BTT1

UniProt ID: P40314
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for BTT1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005854 nascent polypeptide-associated complex
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: nascent polypeptide-associated complex is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005634 nucleus
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for BTT1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005854 nascent polypeptide-associated complex
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: nascent polypeptide-associated complex is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006613 cotranslational protein targeting to membrane
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: cotranslational protein targeting to membrane is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0015031 protein transport
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: protein transport is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:11283351
A comprehensive two-hybrid analysis to explore the yeast pro... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for BTT1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16554755
Global landscape of protein complexes in the yeast Saccharom... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for BTT1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for BTT1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0051083 'de novo' cotranslational protein folding
NAS
PMID:26618777
Functional Dissection of the Nascent Polypeptide-Associated ... 		ACCEPT
Summary: Manual review: 'de novo' cotranslational protein folding is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006613 cotranslational protein targeting to membrane
IGI
PMID:10518932
The nascent polypeptide-associated complex (NAC) of yeast fu... 		ACCEPT
Summary: Manual review: cotranslational protein targeting to membrane is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0030015 CCR4-NOT core complex
IPI
PMID:18214544
Genome wide expression analysis of the CCR4-NOT complex indi... 		KEEP AS NON CORE
Summary: Manual review: CCR4-NOT core complex may be context-dependent or peripheral for BTT1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005854 nascent polypeptide-associated complex
IDA
PMID:10219998
Initial characterization of the nascent polypeptide-associat... 		ACCEPT
Summary: Manual review: nascent polypeptide-associated complex is consistent with known biology of BTT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IMP
PMID:10219998
Initial characterization of the nascent polypeptide-associat... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for BTT1.
Reason: Modified to align with current curation guidance and improve term specificity.

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:10219998
Initial characterization of the nascent polypeptide-associated complex in yeast.
PMID:10518932
The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane.
PMID:11283351
A comprehensive two-hybrid analysis to explore the yeast protein interactome.
PMID:16554755
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
PMID:18214544
Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes.
PMID:26618777
Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae.
PMID:37968396
The social and structural architecture of the yeast protein interactome.

📄 View Raw YAML

 
id: P40314
gene_symbol: BTT1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for BTT1'
existing_annotations:
- term:
    id: GO:0005854
    label: nascent polypeptide-associated complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nascent polypeptide-associated complex is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytosol is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for BTT1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005854
    label: nascent polypeptide-associated complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: nascent polypeptide-associated complex is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006613
    label: cotranslational protein targeting to membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: cotranslational protein targeting to membrane is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0015031
    label: protein transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: protein transport is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11283351
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for BTT1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for BTT1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for BTT1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0051083
    label: '''de novo'' cotranslational protein folding'
  evidence_type: NAS
  original_reference_id: PMID:26618777
  review:
    summary: 'Manual review: ''de novo'' cotranslational protein folding is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006613
    label: cotranslational protein targeting to membrane
  evidence_type: IGI
  original_reference_id: PMID:10518932
  review:
    summary: 'Manual review: cotranslational protein targeting to membrane is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0030015
    label: CCR4-NOT core complex
  evidence_type: IPI
  original_reference_id: PMID:18214544
  review:
    summary: 'Manual review: CCR4-NOT core complex may be context-dependent or peripheral for BTT1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005854
    label: nascent polypeptide-associated complex
  evidence_type: IDA
  original_reference_id: PMID:10219998
  review:
    summary: 'Manual review: nascent polypeptide-associated complex is consistent with known biology of BTT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:10219998
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for BTT1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0051083
      label: '''de novo'' cotranslational protein folding'
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: PMID:10219998
  title: Initial characterization of the nascent polypeptide-associated complex in yeast.
  findings: []
- id: PMID:10518932
  title: The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane.
  findings: []
- id: PMID:11283351
  title: A comprehensive two-hybrid analysis to explore the yeast protein interactome.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:18214544
  title: Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes.
  findings: []
- id: PMID:26618777
  title: Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []