Syk is a non-receptor cytoplasmic tyrosine kinase that couples phosphorylated ITAM- and hemITAM-containing immune receptor adaptors to downstream PLCgamma, PI3K, MAPK, NF-kappaB, cytoskeletal, phagocytic, platelet, and cytokine-response programs. Its tandem SH2 domains bind phosphorylated receptor/adaptor motifs, relieving autoinhibition of the C-terminal kinase domain. In mouse, Syk is essential for B cell development, Fc receptor mast-cell activation, C-type lectin signaling, integrin-linked myeloid functions, and GPVI-dependent platelet activation, while vascular, metabolic, autophagy, and tissue-remodeling phenotypes are treated as context-dependent downstream roles rather than the core molecular function.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004713 protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0000166 nucleotide binding | IEA GO_REF:0000043 | MODIFY | Summary: Nucleotide binding is too broad for Syk kinase catalysis. Reason: Syk specifically uses ATP as the phosphate donor for kinase activity. Proposed replacements: ATP binding Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004672 protein kinase activity | IEA GO_REF:0000120 | MODIFY | Summary: protein kinase activity is a correct ancestor but is less specific than Syk tyrosine kinase activity. Reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase term should be used. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: non-membrane spanning protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0005524 ATP binding | IEA GO_REF:0000120 | ACCEPT | Summary: ATP binding is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0016301 kinase activity | IEA GO_REF:0000120 | MODIFY | Summary: kinase activity is a correct ancestor but is less specific than Syk tyrosine kinase activity. Reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase term should be used. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0016740 transferase activity | IEA GO_REF:0000043 | MODIFY | Summary: transferase activity is a correct ancestor but is less specific than Syk tyrosine kinase activity. Reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase term should be used. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000117 | MODIFY | Summary: protein domain specific binding is too vague or reverses the most informative binding description for Syk. Reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine motifs by tandem SH2 domains. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005515 protein binding | IPI PMID:16410013 Structural basis for the requirement of two phosphotyrosine ... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005515 protein binding | IPI PMID:16713566 Nontranscriptional regulation of SYK by the coactivator OCA-... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005515 protein binding | IPI PMID:20133729 STAT3 is a substrate of SYK tyrosine kinase in B-lineage leu... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0000045 autophagosome assembly | ISO GO_REF:0000119 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning autophagosome assembly to Syk. Reason: Automated transfer requires direct support before retaining this specific autophagy annotation. |
| GO:0001784 phosphotyrosine residue binding | ISO GO_REF:0000119 | ACCEPT | Summary: phosphotyrosine residue binding is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0004672 protein kinase activity | ISO GO_REF:0000096 | MODIFY | Summary: protein kinase activity is a correct ancestor but is less specific than Syk tyrosine kinase activity. Reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase term should be used. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004672 protein kinase activity | ISO GO_REF:0000119 | MODIFY | Summary: protein kinase activity is a correct ancestor but is less specific than Syk tyrosine kinase activity. Reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase term should be used. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004713 protein tyrosine kinase activity | ISO GO_REF:0000096 | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004713 protein tyrosine kinase activity | ISO GO_REF:0000119 | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | ISO GO_REF:0000119 | ACCEPT | Summary: non-membrane spanning protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0005102 signaling receptor binding | ISO GO_REF:0000119 | MODIFY | Summary: signaling receptor binding is too vague or reverses the most informative binding description for Syk. Reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine motifs by tandem SH2 domains. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005178 integrin binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: integrin binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0010507 negative regulation of autophagy | ISO GO_REF:0000119 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning negative regulation of autophagy to Syk. Reason: Automated transfer requires direct support before retaining this specific autophagy annotation. |
| GO:0010508 positive regulation of autophagy | ISO GO_REF:0000119 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning positive regulation of autophagy to Syk. Reason: Automated transfer requires direct support before retaining this specific autophagy annotation. |
| GO:0016170 interleukin-15 receptor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: interleukin-15 receptor binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0016301 kinase activity | ISO GO_REF:0000119 | MODIFY | Summary: kinase activity is a correct ancestor but is less specific than Syk tyrosine kinase activity. Reason: Syk is a non-receptor protein tyrosine kinase, so the more specific tyrosine-kinase term should be used. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0019904 protein domain specific binding | ISO GO_REF:0000096 | MODIFY | Summary: protein domain specific binding is too vague or reverses the most informative binding description for Syk. Reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine motifs by tandem SH2 domains. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0031625 ubiquitin protein ligase binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: ubiquitin protein ligase binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0031669 cellular response to nutrient levels | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to nutrient levels is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0038202 TORC1 signaling | ISO GO_REF:0000119 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning TORC1 signaling to Syk. Reason: Automated transfer requires direct support before retaining this specific nutrient-signaling annotation. |
