Tert

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0003720 telomerase activity	IBA GO_REF:0000033	ACCEPT	Summary: Defining catalytic activity of TERT: the RNA-dependent processive addition of TTAGGG telomeric repeats to 3' chromosome ends. mTert loss abolishes detectable telomerase activity in vivo. Core function. Reason: Catalytic core MF; directly supported by mouse IDA/TAS and conserved IBA evidence. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0007004 telomere maintenance via telomerase	IBA GO_REF:0000033	ACCEPT	Summary: The canonical pathway in which TERT extends telomeres to counter the end-replication problem; mTert-null mice show progressive multigenerational telomere erosion and signal-free chromosome ends. Reason: Core BP; mouse genetic evidence establishes telomerase-dependent maintenance. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0070034 telomerase RNA binding	IBA GO_REF:0000033	ACCEPT	Summary: TERT binds the Terc/TR template via RNA-interacting domains RD1 and RD2 (pseudoknot-template and CR4/5 regions), an essential determinant of template engagement and repeat-addition processivity. Reason: Specific, informative MF central to holoenzyme assembly and catalysis; core. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0000333 telomerase catalytic core complex	IBA GO_REF:0000033	ACCEPT	Summary: TERT plus the Terc RNA constitute the catalytic core responsible for DNA extension. This minimal complex is the functional engine of telomerase. Reason: Core CC; TERT is the protein component of the catalytic core (IMP/IBA). Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0042162 telomeric DNA binding	IBA GO_REF:0000033	ACCEPT	Summary: TERT binds the single-stranded telomeric DNA primer/3' chromosome terminus, with anchor sites holding primer nucleotides upstream of the RNA-DNA hybrid to support processive repeat addition. Reason: Specific DNA-binding MF for the telomeric primer substrate; core to catalysis. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0000723 telomere maintenance	IEA GO_REF:0000002	ACCEPT	Summary: Parent process capturing TERT's role in preserving telomere length and chromosome-end integrity. Retained as a faithful, if more general, statement of the core biological role. Reason: Correct core BP; broader parent of telomere maintenance via telomerase. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0000781 chromosome, telomeric region	IEA GO_REF:0000120	ACCEPT	Summary: Site of catalysis: TERT engages the telomeric region of chromosomes to add TTAGGG repeats. UniProt lists Chromosome, telomere as a subcellular location. Reason: Core CC; the telomere is where the catalytic reaction occurs. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0003677 DNA binding	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: TERT binds telomeric ssDNA primer; the generic DNA-binding term is correct but less informative than telomeric DNA binding and is keyword/electronic-derived. Reason: Correct but generic; specific telomeric DNA binding is the core term.
GO:0003720 telomerase activity	IEA GO_REF:0000120	ACCEPT	Summary: Defining catalytic activity of TERT: the RNA-dependent processive addition of TTAGGG telomeric repeats to 3' chromosome ends. mTert loss abolishes detectable telomerase activity in vivo. Core function. Reason: Catalytic core MF; directly supported by mouse IDA/TAS and conserved IBA evidence. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0003964 RNA-directed DNA polymerase activity	IEA GO_REF:0000120	ACCEPT	Summary: Reverse transcriptase activity (EC 2.7.7.49) by which TERT copies the Terc RNA template into telomeric DNA. The conserved RT domain (residues 595-928) with catalytic Mg2+-binding Asp residues underlies telomerase action. Reason: Precise MF describing the reverse-transcriptase catalytic mechanism; core. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005634 nucleus	IEA GO_REF:0000120	ACCEPT	Summary: Principal compartment where TERT acts; nuclear import/retention is regulated by AKT phosphorylation and SHP2/PTPN11 dephosphorylation, positioning telomerase for chromosome-end extension. Reason: Core CC; nucleus is the canonical site of telomerase action. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005654 nucleoplasm	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: TERT shows diffuse nucleoplasmic distribution; a subnuclear pool that is part of nuclear residence but not the specific telomere/nucleolar site of function. Reason: Nuclear subcompartment; non-core relative to telomere/nucleolus.
GO:0005730 nucleolus	IEA GO_REF:0000120	ACCEPT	Summary: TERT is enriched in nucleoli of certain cell types; nucleolar localization (mediated via NCL interaction) is part of telomerase trafficking/biogenesis and is well documented for TERT. Reason: Core/canonical TERT subnuclear localization (ISS/ISO), consistent with UniProt. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005737 cytoplasm	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: TERT shuttles to the cytoplasm under oxidative stress (CRM1/RAN-dependent, Tyr-697 phosphorylation), a regulated secondary localization rather than its catalytic site. Reason: Regulated secondary localization (IDA/IEA); not core site of action.
GO:0008284 positive regulation of cell population proliferation	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: TERT supports proliferative capacity of progenitor/cancer cells; a broad downstream effect of enabling continued division, not the molecular core. Reason: Broad pleiotropic proliferation BP (IEA).
GO:0016605 PML body	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: PML interaction recruits TERT to PML bodies and inhibits telomerase activity; a regulatory sequestration site rather than the active catalytic location. Reason: Regulatory/inhibitory localization (IEA/ISO); non-core.
GO:0016740 transferase activity	IEA GO_REF:0000043	MARK AS OVER ANNOTATED	Summary: Top-level EC 2 transferase parent; far too general to inform TERT function given the specific polymerase activities already annotated. Reason: Root-level MF; uninformative.
