wdr-23

These computational predictions are reviewed separately from the GOA annotation set used for this review. The assessments below are from this project and do not constitute official GO annotations or endorsement by GO/UniProt. They are not included in the existing annotation review above.

ProtNLM2 External predictions

View prediction review YAML · wdr-23-protnlm-predictions-review.yaml · Review status: COMPLETE

The emitted ribosome-binding and translation-regulator terms are not validated by the direct WDR-23 substrate-receptor experiments. The exact product retains its WD-repeat core but has a distinct N-terminal boundary.

Source documents: genes/worm/wdr-23/wdr-23-protnlm-source.json · genes/worm/wdr-23/wdr-23-notes.md

Review score: 2 = concordant with evidence; 1 = uncertain; 0 = discordant with evidence. This is an assessment score, not a model probability.

GO:0045182 translation regulator activity GO_MF

UNC — Uncertain Review score: 1/2

Prediction method: ProtNLM2 · Version: UniProt API snapshot 2026-09-10 · file:worm/wdr-23/wdr-23-protnlm-source.json

Review rationale: The donor is RACK1, whereas direct worm studies establish WDR-23 substrate recruitment and SKN-1/GEN-1 regulation. WD-repeat architecture alone cannot transfer direct translational regulation. Effects of related WDR23 proteins on other regulatory substrates do not demonstrate this GO activity in S6FN32; an additional role is not experimentally excluded.

Supporting Evidence:

file:worm/wdr-23/wdr-23-prediction-donor.json: ""value": "Small ribosomal subunit protein RACK1""
PMID:19273594: "WDR-23, which interacts with the CUL-4/DDB-1 ubiquitin ligase"
PMID:31409866: "we identify GEN-1, a Holliday junction resolvase, as an evolutionarily conserved WDR-23 substrate"
file:worm/wdr-23/wdr-23-bioinformatics/RESULTS.md: "| 74–571 | 1–498 | 498 |"

GO:0043022 ribosome binding GO_MF

UNC — Uncertain Review score: 1/2

Prediction method: ProtNLM2 · Version: UniProt API snapshot 2026-09-10 · file:worm/wdr-23/wdr-23-protnlm-source.json

Review rationale: The weak sequence match to ribosomal RACK1 does not establish a ribosome-binding interface or ribosome association in this DCAF11/WDR-23 product. Direct WDR-23 studies support a different molecular system, but do not provide a negative ribosome-binding assay.

Supporting Evidence:

file:worm/wdr-23/wdr-23-prediction-donor.json: ""value": "Small ribosomal subunit protein RACK1""
PMID:19273594: "WDR-23, which interacts with the CUL-4/DDB-1 ubiquitin ligase"
file:worm/wdr-23/wdr-23-bioinformatics/RESULTS.md: "| 74–571 | 1–498 | 498 |"

Gene Description

Core Functions

Likely recruits substrates to the CUL-4/DDB-1 system through the conserved WDR-23 WD-repeat region; exact localization and substrate outcome depend on the untested N-terminally shortened product.

References

Suggested Questions for Experts

External Prediction Reviews

ProtNLM2 External predictions

Deep Research

Falcon

📚 Additional Documentation

Notes

Bioinformatics Results

Protnlm Function Review

📄 View Raw YAML