Sodium/glucose cotransporter 1 (SGLT1) is a high-affinity Na+-coupled symporter that actively transports D-glucose and D-galactose across the plasma membrane with 2:1 Na+:glucose stoichiometry. SGLT1 is the primary transporter for dietary hexose absorption across the apical brush-border membrane of enterocytes in the small intestine. In kidney, it functions in the S3 segment of proximal tubules for glucose reabsorption, handling approximately 3% of filtered glucose. Additionally serves as a water channel enabling passive water transport. Located at the blood-brain barrier in endothelial cells.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0016324 apical plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation based on phylogenetic inference. SGLT1 apical localization is well-established across mammals. Direct experimental evidence in rat shows SGLT1 at apical membrane in MDCK cells (PMID:11831390), blood-brain barrier endothelial cells (PMID:14986005), and kidney proximal tubule S3 segments (PMID:16204409). Reason: Core localization for SGLT1 function. Phylogenetic inference is well-supported by multiple direct experimental studies in rat demonstrating apical membrane localization in intestinal epithelium, renal proximal tubules, and brain endothelial cells. The N-terminal domain determines apical targeting (PMID:11831390). Supporting Evidence: PMID:11831390 The products of N-terminal deletion clones up to the 19th amino acid were localized at the apical plasma membrane PMID:14986005 Immunostaining suggested that SGLT1 is located in the luminal membrane of the endothelial cells file:rat/Slc5a1/Slc5a1-deep-research-falcon.md model: Edison Scientific Literature |
| GO:0016324 apical plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: IEA annotation based on UniProtKB/Swiss-Prot subcellular location mapping. Redundant with IBA and IDA annotations for same term. Reason: While redundant with IBA annotation, this IEA represents valid automated inference from UniProt subcellular location annotation. Duplicates are acceptable in GO as they represent independent evidence paths. Core localization is correct. |
| GO:0016324 apical plasma membrane | IDA PMID:14986005 Localization of the Na+-D-glucose cotransporter SGLT1 in the... | ACCEPT | Summary: Direct experimental evidence from immunohistochemistry in rat brain capillaries showing SGLT1 in luminal (apical) membrane of blood-brain barrier endothelial cells. Reason: High-quality experimental evidence demonstrating apical localization in brain endothelial cells. The study showed immunoreactivity in intracerebral capillaries with staining in the luminal membrane. Supporting Evidence: PMID:14986005 Immunostaining suggested that SGLT1 is located in the luminal membrane of the endothelial cells and in intracellular vesicles |
| GO:0016324 apical plasma membrane | IDA PMID:11831390 The apical localization of SGLT1 glucose transporter is dete... | ACCEPT | Summary: Direct experimental evidence from MDCK cell localization studies showing rat SGLT1 localizes to apical plasma membrane. N-terminal deletion analysis identified apical targeting signals. Reason: High-quality experimental evidence. Study used rat SGLT1 expressed in MDCK cells and demonstrated apical localization, with identification of the N-terminal targeting domain. Supporting Evidence: PMID:11831390 SGLT1, an isoform of Na+-dependent glucose cotransporters, is localized at the apical plasma membrane in the epithelial cells of the small intestine and the kidney |
| GO:0016324 apical plasma membrane | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation transferred from other mammalian species by RGD. Redundant with multiple direct experimental annotations (IDA) for rat SGLT1. Reason: Valid ortholog transfer that is consistent with direct rat experimental evidence. Duplicates are acceptable as independent evidence paths. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation for plasma membrane localization. This is a parent term of apical plasma membrane (GO:0016324) which is the more specific correct localization. Reason: While technically correct, this is less specific than apical plasma membrane. The more specific term GO:0016324 better captures SGLT1's polarized localization. Acceptable to retain as it captures the broader membrane context. |
| GO:0005886 plasma membrane | ISO GO_REF:0000121 | KEEP AS NON CORE | Summary: ISO annotation transferred from mammalian orthologs. Less specific than apical plasma membrane annotations. Reason: Valid but less specific than apical plasma membrane. The more specific term GO:0016324 is preferred for capturing SGLT1's polarized epithelial localization. |
| GO:0031526 brush border membrane | IDA PMID:14986005 Localization of the Na+-D-glucose cotransporter SGLT1 in the... | ACCEPT | Summary: Brush border membrane localization is well supported for intestinal SGLT1, but PMID:14986005 itself focuses on brain capillary localization. Accept the term based on direct intestinal apical membrane evidence from other sources. Reason: The brush border membrane term is appropriate for intestinal SGLT1, even though PMID:14986005 is likely a misassigned reference. Experimental data from intestinal apical membrane preparations support this localization. Supporting Evidence: PMID:17272350 Western blotting showed that in each case there was a significant decrease in apical GLUT2 level, but no change in SGLT1 level. |
| GO:0031526 brush border membrane | IDA PMID:17272350 Apical GLUT2 and Cav1.3: regulation of rat intestinal glucos... | ACCEPT | Summary: Direct experimental evidence showing SGLT1 at intestinal brush border membrane in rat jejunum. Western blotting confirmed SGLT1 presence in apical membrane preparations. Reason: High-quality experimental evidence demonstrating SGLT1 at brush border membrane of rat intestinal epithelium. This is a core localization for intestinal glucose absorption. Supporting Evidence: PMID:17272350 Western blotting showed that in each case there was a significant decrease in apical GLUT2 level, but no change in SGLT1 level |
| GO:0005903 brush border | ISO GO_REF:0000121 | MODIFY | Summary: ISO annotation for brush border localization. Brush border (GO:0005903) is the parent of brush border membrane (GO:0031526). The more specific membrane term is more accurate for a transmembrane transporter. Reason: For a transmembrane transporter, the more specific term brush border membrane (GO:0031526) is more appropriate than the general brush border term. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: MGI:MGI:107678 · mouse Slc5a1 SUPPORTS SOURCE BUT NOT TARGET Mouse donor localization evidence is genuine, but for this apical transporter the brush border membrane (GO:0031526) is the appropriate compartment; the issue is term granularity, not the donor. Proposed replacements: brush border membrane |
| GO:0016020 membrane | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Very general IEA annotation based on InterPro record mapping. SGLT1 has many more specific membrane annotations (apical plasma membrane, brush border membrane). Reason: This is too general to be informative. SGLT1 has specific annotations to apical plasma membrane and brush border membrane that are much more informative. While technically correct, this adds no useful information. |
| GO:0043226 organelle | IDA PMID:14986005 Localization of the Na+-D-glucose cotransporter SGLT1 in the... | MODIFY | Summary: The paper mentions intracellular vesicles containing SGLT1 in brain endothelial cells. However, 'organelle' is extremely vague and should be more specific. Reason: The paper specifically mentions intracellular vesicles, not generic organelles. A more specific term would be appropriate if we want to capture this localization. Proposed replacements: cytoplasmic vesicle Supporting Evidence: PMID:14986005 Immunostaining suggested that SGLT1 is located in the luminal membrane of the endothelial cells and in intracellular vesicles |
| GO:0016323 basolateral plasma membrane | TAS PMID:14986005 Localization of the Na+-D-glucose cotransporter SGLT1 in the... | REMOVE | Summary: Questionable annotation. PMID:14986005 specifically shows SGLT1 in the LUMINAL (apical) membrane of brain endothelial cells, not basolateral. This appears to be an error in annotation. Reason: The cited paper explicitly states SGLT1 is in the luminal membrane, which is the apical/blood-facing side of brain capillary endothelium, not basolateral. SGLT1 is canonically an apical transporter; basolateral glucose exit is mediated by GLUT2. Supporting Evidence: PMID:14986005 Immunostaining suggested that SGLT1 is located in the luminal membrane of the endothelial cells |
| GO:0005911 cell-cell junction | IDA PMID:17090404 Asymmetric subcellular distribution of glucose transporters ... | KEEP AS NON CORE | Summary: Direct experimental evidence showing SGLT1 clusters at cell-cell junctions in arterial endothelium. High-density clusters found in proximity to cell-to-cell junctions. Reason: Valid experimental finding in endothelial cells showing SGLT1 clustering near cell-cell junctions. This represents a secondary localization pattern in vascular endothelium, not the primary physiological localization in intestine/kidney. Supporting Evidence: PMID:17090404 Clusters of the glucose transporter isoforms were found at a high density in proximity to the cell-to-cell junctions |
| GO:0005769 early endosome | ISO GO_REF:0000121 | KEEP AS NON CORE | Summary: ISO annotation from mammalian orthologs. SGLT1 trafficking through endosomal compartments is plausible for membrane protein recycling. Reason: Likely reflects trafficking/recycling rather than steady-state functional localization. Not a core localization but may be valid for protein turnover. |
| GO:0048471 perinuclear region of cytoplasm | ISO GO_REF:0000121 | KEEP AS NON CORE | Summary: ISO annotation from orthologs. May reflect biosynthetic pathway localization (ER/Golgi) rather than functional localization. Reason: Likely reflects biosynthetic pathway (ER/Golgi in perinuclear region) rather than functional localization. Not a core localization for SGLT1 function. |
| GO:0005412 D-glucose:sodium symporter activity | IBA GO_REF:0000033 | ACCEPT | Summary: Core molecular function of SGLT1 - IBA based on phylogenetic inference. This is the defining activity of the SGLT1 transporter family. Reason: This is THE core molecular function of SGLT1. The transporter catalyzes 2 Na+ : 1 D-glucose cotransport as established across all species. UniProt confirms this catalytic activity with Rhea reaction annotation. Supporting Evidence: PMID:15829715 the renal brush-border membrane Na+/glucose co-transporter-1 (SGLT1) is a molecular target for Cd2+ toxicity |
| GO:0005412 D-glucose:sodium symporter activity | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation from mammalian orthologs. Consistent with direct rat evidence. Reason: Core molecular function, well-supported by direct rat experimental evidence and consistent phylogenetic conservation. |
| GO:0005412 D-glucose:sodium symporter activity | IDA PMID:15829715 The endogenous CXXC motif governs the cadmium sensitivity of... | ACCEPT | Summary: Direct experimental evidence showing rat SGLT1 Na+/glucose cotransport activity. Study used methyl-D-glucopyranoside uptake assays in SGLT1-expressing cells. Reason: High-quality direct experimental evidence demonstrating the core molecular function in rat SGLT1. Supporting Evidence: PMID:15829715 Cd2+ acted as a noncompetitive, partial inhibitor of methyl-D-glucopyranoside uptake in vesicles from COS-7 cells transiently expressing SGLT1 |
| GO:0005412 D-glucose:sodium symporter activity | TAS PMID:11831390 The apical localization of SGLT1 glucose transporter is dete... | ACCEPT | Summary: TAS annotation from paper on SGLT1 apical localization. Paper discusses SGLT1 as glucose transporter but main focus is localization not transport activity. Reason: The paper refers to SGLT1's known function as Na+-dependent glucose cotransporter. While the experimental focus is localization, the stated function is accurate. Supporting Evidence: PMID:11831390 SGLT1, an isoform of Na+-dependent glucose cotransporters, is localized at the apical plasma membrane |
| GO:0015371 galactose:sodium symporter activity | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation for galactose transport. SGLT1 transports both D-glucose and D-galactose with similar affinity - this is well-established in the literature. Reason: Core molecular function. SGLT1 transports D-galactose as well as D-glucose, both with high affinity. UniProt catalytic activity annotation confirms this. PMID:16204409 used galactose uptake to measure SGLT1 activity. Supporting Evidence: PMID:16204409 The phlorizin-sensitive uptake of d-[(3)H]galactose in BBM vesicles |
| GO:0015371 galactose:sodium symporter activity | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation based on sequence similarity. Consistent with ISO annotation and UniProt functional annotation. Reason: Core molecular function. Galactose transport by SGLT1 is well-established and conserved across species. |
| GO:0005372 water transmembrane transporter activity | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for water transport. SGLT1 functions as a water channel with high water conductivity comparable to aquaporins, enabling passive water transport. Reason: Core molecular function. UniProt describes SGLT1 as having high water conductivity comparable to aquaporins, enabling passive water transport in response to osmotic gradients created during sugar/Na+ uptake. |
| GO:0005372 water transmembrane transporter activity | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation from orthologs for water transport activity. Reason: Core molecular function. Water transport by SGLT1 is well-documented and important for transepithelial water permeability in intestine. |
| GO:0055056 D-glucose transmembrane transporter activity | ISO GO_REF:0000121 | KEEP AS NON CORE | Summary: ISO annotation for general glucose transporter activity. This is less specific than D-glucose:sodium symporter activity which captures the coupling mechanism. Reason: While correct, this is less informative than D-glucose:sodium symporter activity (GO:0005412) which specifies the sodium-coupling mechanism that defines SGLT1. |
| GO:0015151 alpha-glucoside transmembrane transporter activity | ISO GO_REF:0000121 | MARK AS OVER ANNOTATED | Summary: ISO annotation for alpha-glucoside transport. SGLT1 transports glucose (an alpha-glucoside in its cyclic form), but this term is typically used for disaccharide transport (e.g., maltose, sucrose). May be an over-annotation. Reason: SGLT1 transports monosaccharides (glucose, galactose), not alpha-glucosides like maltose or sucrose. The more accurate term is D-glucose:sodium symporter activity. This term implies transport of glycosides/disaccharides which is not the primary function. Propagation Review Root cause: TERM SCOPING PROBLEM Sources checked: UniProtKB:P13866 · human SLC5A1 SUPPORTS SOURCE BUT NOT TARGET Human SGLT1 donor annotation likely reflects transport of the non-physiological model substrate alpha-methyl-D-glucoside; physiological substrates are D-glucose/D-galactose, so the alpha-glucoside term misstates substrate specificity. |
| GO:0015293 symporter activity | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: IEA annotation from UniProtKB keyword mapping. Very general term. Reason: Too general. The specific term D-glucose:sodium symporter activity (GO:0005412) is much more informative and captures the actual substrate specificity. |
| GO:0022857 transmembrane transporter activity | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Very general IEA annotation from InterPro mapping. Reason: Far too general to be informative. Specific molecular function annotations (D-glucose:sodium symporter activity) provide the relevant information. |
| GO:0008324 monoatomic cation transmembrane transporter activity | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: IEA from ARBA machine learning. SGLT1 uses Na+ gradient to drive glucose transport but is not primarily a cation transporter - it is a sugar transporter. Reason: Misleading annotation. While SGLT1 translocates Na+ ions, it is primarily a sugar transporter that uses the Na+ gradient as driving force. The sodium transport is coupled to/incidental to the primary glucose transport function. |
| GO:0001951 intestinal D-glucose absorption | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for intestinal glucose absorption - THE core biological process for SGLT1 in the gut. Reason: Core biological process. SGLT1 is the primary transporter for dietary glucose absorption across enterocyte brush border membrane. Supporting Evidence: PMID:17272350 We have proposed a model of intestinal glucose absorption in which transport by SGLT1 induces rapid insertion and activation of GLUT2 |
| GO:0001951 intestinal D-glucose absorption | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation from orthologs. Consistent with direct rat evidence. Reason: Core biological process, well-supported by rat experimental evidence. |
| GO:0001951 intestinal D-glucose absorption | TAS PMID:15829715 The endogenous CXXC motif governs the cadmium sensitivity of... | ACCEPT | Summary: TAS annotation. The paper's main focus is cadmium inhibition of SGLT1, but mentions intestinal glucose absorption as established SGLT1 function. Reason: Core biological process. While paper focuses on cadmium effects, it references SGLT1's role in intestinal glucose absorption. Supporting Evidence: PMID:15829715 2005 Apr 13. The endogenous CXXC motif governs the cadmium sensitivity of the renal Na+/glucose co-transporter. |
| GO:0035623 renal D-glucose absorption | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation for renal glucose reabsorption. SGLT1 handles glucose reabsorption in S3 segment of proximal tubule (minor fraction, ~3% of total). Reason: Core biological process. PMID:16204409 directly demonstrates SGLT1 in rat kidney S3 proximal tubule segments with functional glucose transport activity. Supporting Evidence: PMID:16204409 SGLT1 (SLC5A1) mediates a part of glucose and galactose reabsorption in the mammalian proximal tubule PMID:16204409 the expression of SGLT1 is represented by a 75-kDa protein localized largely in the PT S3 segments |
| GO:0035623 renal D-glucose absorption | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation from sequence similarity. Consistent with direct rat evidence. Reason: Core biological process, well-supported by direct rat experimental evidence. |
| GO:0035623 renal D-glucose absorption | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation from orthologs. Consistent with IBA and direct rat evidence. Reason: Core biological process with strong experimental support in rat. |
| GO:0098708 D-glucose import across plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation for glucose import. Accurate description of SGLT1's transport direction (import into cell). Reason: Core biological process. SGLT1 imports glucose from lumen into epithelial cells. This is a fundamental aspect of its transport function. |
| GO:0098708 D-glucose import across plasma membrane | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation from orthologs. Consistent with IBA annotation. Reason: Core biological process describing the import direction of SGLT1-mediated glucose transport. |
| GO:1904659 D-glucose transmembrane transport | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation for glucose transmembrane transport. Reason: Core biological process. This is the primary transport function of SGLT1. |
| GO:1904659 D-glucose transmembrane transport | TAS PMID:11831390 The apical localization of SGLT1 glucose transporter is dete... | ACCEPT | Summary: TAS annotation. Paper focuses on localization but references SGLT1's glucose transport function. Reason: Core biological process. While paper's experimental focus is localization, SGLT1's glucose transport function is accurately referenced. Supporting Evidence: PMID:11831390 SGLT1 glucose transporter...plays a pivotal role in the absorption and reabsorption of sugars |
| GO:0015757 galactose transmembrane transport | IEA GO_REF:0000108 | ACCEPT | Summary: IEA annotation based on logical inference. SGLT1 transports galactose with similar affinity to glucose - this is experimentally demonstrated in rat. Reason: Core biological process. Galactose transport by SGLT1 is well-established. PMID:16204409 used galactose uptake assays to measure rat SGLT1 activity. Supporting Evidence: PMID:16204409 SGLT1 (SLC5A1) mediates a part of glucose and galactose reabsorption in the mammalian proximal tubule |
| GO:0050892 intestinal absorption | TAS PMID:16204409 Rat renal glucose transporter SGLT1 exhibits zonal distribut... | ACCEPT | Summary: TAS annotation. The paper primarily focuses on kidney, though it mentions intestinal absorption as SGLT1 function. Reason: Core biological process. SGLT1's role in intestinal absorption is well-established. Supporting Evidence: PMID:16204409 SGLT1 (SLC5A1) mediates a part of glucose and galactose reabsorption in the mammalian proximal tubule |
| GO:0050892 intestinal absorption | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation from orthologs. Consistent with known SGLT1 function. Reason: Core biological process for SGLT1 in the gut. |
| GO:0035377 transepithelial water transport | ISO GO_REF:0000121 | ACCEPT | Summary: ISO annotation for water transport function. SGLT1 acts as a water channel with high conductivity comparable to aquaporins. Reason: Core biological process. SGLT1's water transport activity is important for intestinal water absorption coupled to glucose/Na+ uptake. |
| GO:0098719 sodium ion import across plasma membrane | ISO GO_REF:0000121 | KEEP AS NON CORE | Summary: ISO annotation for sodium import. SGLT1 couples 2 Na+ import per glucose. Reason: While technically accurate (SGLT1 imports 2 Na+ per glucose), sodium transport is secondary to the primary function of glucose transport. The Na+ gradient drives glucose uptake rather than being the primary transported substrate. |
