| Interaction Partner | Complex/Context | Domain Involved in IFT57 | Evidence Type | Functional Significance | Reference |
|---|---|---|---|---|---|
| IFT172 | IFT-B2 subcomplex | CH domain | Crystal structure / pulldown | Stabilizes and positions IFT172 within IFT-B2 architecture (pqac-00000004, pqac-00000005, pqac-00000006) | Taschner 2016 |
| IFT38 | IFT-B2 subcomplex | Coiled-coil domain | Copurification | Forms a stable IFT57–IFT38 heterodimer that supports IFT-B2 assembly (pqac-00000004, pqac-00000005, pqac-00000006) | Taschner 2016 |
| IFT88/IFT52N | IFT-B1/B2 bridge | IFT57/38 complex | GST pulldown | Bridges IFT-B2 to the IFT-B1 core to form the IFT-B holocomplex (pqac-00000007, pqac-00000008, pqac-00000018, pqac-00000021) | Taschner 2016 |
| IFT20 | IFT-B2 subcomplex | Not specified | GST pulldown | Supports shared IFT-B subcomplex organization and likely contributes to kinesin-2 coupling through the IFT20–IFT57 module (pqac-00000025, pqac-00000026) | Follit 2006 |
| KIF3B (kinesin-2) | Motor-IFT interaction | Not specified | Co-IP / Y2H | Implicates IFT57 in anterograde motor coupling of IFT particles (pqac-00000025) | Bhogaraju 2013 |
| Dynein-2 (WDR34) | Motor-IFT interaction | Not specified | Interaction screen | Supports retrograde motor coupling and effective bidirectional IFT coordination (pqac-00000017) | Hiyamizu 2023 |
| IFT80 | IFT-B2 subcomplex | Via IFT172 association | Copurification | Contributes to higher-order IFT-B2 architecture together with the IFT57–IFT172 module (pqac-00000004, pqac-00000005) | Taschner 2016 |
| SANS/USH1G | Ciliary USH network | N-terminal region | Y2H / co-localization | Links the Usher syndrome protein network to IFT-B proteins including IFT57 (pqac-00000000) | Sorusch 2019 |


*Table: This table summarizes experimentally supported protein-protein interactions involving C. elegans CHE-13/IFT57 and conserved orthologous IFT57 complexes. It is useful for linking domain-level interactions to IFT-B assembly, motor coupling, and ciliary disease-related networks.*