pkd-2

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0016020 membrane	IBA GO_REF:0000033	ACCEPT	Summary: PKD-2 is a multi-pass transmembrane protein with 6 transmembrane helices and a pore-forming region (PMID:11553327). Membrane localization is well-established across all PKD2 family members phylogenetically. Reason: PKD-2 is a classic ion channel with multiple transmembrane domains. This IBA annotation is appropriate and supported by extensive experimental evidence including GFP fusion studies showing membrane localization (PMID:11553327). Supporting Evidence: PMID:11553327 Cytoplasmic, nonnuclear staining in cell bodies is punctate, suggesting that one pool of PKD-2 is localized to intracellular membranes while another is found in sensory cilia. file:worm/pkd-2/pkd-2-deep-research-falcon.md model: Edison Scientific Literature
GO:0005262 calcium channel activity	IBA GO_REF:0000033	ACCEPT	Summary: PKD-2 functions as a calcium-permeable cation channel, directly demonstrated by electrophysiological studies in C. elegans (PMID:15862350). This is a core molecular function conserved across the TRPP family. Reason: This is a core molecular function of PKD-2. The IBA annotation is well-supported by direct experimental evidence showing PKD-2 acts as an intracellular Ca2+ release channel that accelerates Ca2+ release from intracellular stores (PMID:15862350). Supporting Evidence: PMID:15862350 we found that polycystin-2 is an intracellular Ca(2+) release channel that is required for the normal pattern of Ca(2+) responses involving IP(3) and ryanodine receptor-mediated Ca(2+) release from intracellular stores.
GO:0050982 detection of mechanical stimulus	IBA GO_REF:0000033	ACCEPT	Summary: PKD-2 functions with LOV-1 as a mechanosensitive receptor-channel complex in sensory cilia (PMID:16481400, PMID:12411744). The polycystins are proposed to act as sensors of the extracellular environment. Reason: This is a well-supported function for the polycystin complex. The LOV-1/PKD-2 complex functions similarly to mammalian PC1/PC2 as mechanosensors. Their localization to sensory cilia and role in detecting hermaphrodite contact supports mechanosensory function (PMID:12411744, PMID:16481400). Supporting Evidence: PMID:12411744 Based on the role of polycystins in C. elegans sensory neuron function and the conservation of PKD pathways we suggest that polycystins act as sensors of the extracellular environment PMID:16481400 In primary cilia of kidney cells, the transient receptor potential polycystin (TRPP) channels polycystin-1 (PC-1) and polycystin-2 (PC-2) act as a mechanosensitive channel
GO:0005509 calcium ion binding	IEA GO_REF:0000002	ACCEPT	Summary: This annotation is based on InterPro domain prediction. PKD-2 belongs to the polycystin family which contains EF-hand-like calcium binding domains. Reason: Reasonable IEA annotation based on domain composition. The PKD2 domain includes calcium-binding capabilities that are important for channel regulation. This is consistent with PKD-2's role as a calcium channel.
GO:0005789 endoplasmic reticulum membrane	IEA GO_REF:0000044	ACCEPT	Summary: PKD-2 localizes to the ER membrane where it functions as a calcium release channel. This is supported by experimental evidence (PMID:16943275, PMID:15862350). Reason: Appropriate IEA annotation that is validated by experimental data. UniProt annotation and direct studies confirm ER localization (PMID:16943275). PKD-2 accelerates Ca2+ release from intracellular stores in the ER (PMID:15862350). Supporting Evidence: PMID:16943275 PKD-2 is directed to moving dendritic particles by the UNC-101/adaptor protein 1 (AP-1) complex PMID:15862350 Polycystin-2, along with the IP(3) and ryanodine receptors, acts as a major calcium-release channel in the endoplasmic reticulum
GO:0005886 plasma membrane	IEA GO_REF:0000044	ACCEPT	Summary: PKD-2 localizes to the plasma membrane, particularly in the ciliary membrane of sensory neurons (PMID:11553327, PMID:16943275). Reason: IEA annotation supported by extensive experimental evidence showing PKD-2 at the plasma membrane, especially in ciliary membrane compartments (PMID:11553327, PMID:16943275). Supporting Evidence: PMID:11553327 LOV-1::GFP and PKD-2::GFP are expressed in the same male-specific sensory neurons and are concentrated in cilia and cell bodies.
