STAT1 is a cytokine-activated signal transducer and RNA polymerase II transcription factor that mediates type I and type II interferon responses. After JAK-dependent phosphorylation it dimerizes, enters the nucleus, binds GAS or ISRE-associated regulatory DNA, and activates interferon-stimulated gene expression.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: cytoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0006952 defense response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: defense response pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0042127 regulation of cell population proliferation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: regulation of cell population proliferation pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: nucleus localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA GO_REF:0000033 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. |
| GO:0006357 regulation of transcription by RNA polymerase II | IBA GO_REF:0000033 | ACCEPT | Summary: Direct STAT1 transcriptional regulation Reason: This term directly reflects STAT1-mediated regulation of target-gene transcription after cytokine-induced activation. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IBA GO_REF:0000033 | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IBA GO_REF:0000033 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. Supporting Evidence: file:mouse/Stat1/Stat1-notes.md STAT1 is a cytokine-activated DNA-binding transcription factor, especially in type I and type II interferon signaling. file:mouse/Stat1/Stat1-deep-research-falcon.md Falcon synthesis supports STAT1 as an interferon-activated STAT-family transcription factor that binds regulatory DNA after JAK-dependent phosphorylation. |
| GO:0070721 ISGF3 complex | IBA GO_REF:0000033 | ACCEPT | Summary: ISGF3 complex interaction or complex context Reason: STAT1 is a core subunit of the STAT1/STAT2/IRF9 ISGF3 transcription factor complex during type I interferon signaling, so this complex-membership annotation is accurate even though the core molecular activity remains DNA-binding transcription factor activity. |
| GO:0043434 response to peptide hormone | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: response to peptide hormone pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0060337 type I interferon-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IEA GO_REF:0000117 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. Supporting Evidence: file:mouse/Stat1/Stat1-notes.md STAT1 is a cytokine-activated DNA-binding transcription factor, especially in type I and type II interferon signaling. |
| GO:0003677 DNA binding | IEA GO_REF:0000120 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. |
| GO:0003700 DNA-binding transcription factor activity | IEA GO_REF:0000002 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: nucleus localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005654 nucleoplasm | IEA GO_REF:0000117 | ACCEPT | Summary: nucleoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: cytoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | IEA GO_REF:0000117 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0006351 DNA-templated transcription | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: DNA-templated transcription pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0006355 regulation of DNA-templated transcription | IEA GO_REF:0000002 | ACCEPT | Summary: Direct STAT1 transcriptional regulation Reason: This term directly reflects STAT1-mediated regulation of target-gene transcription after cytokine-induced activation. |
| GO:0007165 signal transduction | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: signal transduction pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IEA GO_REF:0000117 | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. |
| GO:0008283 cell population proliferation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: cell population proliferation pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0042981 regulation of apoptotic process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: regulation of apoptotic process pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0051093 negative regulation of developmental process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: negative regulation of developmental process pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0051607 defense response to virus | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: defense response to virus pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0060333 type II interferon-mediated signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. |
| GO:0060337 type I interferon-mediated signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. |
| GO:0005515 protein binding | IPI PMID:22306691 The composition and signaling of the IL-35 receptor are unco... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding is too generic to describe STAT1 function and should be replaced by specific complex, DNA-binding, or transcription-factor annotations. Supporting Evidence: PMID:22306691 The composition and signaling of the IL-35 receptor are unconventional. |
| GO:0005515 protein binding | IPI PMID:23749757 Construction of a novel oligonucleotide array-based transcri... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding is too generic to describe STAT1 function and should be replaced by specific complex, DNA-binding, or transcription-factor annotations. Supporting Evidence: PMID:23749757 Jul 22. Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells. |
| GO:0005515 protein binding | IPI PMID:24360797 Hepatic RIG-I predicts survival and interferon-Ξ± therapeutic... | MARK AS OVER ANNOTATED | Summary: Generic protein binding Reason: Protein binding is too generic to describe STAT1 function and should be replaced by specific complex, DNA-binding, or transcription-factor annotations. Supporting Evidence: PMID:24360797 2013 Dec 19. Hepatic RIG-I predicts survival and interferon-Ξ± therapeutic response in hepatocellular carcinoma. |
| GO:0000785 chromatin | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: chromatin pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding | ISO GO_REF:0000119 | ACCEPT | Summary: RNA polymerase II transcription regulatory region sequence-specific DNA binding directly captures STAT1 DNA-binding transcription-factor activity. Reason: STAT1 binds cytokine-responsive regulatory DNA as part of its core transcription factor function. |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | ISO GO_REF:0000119 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. |
| GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding | ISO GO_REF:0000119 | MODIFY | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 binds GAS and ISRE regulatory DNA elements downstream of interferon/cytokine signaling; these are better represented as RNA polymerase II cis-regulatory region sequence-specific DNA binding than as core-promoter binding. Proposed replacements: RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | ISO GO_REF:0000119 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. Supporting Evidence: file:mouse/Stat1/Stat1-notes.md STAT1 is a cytokine-activated DNA-binding transcription factor, especially in type I and type II interferon signaling. |
| GO:0001222 transcription corepressor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: transcription corepressor binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0001223 transcription coactivator binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: transcription coactivator binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0001937 negative regulation of endothelial cell proliferation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of endothelial cell proliferation pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0002230 positive regulation of defense response to virus by host | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of defense response to virus by host pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0003677 DNA binding | ISO GO_REF:0000096 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. |
| GO:0003690 double-stranded DNA binding | ISO GO_REF:0000119 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. |
| GO:0003700 DNA-binding transcription factor activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. |
| GO:0005164 tumor necrosis factor receptor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: tumor necrosis factor receptor binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0005634 nucleus | ISO GO_REF:0000119 | ACCEPT | Summary: nucleus localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005654 nucleoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: nucleoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005730 nucleolus | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: nucleolus pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0005737 cytoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: cytoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | ISO GO_REF:0000119 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0006357 regulation of transcription by RNA polymerase II | ISO GO_REF:0000119 | ACCEPT | Summary: Direct STAT1 transcriptional regulation Reason: This term directly reflects STAT1-mediated regulation of target-gene transcription after cytokine-induced activation. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | ISO GO_REF:0000119 | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. |
| GO:0016525 negative regulation of angiogenesis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of angiogenesis pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0019899 enzyme binding | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Generic enzyme binding annotation Reason: The term is too broad to add useful information for STAT1 relative to specific DNA-binding and transcription-factor terms. |
| GO:0030424 axon | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: axon pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0030425 dendrite | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendrite pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0031730 CCR5 chemokine receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: CCR5 chemokine receptor binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0032727 positive regulation of interferon-alpha production | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of interferon-alpha production pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0032991 protein-containing complex | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Generic protein-containing complex annotation Reason: The term is too broad to add useful information for STAT1 relative to specific DNA-binding and transcription-factor terms. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: tumor necrosis factor-mediated signaling pathway pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0034341 response to type II interferon | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: response to type II interferon pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0035035 histone acetyltransferase binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: histone acetyltransferase binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0035456 response to interferon-beta | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: response to interferon-beta pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0035458 cellular response to interferon-beta | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to interferon-beta pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0038111 interleukin-7-mediated signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: interleukin-7-mediated signaling pathway pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0038113 interleukin-9-mediated signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: interleukin-9-mediated signaling pathway pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0042393 histone binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: histone binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0042802 identical protein binding | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Generic identical protein binding annotation Reason: The term is too broad to add useful information for STAT1 relative to specific DNA-binding and transcription-factor terms. |
| GO:0042803 protein homodimerization activity | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Generic protein homodimerization activity annotation Reason: The term is too broad to add useful information for STAT1 relative to specific DNA-binding and transcription-factor terms. |
| GO:0043124 negative regulation of canonical NF-kappaB signal transduction | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of canonical NF-kappaB signal transduction pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0043565 sequence-specific DNA binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: sequence-specific DNA binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0044389 ubiquitin-like protein ligase binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: ubiquitin-like protein ligase binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0045648 positive regulation of erythrocyte differentiation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of erythrocyte differentiation pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0045893 positive regulation of DNA-templated transcription | ISO GO_REF:0000119 | ACCEPT | Summary: Direct STAT1 transcriptional regulation Reason: This term directly reflects STAT1-mediated regulation of target-gene transcription after cytokine-induced activation. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of transcription by RNA polymerase II pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of receptor signaling pathway via JAK-STAT pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0046725 negative regulation by virus of viral protein levels in host cell | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation by virus of viral protein levels in host cell pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0048471 perinuclear region of cytoplasm | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: perinuclear region of cytoplasm pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0051607 defense response to virus | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: defense response to virus pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0051721 protein phosphatase 2A binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: protein phosphatase 2A binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0060333 type II interferon-mediated signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. |
