CHS7

UniProt ID: P38843
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for CHS7

Existing Annotations Review

GO Term Evidence Action Reason
GO:0006031 chitin biosynthetic process
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: chitin biosynthetic process is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IBA
GO_REF:0000033 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for CHS7.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0005789 endoplasmic reticulum membrane
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0015031 protein transport
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: protein transport is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0071555 cell wall organization
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: cell wall organization is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:18467557
An in vivo map of the yeast protein interactome. 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CHS7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CHS7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005783 endoplasmic reticulum
HDA
PMID:22842922
Dissecting DNA damage response pathways by analysing protein... 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
HDA
PMID:26928762
One library to make them all: streamlining the creation of y... 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005934 cellular bud tip
HDA
PMID:22842922
Dissecting DNA damage response pathways by analysing protein... 		KEEP AS NON CORE
Summary: Manual review: cellular bud tip may be context-dependent or peripheral for CHS7.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005935 cellular bud neck
HDA
PMID:22842922
Dissecting DNA damage response pathways by analysing protein... 		KEEP AS NON CORE
Summary: Manual review: cellular bud neck may be context-dependent or peripheral for CHS7.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005628 prospore membrane
HDA
PMID:24390141
A visual screen of protein localization during sporulation i... 		KEEP AS NON CORE
Summary: Manual review: prospore membrane may be context-dependent or peripheral for CHS7.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005935 cellular bud neck
IDA
PMID:29405545
The chaperone Chs7 forms a stable complex with Chs3 and prom... 		KEEP AS NON CORE
Summary: Manual review: cellular bud neck may be context-dependent or peripheral for CHS7.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005789 endoplasmic reticulum membrane
IDA
PMID:10366589
Chs7p, a new protein involved in the control of protein expo... 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006031 chitin biosynthetic process
IMP
PMID:10366589
Chs7p, a new protein involved in the control of protein expo... 		ACCEPT
Summary: Manual review: chitin biosynthetic process is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IMP
PMID:15623581
Specialized membrane-localized chaperones prevent aggregatio... 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
IDA
PMID:10366589
Chs7p, a new protein involved in the control of protein expo... 		ACCEPT
Summary: Manual review: endoplasmic reticulum to Golgi vesicle-mediated transport is consistent with known biology of CHS7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IMP
PMID:15623581
Specialized membrane-localized chaperones prevent aggregatio... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for CHS7.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PMID:10366589
Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae.
PMID:15623581
Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER.
PMID:18467557
An in vivo map of the yeast protein interactome.
PMID:22842922
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
PMID:24390141
A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast.
PMID:26928762
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
PMID:29405545
The chaperone Chs7 forms a stable complex with Chs3 and promotes its activity at the cell surface.
PMID:37968396
The social and structural architecture of the yeast protein interactome.

📄 View Raw YAML

 
id: P38843
gene_symbol: CHS7
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for CHS7'
existing_annotations:
- term:
    id: GO:0006031
    label: chitin biosynthetic process
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: chitin biosynthetic process is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for CHS7.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0015031
    label: protein transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: protein transport is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0071555
    label: cell wall organization
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: cell wall organization is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18467557
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CHS7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CHS7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:22842922
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:26928762
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005934
    label: cellular bud tip
  evidence_type: HDA
  original_reference_id: PMID:22842922
  review:
    summary: 'Manual review: cellular bud tip may be context-dependent or peripheral for CHS7.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005935
    label: cellular bud neck
  evidence_type: HDA
  original_reference_id: PMID:22842922
  review:
    summary: 'Manual review: cellular bud neck may be context-dependent or peripheral for CHS7.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005628
    label: prospore membrane
  evidence_type: HDA
  original_reference_id: PMID:24390141
  review:
    summary: 'Manual review: prospore membrane may be context-dependent or peripheral for CHS7.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005935
    label: cellular bud neck
  evidence_type: IDA
  original_reference_id: PMID:29405545
  review:
    summary: 'Manual review: cellular bud neck may be context-dependent or peripheral for CHS7.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IDA
  original_reference_id: PMID:10366589
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006031
    label: chitin biosynthetic process
  evidence_type: IMP
  original_reference_id: PMID:10366589
  review:
    summary: 'Manual review: chitin biosynthetic process is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IMP
  original_reference_id: PMID:15623581
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006888
    label: endoplasmic reticulum to Golgi vesicle-mediated transport
  evidence_type: IDA
  original_reference_id: PMID:10366589
  review:
    summary: 'Manual review: endoplasmic reticulum to Golgi vesicle-mediated transport is consistent with known biology of CHS7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:15623581
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for CHS7.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:10366589
  title: Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae.
  findings: []
- id: PMID:15623581
  title: Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER.
  findings: []
- id: PMID:18467557
  title: An in vivo map of the yeast protein interactome.
  findings: []
- id: PMID:22842922
  title: Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
  findings: []
- id: PMID:24390141
  title: A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast.
  findings: []
- id: PMID:26928762
  title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
  findings: []
- id: PMID:29405545
  title: The chaperone Chs7 forms a stable complex with Chs3 and promotes its activity at the cell surface.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []