Ugt2a1

Summary: glucuronosyltransferase activity is retained for Ugt2a1 because it matches the documented core enzymatic role or its direct pathway consequence (IBA, GO_REF:0000033).

Reason: glucuronosyltransferase activity is directly supported by the curated function of Ugt2a1 and is not merely a downstream phenotype or expression response.

Summary: UDP-glycosyltransferase activity captures part of Ugt2a1 biology, but more specific replacement term(s) better represent the supported function (IEA, GO_REF:0000002).

Reason: UDP-glycosyltransferase activity is too broad or imprecise for Ugt2a1; replace with the more specific supported term(s): GO:0015020 glucuronosyltransferase activity.

Proposed replacements: glucuronosyltransferase activity

Summary: glucuronosyltransferase activity is retained for Ugt2a1 because it matches the documented core enzymatic role or its direct pathway consequence (IEA, GO_REF:0000120).

Reason: glucuronosyltransferase activity is directly supported by the curated function of Ugt2a1 and is not merely a downstream phenotype or expression response.

Summary: membrane is too broad; immunogold EM localizes UGT2A1 to the plasma membrane of olfactory cilia, supporting the more specific ciliary membrane term (IEA, GO_REF:0000044).

Reason: membrane is overly generic. Immunogold electron microscopy localizes UGT2A1 to the plasma membrane of olfactory cilia (a cell-projection/plasma membrane location proximal to odorant receptors), so the annotation should be upgraded to the more specific CC term GO:0060170 ciliary membrane.

Proposed replacements: ciliary membrane

Summary: xenobiotic metabolic process is retained for Ugt2a1 because it matches the documented core enzymatic role or its direct pathway consequence (ISO, GO_REF:0000121).

Reason: xenobiotic metabolic process is directly supported by the curated function of Ugt2a1 and is not merely a downstream phenotype or expression response.

Summary: response to symbiont should not be retained for Ugt2a1 based on the combined gene function and cited/source evidence (ISO, GO_REF:0000121).

Reason: The available evidence supports Ugt2a1's curated activity rather than response to symbiont; this annotation is unsupported, assigned to the wrong biological context, or too misleading to keep as non-core.

Summary: glucuronosyltransferase activity is retained for Ugt2a1 because it matches the documented core enzymatic role or its direct pathway consequence (ISS, GO_REF:0000024).

Reason: glucuronosyltransferase activity is directly supported by the curated function of Ugt2a1 and is not merely a downstream phenotype or expression response.

Summary: glucuronosyltransferase activity is retained for Ugt2a1 because it matches the documented core enzymatic role or its direct pathway consequence (ISO, GO_REF:0000121).

Reason: glucuronosyltransferase activity is directly supported by the curated function of Ugt2a1 and is not merely a downstream phenotype or expression response.

Summary: membrane is too broad; immunogold EM localizes UGT2A1 to the plasma membrane of olfactory cilia, supporting the more specific ciliary membrane term (ISS, GO_REF:0000024).

Reason: membrane is overly generic. Immunogold electron microscopy localizes UGT2A1 to the plasma membrane of olfactory cilia (a cell-projection/plasma membrane location proximal to odorant receptors), so the annotation should be upgraded to the more specific CC term GO:0060170 ciliary membrane.

Proposed replacements: ciliary membrane

Summary: sensory perception of chemical stimulus is kept as a non-core process for Ugt2a1. Its enzymatic activity modulates odorant availability in the perireceptor space rather than executing the neurological transduction cascade itself (ISO, GO_REF:0000121).

Reason: GO:0007606 is defined as a neurological process in which an organism receives a chemical stimulus, converts it to a molecular signal, and recognizes/characterizes it. This transduction cascade is executed by olfactory receptor neurons, not by a metabolic enzyme. UGT2A1 glucuronidates odorants and thereby modulates odorant concentration in the perireceptor space (ex vivo electroolfactogram shows topical beta-glucuronidase selectively increases the eugenol response), so it is a modulator of odorant availability rather than a component of the sensory transduction cascade. The annotation is retained as a non-core contextual involvement rather than ACCEPTed as a core function. There is no GO odorant metabolic process term to MODIFY to (the previously suggested GO:0042545 is cell wall modification, a plant term, and GO:0052697 xenobiotic glucuronidation is obsolete); the core metabolic role is captured by the xenobiotic metabolic process and glucuronosyltransferase activity annotations.

Summary: bile acid metabolic process is retained as contextual support for Ugt2a1, but it is not the core function (ISO, GO_REF:0000121).

Reason: bile acid metabolic process records a physiological/substrate context rather than the defining molecular activity of Ugt2a1. This is an ISO annotation transferred from human UGT2A1 (P0DTE4); the supporting Falcon evidence (bile-acid glucuronidation activity) is from human studies, consistent with the ISO basis, and supports retention as a non-core detoxification process distinct from the primary olfactory role.

Summary: response to toxic substance is an over-annotation for Ugt2a1; PMID:1900353 supports odorant glucuronidation and olfactory signal termination rather than a toxicological response process.

Reason: The cited paper establishes glucuronosyltransferase activity toward odorants. That supports the MF annotation and olfactory chemical-stimulus context, but not a broad response to toxic substance biological process. Falcon deep research frames nasal UGTs (including UGT2A1) as a protective metabolic barrier; this is a constitutive detoxification/clearance role rather than an inducible response-to-toxin process, reinforcing that GO:0009636 is an over-annotation.

Summary: glucuronosyltransferase activity is retained for Ugt2a1 because it matches the documented core enzymatic role or its direct pathway consequence (TAS, PMID:1900353).

Reason: glucuronosyltransferase activity is directly supported by the curated function of Ugt2a1 and is not merely a downstream phenotype or expression response.