CCT6

UniProt ID: P39079
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for CCT6

Existing Annotations Review

GO Term Evidence Action Reason
GO:0006457 protein folding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005832 chaperonin-containing T-complex
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: chaperonin-containing T-complex is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IBA
GO_REF:0000033 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for CCT6.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0000166 nucleotide binding
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: nucleotide binding is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005524 ATP binding
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: ATP binding is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005832 chaperonin-containing T-complex
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: chaperonin-containing T-complex is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016887 ATP hydrolysis activity
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: ATP hydrolysis activity is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IEA
GO_REF:0000120 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for CCT6.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0140662 ATP-dependent protein folding chaperone
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: ATP-dependent protein folding chaperone is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:16554755
Global landscape of protein complexes in the yeast Saccharom... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CCT6.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CCT6.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CCT6.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0006457 protein folding
IDA
PMID:16762366
Quantitative actin folding reactions using yeast CCT purifie... 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005832 chaperonin-containing T-complex
IDA
PMID:16762366
Quantitative actin folding reactions using yeast CCT purifie... 		ACCEPT
Summary: Manual review: chaperonin-containing T-complex is consistent with known biology of CCT6.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:16762366
Quantitative actin folding reactions using yeast CCT purifie... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for CCT6.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:16554755
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
PMID:16762366
Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit.
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.
PMID:37968396
The social and structural architecture of the yeast protein interactome.

📄 View Raw YAML

 
id: P39079
gene_symbol: CCT6
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for CCT6'
existing_annotations:
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005832
    label: chaperonin-containing T-complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: chaperonin-containing T-complex is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for CCT6.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0000166
    label: nucleotide binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: nucleotide binding is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005832
    label: chaperonin-containing T-complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: chaperonin-containing T-complex is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for CCT6.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0140662
    label: ATP-dependent protein folding chaperone
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: ATP-dependent protein folding chaperone is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CCT6.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19536198
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CCT6.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CCT6.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IDA
  original_reference_id: PMID:16762366
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005832
    label: chaperonin-containing T-complex
  evidence_type: IDA
  original_reference_id: PMID:16762366
  review:
    summary: 'Manual review: chaperonin-containing T-complex is consistent with known biology of CCT6.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:16762366
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for CCT6.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:16762366
  title: Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit.
  findings: []
- id: PMID:19536198
  title: 'An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.'
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []