_type: IGI
  original_reference_id: PMID:21525037
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14600260
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17000758
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046875
    label: ephrin receptor binding
  evidence_type: IPI
  original_reference_id: PMID:12925710
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14739300
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0020037
    label: heme binding
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045453
    label: bone resorption
  evidence_type: IMP
  original_reference_id: PMID:14739300
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:19920076
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19920076
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090263
    label: positive regulation of canonical Wnt signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:19920076
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-1433273
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-3928622
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-418870
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-420382
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-5218834
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-8964229
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9680646
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9680706
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682158
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682182
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682572
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763891
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763892
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763903
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9764150
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9817994
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9818009
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9700661
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070374
    label: positive regulation of ERK1 and ERK2 cascade
  evidence_type: IMP
  original_reference_id: PMID:17045821
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0033146
    label: regulation of intracellular estrogen receptor signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:16007215
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048477
    label: oogenesis
  evidence_type: IMP
  original_reference_id: PMID:16007215
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060065
    label: uterus development
  evidence_type: IMP
  original_reference_id: PMID:16007215
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060444
    label: branching involved in mammary gland duct morphogenesis
  evidence_type: IMP
  original_reference_id: PMID:16007215
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019904
    label: protein domain specific binding
  evidence_type: IPI
  original_reference_id: PMID:8438166
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:15937334
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016477
    label: cell migration
  evidence_type: IMP
  original_reference_id: PMID:15292044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:12526740
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030900
    label: forebrain development
  evidence_type: IGI
  original_reference_id: PMID:16162939
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016301
    label: kinase activity
  evidence_type: IMP
  original_reference_id: PMID:12808090
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IMP
  original_reference_id: PMID:14636584
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:11274221
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:11274221
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
    vocabulary mapping, accompanied by conservative changes to GO terms applied by
    UniProt
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to
    mouse-rat orthologs
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to
    orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to
    mouse-human orthologs
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10220404
  title: Identification of profilin and src homology 3 domains as binding partners
    for Drosophila enabled.
  findings: []
- id: PMID:11274221
  title: Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth
    factor receptor (EGFR) but are not required for coupling to the mitogen-activated
    protein (MAP) kinase signaling cascade.
  findings: []
- id: PMID:11826110
  title: 'Delphilin: a novel PDZ and formin homology domain-containing protein that
    synaptically colocalizes and interacts with glutamate receptor delta 2 subunit.'
  findings: []
- id: PMID:11864995
  title: Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading
    and neurite extension.
  findings: []
- id: PMID:12091389
  title: Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2
    (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae,
    but no longer forms a high molecular mass hetero-oligomer with caveolin-1.
  findings: []
- id: PMID:12526740
  title: Reelin activates SRC family tyrosine kinases in neurons.
  findings: []
- id: PMID:12615910
  title: Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.
  findings: []
- id: PMID:12808090
  title: Gab1 is an integrator of cell death versus cell survival signals in oxidative
    stress.
  findings: []
- id: PMID:12925710
  title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
  findings: []
- id: PMID:14600260
  title: A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts
    Src localization and activity and induces apoptosis in skeletal myotubes.
  findings: []
- id: PMID:14636584
  title: Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth
    factor-stimulated epithelial morphogenesis.
  findings: []
- id: PMID:14699011
  title: Regulation of connexin43 protein complexes by intracellular acidification.
  findings: []
- id: PMID:14739300
  title: Src kinase activity is essential for osteoclast function.
  findings: []
- id: PMID:15292044
  title: Alterations in cell-adhesive and migratory properties of proximal tubule
    and collecting duct cells from bcl-2 -/- mice.
  findings: []
- id: PMID:15937334
  title: A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective
    pore formation in P2X7 receptor-mediated thymocyte death.
  findings: []
- id: PMID:16007215
  title: c-Src-null mice exhibit defects in normal mammary gland development and ERalpha
    signaling.
  findings: []
- id: PMID:16162939
  title: Absence of Fyn and Src causes a reeler-like phenotype.
  findings: []
- id: PMID:16267818
  title: A proteomics strategy for the enrichment of receptor-associated complexes.
  findings: []
- id: PMID:16298995
  title: EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation
    of focal adhesion kinase and RhoA activation.
  findings: []
- id: PMID:16407161
  title: Role of Src in C3 transient receptor potential channel function and evidence
    for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels.
  findings: []
- id: PMID:16990796
  title: PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor
    complex.
  findings: []
- id: PMID:17000758
  title: Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine
    nucleotide exchange factor Dbs.
  findings: []
- id: PMID:17045821
  title: CD44 is the signaling component of the macrophage migration inhibitory factor-CD74
    receptor complex.
  findings: []
- id: PMID:17344476
  title: The transcriptional repressor Glis2 is a novel binding partner for p120 catenin.
  findings: []
- id: PMID:17623777
  title: The membrane targeting and spatial activation of Src, Yes and Fyn is influenced
    by palmitoylation and distinct RhoB/RhoD endosome requirements.
  findings: []
- id: PMID:17893324
  title: Src-dependent phosphorylation of ASAP1 regulates podosomes.
  findings: []
- id: PMID:18044967
  title: Laminin-induced activation of Rac1 and JNKp46 is initiated by Src family
    kinases and mimics the effects of skeletal muscle contraction.
  findings: []
- id: PMID:18289379
  title: Dramatic inhibition of osteoclast sealing ring formation and bone resorption
    in vitro by a WASP-peptide containing pTyr294 amino acid.
  findings: []
- id: PMID:18560762
  title: Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied
    by paramagnetic NMR.
  findings: []
- id: PMID:18691334
  title: Palmitoylation-dependent endosomal localization of AATYK1A and its interaction
    with Src.
  findings: []
- id: PMID:19122674
  title: Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
  findings: []
- id: PMID:19448635
  title: Impaired gastric acidification negatively affects calcium homeostasis and
    bone mass.
  findings: []
- id: PMID:19920076
  title: Dishevelled-2 docks and activates Src in a Wnt-dependent manner.
  findings: []
- id: PMID:20847314
  title: CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are
    modulated by c-kit activity.
  findings: []
- id: PMID:21199370
  title: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase
    functions.
  findings: []
- id: PMID:21266176
  title: Linker length dependent binding of a focal adhesion kinase derived peptide
    to the Src SH3-SH2 domains.
  findings: []
- id: PMID:21282606
  title: Nε-lysine acetylation determines dissociation from GAP junctions and lateralization
    of connexin 43 in normal and dystrophic heart.
  findings: []
- id: PMID:21525037
  title: The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced
    podosome formation.
  findings: []
- id: PMID:21829547
  title: Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3
    activation and PAI-1 expression.
  findings: []
- id: PMID:22439932
  title: NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling
    in lung adenocarcinoma.
  findings: []
- id: PMID:22732588
  title: Interchangeability of Themis1 and Themis2 in thymocyte development reveals
    two related proteins with conserved molecular function.
  findings: []
- id: PMID:22759635
  title: A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and
    T-lymphocyte differentiation.
  findings: []
- id: PMID:22801373
  title: Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position
    Cas for activation at integrin-mediated focal adhesions.
  findings: []
- id: PMID:23100514
  title: Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.
  findings: []
- id: PMID:23174213
  title: Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially
    affect dentin and enamel mineralization.
  findings: []
- id: PMID:23526378
  title: Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich
    repeat kinase 2 in mice causes severe osteopetrosis.
  findings: []
- id: PMID:23651497
  title: A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the
    activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.
  findings: []
- id: PMID:24127566
  title: Phosphorylation of moesin by Jun N-terminal kinase is important for podosome
    rosette formation in Src-transformed fibroblasts.
  findings: []
- id: PMID:24190966
  title: A reactive oxygen species-mediated, self-perpetuating loop persistently activates
    platelet-derived growth factor receptor α.
  findings: []
- id: PMID:24841674
  title: Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex
    that suppresses anabolic gene expression.
  findings: []
- id: PMID:25017399
  title: Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity
    by regulating cSrc tyrosine kinase.
  findings: []
- id: PMID:25043309
  title: Actin filament-associated protein 1 is required for cSrc activity and secretory
    activation in the lactating mammary gland.
  findings: []
- id: PMID:25259869
  title: Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse
    development and the existence of a novel isoform of tks5.
  findings: []
- id: PMID:25731159
  title: A gp130-Src-YAP module links inflammation to epithelial regeneration.
  findings: []
- id: PMID:27505886
  title: Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization
    and activity.
  findings: []
- id: PMID:27994061
  title: Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses
    Cardiomyocyte Autophagy and Initiates Hypertrophic Growth.
  findings: []
- id: PMID:28054552
  title: c-Src phosphorylation and activation of hexokinase promotes tumorigenesis
    and metastasis.
  findings: []
- id: PMID:35263589
  title: Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine
    pathway in microglia.
  findings: []
- id: PMID:7518772
  title: Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789,
    a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.
  findings: []
- id: PMID:8438166
  title: Identification of a ten-amino acid proline-rich SH3 binding site.
  findings: []
- id: PMID:8861907
  title: Mena, a relative of VASP and Drosophila Enabled, is implicated in the control
    of microfilament dynamics.
  findings: []
- id: PMID:8910389
  title: Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently
    activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine
    phosphorylation of p125 focal adhesion kinase.
  findings: []
- id: Reactome:R-MMU-1433273
  title: Interaction of Src kinases with c-Kit
  findings: []
- id: Reactome:R-MMU-3928622
  title: SFKs phosphorylate Git1
  findings: []
- id: Reactome:R-MMU-418870
  title: Phosphorylation of Unc5C
  findings: []
- id: Reactome:R-MMU-420382
  title: Phosphorylation of FAK by Src kinases
  findings: []
- id: Reactome:R-MMU-5218834
  title: Fak/Src phosphorylate p130Cas
  findings: []
- id: Reactome:R-MMU-8937703
  title: Runx1 binds Src
  findings: []
- id: Reactome:R-MMU-8937738
  title: Src phosphorylates Runx1
  findings: []
- id: Reactome:R-MMU-8964229
  title: G alpha (i):GTP binds Src
  findings: []
- id: Reactome:R-MMU-9011252
  title: Src phosphorylates Robo3.1 in response to Ntn1
  findings: []
- id: Reactome:R-MMU-9680646
  title: Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11
    (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2)  bind
    p-8Y-Csf1r and are activated
  findings: []
- id: Reactome:R-MMU-9680706
  title: Csf1r trans-autophosphorylates on multiple tyrosine residues
  findings: []
- id: Reactome:R-MMU-9682158
  title: Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate
    and 1,2-diacylglycerol
  findings: []
- id: Reactome:R-MMU-9682182
  title: Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
  findings: []
- id: Reactome:R-MMU-9682572
  title: Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
  findings: []
- id: Reactome:R-MMU-9763891
  title: Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl
  findings: []
- id: Reactome:R-MMU-9763892
  title: p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12
  findings: []
- id: Reactome:R-MMU-9763903
  title: Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1
  findings: []
- id: Reactome:R-MMU-9764150
  title: Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r
    dimer:SFK and Grb2:Sos1
  findings: []
- id: Reactome:R-MMU-9817994
  title: Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl
  findings: []
- id: Reactome:R-MMU-9818009
  title: Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1
  findings: []
- id: Reactome:R-NUL-9700655
  title: Active ALK phosphorylates Src
  findings: []
- id: Reactome:R-NUL-9700661
  title: Active ALK binds Src
  findings: []
- id: Reactome:R-NUL-9726861
  title: Src phosphorylates RHOU
  findings: []

Src

Gene Description

Existing Annotations Review

References

📚 Additional Documentation

Deep Research Bioreason

BioReason Chat Export

Thinking Trace

Functional Summary

UniProt Summary

InterPro Domains

GO Terms

Deep Research Bioreason Rl

BioReason Chat Export

Thinking Trace

Functional Summary

UniProt Summary

InterPro Domains

GO Terms

Bioreason Rl Review

BioReason-Pro RL Review: Src (mouse)

Functional Summary Review

Notes on thinking trace

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