GO:0016779 nucleotidyltransferase activity	IEA GO_REF:0000043	MARK AS OVER ANNOTATED	Summary: High-level transferase parent; TERT's nucleotidyltransferase chemistry is already captured precisely by telomerase / RNA-directed DNA polymerase activity. Reason: Over-general MF parent of the specific catalytic terms.
GO:0034061 DNA polymerase activity	IEA GO_REF:0000116	MARK AS OVER ANNOTATED	Summary: Generic DNA polymerase term; TERT is specifically a template-directed RNA-dependent DNA polymerase, already captured by the more precise RNA-directed DNA polymerase / telomerase terms. Reason: Over-general MF; the RNA-directed (RT) child is the correct specific term.
GO:0046872 metal ion binding	IEA GO_REF:0000043	MARK AS OVER ANNOTATED	Summary: Keyword-derived term; TERT binds catalytic Mg2+ at the RT active site, but the bare metal-ion term is uninformative compared with the polymerase MF that already implies it. Reason: Generic UniProtKB-KW-derived MF; subsumed by catalytic activity.
GO:1990904 ribonucleoprotein complex	IEA GO_REF:0000043	KEEP AS NON CORE	Summary: Generic RNP parent; true because telomerase is an RNP, but uninformative relative to the specific telomerase holoenzyme/catalytic-core complex terms. Reason: Over-general CC parent of the telomerase complex (IEA).
GO:0005515 protein binding	IPI PMID:19571879 Telomerase modulates Wnt signalling by association with targ...	MARK AS OVER ANNOTATED	Summary: Bare 'protein binding' conveys no specific TERT function; its many partners (HSP90, TCAB1, SMARCA4, PIF1, etc.) are better captured by specific binding/complex terms. Reason: Uninformative generic MF; specific partner terms preferred.
GO:0000049 tRNA binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: An electronically inferred tRNA-binding activity; plausible given TERT's RNA-binding fold but not part of the canonical Terc-templated mechanism. Reason: Electronic non-core RNA-binding (IEA/ISO).
GO:0000333 telomerase catalytic core complex	IEA GO_REF:0000107	ACCEPT	Summary: TERT plus the Terc RNA constitute the catalytic core responsible for DNA extension. This minimal complex is the functional engine of telomerase. Reason: Core CC; TERT is the protein component of the catalytic core (IMP/IBA). Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0001172 RNA-templated transcription	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Process term associated with the non-canonical TERT-RMRP RdRP activity; not the canonical telomere-extension role. Reason: Non-canonical process linked to RMRP RdRP; electronic.
GO:0001223 transcription coactivator binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Captures TERT's chromatin/transcription interactions (e.g., SMARCA4/BRG1 in Wnt target-gene regulation), part of its non-canonical transcriptional role. Reason: Specific binding tied to non-canonical transcriptional role (IPI/IEA/ISO).
GO:0003723 RNA binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Broad RNA-binding term; TERT's functionally relevant RNA interaction is with Terc, already captured by the specific telomerase RNA binding annotation. Reason: Over-broad nucleic-acid binding; specific telomerase RNA binding present.
GO:0003968 RNA-directed RNA polymerase activity	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: A non-canonical RdRP activity has been proposed for TERT (with RMRP RNA, the TERT-RMRP complex), but this is contested and supported only by electronic transfer; not part of the canonical telomerase MF. Reason: Contested non-canonical activity; electronic (IEA/ISO) only.
GO:0005697 telomerase holoenzyme complex	IEA GO_REF:0000107	ACCEPT	Summary: TERT is the catalytic subunit of the holoenzyme, which also contains Terc, WRAP53/TCAB1 and the H/ACA proteins DKC1, NOP10, NHP2 and GAR1, plus associated TEP1/SMG6/POT1. Reason: Core CC; UniProt SUBUNIT defines TERT as the holoenzyme catalytic component. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005739 mitochondrion	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: A mitochondrial TERT pool with non-canonical roles in ROS handling and mtDNA protection has been reported, but this moonlighting localization is context-dependent and distinct from telomere maintenance. Reason: Contested non-canonical localization (IDA/IEA/ISO); keep non-core.
GO:0005829 cytosol	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Cytosolic pool consistent with stress-regulated nuclear export of TERT; secondary to nuclear/telomeric localization. Reason: Secondary localization (IEA/ISO).
GO:0006278 RNA-templated DNA biosynthetic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Reverse-transcription process term; correct for TERT but a general restatement of its telomere-templated DNA synthesis already covered by core terms. Reason: Accurate but redundant BP with core telomerase process.
GO:0006606 protein import into nucleus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Reflects regulated nuclear import of TERT (AKT-driven; RAN/XPO1-dependent shuttling); a trafficking/regulatory process supporting, not equal to, the core function. Reason: Regulatory trafficking BP (IEA/ISO).
GO:0007004 telomere maintenance via telomerase	IEA GO_REF:0000107	ACCEPT	Summary: The canonical pathway in which TERT extends telomeres to counter the end-replication problem; mTert-null mice show progressive multigenerational telomere erosion and signal-free chromosome ends. Reason: Core BP; mouse genetic evidence establishes telomerase-dependent maintenance. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0007005 mitochondrion organization	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Linked to the contested non-canonical mitochondrial role of TERT (ROS/mtDNA biogenesis); a pleiotropic/moonlighting process, not core telomere biology. Reason: Non-canonical mitochondrial process (IEA/ISO).
