| Source (short citation) | Publication date/year | URL/DOI | What it says about lrx-1 | What it says about related LDL receptor-like genes (LRP-1/Irp-1, RME-2, F14B4.1, T13C2.6) | Evidence type | Notes/limitations |
|---|---|---|---|---|---|---|
| UniProt/WormBase-derived identity in prompt; supported by Shi dissertation summary | Accessed/compiled in 2023 | WormBase URL mentioned in text: https://www.wormbase.org | Identifies **lrx-1 = egf-5 = LRP X(cross)-hybridizing** in *C. elegans* and states it is **predicted** to encode a protein with **LDL receptor domains**; no direct functional assay provided (pqac-00000018) | Uses **lrp-1** as the better-characterized LDL receptor-related comparator in AD-related gene summary (pqac-00000018) | Curated database-derived / secondary summary | Directly relevant to identity verification, but still prediction-level for function; not a primary lrx-1 experiment |
| Shi dissertation (AD-related gene table) | 2023 | Dissertation text cites WormBase; published related paper DOI in dissertation front matter: https://doi.org/10.3390/molecules28041826 | States that reduced LDL receptors increase Aβ deposition in brain and that **Ce lrx-1 is predicted to encode a protein with LDL receptor domains**; treats lrx-1 as an LDL-related candidate, not experimentally validated in worm here (pqac-00000018) | States **Ce lrp-1** resembles **LRP2**, affecting sterol transporter activity, locomotion regulation, larval development, and that decreased expression affects neurotransmission (pqac-00000018) | Thesis/secondary synthesis | Valuable recent mention (2023), but lrx-1 claim is explicitly predictive and sourced from WormBase rather than primary lrx-1 experiments |
| Landaverde thesis (LDL receptor-like genes overview) | 2004 | Not provided in extracted text | No mention of **lrx-1/T04H1.6** in the extracted LDL receptor-like overview (pqac-00000015) | Describes four worm proteins with LDL receptor-like domain architectures: **LRP-1, RME-2, F14B4.1, T13C2.6**; explains LDL-A, Ca2+-binding EGF-like, and YWTD-repeat domains; notes **LRP-1** and **RME-2** have established developmental roles, whereas **F14B4.1** and **T13C2.6** lacked definite function at that time (pqac-00000015) | Thesis/secondary with literature synthesis | Important for domain-based inference, but it does **not** provide direct evidence for lrx-1 |
| Landaverde thesis (LRP-1 / rme-2 functional summary) | 2004 | Not provided in extracted text | No lrx-1-specific information in the extracted section (pqac-00000015) | **lrp-1/Irp-1**: essential for growth/development; null mutants are dumpy, short, slow-growing, fail to shed cuticle; expressed in hypodermis; cholesterol depletion phenocopies mutant, suggesting receptor-mediated cholesterol uptake. **rme-2**: yolk receptor; mutants fail yolk uptake into oocytes and have brood size ~5% of wild type; implicated in cholesterol uptake into oocytes with vitellogenin (pqac-00000015) | Secondary summary of primary experimental literature | Strongest functional context for related genes, but still indirect for lrx-1 |
| Landaverde thesis (RNAi results headings and summaries) | 2004 | Not provided in extracted text | Extracted summaries do **not** identify lrx-1 as an RNAi target; presence of lrx-1 among tested genes cannot be confirmed (pqac-00000011, pqac-00000014) | RNAi targets explicitly or inferentially include **Irp-1/lrp-1, rme-2, F14B4.1, T13C2.6**, plus lipid-handling genes **dsc-4** and **vit-5**. Reported phenotypes include altered egg-laying timing in **clk-1** backgrounds, severe molting/growth defects and early lethality with **Irp-1(RNAi)**, strong fertility defects with **rme-2(RNAi)**, and wild-type-equivalent egg-laying timing restoration by **F14B4.1(RNAi)** in **clk-1;dsc-4** worms (pqac-00000011, pqac-00000012, pqac-00000013, pqac-00000014) | Thesis with experimental RNAi data | Relevant because it shows which LDL receptor-like genes were functionally perturbed; however, lrx-1 is absent from the extracted RNAi evidence |
| Fan et al., Glycobiology | 2005 Oct | https://doi.org/10.1093/glycob/cwi075 | No lrx-1-specific mention in extracted pages (pqac-00000003, pqac-00000004) | Large-scale glycoproteomics identified **117 distinct N-glycosylated proteins** and **199 N-glycosylation sites** in *C. elegans*; establishes that many membrane/extracellular proteins are glycosylated, consistent with receptor biology, but does not directly annotate lrx-1 or the named LDL receptor-like set in the extracted text (pqac-00000003, pqac-00000004) | Experimental proteomics | Useful general support for extracellular/membrane glycoprotein context, but not direct evidence for lrx-1 |
| Yochem & Greenwald PNAS paper (not retrievable here; cited as unobtainable in search results) | 1993 May | https://doi.org/10.1073/pnas.90.10.4572 | Search results indicate existence of a paper on a **low density lipoprotein receptor-related protein** in *C. elegans*, but no extracted text tying it to lrx-1/Q22179 was available (from search commentary reflected in context set) | Likely foundational for worm LDL receptor-related proteins, but the available context does not provide extractable claims beyond existence (pqac-00000015) | Primary literature (unobtainable in session) | Should not be overinterpreted for lrx-1 because the paper text was not available and may concern a different LDLR-family member |
| Overall evidence from retrieved context | 1993-2023 | Mixed; see URLs above | **lrx-1 is verified as the intended *C. elegans* gene symbol/alias set (lrx-1/egf-5; T04H1.6; Q22179), but literature is limited and mainly predictive**; current contextual evidence supports an **LDL receptor domain-containing extracellular/membrane-associated protein** rather than a directly demonstrated molecular function (pqac-00000018) | By contrast, related genes **lrp-1/Irp-1** and **rme-2** have direct functional evidence in molting/development and yolk/oocyte uptake, while **F14B4.1** and **T13C2.6** appear in RNAi/domain studies with more limited annotation (pqac-00000012, pqac-00000013, pqac-00000015) | Integrative summary | Best current conclusion is that lrx-1 functional annotation must rely heavily on domain/family inference because direct primary evidence was not located in the provided context |


*Table: This table summarizes the strongest evidence available in the provided context for *C. elegans* lrx-1/Q22179 and distinguishes direct lrx-1 information from better-supported data on related LDL receptor-like genes. It is useful for showing that lrx-1 is correctly identified but remains sparsely characterized experimentally.*