APJ1

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0001671 ATPase activator activity	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: ATPase activator activity is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034605 cellular response to heat	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: cellular response to heat is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: protein refolding is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IBA GO_REF:0000033	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for APJ1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0005634 nucleus	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: nucleus may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005634 nucleus	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Manual review: nucleus may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Manual review: cytoplasm may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006457 protein folding	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008270 zinc ion binding	IEA GO_REF:0000043	ACCEPT	Summary: Manual review: zinc ion binding is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0030544 Hsp70 protein binding	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: Hsp70 protein binding is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0031072 heat shock protein binding	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: heat shock protein binding is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0046872 metal ion binding	IEA GO_REF:0000043	ACCEPT	Summary: Manual review: metal ion binding is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IEA GO_REF:0000002	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for APJ1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0005515 protein binding	IPI PMID:17892321 Structure-templated predictions of novel protein interaction...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for APJ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0008270 zinc ion binding	RCA PMID:30358795 The cellular economy of the Saccharomyces cerevisiae zinc pr...	ACCEPT	Summary: Manual review: zinc ion binding is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042405 nuclear inclusion body	IDA PMID:32492414 Chaperone-Mediated Protein Disaggregation Triggers Proteolyt...	KEEP AS NON CORE	Summary: Manual review: nuclear inclusion body may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0043335 protein unfolding	IMP PMID:32492414 Chaperone-Mediated Protein Disaggregation Triggers Proteolyt...	ACCEPT	Summary: Manual review: protein unfolding is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IMP PMID:11923285 Increased expression of Hsp40 chaperones, transcriptional fa...	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for APJ1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0005634 nucleus	HDA PMID:14562095 Global analysis of protein localization in budding yeast.	KEEP AS NON CORE	Summary: Manual review: nucleus may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005634 nucleus	HDA PMID:22842922 Dissecting DNA damage response pathways by analysing protein...	KEEP AS NON CORE	Summary: Manual review: nucleus may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm	HDA PMID:14562095 Global analysis of protein localization in budding yeast.	KEEP AS NON CORE	Summary: Manual review: cytoplasm may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005739 mitochondrion	HDA PMID:14576278 The proteome of Saccharomyces cerevisiae mitochondria.	KEEP AS NON CORE	Summary: Manual review: mitochondrion may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005739 mitochondrion	HDA PMID:16823961 Toward the complete yeast mitochondrial proteome: multidimen...	KEEP AS NON CORE	Summary: Manual review: mitochondrion may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0034399 nuclear periphery	IDA PMID:25817432 Cmr1/WDR76 defines a nuclear genotoxic stress body linking g...	KEEP AS NON CORE	Summary: Manual review: nuclear periphery may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0001671 ATPase activator activity	IDA PMID:23329686 Sequential duplications of an ancient member of the DnaJ-fam...	ACCEPT	Summary: Manual review: ATPase activator activity is consistent with known biology of APJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016925 protein sumoylation	IGI PMID:23329686 Sequential duplications of an ancient member of the DnaJ-fam...	KEEP AS NON CORE	Summary: Manual review: protein sumoylation may be context-dependent or peripheral for APJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.

📄 View Raw YAML

id: P53940
gene_symbol: APJ1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for APJ1'
existing_annotations:
- term:
    id: GO:0001671
    label: ATPase activator activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: ATPase activator activity is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034605
    label: cellular response to heat
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cellular response to heat is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for APJ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: protein folding is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008270
    label: zinc ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: zinc ion binding is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0030544
    label: Hsp70 protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: Hsp70 protein binding is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0031072
    label: heat shock protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: heat shock protein binding is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0046872
    label: metal ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: metal ion binding is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for APJ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17892321
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for APJ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0008270
    label: zinc ion binding
  evidence_type: RCA
  original_reference_id: PMID:30358795
  review:
    summary: 'Manual review: zinc ion binding is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042405
    label: nuclear inclusion body
  evidence_type: IDA
  original_reference_id: PMID:32492414
  review:
    summary: 'Manual review: nuclear inclusion body may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0043335
    label: protein unfolding
  evidence_type: IMP
  original_reference_id: PMID:32492414
  review:
    summary: 'Manual review: protein unfolding is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:11923285
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for APJ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: HDA
  original_reference_id: PMID:14562095
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: HDA
  original_reference_id: PMID:22842922
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: HDA
  original_reference_id: PMID:14562095
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:14576278
  review:
    summary: 'Manual review: mitochondrion may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:16823961
  review:
    summary: 'Manual review: mitochondrion may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0034399
    label: nuclear periphery
  evidence_type: IDA
  original_reference_id: PMID:25817432
  review:
    summary: 'Manual review: nuclear periphery may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0001671
    label: ATPase activator activity
  evidence_type: IDA
  original_reference_id: PMID:23329686
  review:
    summary: 'Manual review: ATPase activator activity is consistent with known biology of APJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016925
    label: protein sumoylation
  evidence_type: IGI
  original_reference_id: PMID:23329686
  review:
    summary: 'Manual review: protein sumoylation may be context-dependent or peripheral for APJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:11923285
  title: Increased expression of Hsp40 chaperones, transcriptional factors, and ribosomal protein Rpp0 can cure yeast prions.
  findings: []
- id: PMID:14562095
  title: Global analysis of protein localization in budding yeast.
  findings: []
- id: PMID:14576278
  title: The proteome of Saccharomyces cerevisiae mitochondria.
  findings: []
- id: PMID:16823961
  title: 'Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.'
  findings: []
- id: PMID:17892321
  title: Structure-templated predictions of novel protein interactions from sequence information.
  findings: []
- id: PMID:22842922
  title: Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
  findings: []
- id: PMID:23329686
  title: Sequential duplications of an ancient member of the DnaJ-family expanded the functional chaperone network in the eukaryotic cytosol.
  findings: []
- id: PMID:25817432
  title: Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.
  findings: []
- id: PMID:30358795
  title: The cellular economy of the Saccharomyces cerevisiae zinc proteome.
  findings: []
- id: PMID:32492414
  title: Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions.
  findings: []

Gene Description

Existing Annotations Review

References

📄 View Raw YAML