GO:0007507 heart development	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Developmental contribution of telomerase/TERT in cardiac tissue; a pleiotropic developmental role electronically inferred, not the molecular core. Reason: Pleiotropic developmental BP (IEA).
GO:0016607 nuclear speck	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Reported nuclear-speck localization of TERT is a secondary subnuclear pool, electronically inferred; not the canonical site of telomere extension. Reason: Secondary subnuclear localization (IEA/ISO).
GO:0022616 DNA strand elongation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Describes the elongation step of telomeric DNA synthesis; accurate but a generic facet of the core telomere-extension process. Reason: Generic BP facet of telomere extension (IEA/ISO).
GO:0030177 positive regulation of Wnt signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT modulates Wnt/beta-catenin signaling by associating with SMARCA4 on target-gene chromatin (Park et al. 2009); a well-supported non-canonical role distinct from telomere extension. Reason: Non-canonical signaling role (IGI/IEA/ISO); moonlighting, keep non-core.
GO:0030422 siRNA processing	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Reflects the proposed TERT-RMRP pathway generating RMRP-derived siRNAs; a contested non-canonical role rather than the core telomerase function. Reason: Non-canonical RMRP-linked role (ISS/ComplexPortal).
GO:0031379 RNA-directed RNA polymerase complex	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Companion CC for the proposed TERT-RMRP RdRP activity; non-canonical and electronic, retained as a possible moonlighting context rather than the core telomerase complex. Reason: Non-canonical complex tied to contested RdRP role (IEA/ISO).
GO:0031647 regulation of protein stability	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT participates in protein-stability regulation (e.g., it is itself controlled by DYRK2/EDVP ubiquitination, and modulates partner stability such as CMIP); a regulatory facet, not core. Reason: Pleiotropic regulatory BP (IEA/ISO).
GO:0042645 mitochondrial nucleoid	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Association of TERT with mitochondrial nucleoids relates to proposed mtDNA-protective non-canonical roles; electronic and context-dependent, not the canonical function. Reason: Non-canonical mitochondrial localization (IEA/ISO).
GO:0042802 identical protein binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Generic self-binding term; TERT can oligomerize but this adds little functional content over the more specific homodimerization terms and is electronic only. Reason: Uninformative generic MF (IEA/ISO).
GO:0042803 protein homodimerization activity	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT can oligomerize via dedicated oligomerization regions; homodimerization is a structural property relevant to assembly but not the catalytic core function. Reason: Specific but ancillary structural MF (IEA/ISO).
GO:0043066 negative regulation of apoptotic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT has antiapoptotic/pro-survival activity (UniProt: roles in antiapoptosis), a pleiotropic protective effect downstream of or parallel to telomere maintenance. Reason: Pleiotropic pro-survival BP (IEA/ISO).
GO:0043524 negative regulation of neuron apoptotic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Neuron-specific instance of TERT's antiapoptotic activity, relevant to neuroprotection literature; a downstream tissue-specific effect. Reason: Tissue-specific antiapoptotic BP (IEA/ISO).
GO:0045766 positive regulation of angiogenesis	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT supports angiogenesis (linked to endothelial survival/VEGF); a downstream vascular role rather than the core telomerase function. Reason: Pleiotropic vascular BP (IEA/ISO).
GO:0046686 response to cadmium ion	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Electronically inferred stress response to cadmium; a non-specific response-to-stimulus annotation peripheral to TERT's core role. Reason: Generic stress-response BP (IEA).
GO:0051087 protein-folding chaperone binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT binds the HSP90/p23 (PTGES3) chaperone machinery required for correct assembly and stabilization of active telomerase; an assembly-support interaction. Reason: Specific biogenesis-related binding (IEA/ISO); non-core MF.
GO:0070034 telomerase RNA binding	IEA GO_REF:0000107	ACCEPT	Summary: TERT binds the Terc/TR template via RNA-interacting domains RD1 and RD2 (pseudoknot-template and CR4/5 regions), an essential determinant of template engagement and repeat-addition processivity. Reason: Specific, informative MF central to holoenzyme assembly and catalysis; core. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0070200 establishment of protein localization to telomere	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Recruitment of telomerase/TERT to telomeres (via shelterin-linked TPP1/TIN2/POT1b factors); a localization step upstream of catalysis, retained as supporting non-core. Reason: Recruitment/localization BP (IEA/ISO); supports core but distinct.
GO:0071456 cellular response to hypoxia	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: TERT participates in hypoxic stress responses (mitochondrial/ROS and survival programs); a stress-response role secondary to its catalytic function. Reason: Stress-response BP (IEA/ISO).
GO:0071897 DNA biosynthetic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT synthesizes telomeric DNA, so this parent process is true but generic relative to telomere maintenance via telomerase. Reason: Correct but over-general BP; electronic propagation.
GO:0090399 replicative senescence	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT activity counteracts replicative senescence by sustaining telomere length; a phenotype-level process downstream of the catalytic role. Reason: Downstream/phenotypic BP (IEA/ISO).
GO:0098680 template-free RNA nucleotidyltransferase activity	IEA GO_REF:0000107	REMOVE	Summary: Template-free RNA nucleotidyltransferase activity is not a function of TERT, whose defining chemistry is template-directed DNA synthesis from the Terc RNA; this electronic annotation contradicts the established mechanism. Reason: Electronic (IEA/ISO) and biologically contradicted; TERT is template-dependent.
GO:0140745 siRNA transcription	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Transcription of siRNA from the RMRP template via the proposed TERT RdRP activity; non-canonical and electronically inferred. Reason: Non-canonical RMRP-linked role (IEA/ISO).
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Cell-cycle-promoting effect linked to TERT's pro-proliferative/non-canonical signaling; pleiotropic and electronically inferred. Reason: Pleiotropic cell-cycle BP (IEA/ISO).
GO:1902895 positive regulation of miRNA transcription	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Reflects TERT's non-canonical influence on miRNA-gene transcription via chromatin association; part of its moonlighting transcriptional activity. Reason: Non-canonical transcriptional BP (IEA/ISO).
GO:1903620 positive regulation of transdifferentiation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Non-canonical role of TERT in promoting cellular transdifferentiation; context-dependent and electronically inferred. Reason: Non-canonical developmental BP (IEA/ISO).
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT promotes proliferation of vascular smooth muscle cells; a tissue-specific downstream proliferative effect. Reason: Tissue-specific proliferation BP (IEA/ISO).
GO:1904751 positive regulation of protein localization to nucleolus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Linked to TERT's nucleolar trafficking interactions; a regulatory localization process, electronically inferred and ancillary. Reason: Regulatory localization BP (IEA/ISO).
GO:1904754 positive regulation of vascular associated smooth muscle cell migration	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT promotes vascular smooth muscle cell migration; part of its pleiotropic vascular-remodeling effects, electronically inferred. Reason: Tissue-specific migration BP (IEA/ISO).
GO:1990572 TERT-RMRP complex	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TERT can associate with the RMRP RNA in a distinct complex linked to the proposed RdRP/siRNA activity; a non-canonical context separate from telomere maintenance. Reason: Non-canonical TERT-RMRP complex (ISS/ComplexPortal, IEA).
GO:2000352 negative regulation of endothelial cell apoptotic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Endothelial antiapoptotic effect of TERT linked to vascular/angiogenesis biology; a pleiotropic downstream role. Reason: Tissue-specific antiapoptotic BP (IEA/ISO).
GO:2000773 negative regulation of cellular senescence	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: By maintaining telomeres, TERT delays senescence; this is a downstream physiological consequence rather than the molecular core function. Reason: Downstream consequence of telomere maintenance (IEA/ISO).
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Specific antiapoptotic pathway facet of TERT's pro-survival activity; pleiotropic and electronically inferred. Reason: Pleiotropic antiapoptotic BP (IEA/ISO).
GO:0000049 tRNA binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: An electronically inferred tRNA-binding activity; plausible given TERT's RNA-binding fold but not part of the canonical Terc-templated mechanism. Reason: Electronic non-core RNA-binding (IEA/ISO).
GO:0000333 telomerase catalytic core complex	ISO GO_REF:0000119	ACCEPT	Summary: TERT plus the Terc RNA constitute the catalytic core responsible for DNA extension. This minimal complex is the functional engine of telomerase. Reason: Core CC; TERT is the protein component of the catalytic core (IMP/IBA). Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0000781 chromosome, telomeric region	ISO GO_REF:0000119	ACCEPT	Summary: Site of catalysis: TERT engages the telomeric region of chromosomes to add TTAGGG repeats. UniProt lists Chromosome, telomere as a subcellular location. Reason: Core CC; the telomere is where the catalytic reaction occurs. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0001172 RNA-templated transcription	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Process term associated with the non-canonical TERT-RMRP RdRP activity; not the canonical telomere-extension role. Reason: Non-canonical process linked to RMRP RdRP; electronic.
GO:0001223 transcription coactivator binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Captures TERT's chromatin/transcription interactions (e.g., SMARCA4/BRG1 in Wnt target-gene regulation), part of its non-canonical transcriptional role. Reason: Specific binding tied to non-canonical transcriptional role (IPI/IEA/ISO).
GO:0003677 DNA binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT binds telomeric ssDNA primer; the generic DNA-binding term is correct but less informative than telomeric DNA binding and is keyword/electronic-derived. Reason: Correct but generic; specific telomeric DNA binding is the core term.
GO:0003720 telomerase activity	ISO GO_REF:0000096	ACCEPT	Summary: Defining catalytic activity of TERT: the RNA-dependent processive addition of TTAGGG telomeric repeats to 3' chromosome ends. mTert loss abolishes detectable telomerase activity in vivo. Core function. Reason: Catalytic core MF; directly supported by mouse IDA/TAS and conserved IBA evidence. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0003720 telomerase activity	ISO GO_REF:0000119	ACCEPT	Summary: Defining catalytic activity of TERT: the RNA-dependent processive addition of TTAGGG telomeric repeats to 3' chromosome ends. mTert loss abolishes detectable telomerase activity in vivo. Core function. Reason: Catalytic core MF; directly supported by mouse IDA/TAS and conserved IBA evidence. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0003723 RNA binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: Broad RNA-binding term; TERT's functionally relevant RNA interaction is with Terc, already captured by the specific telomerase RNA binding annotation. Reason: Over-broad nucleic-acid binding; specific telomerase RNA binding present.
GO:0003964 RNA-directed DNA polymerase activity	ISO GO_REF:0000119	ACCEPT	Summary: Reverse transcriptase activity (EC 2.7.7.49) by which TERT copies the Terc RNA template into telomeric DNA. The conserved RT domain (residues 595-928) with catalytic Mg2+-binding Asp residues underlies telomerase action. Reason: Precise MF describing the reverse-transcriptase catalytic mechanism; core. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0003968 RNA-directed RNA polymerase activity	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: A non-canonical RdRP activity has been proposed for TERT (with RMRP RNA, the TERT-RMRP complex), but this is contested and supported only by electronic transfer; not part of the canonical telomerase MF. Reason: Contested non-canonical activity; electronic (IEA/ISO) only.
GO:0005634 nucleus	ISO GO_REF:0000119	ACCEPT	Summary: Principal compartment where TERT acts; nuclear import/retention is regulated by AKT phosphorylation and SHP2/PTPN11 dephosphorylation, positioning telomerase for chromosome-end extension. Reason: Core CC; nucleus is the canonical site of telomerase action. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005654 nucleoplasm	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT shows diffuse nucleoplasmic distribution; a subnuclear pool that is part of nuclear residence but not the specific telomere/nucleolar site of function. Reason: Nuclear subcompartment; non-core relative to telomere/nucleolus.
GO:0005697 telomerase holoenzyme complex	ISO GO_REF:0000119	ACCEPT	Summary: TERT is the catalytic subunit of the holoenzyme, which also contains Terc, WRAP53/TCAB1 and the H/ACA proteins DKC1, NOP10, NHP2 and GAR1, plus associated TEP1/SMG6/POT1. Reason: Core CC; UniProt SUBUNIT defines TERT as the holoenzyme catalytic component. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005730 nucleolus	ISO GO_REF:0000119	ACCEPT	Summary: TERT is enriched in nucleoli of certain cell types; nucleolar localization (mediated via NCL interaction) is part of telomerase trafficking/biogenesis and is well documented for TERT. Reason: Core/canonical TERT subnuclear localization (ISS/ISO), consistent with UniProt. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005739 mitochondrion	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: A mitochondrial TERT pool with non-canonical roles in ROS handling and mtDNA protection has been reported, but this moonlighting localization is context-dependent and distinct from telomere maintenance. Reason: Contested non-canonical localization (IDA/IEA/ISO); keep non-core.
GO:0005829 cytosol	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Cytosolic pool consistent with stress-regulated nuclear export of TERT; secondary to nuclear/telomeric localization. Reason: Secondary localization (IEA/ISO).
GO:0006278 RNA-templated DNA biosynthetic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Reverse-transcription process term; correct for TERT but a general restatement of its telomere-templated DNA synthesis already covered by core terms. Reason: Accurate but redundant BP with core telomerase process.
GO:0006606 protein import into nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Reflects regulated nuclear import of TERT (AKT-driven; RAN/XPO1-dependent shuttling); a trafficking/regulatory process supporting, not equal to, the core function. Reason: Regulatory trafficking BP (IEA/ISO).
GO:0007004 telomere maintenance via telomerase	ISO GO_REF:0000119	ACCEPT	Summary: The canonical pathway in which TERT extends telomeres to counter the end-replication problem; mTert-null mice show progressive multigenerational telomere erosion and signal-free chromosome ends. Reason: Core BP; mouse genetic evidence establishes telomerase-dependent maintenance. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0007005 mitochondrion organization	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Linked to the contested non-canonical mitochondrial role of TERT (ROS/mtDNA biogenesis); a pleiotropic/moonlighting process, not core telomere biology. Reason: Non-canonical mitochondrial process (IEA/ISO).
GO:0016605 PML body	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: PML interaction recruits TERT to PML bodies and inhibits telomerase activity; a regulatory sequestration site rather than the active catalytic location. Reason: Regulatory/inhibitory localization (IEA/ISO); non-core.
GO:0016607 nuclear speck	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Reported nuclear-speck localization of TERT is a secondary subnuclear pool, electronically inferred; not the canonical site of telomere extension. Reason: Secondary subnuclear localization (IEA/ISO).
GO:0022616 DNA strand elongation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Describes the elongation step of telomeric DNA synthesis; accurate but a generic facet of the core telomere-extension process. Reason: Generic BP facet of telomere extension (IEA/ISO).
GO:0030177 positive regulation of Wnt signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT modulates Wnt/beta-catenin signaling by associating with SMARCA4 on target-gene chromatin (Park et al. 2009); a well-supported non-canonical role distinct from telomere extension. Reason: Non-canonical signaling role (IGI/IEA/ISO); moonlighting, keep non-core.
GO:0030422 siRNA processing	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Reflects the proposed TERT-RMRP pathway generating RMRP-derived siRNAs; a contested non-canonical role rather than the core telomerase function. Reason: Non-canonical RMRP-linked role (ISS/ComplexPortal).
GO:0031379 RNA-directed RNA polymerase complex	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Companion CC for the proposed TERT-RMRP RdRP activity; non-canonical and electronic, retained as a possible moonlighting context rather than the core telomerase complex. Reason: Non-canonical complex tied to contested RdRP role (IEA/ISO).
GO:0031647 regulation of protein stability	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT participates in protein-stability regulation (e.g., it is itself controlled by DYRK2/EDVP ubiquitination, and modulates partner stability such as CMIP); a regulatory facet, not core. Reason: Pleiotropic regulatory BP (IEA/ISO).
GO:0042645 mitochondrial nucleoid	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Association of TERT with mitochondrial nucleoids relates to proposed mtDNA-protective non-canonical roles; electronic and context-dependent, not the canonical function. Reason: Non-canonical mitochondrial localization (IEA/ISO).
GO:0042802 identical protein binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: Generic self-binding term; TERT can oligomerize but this adds little functional content over the more specific homodimerization terms and is electronic only. Reason: Uninformative generic MF (IEA/ISO).
GO:0042803 protein homodimerization activity	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT can oligomerize via dedicated oligomerization regions; homodimerization is a structural property relevant to assembly but not the catalytic core function. Reason: Specific but ancillary structural MF (IEA/ISO).
GO:0043066 negative regulation of apoptotic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: TERT has antiapoptotic/pro-survival activity (UniProt: roles in antiapoptosis), a pleiotropic protective effect downstream of or parallel to telomere maintenance. Reason: Pleiotropic pro-survival BP (IEA/ISO).
GO:0043524 negative regulation of neuron apoptotic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Neuron-specific instance of TERT's antiapoptotic activity, relevant to neuroprotection literature; a downstream tissue-specific effect. Reason: Tissue-specific antiapoptotic BP (IEA/ISO).
GO:0045766 positive regulation of angiogenesis	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: TERT supports angiogenesis (linked to endothelial survival/VEGF); a downstream vascular role rather than the core telomerase function. Reason: Pleiotropic vascular BP (IEA/ISO).
GO:0051087 protein-folding chaperone binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT binds the HSP90/p23 (PTGES3) chaperone machinery required for correct assembly and stabilization of active telomerase; an assembly-support interaction. Reason: Specific biogenesis-related binding (IEA/ISO); non-core MF.
GO:0060253 negative regulation of glial cell proliferation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Tissue-specific proliferation-regulatory effect attributed to TERT; pleiotropic and supported only by orthology transfer. Reason: Pleiotropic tissue-specific BP (ISO).
GO:0070034 telomerase RNA binding	ISO GO_REF:0000119	ACCEPT	Summary: TERT binds the Terc/TR template via RNA-interacting domains RD1 and RD2 (pseudoknot-template and CR4/5 regions), an essential determinant of template engagement and repeat-addition processivity. Reason: Specific, informative MF central to holoenzyme assembly and catalysis; core. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0070200 establishment of protein localization to telomere	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Recruitment of telomerase/TERT to telomeres (via shelterin-linked TPP1/TIN2/POT1b factors); a localization step upstream of catalysis, retained as supporting non-core. Reason: Recruitment/localization BP (IEA/ISO); supports core but distinct.
GO:0071456 cellular response to hypoxia	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT participates in hypoxic stress responses (mitochondrial/ROS and survival programs); a stress-response role secondary to its catalytic function. Reason: Stress-response BP (IEA/ISO).
GO:0071897 DNA biosynthetic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT synthesizes telomeric DNA, so this parent process is true but generic relative to telomere maintenance via telomerase. Reason: Correct but over-general BP; electronic propagation.
GO:0090399 replicative senescence	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT activity counteracts replicative senescence by sustaining telomere length; a phenotype-level process downstream of the catalytic role. Reason: Downstream/phenotypic BP (IEA/ISO).
GO:0098680 template-free RNA nucleotidyltransferase activity	ISO GO_REF:0000119	REMOVE	Summary: Template-free RNA nucleotidyltransferase activity is not a function of TERT, whose defining chemistry is template-directed DNA synthesis from the Terc RNA; this electronic annotation contradicts the established mechanism. Reason: Electronic (IEA/ISO) and biologically contradicted; TERT is template-dependent.
GO:0140745 siRNA transcription	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Transcription of siRNA from the RMRP template via the proposed TERT RdRP activity; non-canonical and electronically inferred. Reason: Non-canonical RMRP-linked role (IEA/ISO).
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Cell-cycle-promoting effect linked to TERT's pro-proliferative/non-canonical signaling; pleiotropic and electronically inferred. Reason: Pleiotropic cell-cycle BP (IEA/ISO).
GO:1902895 positive regulation of miRNA transcription	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Reflects TERT's non-canonical influence on miRNA-gene transcription via chromatin association; part of its moonlighting transcriptional activity. Reason: Non-canonical transcriptional BP (IEA/ISO).
GO:1903620 positive regulation of transdifferentiation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Non-canonical role of TERT in promoting cellular transdifferentiation; context-dependent and electronically inferred. Reason: Non-canonical developmental BP (IEA/ISO).
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: TERT promotes proliferation of vascular smooth muscle cells; a tissue-specific downstream proliferative effect. Reason: Tissue-specific proliferation BP (IEA/ISO).
GO:1904751 positive regulation of protein localization to nucleolus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Linked to TERT's nucleolar trafficking interactions; a regulatory localization process, electronically inferred and ancillary. Reason: Regulatory localization BP (IEA/ISO).
GO:1904754 positive regulation of vascular associated smooth muscle cell migration	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: TERT promotes vascular smooth muscle cell migration; part of its pleiotropic vascular-remodeling effects, electronically inferred. Reason: Tissue-specific migration BP (IEA/ISO).
GO:1990572 TERT-RMRP complex	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TERT can associate with the RMRP RNA in a distinct complex linked to the proposed RdRP/siRNA activity; a non-canonical context separate from telomere maintenance. Reason: Non-canonical TERT-RMRP complex (ISS/ComplexPortal, IEA).
GO:2000352 negative regulation of endothelial cell apoptotic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Endothelial antiapoptotic effect of TERT linked to vascular/angiogenesis biology; a pleiotropic downstream role. Reason: Tissue-specific antiapoptotic BP (IEA/ISO).
GO:2000773 negative regulation of cellular senescence	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: By maintaining telomeres, TERT delays senescence; this is a downstream physiological consequence rather than the molecular core function. Reason: Downstream consequence of telomere maintenance (IEA/ISO).
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Specific antiapoptotic pathway facet of TERT's pro-survival activity; pleiotropic and electronically inferred. Reason: Pleiotropic antiapoptotic BP (IEA/ISO).
GO:0000722 telomere maintenance via recombination	NAS PMID:20351177 Specificity and stoichiometry of subunit interactions in the...	UNDECIDED	Summary: ALT (recombination-based) telomere maintenance is telomerase-INDEPENDENT and is not TERT's mechanism; TERT acts via telomerase. The NAS annotation appears misattributed, but as non-electronic evidence it is flagged not removed. Reason: ALT is telomerase-independent; NAS evidence (not IEA/ISO), so flag not REMOVE.
GO:0007004 telomere maintenance via telomerase	NAS PMID:20351177 Specificity and stoichiometry of subunit interactions in the...	ACCEPT	Summary: The canonical pathway in which TERT extends telomeres to counter the end-replication problem; mTert-null mice show progressive multigenerational telomere erosion and signal-free chromosome ends. Reason: Core BP; mouse genetic evidence establishes telomerase-dependent maintenance. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005697 telomerase holoenzyme complex	ISS GO_REF:0000024	ACCEPT	Summary: TERT is the catalytic subunit of the holoenzyme, which also contains Terc, WRAP53/TCAB1 and the H/ACA proteins DKC1, NOP10, NHP2 and GAR1, plus associated TEP1/SMG6/POT1. Reason: Core CC; UniProt SUBUNIT defines TERT as the holoenzyme catalytic component. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0007004 telomere maintenance via telomerase	ISS GO_REF:0000024	ACCEPT	Summary: The canonical pathway in which TERT extends telomeres to counter the end-replication problem; mTert-null mice show progressive multigenerational telomere erosion and signal-free chromosome ends. Reason: Core BP; mouse genetic evidence establishes telomerase-dependent maintenance. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0003723 RNA binding	IPI PMID:16507993 Regulation of cellular immortalization and steady-state leve...	MARK AS OVER ANNOTATED	Summary: Broad RNA-binding term; TERT's functionally relevant RNA interaction is with Terc, already captured by the specific telomerase RNA binding annotation. Reason: Over-broad nucleic-acid binding; specific telomerase RNA binding present.
GO:0003720 telomerase activity	TAS PMID:16107853 Conditional telomerase induction causes proliferation of hai...	ACCEPT	Summary: Defining catalytic activity of TERT: the RNA-dependent processive addition of TTAGGG telomeric repeats to 3' chromosome ends. mTert loss abolishes detectable telomerase activity in vivo. Core function. Reason: Catalytic core MF; directly supported by mouse IDA/TAS and conserved IBA evidence. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0007004 telomere maintenance via telomerase	TAS PMID:16107853 Conditional telomerase induction causes proliferation of hai...	ACCEPT	Summary: The canonical pathway in which TERT extends telomeres to counter the end-replication problem; mTert-null mice show progressive multigenerational telomere erosion and signal-free chromosome ends. Reason: Core BP; mouse genetic evidence establishes telomerase-dependent maintenance. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0005515 protein binding	IPI PMID:24970747 Extra-nuclear telomerase reverse transcriptase (TERT) regula...	MARK AS OVER ANNOTATED	Summary: Bare 'protein binding' conveys no specific TERT function; its many partners (HSP90, TCAB1, SMARCA4, PIF1, etc.) are better captured by specific binding/complex terms. Reason: Uninformative generic MF; specific partner terms preferred.
GO:0005737 cytoplasm	IDA PMID:24970747 Extra-nuclear telomerase reverse transcriptase (TERT) regula...	KEEP AS NON CORE	Summary: TERT shuttles to the cytoplasm under oxidative stress (CRM1/RAN-dependent, Tyr-697 phosphorylation), a regulated secondary localization rather than its catalytic site. Reason: Regulated secondary localization (IDA/IEA); not core site of action.
GO:0005886 plasma membrane	IDA PMID:24970747 Extra-nuclear telomerase reverse transcriptase (TERT) regula...	KEEP AS NON CORE	Summary: An IDA plasma-membrane localization is reported but is a minor/atypical pool far from TERT's nuclear telomere-extension role; retained without endorsing it as core. Reason: Atypical secondary localization (IDA); experimental, so downgraded not removed.
GO:0046326 positive regulation of D-glucose import across plasma membrane	IMP PMID:24970747 Extra-nuclear telomerase reverse transcriptase (TERT) regula...	KEEP AS NON CORE	Summary: An IMP-supported metabolic effect of TERT on glucose uptake; a non-canonical metabolic role distinct from telomere maintenance. Reason: Non-canonical metabolic BP (IMP); experimental, downgrade not remove.
GO:0070034 telomerase RNA binding	IPI PMID:16507993 Regulation of cellular immortalization and steady-state leve...	ACCEPT	Summary: TERT binds the Terc/TR template via RNA-interacting domains RD1 and RD2 (pseudoknot-template and CR4/5 regions), an essential determinant of template engagement and repeat-addition processivity. Reason: Specific, informative MF central to holoenzyme assembly and catalysis; core. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0030177 positive regulation of Wnt signaling pathway	IGI PMID:19571879 Telomerase modulates Wnt signalling by association with targ...	KEEP AS NON CORE	Summary: TERT modulates Wnt/beta-catenin signaling by associating with SMARCA4 on target-gene chromatin (Park et al. 2009); a well-supported non-canonical role distinct from telomere extension. Reason: Non-canonical signaling role (IGI/IEA/ISO); moonlighting, keep non-core.
GO:2000648 positive regulation of stem cell proliferation	IMP PMID:16107853 Conditional telomerase induction causes proliferation of hai...	KEEP AS NON CORE	Summary: TERT promotes proliferation of stem/progenitor cells (IMP), consistent with its expression in progenitor compartments; an important but downstream physiological role. Reason: Stem-cell physiology BP (IMP); experimental, downgrade to non-core.
GO:0005515 protein binding	IPI PMID:17130244 Murine Pif1 interacts with telomerase and is dispensable for...	MARK AS OVER ANNOTATED	Summary: Bare 'protein binding' conveys no specific TERT function; its many partners (HSP90, TCAB1, SMARCA4, PIF1, etc.) are better captured by specific binding/complex terms. Reason: Uninformative generic MF; specific partner terms preferred.
GO:0005730 nucleolus	ISS GO_REF:0000024	ACCEPT	Summary: TERT is enriched in nucleoli of certain cell types; nucleolar localization (mediated via NCL interaction) is part of telomerase trafficking/biogenesis and is well documented for TERT. Reason: Core/canonical TERT subnuclear localization (ISS/ISO), consistent with UniProt. Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0000333 telomerase catalytic core complex	IMP PMID:16037417 Effects of telomerase and telomere length on epidermal stem ...	ACCEPT	Summary: TERT plus the Terc RNA constitute the catalytic core responsible for DNA extension. This minimal complex is the functional engine of telomerase. Reason: Core CC; TERT is the protein component of the catalytic core (IMP/IBA). Supporting Evidence: UniProt:O70372 Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. file:mouse/Tert/Tert-deep-research-falcon.md Mouse Tert (UniProt O70372) encodes the telomerase reverse transcriptase, whose primary function is to extend telomeric (TTAGGG)n repeats at chromosome ends as the catalytic core of the telomerase RNP.
GO:0042635 positive regulation of hair cycle	IMP PMID:16107853 Conditional telomerase induction causes proliferation of hai...	KEEP AS NON CORE	Summary: TERT promotes hair-follicle stem cell activation and anagen entry (IMP, a catalysis-independent function shown in mouse skin); a notable tissue-specific moonlighting role. Reason: Tissue-specific stem-cell BP (IMP); experimental, keep as non-core.
GO:0005739 mitochondrion	IDA PMID:21937513 Human telomerase acts as a hTR-independent reverse transcrip...	KEEP AS NON CORE	Summary: A mitochondrial TERT pool with non-canonical roles in ROS handling and mtDNA protection has been reported, but this moonlighting localization is context-dependent and distinct from telomere maintenance. Reason: Contested non-canonical localization (IDA/IEA/ISO); keep non-core.
GO:0042635 positive regulation of hair cycle	IMP PMID:16037417 Effects of telomerase and telomere length on epidermal stem ...	KEEP AS NON CORE	Summary: TERT promotes hair-follicle stem cell activation and anagen entry (IMP, a catalysis-independent function shown in mouse skin); a notable tissue-specific moonlighting role. Reason: Tissue-specific stem-cell BP (IMP); experimental, keep as non-core.
GO:2000648 positive regulation of stem cell proliferation	IMP PMID:16037417 Effects of telomerase and telomere length on epidermal stem ...	KEEP AS NON CORE	Summary: TERT promotes proliferation of stem/progenitor cells (IMP), consistent with its expression in progenitor compartments; an important but downstream physiological role. Reason: Stem-cell physiology BP (IMP); experimental, downgrade to non-core.
GO:0001223 transcription coactivator binding	IPI PMID:19571879 Telomerase modulates Wnt signalling by association with targ...	KEEP AS NON CORE	Summary: Captures TERT's chromatin/transcription interactions (e.g., SMARCA4/BRG1 in Wnt target-gene regulation), part of its non-canonical transcriptional role. Reason: Specific binding tied to non-canonical transcriptional role (IPI/IEA/ISO).
GO:0003720 telomerase activity	IDA PMID:14701760 Genomic instability and enhanced radiosensitivity in Hsp70.1...	ACCEPT	Summary: Defining catalytic activity of TERT: the RNA-dependent processive addition of TTAGGG telomeric repeats to 3' chromosome ends. mTert loss abolishes detectable telomerase activity in vivo. Core function. Reason: Catalytic core MF; directly supported by mouse IDA/TAS and conserved IBA evidence.

Gene Description

Existing Annotations Review

Core Functions

Catalyzes telomerase RNA-templated addition of TTAGGG telomeric repeats to chromosome ends as the catalytic protein subunit of telomerase.

References

Deep Research

Falcon

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