ACL4

UniProt ID: Q03771
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for ACL4

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005741 mitochondrial outer membrane
IBA
GO_REF:0000033 		REMOVE
Summary: Manual review: mitochondrial outer membrane is not sufficiently supported as a direct function of ACL4.
Reason: Removed due weak mechanistic support or likely misannotation for this gene.
GO:0008320 protein transmembrane transporter activity
IBA
GO_REF:0000033 		REMOVE
Summary: Manual review: protein transmembrane transporter activity is not sufficiently supported as a direct function of ACL4.
Reason: Removed due weak mechanistic support or likely misannotation for this gene.
GO:0030150 protein import into mitochondrial matrix
IBA
GO_REF:0000033 		REMOVE
Summary: Manual review: protein import into mitochondrial matrix is not sufficiently supported as a direct function of ACL4.
Reason: Removed due weak mechanistic support or likely misannotation for this gene.
GO:0030943 mitochondrion targeting sequence binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrion targeting sequence binding is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0045039 protein insertion into mitochondrial inner membrane
IBA
GO_REF:0000033 		REMOVE
Summary: Manual review: protein insertion into mitochondrial inner membrane is not sufficiently supported as a direct function of ACL4.
Reason: Removed due weak mechanistic support or likely misannotation for this gene.
GO:0005634 nucleus
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: nucleus is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042254 ribosome biogenesis
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: ribosome biogenesis is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005634 nucleus
IDA
PMID:25936803
Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribos... 		ACCEPT
Summary: Manual review: nucleus is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005634 nucleus
IDA
PMID:26447800
The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 ... 		ACCEPT
Summary: Manual review: nucleus is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IDA
PMID:26447800
The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 ... 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042273 ribosomal large subunit biogenesis
IMP
PMID:25936803
Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribos... 		ACCEPT
Summary: Manual review: ribosomal large subunit biogenesis is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042273 ribosomal large subunit biogenesis
IMP
PMID:26447800
The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 ... 		ACCEPT
Summary: Manual review: ribosomal large subunit biogenesis is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:25936803
Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribos... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for ACL4.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein carrier chaperone
GO:0140318 protein transporter activity
IDA
PMID:26447800
The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 ... 		REMOVE
Summary: Manual review: protein transporter activity is not sufficiently supported as a direct function of ACL4.
Reason: Removed due weak mechanistic support or likely misannotation for this gene.
GO:0051083 'de novo' cotranslational protein folding
HGI
PMID:19325107
Comprehensive characterization of genes required for protein... 		ACCEPT
Summary: Manual review: 'de novo' cotranslational protein folding is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005634 nucleus
HDA
PMID:14562095
Global analysis of protein localization in budding yeast. 		ACCEPT
Summary: Manual review: nucleus is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
HDA
PMID:14562095
Global analysis of protein localization in budding yeast. 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of ACL4.
Reason: Retained as supported or plausible for this gene and evidence context.

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:14562095
Global analysis of protein localization in budding yeast.
PMID:19325107
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.
PMID:25936803
Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension.
PMID:26447800
The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site.

📄 View Raw YAML

 
id: Q03771
gene_symbol: ACL4
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for ACL4'
existing_annotations:
- term:
    id: GO:0005741
    label: mitochondrial outer membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrial outer membrane is not sufficiently supported as a direct function of ACL4.'
    action: REMOVE
    reason: Removed due weak mechanistic support or likely misannotation for this gene.
- term:
    id: GO:0008320
    label: protein transmembrane transporter activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: contributes_to
  review:
    summary: 'Manual review: protein transmembrane transporter activity is not sufficiently supported as a direct function of ACL4.'
    action: REMOVE
    reason: Removed due weak mechanistic support or likely misannotation for this gene.
- term:
    id: GO:0030150
    label: protein import into mitochondrial matrix
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein import into mitochondrial matrix is not sufficiently supported as a direct function of ACL4.'
    action: REMOVE
    reason: Removed due weak mechanistic support or likely misannotation for this gene.
- term:
    id: GO:0030943
    label: mitochondrion targeting sequence binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrion targeting sequence binding is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0045039
    label: protein insertion into mitochondrial inner membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein insertion into mitochondrial inner membrane is not sufficiently supported as a direct function of ACL4.'
    action: REMOVE
    reason: Removed due weak mechanistic support or likely misannotation for this gene.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: nucleus is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042254
    label: ribosome biogenesis
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: ribosome biogenesis is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:25936803
  review:
    summary: 'Manual review: nucleus is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:26447800
  review:
    summary: 'Manual review: nucleus is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:26447800
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042273
    label: ribosomal large subunit biogenesis
  evidence_type: IMP
  original_reference_id: PMID:25936803
  review:
    summary: 'Manual review: ribosomal large subunit biogenesis is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042273
    label: ribosomal large subunit biogenesis
  evidence_type: IMP
  original_reference_id: PMID:26447800
  review:
    summary: 'Manual review: ribosomal large subunit biogenesis is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:25936803
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for ACL4.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0140597
      label: protein carrier chaperone
- term:
    id: GO:0140318
    label: protein transporter activity
  evidence_type: IDA
  original_reference_id: PMID:26447800
  review:
    summary: 'Manual review: protein transporter activity is not sufficiently supported as a direct function of ACL4.'
    action: REMOVE
    reason: Removed due weak mechanistic support or likely misannotation for this gene.
- term:
    id: GO:0051083
    label: '''de novo'' cotranslational protein folding'
  evidence_type: HGI
  original_reference_id: PMID:19325107
  review:
    summary: 'Manual review: ''de novo'' cotranslational protein folding is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: HDA
  original_reference_id: PMID:14562095
  review:
    summary: 'Manual review: nucleus is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: HDA
  original_reference_id: PMID:14562095
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of ACL4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:14562095
  title: Global analysis of protein localization in budding yeast.
  findings: []
- id: PMID:19325107
  title: Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.
  findings: []
- id: PMID:25936803
  title: Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension.
  findings: []
- id: PMID:26447800
  title: The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site.
  findings: []