COX20

UniProt ID: Q04935
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for COX20

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005739 mitochondrion
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of COX20.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0033617 mitochondrial respiratory chain complex IV assembly
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of COX20.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005743 mitochondrial inner membrane
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: mitochondrial inner membrane is consistent with known biology of COX20.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0033617 mitochondrial respiratory chain complex IV assembly
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of COX20.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:10671482
Identification of Cox20p, a novel protein involved in the ma... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for COX20.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0043069 negative regulation of programmed cell death
IDA
PMID:31752220
A Role for COX20 in Tolerance to Oxidative Stress and Progra... 		KEEP AS NON CORE
Summary: Manual review: negative regulation of programmed cell death may be context-dependent or peripheral for COX20.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0043069 negative regulation of programmed cell death
IMP
PMID:31752220
A Role for COX20 in Tolerance to Oxidative Stress and Progra... 		KEEP AS NON CORE
Summary: Manual review: negative regulation of programmed cell death may be context-dependent or peripheral for COX20.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005739 mitochondrion
HDA
PMID:24769239
Quantitative variations of the mitochondrial proteome and ph... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of COX20.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
HDA
PMID:16823961
Toward the complete yeast mitochondrial proteome: multidimen... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of COX20.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005743 mitochondrial inner membrane
IDA
PMID:10671482
Identification of Cox20p, a novel protein involved in the ma... 		ACCEPT
Summary: Manual review: mitochondrial inner membrane is consistent with known biology of COX20.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0033617 mitochondrial respiratory chain complex IV assembly
IMP
PMID:10671482
Identification of Cox20p, a novel protein involved in the ma... 		ACCEPT
Summary: Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of COX20.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:10671482
Identification of Cox20p, a novel protein involved in the ma... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for COX20.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10671482
Identification of Cox20p, a novel protein involved in the maturation and assembly of cytochrome oxidase subunit 2.
PMID:16823961
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
PMID:24769239
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
PMID:31752220
A Role for COX20 in Tolerance to Oxidative Stress and Programmed Cell Death in Saccharomyces cerevisiae.

📄 View Raw YAML

 
id: Q04935
gene_symbol: COX20
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for COX20'
existing_annotations:
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of COX20.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0033617
    label: mitochondrial respiratory chain complex IV assembly
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of COX20.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: mitochondrial inner membrane is consistent with known biology of COX20.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0033617
    label: mitochondrial respiratory chain complex IV assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of COX20.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10671482
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for COX20.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0043069
    label: negative regulation of programmed cell death
  evidence_type: IDA
  original_reference_id: PMID:31752220
  review:
    summary: 'Manual review: negative regulation of programmed cell death may be context-dependent or peripheral for COX20.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0043069
    label: negative regulation of programmed cell death
  evidence_type: IMP
  original_reference_id: PMID:31752220
  review:
    summary: 'Manual review: negative regulation of programmed cell death may be context-dependent or peripheral for COX20.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:24769239
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of COX20.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:16823961
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of COX20.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IDA
  original_reference_id: PMID:10671482
  review:
    summary: 'Manual review: mitochondrial inner membrane is consistent with known biology of COX20.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0033617
    label: mitochondrial respiratory chain complex IV assembly
  evidence_type: IMP
  original_reference_id: PMID:10671482
  review:
    summary: 'Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of COX20.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:10671482
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for COX20.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10671482
  title: Identification of Cox20p, a novel protein involved in the maturation and assembly of cytochrome oxidase subunit 2.
  findings: []
- id: PMID:16823961
  title: 'Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.'
  findings: []
- id: PMID:24769239
  title: Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
  findings: []
- id: PMID:31752220
  title: A Role for COX20 in Tolerance to Oxidative Stress and Programmed Cell Death in Saccharomyces cerevisiae.
  findings: []