Slc13a2 encodes the apical low-affinity sodium/dicarboxylate cotransporter NaDC-1, transporting citric-acid-cycle dicarboxylates such as succinate, citrate, fumarate, and alpha-ketoglutarate with sodium. The review accepts substrate-specific transporter and transport terms, keeps membrane localization as non-core, and marks lithium response as assay-context activity regulation rather than a gene response process.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: plasma membrane is retained for Slc13a2 as supported contextual biology, but it is not the defining core function (IBA, GO_REF:0000033). Reason: This term records supported membrane or apical plasma-membrane localization rather than the defining transport activity. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015138 fumarate transmembrane transporter activity | IBA GO_REF:0000033 | ACCEPT | Summary: fumarate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IBA, GO_REF:0000033). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015139 alpha-ketoglutarate transmembrane transporter activity | IBA GO_REF:0000033 | ACCEPT | Summary: alpha-ketoglutarate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IBA, GO_REF:0000033). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015141 succinate transmembrane transporter activity | IBA GO_REF:0000033 | ACCEPT | Summary: succinate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IBA, GO_REF:0000033). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015741 fumarate transport | IBA GO_REF:0000033 | ACCEPT | Summary: fumarate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IBA, GO_REF:0000033). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015742 alpha-ketoglutarate transport | IBA GO_REF:0000033 | ACCEPT | Summary: alpha-ketoglutarate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IBA, GO_REF:0000033). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0017153 sodium:dicarboxylate symporter activity | IBA GO_REF:0000033 | ACCEPT | Summary: sodium:dicarboxylate symporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IBA, GO_REF:0000033). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. file:rat/Slc13a2/Slc13a2-deep-research-falcon.md NaDC1 is described as a **Na+-coupled electrogenic symporter**. A review synthesis reports a **Na+:anion coupling ratio of 3:1**, consistent with an electrogenic uptake process. |
| GO:0071285 cellular response to lithium ion | IBA GO_REF:0000033 | MARK AS OVER ANNOTATED | Summary: cellular response to lithium ion is marked as over-annotated for Slc13a2; the evidence supports the gene's core activity or context, not this broader process claim (IBA, GO_REF:0000033). Reason: Lithium is an assay-context cation competitor/inhibitor for Slc13a2-mediated dicarboxylate transport, not evidence that Slc13a2 mediates a cellular response to lithium ion. Treat the GOA row as an over-annotation of transport-assay conditions. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: ROLE CONFLATION CONTEXT OR TISSUE MISMATCH Sources checked: PANTHER:PTN008496849 · PANTHER:PTN008496849 SUPPORTS SOURCE BUT NOT TARGET The IBD at PTN008496849 (PTHR10283, snapshot 20230926) is seeded by rat Slc13a2 itself (RGD:61920; IDA from the cloning paper PMID:9691021) and human SLC13A2 (UniProtKB:Q13183) — both reflecting Li+ sensitivity/inhibition of Na+-dicarboxylate cotransport assays. The node placement is not in question; the term scoping is — Li+ acting as a cation competitor in transport assays is an assay condition, not evidence that these transporters mediate a cellular response to lithium ion, so the mis-scoped term propagates with the IBD. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. |
| GO:0071422 succinate transmembrane transport | IBA GO_REF:0000033 | ACCEPT | Summary: succinate transmembrane transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IBA, GO_REF:0000033). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015370 solute:sodium symporter activity | IEA GO_REF:0000117 | MODIFY | Summary: solute:sodium symporter activity captures part of Slc13a2 biology, but a more specific or better-aspected GO term should replace it (IEA, GO_REF:0000117). Reason: The generic transporter or transport term should be replaced with the specific sodium:dicarboxylate symporter activity or substrate-specific dicarboxylate transport processes. Proposed replacements: sodium:dicarboxylate symporter activity Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015746 citrate transport | IEA GO_REF:0000108 | ACCEPT | Summary: citrate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000108). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. file:rat/Slc13a2/Slc13a2-deep-research-falcon.md NaDC1 is repeatedly positioned as a **primary apical entry step for citrate reabsorption** in proximal tubule, thereby regulating how much citrate remains in urine versus being reclaimed and metabolized. |
| GO:0016020 membrane | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: membrane is retained for Slc13a2 as supported contextual biology, but it is not the defining core function (IEA, GO_REF:0000002). Reason: This term records supported membrane or apical plasma-membrane localization rather than the defining transport activity. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0016324 apical plasma membrane | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: apical plasma membrane is retained for Slc13a2 as supported contextual biology, but it is not the defining core function (IEA, GO_REF:0000120). Reason: This term records supported membrane or apical plasma-membrane localization rather than the defining transport activity. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. file:rat/Slc13a2/Slc13a2-deep-research-falcon.md NaDC1 localizes to the **apical/luminal (brush-border) membrane** of **proximal tubule epithelial cells** and is also discussed as apical in intestine/small intestinal villus epithelium. |
| GO:0022857 transmembrane transporter activity | IEA GO_REF:0000002 | MODIFY | Summary: transmembrane transporter activity captures part of Slc13a2 biology, but a more specific or better-aspected GO term should replace it (IEA, GO_REF:0000002). Reason: The generic transporter or transport term should be replaced with the specific sodium:dicarboxylate symporter activity or substrate-specific dicarboxylate transport processes. Proposed replacements: sodium:dicarboxylate symporter activity Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0035725 sodium ion transmembrane transport | IEA GO_REF:0000108 | ACCEPT | Summary: sodium ion transmembrane transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000108). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0055085 transmembrane transport | IEA GO_REF:0000002 | MODIFY | Summary: transmembrane transport captures part of Slc13a2 biology, but a more specific or better-aspected GO term should replace it (IEA, GO_REF:0000002). Reason: The generic transporter or transport term should be replaced with the specific sodium:dicarboxylate symporter activity or substrate-specific dicarboxylate transport processes. Proposed replacements: succinate transmembrane transport fumarate transport alpha-ketoglutarate transport citrate transport Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015137 citrate transmembrane transporter activity | IEA GO_REF:0000107 | ACCEPT | Summary: citrate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000107). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015138 fumarate transmembrane transporter activity | IEA GO_REF:0000107 | ACCEPT | Summary: fumarate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000107). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015139 alpha-ketoglutarate transmembrane transporter activity | IEA GO_REF:0000107 | ACCEPT | Summary: alpha-ketoglutarate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000107). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015141 succinate transmembrane transporter activity | IEA GO_REF:0000120 | ACCEPT | Summary: succinate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000120). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015741 fumarate transport | IEA GO_REF:0000107 | ACCEPT | Summary: fumarate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000107). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015742 alpha-ketoglutarate transport | IEA GO_REF:0000107 | ACCEPT | Summary: alpha-ketoglutarate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000107). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0017153 sodium:dicarboxylate symporter activity | IEA GO_REF:0000120 | ACCEPT | Summary: sodium:dicarboxylate symporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000120). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0071285 cellular response to lithium ion | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: cellular response to lithium ion is marked as over-annotated for Slc13a2; the evidence supports the gene's core activity or context, not this broader process claim (IEA, GO_REF:0000107). Reason: Lithium is an assay-context cation competitor/inhibitor for Slc13a2-mediated dicarboxylate transport, not evidence that Slc13a2 mediates a cellular response to lithium ion. Treat the GOA row as an over-annotation of transport-assay conditions. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. |
| GO:0071422 succinate transmembrane transport | IEA GO_REF:0000120 | ACCEPT | Summary: succinate transmembrane transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IEA, GO_REF:0000120). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015137 citrate transmembrane transporter activity | ISO GO_REF:0000121 | ACCEPT | Summary: citrate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (ISO, GO_REF:0000121). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0016324 apical plasma membrane | ISO GO_REF:0000121 | KEEP AS NON CORE | Summary: apical plasma membrane is retained for Slc13a2 as supported contextual biology, but it is not the defining core function (ISO, GO_REF:0000121). Reason: This term records supported membrane or apical plasma-membrane localization rather than the defining transport activity. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015138 fumarate transmembrane transporter activity | IDA PMID:9691021 Cloning, functional characterization, and localization of a ... | ACCEPT | Summary: fumarate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IDA, PMID:9691021). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. |
| GO:0015139 alpha-ketoglutarate transmembrane transporter activity | ISO GO_REF:0000121 | ACCEPT | Summary: alpha-ketoglutarate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (ISO, GO_REF:0000121). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015139 alpha-ketoglutarate transmembrane transporter activity | IDA PMID:9691021 Cloning, functional characterization, and localization of a ... | ACCEPT | Summary: alpha-ketoglutarate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IDA, PMID:9691021). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. |