| GO:0006814 sodium ion transport | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: IEA annotation from UniProtKB keyword mapping. Reason: While Na+ is cotransported with glucose, this annotation may give the misleading impression that SGLT1 is primarily a sodium transporter. The primary function is glucose transport using the Na+ gradient. |
| GO:0006811 monoatomic ion transport | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Very general IEA annotation for ion transport. Reason: Too general and misleading. SGLT1 is a sugar transporter that cotransports sodium, not primarily an ion transporter. |
| GO:0055085 transmembrane transport | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Very general IEA annotation from InterPro mapping. Reason: Far too general to be informative. Specific process annotations provide the relevant information about SGLT1 function. |
| GO:0150104 transport across blood-brain barrier | ISO GO_REF:0000121 | KEEP AS NON CORE | Summary: ISO annotation for BBB transport. Rat experimental evidence shows SGLT1 in brain capillary endothelium with upregulation after ischemia. Reason: Valid annotation supported by rat experimental evidence (PMID:14986005). Not a core function (intestine/kidney are primary sites) but represents an established secondary physiological role. Supporting Evidence: PMID:14986005 The data suggest that SGLT1 participates in transport of D-glucose across the blood-brain barrier |
| GO:1902476 chloride transmembrane transport | ISO NOT GO_REF:0000121 | UNDECIDED | Summary: ISO annotation for chloride transport. This is unexpected - SGLT1 is not known as a chloride transporter. May be an erroneous annotation. Reason: SGLT1 is a Na+/glucose symporter, not a chloride transporter. The basis for this annotation is unclear. Would need to trace the original evidence from the ortholog to evaluate. Marking as undecided pending clarification. Propagation Review Root cause: UNRESOLVED Sources checked: UniProtKB:P13866 · human SLC5A1 UNRESOLVED Human SGLT1 donor; the basis for a chloride-transport claim could not be recovered from cached materials, so the transfer cannot be evaluated. |
| GO:0000017 alpha-glucoside transport | ISO GO_REF:0000121 | MARK AS OVER ANNOTATED | Summary: ISO annotation for alpha-glucoside transport. SGLT1 transports monosaccharides, not glucosides (which typically refers to disaccharides). Reason: SGLT1 transports D-glucose and D-galactose (monosaccharides), not alpha-glucosides like maltose or sucrose. This term is misleading for SGLT1's actual substrate specificity. Propagation Review Root cause: TERM SCOPING PROBLEM Sources checked: UniProtKB:P13866 · human SLC5A1 SUPPORTS SOURCE BUT NOT TARGET Human SGLT1 donor annotation likely derives from alpha-methyl-D-glucoside model-substrate assays; SGLT1's physiological substrates are the monosaccharides D-glucose and D-galactose, so the alpha-glucoside term is misleading for the rat gene. |
| GO:0009758 carbohydrate utilization | IDA PMID:25592016 Induction of histone H3K4 methylation at the promoter, enhan... | MODIFY | Summary: IDA annotation from study on dietary regulation of Sglt1 gene expression. The paper shows epigenetic regulation (H3K4 methylation) of Sglt1 in response to high-starch diet, not direct SGLT1 involvement in carbohydrate utilization. Reason: The paper demonstrates transcriptional regulation of Sglt1 by diet, not a direct role for SGLT1 protein in carbohydrate utilization. The appropriate process would be related to glucose absorption/transport, not utilization. Proposed replacements: intestinal D-glucose absorption Supporting Evidence: PMID:25592016 Feeding rats the high-starch/low-fat diet induced mono-, di-, and trimethylation of histone H3K4 on the promoter and transcribed regions of the Si and Sglt1 genes |
| GO:0001656 metanephros development | ISO GO_REF:0000121 | UNDECIDED | Summary: ISO annotation for kidney development. SGLT1 is a glucose transporter that is expressed during kidney development but is not known to have a developmental signaling role. Reason: The basis for this developmental annotation is unclear. SGLT1 may be expressed during kidney development but is primarily a glucose transporter, not a developmental regulator. Would need to evaluate the original ortholog evidence. Propagation Review Root cause: UNRESOLVED Sources checked: MGI:MGI:107678 · mouse Slc5a1 UNRESOLVED Mouse donor; the underlying developmental evidence could not be evaluated from cached materials, and expression during metanephros development would not by itself make Sglt1 a developmental effector. |
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