ATP11

UniProt ID: P32453
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for ATP11

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005739 mitochondrion
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0140777 protein-containing complex stabilizing activity
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein-containing complex stabilizing activity is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrial proton-transporting ATP synthase complex assembly is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0065003 protein-containing complex assembly
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: protein-containing complex assembly is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:27107014
An inter-species protein-protein interaction network across ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for ATP11.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005759 mitochondrial matrix
IDA
PMID:1532796
Characterization of ATP11 and detection of the encoded prote... 		ACCEPT
Summary: Manual review: mitochondrial matrix is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly
IMP
PMID:36596815
The mitochondrial Hsp70 controls the assembly of the F(1)F(O... 		ACCEPT
Summary: Manual review: mitochondrial proton-transporting ATP synthase complex assembly is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
HDA
PMID:24769239
Quantitative variations of the mitochondrial proteome and ph... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
HDA
PMID:16823961
Toward the complete yeast mitochondrial proteome: multidimen... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:10681564
The assembly factor Atp11p binds to the beta-subunit of the ... 		MARK AS OVER ANNOTATED
Summary: ATP11 is a dedicated assembly factor for mitochondrial F1-ATPase, not a general chaperone. GO:0051082 overstates the binding as a standalone function.
Reason: ATP11 functions as a dedicated assembly factor for the F1-ATPase beta subunit, not as a general unfolded protein binding chaperone. The binding interaction is specific to Atp2p assembly and is better captured by the assembly process annotation (GO:0033615).
GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly
IPI
PMID:10681564
The assembly factor Atp11p binds to the beta-subunit of the ... 		ACCEPT
Summary: Manual review: mitochondrial proton-transporting ATP synthase complex assembly is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
IDA
PMID:1532796
Characterization of ATP11 and detection of the encoded prote... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0007005 mitochondrion organization
IMP
PMID:2142305
Identification of two nuclear genes (ATP11, ATP12) required ... 		KEEP AS NON CORE
Summary: Manual review: mitochondrion organization may be context-dependent or peripheral for ATP11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly
IMP
PMID:2142305
Identification of two nuclear genes (ATP11, ATP12) required ... 		ACCEPT
Summary: Manual review: mitochondrial proton-transporting ATP synthase complex assembly is consistent with known biology of ATP11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:12829692
A purified subfragment of yeast Atp11p retains full molecula... 		MARK AS OVER ANNOTATED
Summary: ATP11 is a dedicated assembly factor for mitochondrial F1-ATPase, not a general chaperone. GO:0051082 overstates the binding as a standalone function.
Reason: ATP11 functions as a dedicated assembly factor for the F1-ATPase beta subunit, not as a general unfolded protein binding chaperone. The binding interaction is specific to Atp2p assembly and is better captured by the assembly process annotation (GO:0033615).

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10681564
The assembly factor Atp11p binds to the beta-subunit of the mitochondrial F(1)-ATPase.
PMID:12829692
A purified subfragment of yeast Atp11p retains full molecular chaperone activity.
PMID:1532796
Characterization of ATP11 and detection of the encoded protein in mitochondria of Saccharomyces cerevisiae.
PMID:16823961
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
PMID:2142305
Identification of two nuclear genes (ATP11, ATP12) required for assembly of the yeast F1-ATPase.
PMID:24769239
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
PMID:27107014
An inter-species protein-protein interaction network across vast evolutionary distance.
PMID:36596815
The mitochondrial Hsp70 controls the assembly of the F(1)F(O)-ATP synthase.

📄 View Raw YAML

 
id: P32453
gene_symbol: ATP11
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for ATP11'
existing_annotations:
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0140777
    label: protein-containing complex stabilizing activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein-containing complex stabilizing activity is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0033615
    label: mitochondrial proton-transporting ATP synthase complex assembly
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrial proton-transporting ATP synthase complex assembly is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0065003
    label: protein-containing complex assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: protein-containing complex assembly is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107014
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for ATP11.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005759
    label: mitochondrial matrix
  evidence_type: IDA
  original_reference_id: PMID:1532796
  review:
    summary: 'Manual review: mitochondrial matrix is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0033615
    label: mitochondrial proton-transporting ATP synthase complex assembly
  evidence_type: IMP
  original_reference_id: PMID:36596815
  review:
    summary: 'Manual review: mitochondrial proton-transporting ATP synthase complex assembly is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:24769239
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:16823961
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:10681564
  review:
    summary: 'ATP11 is a dedicated assembly factor for mitochondrial F1-ATPase, not a general chaperone. GO:0051082 overstates the binding as a standalone function.'
    action: MARK_AS_OVER_ANNOTATED
    reason: ATP11 functions as a dedicated assembly factor for the F1-ATPase beta subunit, not as a general unfolded protein binding chaperone. The binding interaction is specific to Atp2p assembly and is better captured by the assembly process annotation (GO:0033615).
- term:
    id: GO:0033615
    label: mitochondrial proton-transporting ATP synthase complex assembly
  evidence_type: IPI
  original_reference_id: PMID:10681564
  review:
    summary: 'Manual review: mitochondrial proton-transporting ATP synthase complex assembly is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IDA
  original_reference_id: PMID:1532796
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0007005
    label: mitochondrion organization
  evidence_type: IMP
  original_reference_id: PMID:2142305
  review:
    summary: 'Manual review: mitochondrion organization may be context-dependent or peripheral for ATP11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0033615
    label: mitochondrial proton-transporting ATP synthase complex assembly
  evidence_type: IMP
  original_reference_id: PMID:2142305
  review:
    summary: 'Manual review: mitochondrial proton-transporting ATP synthase complex assembly is consistent with known biology of ATP11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:12829692
  review:
    summary: 'ATP11 is a dedicated assembly factor for mitochondrial F1-ATPase, not a general chaperone. GO:0051082 overstates the binding as a standalone function.'
    action: MARK_AS_OVER_ANNOTATED
    reason: ATP11 functions as a dedicated assembly factor for the F1-ATPase beta subunit, not as a general unfolded protein binding chaperone. The binding interaction is specific to Atp2p assembly and is better captured by the assembly process annotation (GO:0033615).
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10681564
  title: The assembly factor Atp11p binds to the beta-subunit of the mitochondrial F(1)-ATPase.
  findings: []
- id: PMID:12829692
  title: A purified subfragment of yeast Atp11p retains full molecular chaperone activity.
  findings: []
- id: PMID:1532796
  title: Characterization of ATP11 and detection of the encoded protein in mitochondria of Saccharomyces cerevisiae.
  findings: []
- id: PMID:16823961
  title: 'Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.'
  findings: []
- id: PMID:2142305
  title: Identification of two nuclear genes (ATP11, ATP12) required for assembly of the yeast F1-ATPase.
  findings: []
- id: PMID:24769239
  title: Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
  findings: []
- id: PMID:27107014
  title: An inter-species protein-protein interaction network across vast evolutionary distance.
  findings: []
- id: PMID:36596815
  title: The mitochondrial Hsp70 controls the assembly of the F(1)F(O)-ATP synthase.
  findings: []