Mtmr12

UniProt ID: A0A8I5ZMD5
Organism: Rattus norvegicus
Review Status: COMPLETE
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Gene Description

MTMR12 is a catalytically inactive myotubularin-family protein that binds and stabilizes the active lipid phosphatase MTM1. This interaction supports skeletal-muscle membrane organization and maintenance. Rat A0A8I5ZMD5 retains the complete reference myotubularin domain but has a different N-terminal segment, leaving its trafficking and participation in the cytoplasmic MTM1 complex uncertain.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0016529 sarcoplasmic reticulum
IEA
GO_REF:0000044 		UNDECIDED
Summary: Muscle-membrane localization of MTMR12 is consistent with its MTM1-associated maintenance function, but the selected product has an alternative N-terminus with a predicted secretory signal. The domain is intact; neither absence nor preservation of normal cytoplasmic-side sarcoplasmic-reticulum targeting has been demonstrated for this product.
Supporting Evidence:
PMID:23818870
MTMR12 primarily regulates the function of myotubularin protein by affecting protein levels instead of modulating the enzymatic activity
file:rat/Mtmr12/Mtmr12-bioinformatics/RESULTS.md
| Domain: Myotubularin phosphatase | 206–644 | 439 / 439 | 439 |
file:rat/Mtmr12/Mtmr12-uniprot.txt
SIGNAL 1..20
GO:0030017 sarcomere
IEA
GO_REF:0000044 		UNDECIDED
Summary: MTMR12 affects myofibril and membrane organization, but a muscle phenotype is not by itself localization to the sarcomere. Transfer of the precise localization also requires resolving the selected product’s alternative N-terminal trafficking signal. The available primary report does not assay this rat product.
Supporting Evidence:
PMID:23818870
MTMR12 primarily regulates the function of myotubularin protein by affecting protein levels instead of modulating the enzymatic activity
file:rat/Mtmr12/Mtmr12-bioinformatics/RESULTS.md
| Domain: Myotubularin phosphatase | 206–644 | 439 / 439 | 439 |
file:rat/Mtmr12/Mtmr12-uniprot.txt
SIGNAL 1..20

References

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Suggested Questions for Experts

Q: Is the alternative N-terminus translated and cleaved, and can this rat product bind MTM1 on the cytoplasmic side of muscle membranes?

External Prediction Reviews

These computational predictions are reviewed separately from the GOA annotation set used for this review. The assessments below are from this project and do not constitute official GO annotations or endorsement by GO/UniProt. They are not included in the existing annotation review above.

ProtNLM2 External predictions

View prediction review YAML · Mtmr12-protnlm-predictions-review.yaml · Review status: COMPLETE

MTMR12 has a genuine myotubularin domain and a noncatalytic MTM1-stabilizing role. The selected product’s altered N-terminal sequence makes cytoplasmic localization uncertain.

Source documents: genes/rat/Mtmr12/Mtmr12-protnlm-source.json · genes/rat/Mtmr12/Mtmr12-notes.md

Review score: 2 = concordant with evidence; 1 = uncertain; 0 = discordant with evidence. This is an assessment score, not a model probability.

GO:0005737 cytoplasm GO_CC
UNC — Uncertain Review score: 1/2
Prediction method: ProtNLM2 · Version: UniProt API snapshot 2026-09-10 · file:rat/Mtmr12/Mtmr12-protnlm-source.json
Review rationale: Cytoplasmic MTMR12-MTM1 interactions are well grounded in primary experiments, but the selected product has a divergent N-terminus annotated with a signal peptide. This computational conflict does not establish secretion, yet prevents resolving trafficking of A0A8I5ZMD5 from the canonical partner mechanism alone.
Supporting Evidence:

Deep Research

Falcon

(Mtmr12-deep-research-falcon.md)

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đź“š Additional Documentation

Notes

(Mtmr12-notes.md)

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Bioinformatics Results

(RESULTS.md)

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đź“„ View Raw YAML

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