CNE1

UniProt ID: P27825
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for CNE1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0006457 protein folding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0036503 ERAD pathway
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: ERAD pathway is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005509 calcium ion binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: calcium ion binding is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005509 calcium ion binding
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: calcium ion binding is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0030246 carbohydrate binding
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: carbohydrate binding is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IEA
GO_REF:0000002 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for CNE1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0036503 ERAD pathway
IMP
PMID:7814381
Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticul... 		ACCEPT
Summary: Manual review: ERAD pathway is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IDA
PMID:7814381
Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticul... 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
HDA
PMID:26928762
One library to make them all: streamlining the creation of y... 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CNE1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0051082 unfolded protein binding
IDA
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for CNE1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0006457 protein folding
IMP
PMID:15173200
Expression and characterization of Saccharomyces cerevisiae ... 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CNE1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IMP
PMID:15173200
Expression and characterization of Saccharomyces cerevisiae ... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for CNE1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PMID:15173200
Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue.
PMID:16002399
Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.
PMID:26928762
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
PMID:7814381
Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus.

📄 View Raw YAML

 
id: P27825
gene_symbol: CNE1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for CNE1'
existing_annotations:
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0036503
    label: ERAD pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: ERAD pathway is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005509
    label: calcium ion binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: calcium ion binding is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005509
    label: calcium ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: calcium ion binding is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0030246
    label: carbohydrate binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: carbohydrate binding is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for CNE1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0036503
    label: ERAD pathway
  evidence_type: IMP
  original_reference_id: PMID:7814381
  review:
    summary: 'Manual review: ERAD pathway is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IDA
  original_reference_id: PMID:7814381
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:26928762
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CNE1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for CNE1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IMP
  original_reference_id: PMID:15173200
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CNE1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:15173200
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for CNE1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:15173200
  title: Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue.
  findings: []
- id: PMID:16002399
  title: Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.
  findings: []
- id: PMID:26928762
  title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
  findings: []
- id: PMID:7814381
  title: Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus.
  findings: []