id: P48025
gene_symbol: Syk
aliases:
- ptk72
- Sykb
status: COMPLETE
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: Syk is a non-receptor cytoplasmic tyrosine kinase that couples phosphorylated
  ITAM- and hemITAM-containing immune receptor adaptors to downstream PLCgamma, PI3K, MAPK,
  NF-kappaB, cytoskeletal, phagocytic, platelet, and cytokine-response programs. Its tandem
  SH2 domains bind phosphorylated receptor/adaptor motifs, relieving autoinhibition of the
  C-terminal kinase domain. In mouse, Syk is essential for B cell development, Fc receptor
  mast-cell activation, C-type lectin signaling, integrin-linked myeloid functions, and GPVI-dependent
  platelet activation, while vascular, metabolic, autophagy, and tissue-remodeling phenotypes
  are treated as context-dependent downstream roles rather than the core molecular function.
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat
    orthologs
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to orthologs
    using Ensembl Compara
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human
    orthologs
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10872802
  title: Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
  findings:
  - statement: APS adaptor is tyrosine phosphorylated downstream of BCR signaling
    supporting_text: APS is tyrosine phosphorylated at the C-terminal phosphorylation site
      conserved among the Lnk family adaptor proteins by stimulation of IL-5 or IL-3 as well
      as by crosslinking of B cell receptor complex
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:11672534
  title: Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the
    Src family kinase Fgr.
  findings: []
- id: PMID:11676469
  title: Syk expression and novel function in a wide variety of tissues.
  findings: []
- id: PMID:15845454
  title: Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition
    pathway for C type lectins.
  findings: []
- id: PMID:16410013
  title: Structural basis for the requirement of two phosphotyrosine residues in signaling
    mediated by Syk tyrosine kinase.
  findings: []
- id: PMID:16456001
  title: Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from
    FcepsilonRI.
  findings: []
- id: PMID:16713566
  title: Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple
    stages of B cell development.
  findings: []
- id: PMID:17086186
  title: Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor
    tyrosine-based activation motifs.
  findings: []
- id: PMID:19098920
  title: Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required
    for IL-3-induced IL-4 production in basophils.
  findings: []
- id: PMID:19124738
  title: RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast
    cells.
  findings: []
- id: PMID:19770268
  title: A murine DC-SIGN homologue contributes to early host defense against Mycobacterium
    tuberculosis.
  findings: []
- id: PMID:20133729
  title: STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells
    exposed to oxidative stress.
  findings: []
- id: PMID:22496641
  title: "CEACAM1 negatively regulates IL-1\u03B2 production in LPS activated neutrophils\
    \ by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex."
  findings:
  - statement: Syk forms a complex with TLR4 and CEACAM1 that recruits SHP-1 phosphatase for
      negative regulation
    supporting_text: "CEACAM1 negatively regulates IL-1\u03B2 production in LPS activated\
      \ neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex"
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:23071339
  title: Serine phosphorylation by SYK is critical for nuclear localization and transcription
    factor function of Ikaros.
  findings:
  - statement: Syk phosphorylates Ikaros at serine residues S358 and S361 augmenting its nuclear
      localization and DNA binding
    supporting_text: We demonstrate that SYK phoshorylates Ikaros at unique C-terminal serine
      phosphorylation sites S358 and S361, thereby augmenting its nuclear localization and
      sequence-specific DNA binding activity
    reference_section_type: ABSTRACT
    full_text_unavailable: false
  - statement: Syk-mediated serine phosphorylation is essential for Ikaros transcription factor
      function
    supporting_text: Mechanistically, we establish that SYK-induced Ikaros activation is essential
      for its nuclear localization and optimal transcription factor function
    reference_section_type: ABSTRACT
    full_text_unavailable: false
- id: PMID:26195794
  title: Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of
    CEACAM20 in the intestinal epithelium.
  findings: []
- id: PMID:27609517
  title: TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet
    Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
  findings:
  - statement: TULA-2 phosphatase suppresses Syk activation by specifically dephosphorylating
      Tyr346, a critical regulatory site
    supporting_text: suppression of Syk activation by TULA-2 is mediated, to a substantial
      degree, by dephosphorylation of Tyr(P)346, a regulatory site of Syk, which becomes phosphorylated
      soon after receptor ligation and plays a critical role in initiating the process that
      yields fully activated Syk
    reference_section_type: ABSTRACT
    full_text_unavailable: false
  - statement: Tyr346 phosphorylation is an early checkpoint in Syk activation that precedes
      activation loop phosphorylation
    supporting_text: Tyr 346 and Tyr 342 were strongly phosphorylated in response to GPVI
      agonists, and this phosphorylation correlated with a profound increase in the phosphorylation
      of multiple proteins involved in the GPVI-mediated signaling pathway
    reference_section_type: DISCUSSION
    full_text_unavailable: false
  - statement: Both Tyr342 and Tyr346 are required for full Syk activation with at least one
      site needing phosphorylation
    supporting_text: These experiments indicated that phosphorylation of Tyr 519 -Tyr 520
      , a marker of Syk activity, is significantly, yet only partially, inhibited by a single
      mutation of either Tyr 342 or Tyr 346 but is fully blocked by the Y342F/Y346F double
      mutation
    reference_section_type: RESULTS
    full_text_unavailable: false
- id: PMID:33782605
  title: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation
    in humans and mice.
  findings: []
- id: PMID:7477352
  title: Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase
    Syk.