| GO:0043274 phospholipase binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phospholipase binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:1904262 negative regulation of TORC1 signaling | ISO GO_REF:0000119 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning negative regulation of TORC1 signaling to Syk. Reason: Automated transfer requires direct support before retaining this specific nutrient-signaling annotation. |
| GO:0000045 autophagosome assembly | IEA GO_REF:0000107 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning autophagosome assembly to Syk. Reason: Automated transfer requires direct support before retaining this specific autophagy annotation. |
| GO:0001784 phosphotyrosine residue binding | IEA GO_REF:0000107 | ACCEPT | Summary: phosphotyrosine residue binding is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0004674 protein serine/threonine kinase activity | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: protein serine/threonine kinase activity is retained as a non-core Syk-associated annotation. Reason: The term describes a downstream, localization, or context-specific consequence of Syk signaling rather than the primary kinase activity. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0005102 signaling receptor binding | IEA GO_REF:0000107 | MODIFY | Summary: signaling receptor binding is too vague or reverses the most informative binding description for Syk. Reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine motifs by tandem SH2 domains. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005178 integrin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: integrin binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0006606 protein import into nucleus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: protein import into nucleus is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0010507 negative regulation of autophagy | IEA GO_REF:0000107 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning negative regulation of autophagy to Syk. Reason: Automated transfer requires direct support before retaining this specific autophagy annotation. |
| GO:0010508 positive regulation of autophagy | IEA GO_REF:0000107 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning positive regulation of autophagy to Syk. Reason: Automated transfer requires direct support before retaining this specific autophagy annotation. |
| GO:0016170 interleukin-15 receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: interleukin-15 receptor binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0031669 cellular response to nutrient levels | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cellular response to nutrient levels is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0038202 TORC1 signaling | IEA GO_REF:0000107 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning TORC1 signaling to Syk. Reason: Automated transfer requires direct support before retaining this specific nutrient-signaling annotation. |
| GO:0043274 phospholipase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: phospholipase binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:1904262 negative regulation of TORC1 signaling | IEA GO_REF:0000107 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning negative regulation of TORC1 signaling to Syk. Reason: Automated transfer requires direct support before retaining this specific nutrient-signaling annotation. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:8629002 Activation of BTK by a phosphorylation mechanism initiated b... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:9199344 Shc contains two Grb2 binding sites needed for efficient for... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:33782605 Gain-of-function variants in SYK cause immune dysregulation ... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:8626447 Reconstitution of B cell antigen receptor-induced signaling ... | ACCEPT | Summary: positive regulation of MAPK cascade is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0043410 positive regulation of MAPK cascade | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | ACCEPT | Summary: positive regulation of MAPK cascade is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0032752 positive regulation of interleukin-3 production | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | KEEP AS NON CORE | Summary: positive regulation of interleukin-3 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0005515 protein binding | IPI PMID:19098920 Fc receptor gamma-chain, a constitutive component of the IL-... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0006606 protein import into nucleus | ISO PMID:23071339 Serine phosphorylation by SYK is critical for nuclear locali... | KEEP AS NON CORE | Summary: protein import into nucleus is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:27609517 TULA-2 Protein Phosphatase Suppresses Activation of Syk thro... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway | IMP PMID:27609517 TULA-2 Protein Phosphatase Suppresses Activation of Syk thro... | ACCEPT | Summary: collagen-activated tyrosine kinase receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0042169 SH2 domain binding | IDA PMID:27609517 TULA-2 Protein Phosphatase Suppresses Activation of Syk thro... | MODIFY | Summary: SH2 domain binding is too vague or reverses the most informative binding description for Syk. Reason: The relevant molecular recognition is binding of phosphorylated ITAM/phosphotyrosine motifs by tandem SH2 domains. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005515 protein binding | IPI PMID:26195794 Protein tyrosine phosphatase SAP-1 protects against colitis ... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005515 protein binding | IPI PMID:22496641 CEACAM1 negatively regulates IL-1Ξ² production in LPS activat... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0019902 phosphatase binding | IPI PMID:22496641 CEACAM1 negatively regulates IL-1Ξ² production in LPS activat... | KEEP AS NON CORE | Summary: phosphatase binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0035325 Toll-like receptor binding | IPI PMID:22496641 CEACAM1 negatively regulates IL-1Ξ² production in LPS activat... | KEEP AS NON CORE | Summary: Toll-like receptor binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0004674 protein serine/threonine kinase activity | ISO PMID:23071339 Serine phosphorylation by SYK is critical for nuclear locali... | KEEP AS NON CORE | Summary: protein serine/threonine kinase activity is retained as a non-core Syk-associated annotation. Reason: The term describes a downstream, localization, or context-specific consequence of Syk signaling rather than the primary kinase activity. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0005515 protein binding | IPI PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005515 protein binding | IPI PMID:8626447 Reconstitution of B cell antigen receptor-induced signaling ... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0001819 positive regulation of cytokine production | IGI PMID:19770268 A murine DC-SIGN homologue contributes to early host defense... | KEEP AS NON CORE | Summary: positive regulation of cytokine production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0005515 protein binding | IPI PMID:17086186 Integrin signaling in neutrophils and macrophages uses adapt... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005515 protein binding | IPI PMID:15845454 Syk-dependent cytokine induction by Dectin-1 reveals a novel... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0019901 protein kinase binding | IPI PMID:11672534 Inhibition of beta 2 integrin receptor and Syk kinase signal... | KEEP AS NON CORE | Summary: protein kinase binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:16456001 Scaffolding adapter Grb2-associated binder 2 requires Syk to... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0005515 protein binding | IPI PMID:16456001 Scaffolding adapter Grb2-associated binder 2 requires Syk to... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0005515 protein binding | IPI PMID:19124738 RhoH plays critical roles in Fc epsilon RI-dependent signal ... | MARK AS OVER ANNOTATED | Summary: protein binding records a physical association but is too generic to describe the gene product function. Reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone protein binding function; more informative molecular and pathway terms capture the biology. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md **ITAM binding relieves SYK autoinhibition**, enabling kinase activation and downstream phosphorylation cascades |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7499277 Selective regulation of Lyn tyrosine kinase by CD45 in immat... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0050853 B cell receptor signaling pathway | IDA PMID:7499277 Selective regulation of Lyn tyrosine kinase by CD45 in immat... | ACCEPT | Summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0043366 beta selection | IGI PMID:9275205 The Syk and ZAP-70 SH2-containing tyrosine kinases are impli... | KEEP AS NON CORE | Summary: beta selection is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:8798454 Differential intrinsic enzymatic activity of Syk and Zap-70 ... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:8626447 Reconstitution of B cell antigen receptor-induced signaling ... | ACCEPT | Summary: non-membrane spanning protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0007166 cell surface receptor signaling pathway | IDA PMID:9099676 Syk activation and dissociation from the B-cell antigen rece... | MODIFY | Summary: cell surface receptor signaling pathway is a broad signaling parent for Syk. Reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin, integrin-associated, and related ITAM signaling pathways. Proposed replacements: antigen receptor-mediated signaling pathway Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0035556 intracellular signal transduction | IDA PMID:8626447 Reconstitution of B cell antigen receptor-induced signaling ... | MODIFY | Summary: intracellular signal transduction is a broad signaling parent for Syk. Reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin, integrin-associated, and related ITAM signaling pathways. Proposed replacements: antigen receptor-mediated signaling pathway Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0045579 positive regulation of B cell differentiation | IMP PMID:7477353 Syk tyrosine kinase required for mouse viability and B-cell ... | KEEP AS NON CORE | Summary: positive regulation of B cell differentiation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0045588 positive regulation of gamma-delta T cell differentiation | IMP PMID:8790395 Disruption of epithelial gamma delta T cell repertoires by m... | KEEP AS NON CORE | Summary: positive regulation of gamma-delta T cell differentiation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0046638 positive regulation of alpha-beta T cell differentiation | IGI PMID:9275205 The Syk and ZAP-70 SH2-containing tyrosine kinases are impli... | KEEP AS NON CORE | Summary: positive regulation of alpha-beta T cell differentiation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0046641 positive regulation of alpha-beta T cell proliferation | IGI PMID:9275205 The Syk and ZAP-70 SH2-containing tyrosine kinases are impli... | KEEP AS NON CORE | Summary: positive regulation of alpha-beta T cell proliferation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0050853 B cell receptor signaling pathway | IDA PMID:8626447 Reconstitution of B cell antigen receptor-induced signaling ... | ACCEPT | Summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0050850 positive regulation of calcium-mediated signaling | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | ACCEPT | Summary: positive regulation of calcium-mediated signaling is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0001820 serotonin secretion | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | KEEP AS NON CORE | Summary: serotonin secretion is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:9099676 Syk activation and dissociation from the B-cell antigen rece... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0007166 cell surface receptor signaling pathway | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | MODIFY | Summary: cell surface receptor signaling pathway is a broad signaling parent for Syk. Reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin, integrin-associated, and related ITAM signaling pathways. Proposed replacements: antigen receptor-mediated signaling pathway Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0019370 leukotriene biosynthetic process | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | KEEP AS NON CORE | Summary: leukotriene biosynthetic process is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | KEEP AS NON CORE | Summary: positive regulation of granulocyte macrophage colony-stimulating factor production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0035556 intracellular signal transduction | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | MODIFY | Summary: intracellular signal transduction is a broad signaling parent for Syk. Reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin, integrin-associated, and related ITAM signaling pathways. Proposed replacements: antigen receptor-mediated signaling pathway Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0043306 positive regulation of mast cell degranulation | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | KEEP AS NON CORE | Summary: positive regulation of mast cell degranulation is a directly supported Fc-epsilon receptor downstream output, but it is not Syk's core molecular function. Reason: Syk is the receptor-proximal kinase required for this mast-cell response, so the process is supported as a context-specific signaling output. Supporting Evidence: PMID:9000133 Using Syk-deficient mast cells we show that they fail to degranulate, synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI, conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling |
| GO:0005524 ATP binding | IDA PMID:8798454 Differential intrinsic enzymatic activity of Syk and Zap-70 ... | ACCEPT | Summary: ATP binding is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0045579 positive regulation of B cell differentiation | IMP PMID:7477352 Perinatal lethality and blocked B-cell development in mice l... | KEEP AS NON CORE | Summary: positive regulation of B cell differentiation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0045588 positive regulation of gamma-delta T cell differentiation | IMP PMID:7477352 Perinatal lethality and blocked B-cell development in mice l... | KEEP AS NON CORE | Summary: positive regulation of gamma-delta T cell differentiation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7744830 Association of p72syk with the src homology-2 (SH2) domains ... | ACCEPT | Summary: protein tyrosine kinase activity is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0007167 enzyme-linked receptor protein signaling pathway | IDA PMID:7744830 Association of p72syk with the src homology-2 (SH2) domains ... | MODIFY | Summary: enzyme-linked receptor protein signaling pathway is a broad signaling parent for Syk. Reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin, integrin-associated, and related ITAM signaling pathways. Proposed replacements: antigen receptor-mediated signaling pathway Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0007186 G protein-coupled receptor signaling pathway | TAS PMID:11676469 Syk expression and novel function in a wide variety of tissu... | MARK AS OVER ANNOTATED | Summary: GPCR signaling is not a core or well-supported primary Syk pathway. Reason: The Syk evidence base centers on ITAM/hemITAM and innate immune receptor signaling rather than direct GPCR pathway execution. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: plasma membrane is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0050853 B cell receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0002250 adaptive immune response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: adaptive immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002281 macrophage activation involved in immune response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: macrophage activation involved in immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002283 neutrophil activation involved in immune response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: neutrophil activation involved in immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0033630 positive regulation of cell adhesion mediated by integrin | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: positive regulation of cell adhesion mediated by integrin is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0001525 angiogenesis | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: angiogenesis is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002250 adaptive immune response | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: adaptive immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002376 immune system process | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: immune system process is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0035556 intracellular signal transduction | IEA GO_REF:0000120 | MODIFY | Summary: intracellular signal transduction is a broad signaling parent for Syk. Reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin, integrin-associated, and related ITAM signaling pathways. Proposed replacements: antigen receptor-mediated signaling pathway Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0043306 positive regulation of mast cell degranulation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: positive regulation of mast cell degranulation is a directly supported Fc-epsilon receptor downstream output, but it is not Syk's core molecular function. Reason: Syk is the receptor-proximal kinase required for this mast-cell response, so the process is supported as a context-specific signaling output. Supporting Evidence: PMID:9000133 Using Syk-deficient mast cells we show that they fail to degranulate, synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI, conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling |
| GO:0043366 beta selection | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: beta selection is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0045087 innate immune response | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: innate immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0046638 positive regulation of alpha-beta T cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: positive regulation of alpha-beta T cell differentiation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0046641 positive regulation of alpha-beta T cell proliferation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: positive regulation of alpha-beta T cell proliferation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0050850 positive regulation of calcium-mediated signaling | IEA GO_REF:0000117 | ACCEPT | Summary: positive regulation of calcium-mediated signaling is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0050851 antigen receptor-mediated signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: antigen receptor-mediated signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0002752 cell surface pattern recognition receptor signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: cell surface pattern recognition receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0007159 leukocyte cell-cell adhesion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: leukocyte cell-cell adhesion is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: regulation of tumor necrosis factor-mediated signaling pathway is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0030593 neutrophil chemotaxis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: neutrophil chemotaxis is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0031334 positive regulation of protein-containing complex assembly | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of protein-containing complex assembly is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032733 positive regulation of interleukin-10 production | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of interleukin-10 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032735 positive regulation of interleukin-12 production | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of interleukin-12 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032755 positive regulation of interleukin-6 production | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of interleukin-6 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032757 positive regulation of interleukin-8 production | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of interleukin-8 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032760 positive regulation of tumor necrosis factor production | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of tumor necrosis factor production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032930 positive regulation of superoxide anion generation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of superoxide anion generation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0035556 intracellular signal transduction | ISO GO_REF:0000119 | MODIFY | Summary: intracellular signal transduction is a broad signaling parent for Syk. Reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin, integrin-associated, and related ITAM signaling pathways. Proposed replacements: antigen receptor-mediated signaling pathway Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0043306 positive regulation of mast cell degranulation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of mast cell degranulation is a directly supported Fc-epsilon receptor downstream output, but it is not Syk's core molecular function. Reason: Syk is the receptor-proximal kinase required for this mast-cell response, so the process is supported as a context-specific signaling output. Supporting Evidence: PMID:9000133 Using Syk-deficient mast cells we show that they fail to degranulate, synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI, conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling |
| GO:0045579 positive regulation of B cell differentiation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of B cell differentiation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0050776 regulation of immune response | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: regulation of immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0050853 B cell receptor signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0071396 cellular response to lipid | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to lipid is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0071639 positive regulation of monocyte chemotactic protein-1 production | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of monocyte chemotactic protein-1 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0097110 scaffold protein binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: scaffold protein binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0097190 apoptotic signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: apoptotic signaling pathway is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0097242 amyloid-beta clearance | ISO GO_REF:0000119 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning amyloid-beta clearance to Syk. Reason: Automated transfer requires direct support before retaining this specific amyloid-beta annotation. |
| GO:1904263 positive regulation of TORC1 signaling | ISO GO_REF:0000119 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning positive regulation of TORC1 signaling to Syk. Reason: Automated transfer requires direct support before retaining this specific nutrient-signaling annotation. |
| GO:1904646 cellular response to amyloid-beta | ISO GO_REF:0000119 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning cellular response to amyloid-beta to Syk. Reason: Automated transfer requires direct support before retaining this specific amyloid-beta annotation. |
| GO:0002752 cell surface pattern recognition receptor signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: cell surface pattern recognition receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0005634 nucleus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: nucleus is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0007159 leukocyte cell-cell adhesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: leukocyte cell-cell adhesion is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of tumor necrosis factor-mediated signaling pathway is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0030593 neutrophil chemotaxis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: neutrophil chemotaxis is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0031334 positive regulation of protein-containing complex assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of protein-containing complex assembly is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032733 positive regulation of interleukin-10 production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of interleukin-10 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032735 positive regulation of interleukin-12 production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of interleukin-12 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032755 positive regulation of interleukin-6 production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of interleukin-6 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032757 positive regulation of interleukin-8 production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of interleukin-8 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032760 positive regulation of tumor necrosis factor production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of tumor necrosis factor production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032930 positive regulation of superoxide anion generation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of superoxide anion generation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0045579 positive regulation of B cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of B cell differentiation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0050853 B cell receptor signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0071396 cellular response to lipid | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cellular response to lipid is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0071639 positive regulation of monocyte chemotactic protein-1 production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of monocyte chemotactic protein-1 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0097110 scaffold protein binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: scaffold protein binding is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0097190 apoptotic signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: apoptotic signaling pathway is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0097242 amyloid-beta clearance | IEA GO_REF:0000107 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning amyloid-beta clearance to Syk. Reason: Automated transfer requires direct support before retaining this specific amyloid-beta annotation. |
| GO:1904263 positive regulation of TORC1 signaling | IEA GO_REF:0000107 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning positive regulation of TORC1 signaling to Syk. Reason: Automated transfer requires direct support before retaining this specific nutrient-signaling annotation. |
| GO:1904646 cellular response to amyloid-beta | IEA GO_REF:0000107 | UNDECIDED | Summary: The current local evidence does not provide term-specific support for assigning cellular response to amyloid-beta to Syk. Reason: Automated transfer requires direct support before retaining this specific amyloid-beta annotation. |
| GO:0050853 B cell receptor signaling pathway | IDA PMID:9199344 Shc contains two Grb2 binding sites needed for efficient for... | ACCEPT | Summary: B cell receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0001775 cell activation | IMP PMID:19136564 Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+... | KEEP AS NON CORE | Summary: cell activation is retained as a non-core Syk-associated annotation. Reason: The term describes a downstream, localization, or context-specific consequence of Syk signaling rather than the primary kinase activity. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002223 stimulatory C-type lectin receptor signaling pathway | IMP PMID:19136564 Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+... | ACCEPT | Summary: stimulatory C-type lectin receptor signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0035556 intracellular signal transduction | IMP PMID:19136564 Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+... | MODIFY | Summary: intracellular signal transduction is a broad signaling parent for Syk. Reason: Syk is best represented as a receptor-proximal kinase in antigen, Fc, C-type lectin, integrin-associated, and related ITAM signaling pathways. Proposed replacements: antigen receptor-mediated signaling pathway Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:1990858 cellular response to lectin | IMP PMID:19136564 Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+... | KEEP AS NON CORE | Summary: cellular response to lectin is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0018108 peptidyl-tyrosine phosphorylation | ISS GO_REF:0000024 | ACCEPT | Summary: peptidyl-tyrosine phosphorylation is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0120162 positive regulation of cold-induced thermogenesis | IMP PMID:29235464 SYK kinase mediates brown fat differentiation and activation... | KEEP AS NON CORE | Summary: positive regulation of cold-induced thermogenesis is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032753 positive regulation of interleukin-4 production | IMP PMID:19098920 Fc receptor gamma-chain, a constitutive component of the IL-... | KEEP AS NON CORE | Summary: positive regulation of interleukin-4 production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0038156 interleukin-3-mediated signaling pathway | IMP PMID:19098920 Fc receptor gamma-chain, a constitutive component of the IL-... | KEEP AS NON CORE | Summary: interleukin-3-mediated signaling pathway is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0031623 receptor internalization | IDA PMID:23395392 Multimolecular signaling complexes enable Syk-mediated signa... | KEEP AS NON CORE | Summary: receptor internalization is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0071404 cellular response to low-density lipoprotein particle stimulus | IDA PMID:23395392 Multimolecular signaling complexes enable Syk-mediated signa... | KEEP AS NON CORE | Summary: cellular response to low-density lipoprotein particle stimulus is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0005634 nucleus | ISO PMID:23071339 Serine phosphorylation by SYK is critical for nuclear locali... | KEEP AS NON CORE | Summary: nucleus is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002092 positive regulation of receptor internalization | IMP PMID:22078883 CD14 controls the LPS-induced endocytosis of Toll-like recep... | KEEP AS NON CORE | Summary: positive regulation of receptor internalization is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032481 positive regulation of type I interferon production | IMP PMID:22078883 CD14 controls the LPS-induced endocytosis of Toll-like recep... | KEEP AS NON CORE | Summary: positive regulation of type I interferon production is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002092 positive regulation of receptor internalization | IMP PMID:23962979 The tyrosine kinase Syk differentially regulates Toll-like r... | KEEP AS NON CORE | Summary: positive regulation of receptor internalization is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002250 adaptive immune response | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: adaptive immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002281 macrophage activation involved in immune response | IMP PMID:17086186 Integrin signaling in neutrophils and macrophages uses adapt... | KEEP AS NON CORE | Summary: macrophage activation involved in immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002283 neutrophil activation involved in immune response | IMP PMID:17086186 Integrin signaling in neutrophils and macrophages uses adapt... | KEEP AS NON CORE | Summary: neutrophil activation involved in immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0007159 leukocyte cell-cell adhesion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: leukocyte cell-cell adhesion is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0007229 integrin-mediated signaling pathway | IMP PMID:17086186 Integrin signaling in neutrophils and macrophages uses adapt... | ACCEPT | Summary: integrin-mediated signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0030593 neutrophil chemotaxis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: neutrophil chemotaxis is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002366 leukocyte activation involved in immune response | IMP PMID:15845454 Syk-dependent cytokine induction by Dectin-1 reveals a novel... | KEEP AS NON CORE | Summary: leukocyte activation involved in immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032928 regulation of superoxide anion generation | IMP PMID:19797524 Neutrophil-specific deletion of Syk kinase results in reduce... | KEEP AS NON CORE | Summary: regulation of superoxide anion generation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0042742 defense response to bacterium | IMP PMID:19797524 Neutrophil-specific deletion of Syk kinase results in reduce... | KEEP AS NON CORE | Summary: defense response to bacterium is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0043313 regulation of neutrophil degranulation | IMP PMID:19797524 Neutrophil-specific deletion of Syk kinase results in reduce... | KEEP AS NON CORE | Summary: regulation of neutrophil degranulation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0045087 innate immune response | IMP PMID:15845454 Syk-dependent cytokine induction by Dectin-1 reveals a novel... | KEEP AS NON CORE | Summary: innate immune response is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0050764 regulation of phagocytosis | IMP PMID:19797524 Neutrophil-specific deletion of Syk kinase results in reduce... | KEEP AS NON CORE | Summary: regulation of phagocytosis is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0070372 regulation of ERK1 and ERK2 cascade | IMP PMID:19797524 Neutrophil-specific deletion of Syk kinase results in reduce... | KEEP AS NON CORE | Summary: regulation of ERK1 and ERK2 cascade is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0071226 cellular response to molecule of fungal origin | IMP PMID:15845454 Syk-dependent cytokine induction by Dectin-1 reveals a novel... | KEEP AS NON CORE | Summary: cellular response to molecule of fungal origin is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0002554 serotonin secretion by platelet | IMP PMID:9171347 The Fc receptor gamma-chain and the tyrosine kinase Syk are ... | KEEP AS NON CORE | Summary: serotonin secretion by platelet is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0007229 integrin-mediated signaling pathway | IMP PMID:11940607 Coordinate interactions of Csk, Src, and Syk kinases with [a... | ACCEPT | Summary: integrin-mediated signaling pathway is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is presented as a **central kinase downstream of ITAM-coupled immune receptors** |
| GO:0010543 regulation of platelet activation | IMP PMID:9171347 The Fc receptor gamma-chain and the tyrosine kinase Syk are ... | KEEP AS NON CORE | Summary: regulation of platelet activation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0033630 positive regulation of cell adhesion mediated by integrin | IMP PMID:11940607 Coordinate interactions of Csk, Src, and Syk kinases with [a... | KEEP AS NON CORE | Summary: positive regulation of cell adhesion mediated by integrin is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0045780 positive regulation of bone resorption | IMP PMID:17353363 Syk, c-Src, the alphavbeta3 integrin, and ITAM immunorecepto... | KEEP AS NON CORE | Summary: positive regulation of bone resorption is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0090237 regulation of arachidonate secretion | IMP PMID:9171347 The Fc receptor gamma-chain and the tyrosine kinase Syk are ... | KEEP AS NON CORE | Summary: regulation of arachidonate secretion is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0090330 regulation of platelet aggregation | IMP PMID:9171347 The Fc receptor gamma-chain and the tyrosine kinase Syk are ... | KEEP AS NON CORE | Summary: regulation of platelet aggregation is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0001945 lymph vessel development | IMP PMID:12522250 Regulation of blood and lymphatic vascular separation