GO:0005929 cilium	IEA GO_REF:0000044	ACCEPT	Summary: PKD-2 localizes to sensory cilia of male-specific neurons. This is one of the best-characterized aspects of PKD-2 biology. Reason: Core localization well-established by multiple IDA annotations (PMID:11553327, PMID:16943275, PMID:27930654). The IEA appropriately captures this localization.
GO:0006811 monoatomic ion transport	IEA GO_REF:0000043	ACCEPT	Summary: PKD-2 is a cation channel that transports calcium ions. This broad term encompasses its more specific calcium transport function. Reason: Accurate but general annotation. PKD-2 does transport monoatomic ions (calcium). More specific terms (calcium ion transport) are also annotated.
GO:0016020 membrane	IEA GO_REF:0000002	ACCEPT	Summary: PKD-2 is an integral membrane protein with multiple transmembrane domains. This is a basic structural annotation. Reason: Duplicate of IBA annotation above. Both appropriately capture membrane localization based on different evidence sources (InterPro and phylogenetic inference).
GO:0030424 axon	IEA GO_REF:0000044	ACCEPT	Summary: PKD-2 is found in axons of male-specific sensory neurons, as shown by GFP localization studies (PMID:11553327, PMID:15563610). Reason: IEA annotation validated by multiple IDA studies showing axonal localization in male sensory neurons.
GO:0030425 dendrite	IEA GO_REF:0000044	ACCEPT	Summary: PKD-2 localizes to dendrites of male-specific sensory neurons (PMID:11553327, PMID:18037411). Reason: IEA annotation validated by experimental evidence. The dendritic localization is important for PKD-2 trafficking to cilia.
GO:0034220 monoatomic ion transmembrane transport	IEA GO_REF:0000043	ACCEPT	Summary: PKD-2 mediates transmembrane transport of calcium ions as a TRP channel. Reason: Appropriate IEA annotation based on ion channel keyword. Consistent with PKD-2's established function as a calcium channel (PMID:15862350).
GO:0043204 perikaryon	IEA GO_REF:0000044	ACCEPT	Summary: PKD-2 localizes to neuronal cell bodies (perikarya) in addition to cilia and dendrites (PMID:11553327, PMID:18037411). Reason: IEA annotation consistent with experimental data showing cell body localization.
GO:0060170 ciliary membrane	IEA GO_REF:0000044	ACCEPT	Summary: PKD-2 is concentrated in the ciliary membrane of male sensory neurons where it functions in sensory signaling (PMID:16943275). Reason: Key localization for PKD-2 function. Well-supported by experimental evidence showing specific targeting to ciliary membranes (PMID:16943275). Supporting Evidence: PMID:16943275 Ciliary localization of the transient receptor potential polycystin 2 channel (TRPP2/PKD-2) is evolutionarily conserved
GO:0070588 calcium ion transmembrane transport	IEA GO_REF:0000108	ACCEPT	Summary: Logical inference from calcium channel activity. PKD-2 mediates calcium ion transmembrane transport. Reason: Appropriate inference from calcium channel activity (GO:0005262). Directly supported by experimental evidence (PMID:15862350).
GO:0071683 sensory dendrite	NAS PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2 localizes to sensory dendrites of male-specific neurons in C. elegans. Reason: Appropriate localization annotation. The 2001 paper demonstrates PKD-2::GFP localization in male sensory neurons including their dendritic processes (PMID:11553327). Supporting Evidence: PMID:11553327 LOV-1::GFP and PKD-2::GFP are expressed in the same male-specific sensory neurons and are concentrated in cilia and cell bodies.
GO:1902435 regulation of male mating behavior	NAS PMID:10517638 A polycystic kidney-disease gene homologue required for male...	ACCEPT	Summary: PKD-2 is required for male mating behavior in C. elegans (PMID:10517638, PMID:11553327). Reason: Core biological function. The 1999 Nature paper established PKD-2's role in male mating behavior. The NAS evidence is appropriate for the regulatory aspect implied in the term. Supporting Evidence: PMID:10517638 PKD-2, the C. elegans homologue of PKD2, is localized to the same neurons as LOV-1, suggesting that they function in the same pathway.
GO:0005929 cilium	IDA PMID:27930654 Whole-Organism Developmental Expression Profiling Identifies...	ACCEPT	Summary: Direct experimental evidence for ciliary localization of PKD-2 using GFP reporters (PMID:27930654). The study used PKD-2::GFP as a marker for ciliary localization in male sensory neurons. Reason: IDA evidence from developmental expression profiling study that used PKD-2::GFP to examine ciliary localization. Ciliary localization well-established by primary studies (PMID:11553327). Supporting Evidence: PMID:11553327 LOV-1::GFP and PKD-2::GFP are expressed in the same male-specific sensory neurons and are concentrated in cilia and cell bodies. PMID:27930654 eCollection 2016 Dec.