| GO:0060337 type I interferon-mediated signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. |
| GO:0061326 renal tubule development | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: renal tubule development pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0070106 interleukin-27-mediated signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: interleukin-27-mediated signaling pathway pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0070721 ISGF3 complex | ISO GO_REF:0000119 | ACCEPT | Summary: ISGF3 complex interaction or complex context Reason: STAT1 is a core subunit of the STAT1/STAT2/IRF9 ISGF3 transcription factor complex during type I interferon signaling, so this complex-membership annotation is accurate even though the core molecular activity remains DNA-binding transcription factor activity. |
| GO:0071346 cellular response to type II interferon | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to type II interferon pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0090575 RNA polymerase II transcription regulator complex | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: RNA polymerase II transcription regulator complex pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0097696 cell surface receptor signaling pathway via STAT | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cell surface receptor signaling pathway via STAT pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:1990841 promoter-specific chromatin binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: promoter-specific chromatin binding pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0061326 renal tubule development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: renal tubule development pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0043065 positive regulation of apoptotic process | IMP PMID:10692450 Thrombin inhibits tumor cell growth in association with up-r... | KEEP AS NON CORE | Summary: positive regulation of apoptotic process pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. Supporting Evidence: PMID:10692450 Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of transcription by RNA polymerase II pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:37327784 Gasdermin D licenses MHCII induction to maintain food tolera... | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. Supporting Evidence: file:mouse/Stat1/Stat1-uniprot.txt associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphoryla... | ACCEPT | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 directly binds regulatory DNA elements and functions as a transcription factor downstream of interferon/cytokine signaling. Supporting Evidence: PMID:11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. file:mouse/Stat1/Stat1-notes.md STAT1 is a cytokine-activated DNA-binding transcription factor, especially in type I and type II interferon signaling. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphoryla... | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. Supporting Evidence: PMID:11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. |
| GO:0034341 response to type II interferon | IDA PMID:11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphoryla... | KEEP AS NON CORE | Summary: response to type II interferon pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. Supporting Evidence: PMID:11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. |
| GO:0008283 cell population proliferation | IGI PMID:15781341 Differential effects of a novel IFN-zeta/limitin and IFN-alp... | KEEP AS NON CORE | Summary: cell population proliferation pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. Supporting Evidence: PMID:15781341 Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes. |
| GO:0051607 defense response to virus | IMP PMID:32270034 IL-27 signaling activates skin cells to induce innate antivi... | KEEP AS NON CORE | Summary: defense response to virus pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. Supporting Evidence: PMID:32270034 2020 Apr. IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection. |
| GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding | ISS GO_REF:0000024 | MODIFY | Summary: Core STAT1 DNA-binding transcription factor activity Reason: STAT1 binds GAS and ISRE regulatory DNA elements downstream of interferon/cytokine signaling; these are better represented as RNA polymerase II cis-regulatory region sequence-specific DNA binding than as core-promoter binding. Proposed replacements: RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0032727 positive regulation of interferon-alpha production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of interferon-alpha production pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0042803 protein homodimerization activity | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: Generic protein homodimerization activity annotation Reason: The term is too broad to add useful information for STAT1 relative to specific DNA-binding and transcription-factor terms. |
| GO:0051607 defense response to virus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: defense response to virus pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9676907 | ACCEPT | Summary: nucleoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9705459 | ACCEPT | Summary: nucleoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9705472 | ACCEPT | Summary: nucleoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9943422 | ACCEPT | Summary: nucleoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9943424 | ACCEPT | Summary: nucleoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0045648 positive regulation of erythrocyte differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of erythrocyte differentiation pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0071345 cellular response to cytokine stimulus | ISO PMID:19414010 JANEX-1, a JAK3 inhibitor, protects pancreatic islets from c... | KEEP AS NON CORE | Summary: cellular response to cytokine stimulus pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. Supporting Evidence: PMID:19414010 Epub 2009 May 3. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. |
| GO:0034340 response to type I interferon | IDA PMID:24882218 Unanchored K48-linked polyubiquitin synthesized by the E3-ub... | KEEP AS NON CORE | Summary: response to type I interferon pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. Supporting Evidence: PMID:24882218 2014 May 29. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKΞ΅ kinase-mediated antiviral response. |
