id: A0A8I5ZMD5
gene_symbol: Mtmr12
taxon:
  id: NCBITaxon:10116
  label: Rattus norvegicus
status: COMPLETE
description: MTMR12 has a genuine myotubularin domain and a noncatalytic MTM1-stabilizing role. The selected
  product’s altered N-terminal sequence makes cytoplasmic localization uncertain.
source_documents:
- genes/rat/Mtmr12/Mtmr12-protnlm-source.json
- genes/rat/Mtmr12/Mtmr12-notes.md
references:
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping,
    accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:23818870
  title: Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin
    stability and promotes centronuclear myopathy in zebrafish.
  findings:
  - statement: Cell and animal experiments distinguish inactive MTMR12 from its catalytically active MTM1
      partner and support a protein-stability mechanism.
    supporting_text: MTMR12 primarily regulates the function of myotubularin protein by affecting protein
      levels instead of modulating the enzymatic activity
  - statement: Partial compensation in zebrafish supports noncatalytic MTMR12 function, not intrinsic
      phosphoinositide phosphatase activity.
    supporting_text: the catalytically inactive MTMR12 only partially but significantly rescues myotubularin
      function
  full_text_unavailable: false
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Primary report checked against the cached abstract/full text; the evidence scope is
      stated in the finding.
- id: file:rat/Mtmr12/Mtmr12-bioinformatics/RESULTS.md
  title: Exact Mtmr12 product-to-reference sequence comparison
- id: file:rat/Mtmr12/Mtmr12-uniprot.txt
  title: Machine-fetched exact rat MTMR12 record; signal peptide is computational
- id: file:rat/Mtmr12/Mtmr12-protnlm-source.json
  title: Frozen exact-input ProtNLM output and UniProt sequence for A0A8I5ZMD5
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-10
  source_reference_id: file:rat/Mtmr12/Mtmr12-protnlm-source.json
  predicted_term:
    id: GO:0005737
    label: cytoplasm
  predicted_term_type: GO_CC
  review:
    assessment: UNC
    confidence_score: 1
    summary: Cytoplasmic MTMR12-MTM1 interactions are well grounded in primary experiments, but the selected
      product has a divergent N-terminus annotated with a signal peptide. This computational conflict
      does not establish secretion, yet prevents resolving trafficking of A0A8I5ZMD5 from the canonical
      partner mechanism alone.
    supported_by:
    - reference_id: PMID:23818870
      supporting_text: MTMR12 primarily regulates the function of myotubularin protein by affecting protein
        levels instead of modulating the enzymatic activity
    - reference_id: file:rat/Mtmr12/Mtmr12-bioinformatics/RESULTS.md
      supporting_text: '| Domain: Myotubularin phosphatase | 206–644 | 439 / 439 | 439 |'
    - reference_id: file:rat/Mtmr12/Mtmr12-uniprot.txt
      supporting_text: SIGNAL          1..20