GO:0071683 sensory dendrite	IDA PMID:27930654 Whole-Organism Developmental Expression Profiling Identifies...	ACCEPT	Summary: Direct evidence for sensory dendrite localization from GFP studies. Reason: IDA evidence supporting sensory dendrite localization, consistent with other publications. Dendritic localization established by primary papers (PMID:18037411). Supporting Evidence: PMID:18037411 The Caenorhabditis elegans TRPP2 homolog, PKD-2, is restricted to the somatodendritic (cell body and dendrite) and ciliary compartments of male specific sensory neurons. PMID:27930654 eCollection 2016 Dec.
GO:0043025 neuronal cell body	IDA PMID:16481400 Casein kinase II and calcineurin modulate TRPP function and ...	ACCEPT	Summary: PKD-2 localizes to neuronal cell bodies in male-specific sensory neurons, with phosphorylation state affecting its distribution (PMID:16481400). Reason: Strong IDA evidence from study on CK2 and calcineurin regulation of PKD-2. Supporting Evidence: PMID:16481400 CK2 and the calcineurin phosphatase TAX-6 modulate male mating behavior and PKD-2 ciliary localization.
GO:0097730 non-motile cilium	IDA PMID:16481400 Casein kinase II and calcineurin modulate TRPP function and ...	ACCEPT	Summary: PKD-2 localizes to non-motile sensory cilia in male neurons (PMID:16481400). Reason: C. elegans sensory cilia are non-motile (primary) cilia. This is a core localization for PKD-2 function in sensory signaling. Supporting Evidence: PMID:16481400 Feb 15. Casein kinase II and calcineurin modulate TRPP function and ciliary localization.
GO:0023041 neuronal signal transduction	IC PMID:15817158 Functional characterization of the C. elegans nephrocystins ...	ACCEPT	Summary: PKD-2's role in neuronal signal transduction is inferred from its ciliary localization and function in sensory behaviors (PMID:15817158). Reason: Reasonable IC annotation. PKD-2 functions in ciliary sensory signal transduction as a channel component of the sensory machinery (PMID:15817158). Supporting Evidence: PMID:15817158 We propose that NPHP-1 and NPHP-4 proteins play important and redundant roles in facilitating ciliary sensory signal transduction.
GO:0034606 response to hermaphrodite contact	IMP PMID:15817158 Functional characterization of the C. elegans nephrocystins ...	ACCEPT	Summary: pkd-2 mutants show defects in response to hermaphrodite contact, a specific step in male mating behavior (PMID:15817158, PMID:11553327). Reason: Core biological function. This is one of the two main behavioral defects in pkd-2 mutants (PMID:11553327, PMID:15817158). Supporting Evidence: PMID:11553327 Mutations in either lov-1 or pkd-2 result in identical male sensory behavioral defects. PMID:15817158 Functional characterization of the C.
GO:0034608 vulval location	IMP PMID:15817158 Functional characterization of the C. elegans nephrocystins ...	ACCEPT	Summary: pkd-2 mutants are defective in vulval location, a specific step in male mating behavior (PMID:15817158, PMID:11553327). Reason: Core biological function. This is one of the two main behavioral defects in pkd-2 mutants along with response behavior (PMID:11553327). Supporting Evidence: PMID:11553327 Mutations in either lov-1 or pkd-2 result in identical male sensory behavioral defects. PMID:15817158 Functional characterization of the C.
GO:0097730 non-motile cilium	IDA PMID:15817158 Functional characterization of the C. elegans nephrocystins ...	ACCEPT	Summary: PKD-2 colocalizes with nephrocystins in non-motile sensory cilia (PMID:15817158). Reason: IDA evidence consistent with other studies showing non-motile cilium localization. Supporting Evidence: PMID:15817158 GFP-tagged NPHP-1 and NPHP-4 proteins localize to ciliated sensory endings of dendrites and colocalize with PKD-2 in male-specific sensory cilia.