  findings:
  - statement: Syk knockout mice show perinatal lethality with hemorrhaging, indicating a
      critical role in vascular integrity
    supporting_text: we created mice null for the syk gene which showed petechiae in utero
      and died shortly after birth
    reference_section_type: ABSTRACT
    full_text_unavailable: true
  - statement: Syk is absolutely required for B cell development with complete block at pro-B
      to pre-B cell transition
    supporting_text: Irradiated mice reconstituted with Syk-deficient fetal liver showed a
      block in B-cell development at the pro-B to pre-B cell transition, consistent with a
      key role for Syk in pre-B-cell receptor signalling
    reference_section_type: ABSTRACT
    full_text_unavailable: true
  - statement: "Syk deficiency impairs development of V\u03B33+ gamma-delta T cells while\
      \ alpha-beta T cell development proceeds normally"
    supporting_text: whereas the development of alpha beta T cells proceeded normally, Syk-deficient
      mice showed impaired development of thymocytes using the V gamma 3 variable region gene
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:7477353
  title: Syk tyrosine kinase required for mouse viability and B-cell development.
  findings:
  - statement: Syk contains tandem SH2 domains that bind to dual phosphotyrosine sites in
      ITAM motifs leading to Syk activation
    supporting_text: the tandem SH2 domains of Syk bind dual phosphotyrosine sites in the
      conserved ITAM motifs of receptor signalling chains, such as the immunoglobulin alpha
      and beta-chains of the BCR, leading to Syk activation
    reference_section_type: ABSTRACT
    full_text_unavailable: true
  - statement: Syk mutation disrupts pre-BCR signaling preventing clonal expansion and maturation
      of pre-B cells
    supporting_text: the syk mutation impaired the differentiation of B-lineage cells, apparently
      by disrupting signalling from the pre-BCR complex and thereby preventing the clonal
      expansion, and further maturation, of pre-B cells
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:7499277
  title: Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells.
  findings:
  - statement: Syk functions in BCR signaling pathway in immature B cells
    supporting_text: Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:7744830
  title: Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes.
  findings:
  - statement: "Syk associates with PLC\u03B31 SH2 domains in BCR-stimulated B cells through\
      \ physical interaction"
    supporting_text: The PLC gamma 1 SH2 domains associate with a prominent 70-72-kDa tyrosine
      phosphoprotein from anti-mu-stimulated, but not resting, B cells...definitively identify
      this protein as p72syk
    reference_section_type: ABSTRACT
    full_text_unavailable: true
  - statement: "Syk-PLC\u03B31 interaction implicates Syk in PLC\u03B31 activation during\
      \ BCR signaling"
    supporting_text: our ability to co-immunoprecipitate p72syk and PLC gamma 1 from lysates
      of anti-mu-stimulated B cells. These results implicate p72syk in the activation of phospholipase
      C gamma 1 during B cell antigen receptor signaling
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:8626447
  title: Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid
    cell line by expressing the Syk protein-tyrosine kinase.
  findings:
  - statement: Syk expression in non-lymphoid cells reconstitutes BCR signaling including
      tyrosine phosphorylation and MAPK activation
    supporting_text: Syk expression reconstituted several signaling events upon anti-IgM stimulation,
      including Syk phosphorylation and association with the BCR, tyrosine phosphorylation
      of numerous proteins including Shc, and activation of mitogen-activated protein kinase
    reference_section_type: ABSTRACT
    full_text_unavailable: true
  - statement: Catalytically active Syk is required for BCR signal transduction as inactive
      mutants cannot reconstitute signaling
    supporting_text: A catalytically inactive Syk mutant could associate with the BCR and
      become tyrosine phosphorylated but could not reconstitute downstream signaling events
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:8629002
  title: Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
  findings:
  - statement: Syk participates in transphosphorylation of BTK at tyrosine 551 leading to
      BTK activation
    supporting_text: This interaction of BTK with SRC kinases transphosphorylated BTK on tyrosine
      at residue 551, which led to BTK activation
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:8790395
  title: Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine
    kinase.
  findings:
  - statement: Syk is required for development of epithelial gamma-delta T cells
    supporting_text: Disruption of epithelial gamma delta T cell repertoires by mutation of
      the Syk tyrosine kinase
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:8798454
  title: Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases.
  findings:
  - statement: Syk has at least 100-fold greater intrinsic enzymatic activity than ZAP-70
      for autophosphorylation and substrate phosphorylation
    supporting_text: the ability of Syk and SykB to undergo autophosphorylation and to phosphorylate
      erythrocyte band 3 in immune complex kinase reactions was at least 100-fold greater
      than that of Zap-70
    reference_section_type: ABSTRACT
    full_text_unavailable: true
  - statement: The superior enzymatic activity of Syk versus ZAP-70 is determined by structural
      variations in the catalytic domain
    supporting_text: the intrinsic enzymatic activity of Syk and SykB is superior to that
      of Zap-70 and that such a distinction relates to structural variations in the catalytic
      domain
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:9000133
  title: Critical role for the tyrosine kinase Syk in signalling through the high affinity
    IgE receptor of mast cells.
  findings:
  - statement: "Syk is essential for Fc\u03B5RI-mediated mast cell degranulation, leukotriene\
      \ synthesis and cytokine secretion"
    supporting_text: Using Syk-deficient mast cells we show that they fail to degranulate,
      synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI,
      conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling
    reference_section_type: ABSTRACT
    full_text_unavailable: true
  - statement: "Fc\u03B5RI engagement leads to sequential activation of Lyn followed by Syk\
      \ in mast cells"
    supporting_text: our data strongly supports a model of Fc epsilon RI engagement leading
      to the sequential activation of the tyrosine kinases Lyn and then Syk
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:9099676
  title: Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation
    of tyrosine 130.
  findings:
  - statement: Phosphorylation of Syk Tyr130 mediates both activation and dissociation from
      BCR
    supporting_text: Syk activation and dissociation from the B-cell antigen receptor is mediated
      by phosphorylation of tyrosine 130
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:9199344
  title: Shc contains two Grb2 binding sites needed for efficient formation of complexes with
    SOS in B lymphocytes.
  findings:
  - statement: Syk participates in Shc phosphorylation contributing to Grb2-SOS complex formation
      in B cells
    supporting_text: Shc contains two Grb2 binding sites needed for efficient formation of
      complexes with SOS in B lymphocytes
    reference_section_type: ABSTRACT
    full_text_unavailable: true
- id: PMID:9275205
  title: The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor
    signaling.
  findings:
  - statement: Syk and ZAP-70 have overlapping and essential functions in pre-TCR signaling
      for DN to DP thymocyte transition
    supporting_text: in mice lacking both Syk and ZAP-70, DN thymocytes undergo beta chain
      gene rearrangement but fail to initiate clonal expansion and are incapable of differentiating
      into DP cells after expression of the pre-TCR
    reference_section_type: ABSTRACT
    full_text_unavailable: false
  - statement: Syk can partially compensate for ZAP-70 in pre-TCR signaling but not in mature
      TCR signaling
    supporting_text: "in \u03B1\u03B2 lineage T cells, Syk and ZAP-70 act jointly in the differentiation\
      \ of DN to DP cells, most probably due to a role in signaling by the pre-TCR"
    reference_section_type: DISCUSSION
    full_text_unavailable: false
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: PMID:11940607
  title: Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate
    integrin signaling to the cytoskeleton.
  findings: []
- id: PMID:12522250
  title: Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76
    and Syk.
  findings: []
- id: PMID:17353363
  title: Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate
    osteoclastic bone resorption.
  findings: []
- id: PMID:19136564
  title: Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production
    in dendritic cells.
  findings: []
- id: PMID:19797524
  title: Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial
    infection.
  findings: []
- id: PMID:22078883
  title: CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.
  findings: []
- id: PMID:23395392
  title: Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.
  findings: []
- id: PMID:23962979
  title: The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream
    of the adaptor molecules TRAF6 and TRAF3.
  findings: []
- id: PMID:29235464
  title: SYK kinase mediates brown fat differentiation and activation.
  findings: []
- id: PMID:9171347
  title: The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation
    of mouse platelets by collagen.
  findings: []
- id: GO_REF:0000008
  title: Gene Ontology annotation by the MGI curatorial staff, curated orthology
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary
    mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:22451653
  title: Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating
    protein of 12 kDa (DAP12).
  findings: []
- id: Reactome:R-MMU-442289
  title: Syk binds Vav2
  findings: []
- id: Reactome:R-MMU-5607754
  title: 1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2
  findings: []
- id: Reactome:R-MMU-5621346
  title: Plcg1 binds p-Y348,352,525,526-Syk
  findings: []
- id: Reactome:R-MMU-9607032
  title: Lyn, p-Syk phosphorylate Btk
  findings: []
- id: Reactome:R-MMU-9674908
  title: p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5
  findings: []
- id: Reactome:R-MMU-9674931
  title: Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates
    yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5
  findings: []
- id: Reactome:R-MMU-9674959
  title: Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5
  findings: []
- id: Reactome:R-MMU-9674973
  title: Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates
    Shc1, Grb2, Gab2, and Ptpn11
  findings: []
- id: Reactome:R-MMU-9676072
  title: Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2
  findings: []
- id: Reactome:R-MMU-9705471
  title: Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2
  findings: []
- id: Reactome:R-MMU-9707972
  title: Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5,
    EloB, EloC, and Rnf7
  findings: []
- id: Reactome:R-MMU-9707979
  title: Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed
  findings: []
- id: file:mouse/Syk/Syk-deep-research-falcon.md
  title: Falcon deep research summary for mouse Syk
  findings: []
- id: file:mouse/Syk/Syk-deep-research.md
  title: Deep research summary for mouse Syk
  findings: []
existing_annotations:
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0000166
    label: nucleotide binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: Nucleotide binding is too broad for Syk kinase catalysis.
    action: MODIFY
    reason: Syk specifically uses ATP as the phosphate donor for kinase activity.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
    proposed_replacement_terms:
    - id: GO:0005524
      label: ATP binding
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: protein kinase activity is a correct ancestor but is less specific than Syk tyrosine
      kinase activity.
    action: MODIFY
    reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase
      term should be used.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
    proposed_replacement_terms:
    - &id001
      id: GO:0004715
      label: non-membrane spanning protein tyrosine kinase activity
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: non-membrane spanning protein tyrosine kinase activity is consistent with core
      Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: ATP binding is consistent with core Syk kinase, receptor-proximal signaling,
      or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0016301
    label: kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: kinase activity is a correct ancestor but is less specific than Syk tyrosine
      kinase activity.
    action: MODIFY
    reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase
      term should be used.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0016740
    label: transferase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: transferase activity is a correct ancestor but is less specific than Syk tyrosine
      kinase activity.
    action: MODIFY
    reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase
      term should be used.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0019904
    label: protein domain specific binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: protein domain specific binding is too vague or reverses the most informative
      binding description for Syk.
    action: MODIFY
    reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine
      motifs by tandem SH2 domains.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
    proposed_replacement_terms:
    - &id002
      id: GO:0001784
      label: phosphotyrosine residue binding
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16410013
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16713566
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20133729
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0000045
    label: autophagosome assembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      autophagosome assembly to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific autophagy
      annotation.
- term:
    id: GO:0001784
    label: phosphotyrosine residue binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: phosphotyrosine residue binding is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein kinase activity is a correct ancestor but is less specific than Syk tyrosine
      kinase activity.
    action: MODIFY
    reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase
      term should be used.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: protein kinase activity is a correct ancestor but is less specific than Syk tyrosine
      kinase activity.
    action: MODIFY
    reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase
      term should be used.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: non-membrane spanning protein tyrosine kinase activity is consistent with core
      Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: signaling receptor binding is too vague or reverses the most informative binding
      description for Syk.
    action: MODIFY
    reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine
      motifs by tandem SH2 domains.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0005178
    label: integrin binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: integrin binding is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0010507
    label: negative regulation of autophagy
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      negative regulation of autophagy to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific autophagy
      annotation.