| GO:0015141 succinate transmembrane transporter activity | IDA PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. | ACCEPT | Summary: succinate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IDA, PMID:9694847). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. |
| GO:0015741 fumarate transport | ISO GO_REF:0000121 | ACCEPT | Summary: fumarate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (ISO, GO_REF:0000121). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015741 fumarate transport | IDA PMID:9691021 Cloning, functional characterization, and localization of a ... | ACCEPT | Summary: fumarate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IDA, PMID:9691021). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. |
| GO:0015742 alpha-ketoglutarate transport | ISO GO_REF:0000121 | ACCEPT | Summary: alpha-ketoglutarate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (ISO, GO_REF:0000121). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015742 alpha-ketoglutarate transport | IDA PMID:9691021 Cloning, functional characterization, and localization of a ... | ACCEPT | Summary: alpha-ketoglutarate transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IDA, PMID:9691021). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. |
| GO:0016324 apical plasma membrane | IDA PMID:9691021 Cloning, functional characterization, and localization of a ... | KEEP AS NON CORE | Summary: apical plasma membrane is retained for Slc13a2 as supported contextual biology, but it is not the defining core function (IDA, PMID:9691021). Reason: This term records supported membrane or apical plasma-membrane localization rather than the defining transport activity. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. |
| GO:0017153 sodium:dicarboxylate symporter activity | ISO GO_REF:0000121 | ACCEPT | Summary: sodium:dicarboxylate symporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (ISO, GO_REF:0000121). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0017153 sodium:dicarboxylate symporter activity | IDA PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. | ACCEPT | Summary: sodium:dicarboxylate symporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IDA, PMID:9694847). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. |
| GO:0071285 cellular response to lithium ion | ISO GO_REF:0000121 | MARK AS OVER ANNOTATED | Summary: cellular response to lithium ion is marked as over-annotated for Slc13a2; the evidence supports the gene's core activity or context, not this broader process claim (ISO, GO_REF:0000121). Reason: Lithium is an assay-context cation competitor/inhibitor for Slc13a2-mediated dicarboxylate transport, not evidence that Slc13a2 mediates a cellular response to lithium ion. Treat the GOA row as an over-annotation of transport-assay conditions. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: ROLE CONFLATION CONTEXT OR TISSUE MISMATCH Sources checked: UniProtKB:Q13183 · human SLC13A2 SUPPORTS SOURCE BUT NOT TARGET The human SLC13A2 lithium annotation derives from Li+ competition/inhibition in transport assays; the assay condition should not propagate to rat Slc13a2 as a cellular response process. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. |
| GO:0071285 cellular response to lithium ion | IDA PMID:9691021 Cloning, functional characterization, and localization of a ... | MARK AS OVER ANNOTATED | Summary: cellular response to lithium ion is marked as over-annotated for Slc13a2; the evidence supports the gene's core activity or context, not this broader process claim (IDA, PMID:9691021). Reason: Lithium is an assay-context cation competitor/inhibitor for Slc13a2-mediated dicarboxylate transport, not evidence that Slc13a2 mediates a cellular response to lithium ion. Treat the GOA row as an over-annotation of transport-assay conditions. Supporting Evidence: PMID:9691021 Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. |
| GO:0071422 succinate transmembrane transport | IDA PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. | ACCEPT | Summary: succinate transmembrane transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (IDA, PMID:9694847). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: PMID:9694847 Characterization of a rat Na+-dicarboxylate cotransporter. |
| GO:0015138 fumarate transmembrane transporter activity | ISO GO_REF:0000121 | ACCEPT | Summary: fumarate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (ISO, GO_REF:0000121). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0015141 succinate transmembrane transporter activity | ISO GO_REF:0000121 | ACCEPT | Summary: succinate transmembrane transporter activity is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (ISO, GO_REF:0000121). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
| GO:0071422 succinate transmembrane transport | ISO GO_REF:0000121 | ACCEPT | Summary: succinate transmembrane transport is retained for Slc13a2 because it matches the documented core molecular role or a direct pathway consequence (ISO, GO_REF:0000121). Reason: This term is directly supported by Slc13a2 sodium-coupled dicarboxylate transport of succinate, citrate, fumarate, and alpha-ketoglutarate. Supporting Evidence: UniProtKB:P70545 FUNCTION: Low-affinity sodium-dicarboxylate cotransporter that mediates entry of succinate, citrate, fumarate and alpha-ketoglutarate into small intestine and renal proximal tubule; probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate. |
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