GO:0030425 dendrite	IDA PMID:18037411 Distinct protein domains regulate ciliary targeting and func...	ACCEPT	Summary: PKD-2 localizes to dendrites with distinct domains regulating this localization (PMID:18037411). Reason: Strong IDA evidence from structure-function study. Supporting Evidence: PMID:18037411 The Caenorhabditis elegans TRPP2 homolog, PKD-2, is restricted to the somatodendritic (cell body and dendrite) and ciliary compartments of male specific sensory neurons.
GO:0043025 neuronal cell body	IDA PMID:18037411 Distinct protein domains regulate ciliary targeting and func...	ACCEPT	Summary: PKD-2 localizes to neuronal cell bodies with cytoplasmic tails regulating this localization (PMID:18037411). Reason: IDA evidence from domain function analysis. Supporting Evidence: PMID:18037411 the PKD-2 cytosolic termini regulate subcellular distribution and function
GO:0048471 perinuclear region of cytoplasm	IDA PMID:18037411 Distinct protein domains regulate ciliary targeting and func...	ACCEPT	Summary: PKD-2 shows perinuclear localization consistent with ER/Golgi localization during biosynthesis (PMID:18037411). Reason: IDA evidence supporting perinuclear localization, consistent with ER-based synthesis and trafficking. Supporting Evidence: PMID:18037411 Epub 2007 Nov 1. Distinct protein domains regulate ciliary targeting and function of C.
GO:0097730 non-motile cilium	IDA PMID:18037411 Distinct protein domains regulate ciliary targeting and func...	ACCEPT	Summary: PKD-2 localizes to non-motile cilia with transmembrane domains sufficient for this targeting (PMID:18037411). Reason: Key IDA evidence from structure-function study. Supporting Evidence: PMID:18037411 somatodendritic and ciliary targeting requires the transmembrane (TM) region of PKD-2
GO:0034606 response to hermaphrodite contact	IMP PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: pkd-2 mutants are defective in response behavior (PMID:11553327). Reason: Core IMP evidence from the foundational 2001 paper establishing pkd-2 function. Supporting Evidence: PMID:11553327 Mutations in either lov-1 or pkd-2 result in identical male sensory behavioral defects.
GO:0034606 response to hermaphrodite contact	IMP PMID:12411744 Towards understanding the polycystins.	ACCEPT	Summary: Additional IMP evidence for response behavior defect (PMID:12411744). Reason: Confirms behavioral phenotype from independent study. Supporting Evidence: PMID:12411744 Mutation analysis in C. elegans showed similarly compromised male mating behaviors in all single and double lov-1 and pkd-2 mutants
GO:0034606 response to hermaphrodite contact	IMP PMID:15862350 Polycystin-2 accelerates Ca2+ release from intracellular sto...	ACCEPT	Summary: pkd-2 mutants show response defects linked to calcium signaling abnormalities (PMID:15862350). Reason: IMP evidence connecting behavioral phenotype to calcium channel function. Supporting Evidence: PMID:15862350 A homologue in Caenorhabditis elegans is necessary for male mating behavior.
GO:0034608 vulval location	IMP PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: pkd-2 mutants are defective in vulval location behavior (PMID:11553327). Reason: Core IMP evidence from foundational study. Supporting Evidence: PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.
GO:0034608 vulval location	IMP PMID:12411744 Towards understanding the polycystins.	ACCEPT	Summary: Vulval location defect confirmed in independent study (PMID:12411744). Reason: Confirming IMP evidence. Supporting Evidence: PMID:12411744 Towards understanding the polycystins.
GO:0034608 vulval location	IMP PMID:15862350 Polycystin-2 accelerates Ca2+ release from intracellular sto...	ACCEPT	Summary: Vulval location defect in pkd-2 mutants (PMID:15862350). Reason: Additional IMP evidence supporting this behavioral function. Supporting Evidence: PMID:15862350 2005 Apr 14. Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans.
GO:0005262 calcium channel activity	IDA PMID:15862350 Polycystin-2 accelerates Ca2+ release from intracellular sto...	ACCEPT	Summary: Direct electrophysiological evidence that PKD-2 functions as a calcium channel accelerating Ca2+ release from intracellular stores (PMID:15862350). Reason: This is the key IDA evidence for PKD-2's molecular function as a calcium channel. The study compared calcium signaling in wild-type and pkd-2 mutants. Supporting Evidence: PMID:15862350 we found that polycystin-2 is an intracellular Ca(2+) release channel that is required for the normal pattern of Ca(2+) responses involving IP(3) and ryanodine receptor-mediated Ca(2+) release from intracellular stores.
GO:0005783 endoplasmic reticulum	IDA PMID:16943275 General and cell-type specific mechanisms target TRPP2/PKD-2...	ACCEPT	Summary: PKD-2 localizes to the ER during its biosynthesis and trafficking pathway (PMID:16943275, PMID:15862350). Reason: IDA evidence from trafficking study. ER localization supported by functional studies showing PKD-2 acts as a calcium channel in the ER. Supporting Evidence: PMID:15862350 Polycystin-2, along with the IP(3) and ryanodine receptors, acts as a major calcium-release channel in the endoplasmic reticulum in cells where rapid calcium signaling is required PMID:16943275 General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.
GO:0005886 plasma membrane	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2::GFP localizes to plasma membrane in male sensory neurons (PMID:11553327). Reason: IDA evidence from GFP localization studies. Supporting Evidence: PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.
GO:0005929 cilium	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2::GFP concentrates in sensory cilia of male neurons (PMID:11553327). Reason: Foundational IDA evidence for ciliary localization. Supporting Evidence: PMID:11553327 LOV-1::GFP and PKD-2::GFP are expressed in the same male-specific sensory neurons and are concentrated in cilia and cell bodies.
GO:0005929 cilium	IDA PMID:16943275 General and cell-type specific mechanisms target TRPP2/PKD-2...	ACCEPT	Summary: Detailed analysis of PKD-2 ciliary targeting mechanisms (PMID:16943275). Reason: Key IDA study on ciliary targeting. Supporting Evidence: PMID:16943275 Ciliary localization of the transient receptor potential polycystin 2 channel (TRPP2/PKD-2) is evolutionarily conserved
GO:0006816 calcium ion transport	IDA PMID:15862350 Polycystin-2 accelerates Ca2+ release from intracellular sto...	ACCEPT	Summary: PKD-2 mediates calcium ion transport as demonstrated by electrophysiology and calcium imaging (PMID:15862350). Reason: Core biological process supported by direct experimental evidence. Supporting Evidence: PMID:15862350 Activity of polycystin-2 creates brief cytosolic Ca(2+) transients with increased amplitude and decreased duration.
GO:0016020 membrane	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2 is a membrane protein as shown by GFP localization (PMID:11553327). Reason: Basic IDA evidence for membrane localization. Supporting Evidence: PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.
GO:0043025 neuronal cell body	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2::GFP localizes to neuronal cell bodies (PMID:11553327). Reason: IDA evidence from foundational study. Supporting Evidence: PMID:11553327 LOV-1::GFP and PKD-2::GFP are expressed in the same male-specific sensory neurons and are concentrated in cilia and cell bodies.
GO:0043025 neuronal cell body	IDA PMID:12411744 Towards understanding the polycystins.	ACCEPT	Summary: Cell body localization confirmed (PMID:12411744). Reason: Confirming IDA evidence. Supporting Evidence: PMID:12411744 Expression analysis localized LOV-1 and PKD-2 to the ends of sensory neurons in male tails
GO:0043025 neuronal cell body	IDA PMID:16943275 General and cell-type specific mechanisms target TRPP2/PKD-2...	ACCEPT	Summary: Cell body localization in context of trafficking (PMID:16943275). Reason: IDA evidence supporting cell body localization as part of trafficking pathway. Supporting Evidence: PMID:16943275 General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.
GO:0060170 ciliary membrane	IDA PMID:16943275 General and cell-type specific mechanisms target TRPP2/PKD-2...	ACCEPT	Summary: PKD-2 specifically localizes to the ciliary membrane compartment (PMID:16943275). Reason: Key IDA evidence for ciliary membrane localization. Supporting Evidence: PMID:16943275 PKD-2 stabilization in cilia and cell bodies requires LOV-1, a functional partner and a TRPP1 homolog.
GO:0060179 male mating behavior	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: pkd-2 is required for male mating behavior with mutants showing specific defects in response and vulval location (PMID:11553327). Reason: Core biological function. Evidence code is technically IMP based on mutant phenotype, but the annotation captures the essential function. Supporting Evidence: PMID:11553327 Mutations in either lov-1 or pkd-2 result in identical male sensory behavioral defects.