- term:
    id: GO:0010508
    label: positive regulation of autophagy
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      positive regulation of autophagy to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific autophagy
      annotation.
- term:
    id: GO:0016170
    label: interleukin-15 receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: interleukin-15 receptor binding is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0016301
    label: kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: kinase activity is a correct ancestor but is less specific than Syk tyrosine
      kinase activity.
    action: MODIFY
    reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase
      term should be used.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0019904
    label: protein domain specific binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein domain specific binding is too vague or reverses the most informative
      binding description for Syk.
    action: MODIFY
    reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine
      motifs by tandem SH2 domains.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: ubiquitin protein ligase binding is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0031669
    label: cellular response to nutrient levels
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cellular response to nutrient levels is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0038202
    label: TORC1 signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      TORC1 signaling to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific nutrient-signaling
      annotation.
- term:
    id: GO:0043274
    label: phospholipase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: phospholipase binding is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:1904262
    label: negative regulation of TORC1 signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      negative regulation of TORC1 signaling to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific nutrient-signaling
      annotation.
- term:
    id: GO:0000045
    label: autophagosome assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      autophagosome assembly to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific autophagy
      annotation.
- term:
    id: GO:0001784
    label: phosphotyrosine residue binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: phosphotyrosine residue binding is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: protein serine/threonine kinase activity is retained as a non-core Syk-associated
      annotation.
    action: KEEP_AS_NON_CORE
    reason: The term describes a downstream, localization, or context-specific consequence
      of Syk signaling rather than the primary kinase activity.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: signaling receptor binding is too vague or reverses the most informative binding
      description for Syk.
    action: MODIFY
    reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine
      motifs by tandem SH2 domains.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0005178
    label: integrin binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: integrin binding is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0006606
    label: protein import into nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: protein import into nucleus is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0010507
    label: negative regulation of autophagy
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      negative regulation of autophagy to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific autophagy
      annotation.
- term:
    id: GO:0010508
    label: positive regulation of autophagy
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      positive regulation of autophagy to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific autophagy
      annotation.
- term:
    id: GO:0016170
    label: interleukin-15 receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: interleukin-15 receptor binding is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0031669
    label: cellular response to nutrient levels
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to nutrient levels is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0038202
    label: TORC1 signaling
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      TORC1 signaling to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific nutrient-signaling
      annotation.
- term:
    id: GO:0043274
    label: phospholipase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: phospholipase binding is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:1904262
    label: negative regulation of TORC1 signaling
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      negative regulation of TORC1 signaling to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific nutrient-signaling
      annotation.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:8629002
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:9199344
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IMP
  original_reference_id: PMID:33782605
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0043410
    label: positive regulation of MAPK cascade
  evidence_type: IDA
  original_reference_id: PMID:8626447
  review:
    summary: positive regulation of MAPK cascade is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0043410
    label: positive regulation of MAPK cascade
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: positive regulation of MAPK cascade is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0032752
    label: positive regulation of interleukin-3 production
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: positive regulation of interleukin-3 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19098920
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0006606
    label: protein import into nucleus
  evidence_type: ISO
  original_reference_id: PMID:23071339
  review:
    summary: protein import into nucleus is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:27609517
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0038063
    label: collagen-activated tyrosine kinase receptor signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:27609517
  review:
    summary: collagen-activated tyrosine kinase receptor signaling pathway is consistent with
      core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0042169
    label: SH2 domain binding
  evidence_type: IDA
  original_reference_id: PMID:27609517
  review:
    summary: SH2 domain binding is too vague or reverses the most informative binding description
      for Syk.
    action: MODIFY
    reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine
      motifs by tandem SH2 domains.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26195794
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22496641
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0019902
    label: phosphatase binding
  evidence_type: IPI
  original_reference_id: PMID:22496641
  review:
    summary: phosphatase binding is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0035325
    label: Toll-like receptor binding
  evidence_type: IPI
  original_reference_id: PMID:22496641
  review:
    summary: Toll-like receptor binding is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: ISO
  original_reference_id: PMID:23071339
  review:
    summary: protein serine/threonine kinase activity is retained as a non-core Syk-associated
      annotation.
    action: KEEP_AS_NON_CORE
    reason: The term describes a downstream, localization, or context-specific consequence
      of Syk signaling rather than the primary kinase activity.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10872802
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8626447
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0001819
    label: positive regulation of cytokine production
  evidence_type: IGI
  original_reference_id: PMID:19770268
  review:
    summary: positive regulation of cytokine production is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17086186
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15845454
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0019901
    label: protein kinase binding
  evidence_type: IPI
  original_reference_id: PMID:11672534
  review:
    summary: protein kinase binding is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IMP
  original_reference_id: PMID:16456001
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16456001
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19124738
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
        and downstream phosphorylation cascades'
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:7499277
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0050853
    label: B cell receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:7499277
  review:
    summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0043366
    label: beta selection
  evidence_type: IGI
  original_reference_id: PMID:9275205
  review:
    summary: beta selection is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:10872802
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8798454
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8626447
  review:
    summary: non-membrane spanning protein tyrosine kinase activity is consistent with core
      Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0007166
    label: cell surface receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:9099676
  review:
    summary: cell surface receptor signaling pathway is a broad signaling parent for Syk.
    action: MODIFY
    reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin,
      integrin-associated, and related ITAM signaling pathways.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
    proposed_replacement_terms:
    - &id003
      id: GO:0050851
      label: antigen receptor-mediated signaling pathway
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IDA
  original_reference_id: PMID:8626447
  review:
    summary: intracellular signal transduction is a broad signaling parent for Syk.
