{
  "accession": "S6FN32",
  "retrieved_at": "2026-09-10T14:34:38.269410+00:00",
  "prediction_url": "https://rest.uniprot.org/uniprotkb/protnlm/S6FN32",
  "prediction_status": 200,
  "prediction": {
    "entryType": "UniProtKB unreviewed (TrEMBL)",
    "primaryAccession": "S6FN32",
    "uniProtkbId": "S6FN32_CAEEL",
    "entryAudit": {
      "firstPublicDate": "1111-11-10",
      "lastAnnotationUpdateDate": "1111-11-10",
      "lastSequenceUpdateDate": "1111-11-10",
      "entryVersion": 1,
      "sequenceVersion": 1
    },
    "annotationScore": 0.0,
    "proteinExistence": "5: Uncertain",
    "proteinDescription": {
      "recommendedName": {
        "fullName": {
          "evidences": [
            {
              "evidenceCode": "ECO:0008006",
              "source": "Google",
              "id": "ProtNLM2",
              "properties": [
                {
                  "key": "model_score",
                  "value": "0.95"
                },
                {
                  "key": "string_match_text",
                  "value": "PTHR19847"
                },
                {
                  "key": "string_match_location",
                  "value": "PANTHER"
                },
                {
                  "key": "string_match_type",
                  "value": "exact_sanitized"
                }
              ]
            }
          ],
          "value": "DDB1- and CUL4-associated factor 11"
        }
      }
    },
    "comments": [
      {
        "commentType": "SUBCELLULAR LOCATION",
        "subcellularLocations": [
          {
            "location": {
              "evidences": [
                {
                  "evidenceCode": "ECO:0008006",
                  "source": "Google",
                  "id": "ProtNLM2",
                  "properties": [
                    {
                      "key": "model_score",
                      "value": "0.75"
                    },
                    {
                      "key": "phmmer_accession",
                      "value": "Q9USN3"
                    },
                    {
                      "key": "phmmer_score",
                      "value": "98.9"
                    }
                  ]
                }
              ],
              "value": "Nucleus",
              "id": "SL-0191"
            }
          }
        ]
      },
      {
        "texts": [
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0008006",
                "source": "Google",
                "id": "ProtNLM2",
                "properties": [
                  {
                    "key": "model_score",
                    "value": "0.17"
                  },
                  {
                    "key": "phmmer_accession",
                    "value": "Q5E9I8"
                  },
                  {
                    "key": "phmmer_score",
                    "value": "336.4"
                  }
                ]
              }
            ],
            "value": "May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex"
          }
        ],
        "commentType": "FUNCTION"
      }
    ],
    "references": [
      {
        "referenceNumber": 1,
        "citation": {
          "id": "CI-FC84BSHK1H4IL",
          "citationType": "unpublished observations"
        },
        "referencePositions": [
          "required field"
        ]
      }
    ],
    "uniProtKBCrossReferences": [
      {
        "database": "GO",
        "id": "GO:0045182",
        "properties": [
          {
            "key": "GoTerm",
            "value": "F:translation regulator activity"
          },
          {
            "key": "GoEvidenceType",
            "value": ":-"
          }
        ],
        "evidences": [
          {
            "evidenceCode": "ECO:0008006",
            "source": "Google",
            "id": "ProtNLM2",
            "properties": [
              {
                "key": "model_score",
                "value": "0.22"
              },
              {
                "key": "phmmer_accession",
                "value": "P69103"
              },
              {
                "key": "phmmer_score",
                "value": "57.9"
              }
            ]
          }
        ]
      },
      {
        "database": "GO",
        "id": "GO:0043022",
        "properties": [
          {
            "key": "GoTerm",
            "value": "F:ribosome binding"
          },
          {
            "key": "GoEvidenceType",
            "value": ":-"
          }
        ],
        "evidences": [
          {
            "evidenceCode": "ECO:0008006",
            "source": "Google",
            "id": "ProtNLM2",
            "properties": [
              {
                "key": "model_score",
                "value": "0.22"
              },
              {
                "key": "phmmer_accession",
                "value": "P69103"
              },
              {
                "key": "phmmer_score",
                "value": "57.9"
              }
            ]
          }
        ]
      }
    ],
    "extraAttributes": {
      "countByCommentType": {
        "SUBCELLULAR LOCATION": 1,
        "FUNCTION": 1
      }
    }
  },
  "uniprot_url": "https://rest.uniprot.org/uniprotkb/S6FN32.json",
  "uniprot_status": 200,
  "uniprot": {
    "entryType": "UniProtKB unreviewed (TrEMBL)",
    "primaryAccession": "S6FN32",
    "uniProtkbId": "S6FN32_CAEEL",
    "entryAudit": {
      "firstPublicDate": "2013-10-16",
      "lastAnnotationUpdateDate": "2025-10-08",
      "lastSequenceUpdateDate": "2013-10-16",
      "entryVersion": 66,
      "sequenceVersion": 1
    },
    "annotationScore": 1.0,
    "organism": {
      "scientificName": "Caenorhabditis elegans",
      "taxonId": 6239,
      "evidences": [
        {
          "evidenceCode": "ECO:0000313",
          "source": "EMBL",
          "id": "CDG24145.1"
        },
        {
          "evidenceCode": "ECO:0000313",
          "source": "Proteomes",
          "id": "UP000001940"
        }
      ],
      "lineage": [
        "Eukaryota",
        "Metazoa",
        "Ecdysozoa",
        "Nematoda",
        "Chromadorea",
        "Rhabditida",
        "Rhabditina",
        "Rhabditomorpha",
        "Rhabditoidea",
        "Rhabditidae",
        "Peloderinae",
        "Caenorhabditis"
      ]
    },
    "proteinExistence": "3: Inferred from homology",
    "proteinDescription": {
      "recommendedName": {
        "fullName": {
          "evidences": [
            {
              "evidenceCode": "ECO:0000256",
              "source": "ARBA",
              "id": "ARBA00071980"
            },
            {
              "evidenceCode": "ECO:0000256",
              "source": "PIRNR",
              "id": "PIRNR038135"
            }
          ],
          "value": "DDB1- and CUL4-associated factor 11 homolog"
        }
      }
    },
    "genes": [
      {
        "geneName": {
          "evidences": [
            {
              "evidenceCode": "ECO:0000313",
              "source": "EMBL",
              "id": "CDG24145.1"
            },
            {
              "evidenceCode": "ECO:0000313",
              "source": "WormBase",
              "id": "D2030.9d"
            }
          ],
          "value": "wdr-23"
        },
        "orfNames": [
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0000313",
                "source": "EMBL",
                "id": "CDG24145.1"
              }
            ],
            "value": "CELE_D2030.9"
          },
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0000313",
                "source": "WormBase",
                "id": "D2030.9d"
              }
            ],
            "value": "D2030.9"
          }
        ]
      }
    ],
    "comments": [
      {
        "texts": [
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0000256",
                "source": "PIRNR",
                "id": "PIRNR038135"
              }
            ],
            "value": "Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+)"
          }
        ],
        "commentType": "FUNCTION"
      },
      {
        "texts": [
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0000256",
                "source": "ARBA",
                "id": "ARBA00061298"
              },
              {
                "evidenceCode": "ECO:0000256",
                "source": "PIRNR",
                "id": "PIRNR038135"
              }
            ],
            "value": "Belongs to the WD repeat LEC14B family"
          }
        ],
        "commentType": "SIMILARITY"
      }
    ],
    "features": [
      {
        "type": "Repeat",
        "location": {
          "start": {
            "value": 234,
            "modifier": "EXACT"
          },
          "end": {
            "value": 267,
            "modifier": "EXACT"
          }
        },
        "description": "WD",
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "PROSITE-ProRule",
            "id": "PRU00221"
          }
        ]
      },
      {
        "type": "Repeat",
        "location": {
          "start": {
            "value": 282,
            "modifier": "EXACT"
          },
          "end": {
            "value": 323,
            "modifier": "EXACT"
          }
        },
        "description": "WD",
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "PROSITE-ProRule",
            "id": "PRU00221"
          }
        ]
      },
      {
        "type": "Repeat",
        "location": {
          "start": {
            "value": 407,
            "modifier": "EXACT"
          },
          "end": {
            "value": 438,
            "modifier": "EXACT"
          }
        },
        "description": "WD",
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "PROSITE-ProRule",
            "id": "PRU00221"
          }
        ]
      }
    ],
    "keywords": [
      {
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "ARBA",
            "id": "ARBA00022553"
          }
        ],
        "id": "KW-0597",
        "category": "PTM",
        "name": "Phosphoprotein"
      },
      {
        "evidences": [
          {
            "evidenceCode": "ECO:0000313",
            "source": "Proteomes",
            "id": "UP000001940"
          }
        ],
        "id": "KW-1185",
        "category": "Technical term",
        "name": "Reference proteome"
      },
      {
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "ARBA",
            "id": "ARBA00022737"
          }
        ],
        "id": "KW-0677",
        "category": "Domain",
        "name": "Repeat"
      },
      {
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "ARBA",
            "id": "ARBA00022574"
          },
          {
            "evidenceCode": "ECO:0000256",
            "source": "PROSITE-ProRule",
            "id": "PRU00221"
          }
        ],
        "id": "KW-0853",
        "category": "Domain",
        "name": "WD repeat"
      }
    ],
    "references": [
      {
        "referenceNumber": 1,
        "citation": {
          "id": "9851916",
          "citationType": "journal article",
          "authoringGroup": [
            "The C. elegans sequencing consortium"
          ],
          "authors": [
            "Sulson J.E.",
            "Waterston R."
          ],
          "citationCrossReferences": [
            {
              "database": "PubMed",
              "id": "9851916"
            },
            {
              "database": "DOI",
              "id": "10.1126/science.282.5396.2012"
            }
          ],
          "title": "Genome sequence of the nematode C. elegans: a platform for investigating biology.",
          "publicationDate": "1998",
          "journal": "Science",
          "firstPage": "2012",
          "lastPage": "2018",
          "volume": "282"
        },
        "referencePositions": [
          "NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"
        ],
        "referenceComments": [
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0000313",
                "source": "EMBL",
                "id": "CDG24145.1"
              },
              {
                "evidenceCode": "ECO:0000313",
                "source": "Proteomes",
                "id": "UP000001940"
              }
            ],
            "value": "Bristol N2",
            "type": "STRAIN"
          }
        ],
        "evidences": [
          {
            "evidenceCode": "ECO:0000313",
            "source": "EMBL",
            "id": "CDG24145.1"
          },
          {
            "evidenceCode": "ECO:0000313",
            "source": "Proteomes",
            "id": "UP000001940"
          }
        ]
      }
    ],
    "uniProtKBCrossReferences": [
      {
        "database": "EMBL",
        "id": "BX284601",
        "properties": [
          {
            "key": "ProteinId",
            "value": "CDG24145.1"
          },
          {
            "key": "Status",
            "value": "-"
          },
          {
            "key": "MoleculeType",
            "value": "Genomic_DNA"
          }
        ]
      },
      {
        "database": "RefSeq",
        "id": "NP_001293282.1",
        "properties": [
          {
            "key": "NucleotideSequenceId",
            "value": "NM_001306353.3"
          }
        ]
      },
      {
        "database": "AlphaFoldDB",
        "id": "S6FN32",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "SMR",
        "id": "S6FN32",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "GeneID",
        "id": "172518",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "AGR",
        "id": "WB:WBGene00008419",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "CTD",
        "id": "172518",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "WormBase",
        "id": "D2030.9d",
        "properties": [
          {
            "key": "ProteinId",
            "value": "CE48434"
          },
          {
            "key": "GeneId",
            "value": "WBGene00008419"
          },
          {
            "key": "GeneName",
            "value": "wdr-23"
          }
        ]
      },
      {
        "database": "OrthoDB",
        "id": "63070at2759",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "Proteomes",
        "id": "UP000001940",
        "properties": [
          {
            "key": "Component",
            "value": "Chromosome I"
          }
        ]
      },
      {
        "database": "Bgee",
        "id": "WBGene00008419",
        "properties": [
          {
            "key": "ExpressionPatterns",
            "value": "Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"
          }
        ]
      },
      {
        "database": "ExpressionAtlas",
        "id": "S6FN32",
        "properties": [
          {
            "key": "ExpressionPatterns",
            "value": "baseline and differential"
          }
        ]
      },
      {
        "database": "FunFam",
        "id": "2.130.10.10:FF:001891",
        "properties": [
          {
            "key": "EntryName",
            "value": "DDB1-and CUL4-associated factor 11 homolog"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "FunFam",
        "id": "2.130.10.10:FF:002367",
        "properties": [
          {
            "key": "EntryName",
            "value": "DDB1-and CUL4-associated factor 11 homolog"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "Gene3D",
        "id": "2.130.10.10",
        "properties": [
          {