| GO:0071222 cellular response to lipopolysaccharide | IMP PMID:21606371 Glucocorticoids target suppressor of cytokine signaling 1 (S... | KEEP AS NON CORE | Summary: cellular response to lipopolysaccharide pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. Supporting Evidence: PMID:21606371 Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-1169206 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9674908 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9674931 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9676907 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9676912 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9680646 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9682158 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9682182 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0060337 type I interferon-mediated signaling pathway | IMP PMID:24598055 TLR ligands up-regulate Trex1 expression in murine conventio... | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. Supporting Evidence: PMID:24598055 Mar 5. TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-ΞΊB-dependent signaling pathways. |
| GO:0034240 negative regulation of macrophage fusion | IMP PMID:22865856 An essential role for STAT6-STAT1 protein signaling in promo... | KEEP AS NON CORE | Summary: negative regulation of macrophage fusion pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. Supporting Evidence: PMID:22865856 2012 Aug 3. An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion. |
| GO:0060333 type II interferon-mediated signaling pathway | IMP PMID:12138178 Identification of a nuclear Stat1 protein tyrosine phosphata... | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. Supporting Evidence: PMID:12138178 Identification of a nuclear Stat1 protein tyrosine phosphatase. |
| GO:0060337 type I interferon-mediated signaling pathway | IMP PMID:12138178 Identification of a nuclear Stat1 protein tyrosine phosphata... | ACCEPT | Summary: Core interferon/JAK-STAT signaling role Reason: STAT1 is a direct transcription factor effector of type I and type II interferon JAK-STAT signaling. Supporting Evidence: PMID:12138178 Identification of a nuclear Stat1 protein tyrosine phosphatase. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of transcription by RNA polymerase II pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0002053 positive regulation of mesenchymal cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of mesenchymal cell proliferation pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: metanephric mesenchymal cell proliferation involved in metanephros development pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0072162 metanephric mesenchymal cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: metanephric mesenchymal cell differentiation pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. |
| GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of metanephric nephron tubule epithelial cell differentiation pathway context Reason: This regulatory annotation is plausible for STAT1 biology but is broader or more downstream than the core transcription-factor function. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-1169142 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9008004 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9674959 | ACCEPT | Summary: cytosol localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. |
| GO:0005737 cytoplasm | IDA PMID:15661922 Immune activation of type I IFNs by Listeria monocytogenes o... | ACCEPT | Summary: cytoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. Supporting Evidence: PMID:15661922 Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. |
| GO:0009617 response to bacterium | IDA PMID:15661922 Immune activation of type I IFNs by Listeria monocytogenes o... | KEEP AS NON CORE | Summary: response to bacterium pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. Supporting Evidence: PMID:15661922 Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:12872135 Identification of Lps2 as a key transducer of MyD88-independ... | KEEP AS NON CORE | Summary: cytokine-mediated signaling pathway pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. Supporting Evidence: PMID:12872135 Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. |
| GO:0031663 lipopolysaccharide-mediated signaling pathway | IDA PMID:12872135 Identification of Lps2 as a key transducer of MyD88-independ... | KEEP AS NON CORE | Summary: lipopolysaccharide-mediated signaling pathway pathway context Reason: The annotation is compatible with STAT1 cytokine-response biology but represents a pathway, localization, or downstream process rather than the core molecular function. Supporting Evidence: PMID:12872135 Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. |
| GO:0032496 response to lipopolysaccharide | IDA PMID:12872135 Identification of Lps2 as a key transducer of MyD88-independ... | KEEP AS NON CORE | Summary: response to lipopolysaccharide pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. Supporting Evidence: PMID:12872135 Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. |
| GO:0043330 response to exogenous dsRNA | IDA PMID:12872135 Identification of Lps2 as a key transducer of MyD88-independ... | KEEP AS NON CORE | Summary: response to exogenous dsRNA pathway context Reason: This term describes an upstream stimulus or immune outcome of STAT1 activation, not its core molecular activity. Supporting Evidence: PMID:12872135 Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. |
| GO:0003700 DNA-binding transcription factor activity | IMP PMID:15485925 Interferon-inducible ubiquitin E2, Ubc8, is a conjugating en... | UNDECIDED | Summary: PMID:15485925 supports Ubc8/ISGylation in the cached abstract but does not directly mention STAT1 DNA-binding transcription factor activity. Reason: Direct STAT1 evidence from full text or another source would be needed before accepting this PMID-specific annotation. |
| GO:0006351 DNA-templated transcription | IMP PMID:15485925 Interferon-inducible ubiquitin E2, Ubc8, is a conjugating en... | UNDECIDED | Summary: PMID:15485925 supports Ubc8/ISGylation in the cached abstract but does not directly mention STAT1-dependent transcription. Reason: Direct STAT1 transcription evidence from full text or another source would be needed before accepting this PMID-specific annotation. |
| GO:0005634 nucleus | IDA PMID:12957148 Erythrocyte and leukocyte dynamics in the retinal capillarie... | UNDECIDED | Summary: PMID:12957148 is a retinal capillary dynamics paper in the cached abstract and does not directly support STAT1 nuclear localization. Reason: Full-text or corrected evidence would be needed before accepting this evidence-specific nucleus annotation. |
| GO:0005737 cytoplasm | IDA PMID:14522949 Beta1 integrins regulate chondrocyte rotation, G1 progressio... | UNDECIDED | Summary: PMID:14522949 supports nuclear translocation of Stat1/Stat5a in the cached abstract, not cytoplasmic localization. Reason: Full-text or corrected cytoplasmic localization evidence would be needed before accepting this evidence-specific annotation. |
| GO:0005737 cytoplasm | IDA PMID:12634107 Expression and activation of STAT proteins during mouse reti... | ACCEPT | Summary: cytoplasm localization Reason: STAT1 shuttles between cytoplasm/cytosol and nucleus during activation and transcriptional response. Supporting Evidence: PMID:12634107 Expression and activation of STAT proteins during mouse retina development. |
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