    action: MODIFY
    reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin,
      integrin-associated, and related ITAM signaling pathways.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
    proposed_replacement_terms:
    - *id003
- term:
    id: GO:0045579
    label: positive regulation of B cell differentiation
  evidence_type: IMP
  original_reference_id: PMID:7477353
  review:
    summary: positive regulation of B cell differentiation is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0045588
    label: positive regulation of gamma-delta T cell differentiation
  evidence_type: IMP
  original_reference_id: PMID:8790395
  review:
    summary: positive regulation of gamma-delta T cell differentiation is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0046638
    label: positive regulation of alpha-beta T cell differentiation
  evidence_type: IGI
  original_reference_id: PMID:9275205
  review:
    summary: positive regulation of alpha-beta T cell differentiation is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0046641
    label: positive regulation of alpha-beta T cell proliferation
  evidence_type: IGI
  original_reference_id: PMID:9275205
  review:
    summary: positive regulation of alpha-beta T cell proliferation is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0050853
    label: B cell receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:8626447
  review:
    summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0050850
    label: positive regulation of calcium-mediated signaling
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: positive regulation of calcium-mediated signaling is consistent with core Syk
      kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0001820
    label: serotonin secretion
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: serotonin secretion is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:9099676
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0007166
    label: cell surface receptor signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: cell surface receptor signaling pathway is a broad signaling parent for Syk.
    action: MODIFY
    reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin,
      integrin-associated, and related ITAM signaling pathways.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
    proposed_replacement_terms:
    - *id003
- term:
    id: GO:0019370
    label: leukotriene biosynthetic process
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: leukotriene biosynthetic process is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032725
    label: positive regulation of granulocyte macrophage colony-stimulating factor production
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: positive regulation of granulocyte macrophage colony-stimulating factor production
      is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: intracellular signal transduction is a broad signaling parent for Syk.
    action: MODIFY
    reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin,
      integrin-associated, and related ITAM signaling pathways.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
    proposed_replacement_terms:
    - *id003
- term:
    id: GO:0043306
    label: positive regulation of mast cell degranulation
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: positive regulation of mast cell degranulation is a directly supported Fc-epsilon
      receptor downstream output, but it is not Syk's core molecular function.
    action: KEEP_AS_NON_CORE
    reason: Syk is the receptor-proximal kinase required for this mast-cell response, so the
      process is supported as a context-specific signaling output.
    supported_by:
    - reference_id: PMID:9000133
      supporting_text: Using Syk-deficient mast cells we show that they fail to degranulate,
        synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI,
        conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IDA
  original_reference_id: PMID:8798454
  review:
    summary: ATP binding is consistent with core Syk kinase, receptor-proximal signaling,
      or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0045579
    label: positive regulation of B cell differentiation
  evidence_type: IMP
  original_reference_id: PMID:7477352
  review:
    summary: positive regulation of B cell differentiation is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0045588
    label: positive regulation of gamma-delta T cell differentiation
  evidence_type: IMP
  original_reference_id: PMID:7477352
  review:
    summary: positive regulation of gamma-delta T cell differentiation is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:7744830
  review:
    summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0007167
    label: enzyme-linked receptor protein signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:7744830
  review:
    summary: enzyme-linked receptor protein signaling pathway is a broad signaling parent
      for Syk.
    action: MODIFY
    reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin,
      integrin-associated, and related ITAM signaling pathways.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
    proposed_replacement_terms:
    - *id003
- term:
    id: GO:0007186
    label: G protein-coupled receptor signaling pathway
  evidence_type: TAS
  original_reference_id: PMID:11676469
  review:
    summary: GPCR signaling is not a core or well-supported primary Syk pathway.
    action: MARK_AS_OVER_ANNOTATED
    reason: The Syk evidence base centers on ITAM/hemITAM and innate immune receptor signaling
      rather than direct GPCR pathway execution.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: plasma membrane is consistent with core Syk kinase, receptor-proximal signaling,
      or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0050853
    label: B cell receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0002250
    label: adaptive immune response
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: adaptive immune response is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002281
    label: macrophage activation involved in immune response
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: macrophage activation involved in immune response is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002283
    label: neutrophil activation involved in immune response
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: neutrophil activation involved in immune response is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0033630
    label: positive regulation of cell adhesion mediated by integrin
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: positive regulation of cell adhesion mediated by integrin is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0001525
    label: angiogenesis
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: angiogenesis is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002250
    label: adaptive immune response
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: adaptive immune response is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002376
    label: immune system process
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: immune system process is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: intracellular signal transduction is a broad signaling parent for Syk.
    action: MODIFY
    reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin,
      integrin-associated, and related ITAM signaling pathways.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
    proposed_replacement_terms:
    - *id003
- term:
    id: GO:0043306
    label: positive regulation of mast cell degranulation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: positive regulation of mast cell degranulation is a directly supported Fc-epsilon
      receptor downstream output, but it is not Syk's core molecular function.
    action: KEEP_AS_NON_CORE
    reason: Syk is the receptor-proximal kinase required for this mast-cell response, so the
      process is supported as a context-specific signaling output.