            "key": "EntryName",
            "value": "YVTN repeat-like/Quinoprotein amine dehydrogenase"
          },
          {
            "key": "MatchStatus",
            "value": "2"
          }
        ]
      },
      {
        "database": "InterPro",
        "id": "IPR051859",
        "properties": [
          {
            "key": "EntryName",
            "value": "DCAF"
          }
        ]
      },
      {
        "database": "InterPro",
        "id": "IPR017399",
        "properties": [
          {
            "key": "EntryName",
            "value": "DCAF11/LEC14B"
          }
        ]
      },
      {
        "database": "InterPro",
        "id": "IPR015943",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD40/YVTN_repeat-like_dom_sf"
          }
        ]
      },
      {
        "database": "InterPro",
        "id": "IPR020472",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD40_PAC1"
          }
        ]
      },
      {
        "database": "InterPro",
        "id": "IPR036322",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD40_repeat_dom_sf"
          }
        ]
      },
      {
        "database": "InterPro",
        "id": "IPR001680",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD40_rpt"
          }
        ]
      },
      {
        "database": "PANTHER",
        "id": "PTHR19847",
        "properties": [
          {
            "key": "EntryName",
            "value": "DDB1- AND CUL4-ASSOCIATED FACTOR 11"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "PANTHER",
        "id": "PTHR19847:SF7",
        "properties": [
          {
            "key": "EntryName",
            "value": "DDB1- AND CUL4-ASSOCIATED FACTOR 11"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "Pfam",
        "id": "PF00400",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD40"
          },
          {
            "key": "MatchStatus",
            "value": "3"
          }
        ]
      },
      {
        "database": "PIRSF",
        "id": "PIRSF038135",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD_repeat_p23"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "PRINTS",
        "id": "PR00320",
        "properties": [
          {
            "key": "EntryName",
            "value": "GPROTEINBRPT"
          }
        ]
      },
      {
        "database": "SMART",
        "id": "SM00320",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD40"
          },
          {
            "key": "MatchStatus",
            "value": "6"
          }
        ]
      },
      {
        "database": "SUPFAM",
        "id": "SSF50978",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD40 repeat-like"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "PROSITE",
        "id": "PS50082",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD_REPEATS_2"
          },
          {
            "key": "MatchStatus",
            "value": "3"
          }
        ]
      },
      {
        "database": "PROSITE",
        "id": "PS50294",
        "properties": [
          {
            "key": "EntryName",
            "value": "WD_REPEATS_REGION"
          },
          {
            "key": "MatchStatus",
            "value": "3"
          }
        ]
      }
    ],
    "sequence": {
      "value": "MTPHEEQQMFEREQHIAFSGRCHIGDPESCTQLRNEINSRCGPRPSTSNNMEFILNRDLQKRGTSISNPRTVARVLNSHLPNQKRRVDRVATKSFCTQYIQNGTKIVVASQDEKIRFYQRNPDKSKYRSKYMKSDELRVDQCGWSILDTAISLNGDLIAYGTWKDAVFVGKLDFTERQNITWFPIDLNGEPGRDHCAVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIVNAHEDDVNSVCFADLGSNLIYSAGDDGLVKVWDKRAWSDGDVEPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLRKFSNMSGVEATRACVQSQHWDYRWQPAPPGLCQPVAGDTSVMTLRGHSVLHTLVRANFSPESTGRRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTENEIVSSAWDGVTTVWTWDERQEGVIAPYDHPNISQFGDEDSCDELFQPVKKQCRRQRKTMSSRGHPCSSSSISQN",
      "length": 498,
      "molWeight": 56673,
      "crc64": "3D448E7CAD0126BD",
      "md5": "9DCD7EFD13616D5F98BD7A33DCA42E71"
    },
    "extraAttributes": {
      "countByCommentType": {
        "FUNCTION": 1,
        "SIMILARITY": 1
      },
      "countByFeatureType": {
        "Repeat": 3
      },
      "uniParcId": "UPI00035AC7A6"
    }
  }
}