by sig... | KEEP AS NON CORE | Summary: lymph vessel development is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0048514 blood vessel morphogenesis | IMP PMID:12522250 Regulation of blood and lymphatic vascular separation by sig... | KEEP AS NON CORE | Summary: blood vessel morphogenesis is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0018108 peptidyl-tyrosine phosphorylation | IMP PMID:16456001 Scaffolding adapter Grb2-associated binder 2 requires Syk to... | ACCEPT | Summary: peptidyl-tyrosine phosphorylation is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is a **protein tyrosine kinase** that catalyzes **transfer of phosphate to tyrosine residues** on protein substrates in signaling complexes |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: cytoplasm is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | IEA GO_REF:0000120 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: plasma membrane is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0031410 cytoplasmic vesicle | IEA GO_REF:0000043 | ACCEPT | Summary: cytoplasmic vesicle is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0045335 phagocytic vesicle | IEA GO_REF:0000044 | ACCEPT | Summary: phagocytic vesicle is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0032991 protein-containing complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: protein-containing complex is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0042101 T cell receptor complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: T cell receptor complex is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9674908 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9674931 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9674959 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9674973 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9676072 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9705471 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9707972 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9707979 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-5621346 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-9607032 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0032991 protein-containing complex | IDA PMID:22451653 Siglec-15 protein regulates formation of functional osteocla... | KEEP AS NON CORE | Summary: protein-containing complex is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0032991 protein-containing complex | ISO PMID:23071339 Serine phosphorylation by SYK is critical for nuclear locali... | KEEP AS NON CORE | Summary: protein-containing complex is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0005737 cytoplasm | ISO PMID:23071339 Serine phosphorylation by SYK is critical for nuclear locali... | ACCEPT | Summary: cytoplasm is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0032009 early phagosome | IDA PMID:15845454 Syk-dependent cytokine induction by Dectin-1 reveals a novel... | ACCEPT | Summary: early phagosome is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-442289 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0005829 cytosol | TAS Reactome:R-MMU-5607754 | ACCEPT | Summary: cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization. Reason: This annotation matches Syk function as a cytoplasmic tyrosine kinase recruited to phosphorylated immune receptor signaling complexes. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md SYK is predominantly a **cytoplasmic kinase** that is recruited to **membrane-proximal receptor signaling complexes** upon ITAM phosphorylation |
| GO:0019815 B cell receptor complex | IDA PMID:8626447 Reconstitution of B cell antigen receptor-induced signaling ... | KEEP AS NON CORE | Summary: B cell receptor complex is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0042101 T cell receptor complex | ISO GO_REF:0000008 | KEEP AS NON CORE | Summary: T cell receptor complex is a supported downstream or context-specific Syk role. Reason: The annotation is biologically plausible for Syk-dependent immune, platelet, myeloid, vascular, or tissue-specific signaling but should not be treated as the core molecular function. Supporting Evidence: file:mouse/Syk/Syk-deep-research-falcon.md Activated SYK drives phagocytosis, ROS generation, cytokine secretion, cytoskeletal remodeling, proliferation/survival signaling, and immune receptor signal amplification. |
| GO:0030168 platelet activation | IMP PMID:9171347 The Fc receptor gamma-chain and the tyrosine kinase Syk are ... | NEW | Summary: platelet activation is a directly supported proposed Syk signaling annotation. Reason: This proposed annotation reflects experimentally supported Syk signaling output and is not inferred merely from broad phenotype. Supporting Evidence: PMID:9171347 The absence of Fc receptor gamma-chain or Syk is accompanied by a loss of secretion and aggregation responses in collagen- but not thrombin-stimulated platelets. |
| GO:0038095 Fc-epsilon receptor signaling pathway | IMP PMID:9000133 Critical role for the tyrosine kinase Syk in signalling thro... | NEW | Summary: Fc-epsilon receptor signaling pathway is a directly supported proposed Syk signaling annotation. Reason: This proposed annotation reflects experimentally supported Syk signaling output and is not inferred merely from broad phenotype. Supporting Evidence: PMID:9000133 Stimulation of Fc epsilon RI results in the rapid association and activation of the Syk tyrosine kinase. |
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Download this section (compressed HTML)Q: Which Syk receptor contexts in mouse should be considered core gene-product functions rather than immune-cell-specific downstream outputs?
Q: Which Syk isoform/localization differences are sufficiently supported for isoform-specific GO annotation?
Experiment: Compare kinase-dead, SH2-binding-defective, and isoform-specific Syk rescue alleles in mouse immune-cell receptor signaling assays.
Hypothesis: Syk core functions partition into phosphotyrosine docking and tyrosine kinase catalytic modules that have receptor-context-specific requirements.
Type: Genetic rescue and phosphoproteomics
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Download this section (compressed HTML)π View Pathway Visualization Interactive pathway diagram with detailed annotations