| Property | Details |
|---|---|
| Gene name/synonyms | **odr-1**; synonym **gcy-10**; protein described as receptor-type guanylate cyclase / Odorant response abnormal protein 1 in *Caenorhabditis elegans* (pqac-00000015) |
| UniProt accession | **B1Q257** (user-supplied target identity) |
| Protein type | Single-pass **receptor-type guanylyl cyclase (rGC)** in the adenylyl cyclase class-4/guanylyl cyclase family; function is mediated primarily by its intracellular cyclase domain rather than the extracellular domain in olfactory signaling (pqac-00000003, pqac-00000009) |
| Enzymatic reaction | Catalyzes **GTP → cGMP**; like other rGCs, catalytic activity requires dimerization of cyclase domains to form the active site for cGMP synthesis (pqac-00000008, pqac-00000027) |
| Dimerization partner | Strong evidence supports functional partnership with **DAF-11**; ODR-1 and DAF-11 likely form an **obligate heterodimer** because each individually lacks key catalytic residues, but together can form an active catalytic site (pqac-00000002, pqac-00000003, pqac-00000009) |
| Neurons expressing ODR-1 | Reported in **AWC, AWB, ASI, ASJ, and ASK** sensory neurons; canonical olfactory roles are best established in AWC and AWB, with ASK/ASI/ASJ implicated in broader cGMP signaling and circuit modulation (pqac-00000015, pqac-00000023, pqac-00000025) |
| Subcellular localization | Functions at **sensory cilia/ciliated sensory endings** as a transmembrane rGC; recent work also links ODR-1 to regulation of **AWC cilia and dendrite** state, and odr-1 mutants show distorted AWC cilia morphology (pqac-00000014, pqac-00000020, pqac-00000032) |
| Key pathway components (upstream and downstream) | **Upstream:** odor-responsive GPCR signaling and the Gα subunit **ODR-3**; ODR-1 is thought to be regulated mainly via intracellular/G-protein-linked mechanisms rather than classical extracellular ligand binding in AWC. **Core transduction:** **ODR-1/DAF-11 → cGMP → TAX-2/TAX-4 CNG channels → Ca2+ influx/voltage-gated Ca2+ channels**. **Adaptation/plasticity:** **EGL-4/PKG**, HPL-2, phosphodiesterases, and calcium-dependent feedback regulators. In another circuit context, ODR-1-generated cGMP can travel via gap junctions to **ASH** to modulate nociception (pqac-00000003, pqac-00000027, pqac-00000029, pqac-00000031, pqac-00000024) |
| Primary biological functions | Required for **AWC- and AWB-mediated olfactory behaviors**, especially chemotaxis to attractive volatile odorants and aspects of repellent sensing; contributes to **olfactory adaptation/plasticity** through cGMP-EGL-4 signaling; also has **non-cell-autonomous modulatory roles** in sensory circuits by supplying cGMP that dampens ASH aversive signaling (pqac-00000002, pqac-00000020, pqac-00000024, pqac-00000029) |
| Known phenotypes of odr-1 mutants | Mutants are defective in **AWC/AWB olfactory responses** and chemotaxis to AWC-sensed odors; can show altered olfactory adaptation/plasticity, hypersensitivity in **ASH-mediated aversive responses** when ODR-1-derived cGMP modulation is lost, and **distorted AWC cilia morphology** in recent studies; dauer formation is reported as largely normal compared with daf-11 mutants (pqac-00000015, pqac-00000023, pqac-00000024, pqac-00000032) |


*Table: This table summarizes the main molecular, cellular, and functional properties of the C. elegans ODR-1/GCY-10 receptor guanylyl cyclase. It is useful as a compact reference for its enzymatic activity, expression pattern, pathway position, and mutant phenotypes.*