id: Q09499
gene_symbol: ire-1
taxon:
  id: NCBITaxon:6239
  label: Caenorhabditis elegans
status: DRAFT
description: 'BioReason-Pro RL web export for ire-1 (worm). GO-GPT produced 29 non-root terms; 11 non-generic IS_A leaf terms
  retained (MF:2 BP:3 CC:6). Deterministic exact comparison against current AIGR: CNN:4 NPI:0 UNC:7. Remaining UNC entries
  require manual assessment. [ONTOLOGY_LABEL_AUDIT] The raw export contained 3 ID/label pairs that differ from current GO
  labels; structured leaf labels were normalized and the raw source was retained.'
references:
- id: doi:10.64898/2026.03.19.712954
  title: 'BioReason-Pro: Advancing Protein Function Prediction with Multimodal Biological Reasoning'
source_documents:
- genes/worm/ire-1/ire-1-bioreason-rl-predictions.md
predictions:
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0016788
    label: hydrolase activity, acting on ester bonds
  predicted_term_type: GO_MF
  review:
    assessment: UNC
    confidence_score: 1
    summary: No deterministic exact-action match resolves this prediction in the current AIGR review. Requires manual assessment.
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0004521
    label: RNA endonuclease activity
  predicted_term_type: GO_MF
  review:
    assessment: CNN
    confidence_score: 2
    summary: 'Deterministic exact-match comparison: current AIGR action(s) ACCEPT retain this GO term, so it is correct but
      not novel.'
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0042221
    label: response to chemical
  predicted_term_type: GO_BP
  review:
    assessment: UNC
    confidence_score: 1
    summary: No deterministic exact-action match resolves this prediction in the current AIGR review. Requires manual assessment.
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0010033
    label: obsolete response to organic substance
  predicted_term_type: GO_BP
  review:
    assessment: UNC
    confidence_score: 1
    summary: No deterministic exact-action match resolves this prediction in the current AIGR review. Requires manual assessment.
      [ONTOLOGY_LABEL_AUDIT] Raw BioReason label 'response to organic substance' did not match the current GO label 'obsolete
      response to organic substance'; the structured label was normalized from GO and the raw source was retained.
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0035966
    label: response to topologically incorrect protein
  predicted_term_type: GO_BP
  review:
    assessment: CNN
    confidence_score: 2
    summary: 'Deterministic exact-match comparison: current AIGR action(s) KEEP_AS_NON_CORE retain this GO term, so it is
      correct but not novel.'
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0005737
    label: cytoplasm
  predicted_term_type: GO_CC
  review:
    assessment: UNC
    confidence_score: 1
    summary: No deterministic exact-action match resolves this prediction in the current AIGR review. Requires manual assessment.
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0012505
    label: endomembrane system
  predicted_term_type: GO_CC
  review:
    assessment: UNC
    confidence_score: 1
    summary: No deterministic exact-action match resolves this prediction in the current AIGR review. Requires manual assessment.
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0042175
    label: nuclear outer membrane-endoplasmic reticulum membrane network
  predicted_term_type: GO_CC
  review:
    assessment: UNC
    confidence_score: 1
    summary: No deterministic exact-action match resolves this prediction in the current AIGR review. Requires manual assessment.
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0005783
    label: endoplasmic reticulum
  predicted_term_type: GO_CC
  review:
    assessment: CNN
    confidence_score: 2
    summary: 'Deterministic exact-match comparison: current AIGR action(s) ACCEPT retain this GO term, so it is correct but
      not novel.'
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0098827
    label: endoplasmic reticulum subcompartment
  predicted_term_type: GO_CC
  review:
    assessment: UNC
    confidence_score: 1
    summary: No deterministic exact-action match resolves this prediction in the current AIGR review. Requires manual assessment.
- source_method: GO-GPT
  source_version: bioreason.net/2026-03/rl
  source_reference_id: doi:10.64898/2026.03.19.712954
  predicted_term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  predicted_term_type: GO_CC
  review:
    assessment: CNN
    confidence_score: 2
    summary: 'Deterministic exact-match comparison: current AIGR action(s) ACCEPT retain this GO term, so it is correct but
      not novel.'