GO:0097730 non-motile cilium	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2 localizes to non-motile sensory cilia which remain structurally normal in pkd-2 mutants (PMID:11553327). Reason: IDA evidence establishing that PKD-2 is in non-motile cilia. Supporting Evidence: PMID:11553327 the cilia of lov-1 and pkd-2 single mutants and of lov-1;pkd-2 double mutants are normal as judged by electron microscopy
GO:0097730 non-motile cilium	IDA PMID:15563610 ATP-2 interacts with the PLAT domain of LOV-1 and is involve...	ACCEPT	Summary: PKD-2 colocalizes with ATP-2 in non-motile cilia (PMID:15563610). Reason: IDA evidence from polycystin signaling study. Supporting Evidence: PMID:15563610 ATP-2 and other ATP synthase components colocalize with LOV-1 and PKD-2 in cilia.
GO:0097730 non-motile cilium	IDA PMID:17581863 STAM and Hrs down-regulate ciliary TRP receptors.	ACCEPT	Summary: PKD-2 ciliary localization regulated by STAM-Hrs complex (PMID:17581863). Reason: IDA evidence from study on ciliary receptor regulation. Supporting Evidence: PMID:17581863 overexpression of STAM or Hrs promotes the removal of PKD-2 from cilia
GO:0030425 dendrite	IDA PMID:17581863 STAM and Hrs down-regulate ciliary TRP receptors.	ACCEPT	Summary: PKD-2 in dendrites as part of trafficking pathway (PMID:17581863). Reason: IDA evidence for dendritic localization. Supporting Evidence: PMID:17581863 Jun 20. STAM and Hrs down-regulate ciliary TRP receptors.
GO:0043025 neuronal cell body	IDA PMID:17581863 STAM and Hrs down-regulate ciliary TRP receptors.	ACCEPT	Summary: PKD-2 cell body localization regulated by STAM-Hrs (PMID:17581863). Reason: IDA evidence for cell body localization. Supporting Evidence: PMID:17581863 Jun 20. STAM and Hrs down-regulate ciliary TRP receptors.
GO:0030424 axon	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2::GFP present in axons of male sensory neurons (PMID:11553327). Reason: IDA evidence for axonal localization. Supporting Evidence: PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.
GO:0030424 axon	IDA PMID:15563610 ATP-2 interacts with the PLAT domain of LOV-1 and is involve...	ACCEPT	Summary: Axon localization confirmed (PMID:15563610). Reason: Confirming IDA evidence. Supporting Evidence: PMID:15563610 Nov 24. ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.
GO:0030425 dendrite	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2 in dendrites of male sensory neurons (PMID:11553327). Reason: IDA evidence from foundational study. Supporting Evidence: PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.
GO:0030425 dendrite	IDA PMID:15563610 ATP-2 interacts with the PLAT domain of LOV-1 and is involve...	ACCEPT	Summary: Dendritic localization confirmed in polycystin signaling study (PMID:15563610). Reason: Confirming IDA evidence. Supporting Evidence: PMID:15563610 Nov 24. ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.
GO:0043025 neuronal cell body	IDA PMID:15563610 ATP-2 interacts with the PLAT domain of LOV-1 and is involve...	ACCEPT	Summary: Cell body localization in polycystin complex study (PMID:15563610). Reason: IDA evidence. Supporting Evidence: PMID:15563610 Nov 24. ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.
GO:0007617 mating behavior	IMP PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: pkd-2 mutants have defective mating behavior (PMID:11553327). Reason: Core biological function. IMP evidence from mutant analysis. Supporting Evidence: PMID:11553327 Mutations in either lov-1 or pkd-2 result in identical male sensory behavioral defects.
GO:0007617 mating behavior	IGI PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: pkd-2 and lov-1 act in the same pathway for mating behavior (PMID:11553327). Reason: IGI evidence from double mutant analysis showing epistasis. Supporting Evidence: PMID:11553327 pkd-2;lov-1 double mutants are no more severe than either of the single mutants, indicating that lov-1 and pkd-2 act together.
GO:0031090 organelle membrane	IDA PMID:11553327 The Caenorhabditis elegans autosomal dominant polycystic kid...	ACCEPT	Summary: PKD-2 localizes to intracellular organelle membranes (PMID:11553327). Reason: IDA evidence for intracellular membrane localization. Supporting Evidence: PMID:11553327 Cytoplasmic, nonnuclear staining in cell bodies is punctate, suggesting that one pool of PKD-2 is localized to intracellular membranes

Gene Description

Existing Annotations Review

Core Functions

PKD-2 functions as a calcium-permeable TRP channel in ciliary membranes of male sensory neurons, mediating detection of mechanical/chemical stimuli during mating behavior.

References

Tags

Deep Research

Falcon

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