    supported_by:
    - reference_id: PMID:9000133
      supporting_text: Using Syk-deficient mast cells we show that they fail to degranulate,
        synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI,
        conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling
- term:
    id: GO:0043366
    label: beta selection
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: beta selection is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0045087
    label: innate immune response
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: innate immune response is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0046638
    label: positive regulation of alpha-beta T cell differentiation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: positive regulation of alpha-beta T cell differentiation is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0046641
    label: positive regulation of alpha-beta T cell proliferation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: positive regulation of alpha-beta T cell proliferation is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0050850
    label: positive regulation of calcium-mediated signaling
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: positive regulation of calcium-mediated signaling is consistent with core Syk
      kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0050851
    label: antigen receptor-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: antigen receptor-mediated signaling pathway is consistent with core Syk kinase,
      receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0002752
    label: cell surface pattern recognition receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cell surface pattern recognition receptor signaling pathway is consistent with
      core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0007159
    label: leukocyte cell-cell adhesion
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: leukocyte cell-cell adhesion is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0010803
    label: regulation of tumor necrosis factor-mediated signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: regulation of tumor necrosis factor-mediated signaling pathway is a supported
      downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0030593
    label: neutrophil chemotaxis
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: neutrophil chemotaxis is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0031334
    label: positive regulation of protein-containing complex assembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of protein-containing complex assembly is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032733
    label: positive regulation of interleukin-10 production
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of interleukin-10 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032735
    label: positive regulation of interleukin-12 production
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of interleukin-12 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032755
    label: positive regulation of interleukin-6 production
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of interleukin-6 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032757
    label: positive regulation of interleukin-8 production
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of interleukin-8 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032760
    label: positive regulation of tumor necrosis factor production
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of tumor necrosis factor production is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032930
    label: positive regulation of superoxide anion generation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of superoxide anion generation is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: intracellular signal transduction is a broad signaling parent for Syk.
    action: MODIFY
    reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin,
      integrin-associated, and related ITAM signaling pathways.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
    proposed_replacement_terms:
    - *id003
- term:
    id: GO:0043306
    label: positive regulation of mast cell degranulation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of mast cell degranulation is a directly supported Fc-epsilon
      receptor downstream output, but it is not Syk's core molecular function.
    action: KEEP_AS_NON_CORE
    reason: Syk is the receptor-proximal kinase required for this mast-cell response, so the
      process is supported as a context-specific signaling output.
    supported_by:
    - reference_id: PMID:9000133
      supporting_text: Using Syk-deficient mast cells we show that they fail to degranulate,
        synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI,
        conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling
- term:
    id: GO:0045579
    label: positive regulation of B cell differentiation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of B cell differentiation is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0050776
    label: regulation of immune response
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: regulation of immune response is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0050853
    label: B cell receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0071396
    label: cellular response to lipid
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cellular response to lipid is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0071639
    label: positive regulation of monocyte chemotactic protein-1 production
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of monocyte chemotactic protein-1 production is a supported
      downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: scaffold protein binding is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0097190
    label: apoptotic signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: apoptotic signaling pathway is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0097242
    label: amyloid-beta clearance
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      amyloid-beta clearance to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific amyloid-beta
      annotation.
- term:
    id: GO:1904263
    label: positive regulation of TORC1 signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      positive regulation of TORC1 signaling to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific nutrient-signaling
      annotation.
- term:
    id: GO:1904646
    label: cellular response to amyloid-beta
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      cellular response to amyloid-beta to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific amyloid-beta
      annotation.
- term:
    id: GO:0002752
    label: cell surface pattern recognition receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cell surface pattern recognition receptor signaling pathway is consistent with
      core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: nucleus is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0007159
    label: leukocyte cell-cell adhesion
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: leukocyte cell-cell adhesion is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0010803
    label: regulation of tumor necrosis factor-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: regulation of tumor necrosis factor-mediated signaling pathway is a supported
      downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0030593
    label: neutrophil chemotaxis
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: neutrophil chemotaxis is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0031334
    label: positive regulation of protein-containing complex assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of protein-containing complex assembly is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032733
    label: positive regulation of interleukin-10 production
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of interleukin-10 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032735
    label: positive regulation of interleukin-12 production
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of interleukin-12 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032755
    label: positive regulation of interleukin-6 production
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of interleukin-6 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032757
    label: positive regulation of interleukin-8 production
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of interleukin-8 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032760
    label: positive regulation of tumor necrosis factor production
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of tumor necrosis factor production is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032930
    label: positive regulation of superoxide anion generation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of superoxide anion generation is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0045579
    label: positive regulation of B cell differentiation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of B cell differentiation is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0050853
    label: B cell receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0071396
    label: cellular response to lipid
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to lipid is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0071639
    label: positive regulation of monocyte chemotactic protein-1 production
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of monocyte chemotactic protein-1 production is a supported
      downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: scaffold protein binding is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0097190
    label: apoptotic signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: apoptotic signaling pathway is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0097242
    label: amyloid-beta clearance
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      amyloid-beta clearance to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific amyloid-beta
      annotation.
- term:
    id: GO:1904263
    label: positive regulation of TORC1 signaling
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      positive regulation of TORC1 signaling to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific nutrient-signaling
      annotation.
- term:
    id: GO:1904646
    label: cellular response to amyloid-beta
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: The current local evidence does not provide term-specific support for assigning
      cellular response to amyloid-beta to Syk.
    action: UNDECIDED
    reason: Automated transfer requires direct support before retaining this specific amyloid-beta
      annotation.
- term:
    id: GO:0050853
    label: B cell receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:9199344
  review:
    summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0001775
    label: cell activation
  evidence_type: IMP
  original_reference_id: PMID:19136564
  review:
    summary: cell activation is retained as a non-core Syk-associated annotation.
    action: KEEP_AS_NON_CORE
    reason: The term describes a downstream, localization, or context-specific consequence
      of Syk signaling rather than the primary kinase activity.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002223
    label: stimulatory C-type lectin receptor signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:19136564
  review:
    summary: stimulatory C-type lectin receptor signaling pathway is consistent with core
      Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IMP
  original_reference_id: PMID:19136564
  review:
    summary: intracellular signal transduction is a broad signaling parent for Syk.
    action: MODIFY
    reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin,
      integrin-associated, and related ITAM signaling pathways.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
    proposed_replacement_terms:
    - *id003
- term:
    id: GO:1990858
    label: cellular response to lectin
  evidence_type: IMP
  original_reference_id: PMID:19136564
  review:
    summary: cellular response to lectin is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: peptidyl-tyrosine phosphorylation is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0120162
    label: positive regulation of cold-induced thermogenesis
  evidence_type: IMP
  original_reference_id: PMID:29235464
  review:
    summary: positive regulation of cold-induced thermogenesis is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032753
    label: positive regulation of interleukin-4 production
  evidence_type: IMP
  original_reference_id: PMID:19098920
  review:
    summary: positive regulation of interleukin-4 production is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0038156
    label: interleukin-3-mediated signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:19098920
  review:
    summary: interleukin-3-mediated signaling pathway is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0031623
    label: receptor internalization
  evidence_type: IDA
  original_reference_id: PMID:23395392
  review:
    summary: receptor internalization is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0071404
    label: cellular response to low-density lipoprotein particle stimulus
  evidence_type: IDA
  original_reference_id: PMID:23395392
  review:
    summary: cellular response to low-density lipoprotein particle stimulus is a supported
      downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: ISO
  original_reference_id: PMID:23071339
  review:
    summary: nucleus is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002092
    label: positive regulation of receptor internalization
  evidence_type: IMP
  original_reference_id: PMID:22078883
  review:
    summary: positive regulation of receptor internalization is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032481
    label: positive regulation of type I interferon production
  evidence_type: IMP
  original_reference_id: PMID:22078883
  review:
    summary: positive regulation of type I interferon production is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002092
    label: positive regulation of receptor internalization
  evidence_type: IMP
  original_reference_id: PMID:23962979
  review:
    summary: positive regulation of receptor internalization is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002250
    label: adaptive immune response
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: adaptive immune response is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002281
    label: macrophage activation involved in immune response
  evidence_type: IMP
  original_reference_id: PMID:17086186
  review:
    summary: macrophage activation involved in immune response is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002283
    label: neutrophil activation involved in immune response
  evidence_type: IMP
  original_reference_id: PMID:17086186
  review:
    summary: neutrophil activation involved in immune response is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0007159
    label: leukocyte cell-cell adhesion
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: leukocyte cell-cell adhesion is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0007229
    label: integrin-mediated signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:17086186
  review:
    summary: integrin-mediated signaling pathway is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0030593
    label: neutrophil chemotaxis
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: neutrophil chemotaxis is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002366
    label: leukocyte activation involved in immune response
  evidence_type: IMP
  original_reference_id: PMID:15845454
  review:
    summary: leukocyte activation involved in immune response is a supported downstream or
      context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032928
    label: regulation of superoxide anion generation
  evidence_type: IMP
  original_reference_id: PMID:19797524
  review:
    summary: regulation of superoxide anion generation is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0042742
    label: defense response to bacterium
  evidence_type: IMP
  original_reference_id: PMID:19797524
  review:
    summary: defense response to bacterium is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0043313
    label: regulation of neutrophil degranulation
  evidence_type: IMP
  original_reference_id: PMID:19797524
  review:
    summary: regulation of neutrophil degranulation is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0045087
    label: innate immune response
  evidence_type: IMP
  original_reference_id: PMID:15845454
  review:
    summary: innate immune response is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0050764
    label: regulation of phagocytosis
  evidence_type: IMP
  original_reference_id: PMID:19797524
  review:
    summary: regulation of phagocytosis is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0070372
    label: regulation of ERK1 and ERK2 cascade
  evidence_type: IMP
  original_reference_id: PMID:19797524
  review:
    summary: regulation of ERK1 and ERK2 cascade is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0071226
    label: cellular response to molecule of fungal origin
  evidence_type: IMP
  original_reference_id: PMID:15845454
  review:
    summary: cellular response to molecule of fungal origin is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0002554
    label: serotonin secretion by platelet
  evidence_type: IMP
  original_reference_id: PMID:9171347
  review:
    summary: serotonin secretion by platelet is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0007229
    label: integrin-mediated signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:11940607
  review:
    summary: integrin-mediated signaling pathway is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is presented as a **central kinase downstream of ITAM-coupled immune
        receptors**
- term:
    id: GO:0010543
    label: regulation of platelet activation
  evidence_type: IMP
  original_reference_id: PMID:9171347
  review:
    summary: regulation of platelet activation is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0033630
    label: positive regulation of cell adhesion mediated by integrin
  evidence_type: IMP
  original_reference_id: PMID:11940607
  review:
    summary: positive regulation of cell adhesion mediated by integrin is a supported downstream
      or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0045780
    label: positive regulation of bone resorption
  evidence_type: IMP
  original_reference_id: PMID:17353363
  review:
    summary: positive regulation of bone resorption is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0090237
    label: regulation of arachidonate secretion
  evidence_type: IMP
  original_reference_id: PMID:9171347
  review:
    summary: regulation of arachidonate secretion is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0090330
    label: regulation of platelet aggregation
  evidence_type: IMP
  original_reference_id: PMID:9171347
  review:
    summary: regulation of platelet aggregation is a supported downstream or context-specific
      Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0001945
    label: lymph vessel development
  evidence_type: IMP
  original_reference_id: PMID:12522250
  review:
    summary: lymph vessel development is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0048514
    label: blood vessel morphogenesis
  evidence_type: IMP
  original_reference_id: PMID:12522250
  review:
    summary: blood vessel morphogenesis is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:16456001
  review:
    summary: peptidyl-tyrosine phosphorylation is consistent with core Syk kinase, receptor-proximal
      signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
        to tyrosine residues** on protein substrates in signaling complexes
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: cytoplasm is consistent with core Syk kinase, receptor-proximal signaling, or
      localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: plasma membrane is consistent with core Syk kinase, receptor-proximal signaling,
      or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0031410
    label: cytoplasmic vesicle
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: cytoplasmic vesicle is consistent with core Syk kinase, receptor-proximal signaling,
      or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0045335
    label: phagocytic vesicle
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: phagocytic vesicle is consistent with core Syk kinase, receptor-proximal signaling,
      or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0032991
    label: protein-containing complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: protein-containing complex is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0042101
    label: T cell receptor complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: T cell receptor complex is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9674908
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9674931
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9674959
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9674973
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9676072
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9705471
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9707972
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9707979
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-5621346
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9607032
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0032991
    label: protein-containing complex
  evidence_type: IDA
  original_reference_id: PMID:22451653
  review:
    summary: protein-containing complex is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0032991
    label: protein-containing complex
  evidence_type: ISO
  original_reference_id: PMID:23071339
  review:
    summary: protein-containing complex is a supported downstream or context-specific Syk
      role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISO
  original_reference_id: PMID:23071339
  review:
    summary: cytoplasm is consistent with core Syk kinase, receptor-proximal signaling, or
      localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0032009
    label: early phagosome
  evidence_type: IDA
  original_reference_id: PMID:15845454
  review:
    summary: early phagosome is consistent with core Syk kinase, receptor-proximal signaling,
      or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-442289
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-5607754
  review:
    summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
    action: ACCEPT
    reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited
      to phosphorylated immune receptor signaling complexes.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: SYK is predominantly a **cytoplasmic kinase** that is recruited to
        **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation
- term:
    id: GO:0019815
    label: B cell receptor complex
  evidence_type: IDA
  original_reference_id: PMID:8626447
  review:
    summary: B cell receptor complex is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0042101
    label: T cell receptor complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000008
  review:
    summary: T cell receptor complex is a supported downstream or context-specific Syk role.
    action: KEEP_AS_NON_CORE
    reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid,
      vascular, or tissue-specific signaling but should not be treated as the core molecular
      function.
    supported_by:
    - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
      supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
        cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
        amplification.
- term:
    id: GO:0030168
    label: platelet activation
  evidence_type: IMP
  original_reference_id: PMID:9171347
  review:
    summary: platelet activation is a directly supported proposed Syk signaling annotation.
    action: NEW
    reason: This proposed annotation reflects experimentally supported Syk signaling output
      and is not inferred merely from broad phenotype.
    supported_by:
    - reference_id: PMID:9171347
      supporting_text: The absence of Fc receptor gamma-chain or Syk is accompanied by a loss
        of secretion and aggregation responses in collagen- but not thrombin-stimulated platelets.
- term:
    id: GO:0038095
    label: Fc-epsilon receptor signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:9000133
  review:
    summary: Fc-epsilon receptor signaling pathway is a directly supported proposed Syk signaling
      annotation.
    action: NEW
    reason: This proposed annotation reflects experimentally supported Syk signaling output
      and is not inferred merely from broad phenotype.
    supported_by:
    - reference_id: PMID:9000133
      supporting_text: Stimulation of Fc epsilon RI results in the rapid association and activation
        of the Syk tyrosine kinase.
core_functions:
- description: Binds phosphorylated ITAM/hemITAM receptor adaptors through tandem SH2 domains,
    relieving autoinhibition and recruiting Syk to receptor-proximal signaling complexes.
  molecular_function: *id002
  directly_involved_in:
  - id: GO:0050851
    label: antigen receptor-mediated signaling pathway
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005886
    label: plasma membrane
  supported_by:
  - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
    supporting_text: '**ITAM binding relieves SYK autoinhibition**, enabling kinase activation
      and downstream phosphorylation cascades'
- description: Catalyzes tyrosine phosphorylation of receptor-proximal substrates to propagate
    BCR, Fc receptor, C-type lectin, integrin-associated, platelet GPVI, and innate immune
    signaling.
  molecular_function: *id001
  directly_involved_in:
  - id: GO:0050853
    label: B cell receptor signaling pathway
  - id: GO:0038095
    label: Fc-epsilon receptor signaling pathway
  - id: GO:0002223
    label: stimulatory C-type lectin receptor signaling pathway
  locations:
  - id: GO:0005829
    label: cytosol
  supported_by:
  - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
    supporting_text: SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate
      to tyrosine residues** on protein substrates in signaling complexes
- description: Links ITAM-dependent receptor activation to phagocytosis, cytokine production,
    platelet activation, and cytoskeletal remodeling in immune and hemostatic cells.
  molecular_function:
    id: GO:0004713
    label: protein tyrosine kinase activity
  directly_involved_in:
  - id: GO:0030168
    label: platelet activation
  - id: GO:0038095
    label: Fc-epsilon receptor signaling pathway
  - id: GO:0050853
    label: B cell receptor signaling pathway
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0045335
    label: phagocytic vesicle
  supported_by:
  - reference_id: file:mouse/Syk/Syk-deep-research-falcon.md
    supporting_text: Activated SYK drives phagocytosis, ROS generation, cytokine secretion,
      cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal
      amplification.
proposed_new_terms: []
suggested_questions:
- question: Which Syk receptor contexts in mouse should be considered core gene-product functions
    rather than immune-cell-specific downstream outputs?
- question: Which Syk isoform/localization differences are sufficiently supported for isoform-specific
    GO annotation?
suggested_experiments:
- description: Compare kinase-dead, SH2-binding-defective, and isoform-specific Syk rescue
    alleles in mouse immune-cell receptor signaling assays.
  hypothesis: Syk core functions partition into phosphotyrosine docking and tyrosine kinase
    catalytic modules that have receptor-context-specific requirements.
  experiment_type: Genetic rescue and phosphoproteomics