CPR7

UniProt ID: P47103
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for CPR7

Existing Annotations Review

GO Term Evidence Action Reason
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: peptidyl-prolyl cis-trans isomerase activity is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016018 cyclosporin A binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: cyclosporin A binding is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: peptidyl-prolyl cis-trans isomerase activity is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016853 isomerase activity
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: isomerase activity is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: protein refolding is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IEA
GO_REF:0000117 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:15766533
Navigating the chaperone network: an integrative map of phys... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16554755
Global landscape of protein complexes in the yeast Saccharom... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:23396352
Integration of the accelerator Aha1 in the Hsp90 co-chaperon... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:8873448
Identification of two CyP-40-like cyclophilins in Saccharomy... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:9819421
CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:9819422
Cns1 is an essential protein associated with the hsp90 chape... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005829 cytosol
IPI
PMID:10942767
Cpr6 and Cpr7, two closely related Hsp90-associated immunoph... 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
IDA
PMID:10942767
Cpr6 and Cpr7, two closely related Hsp90-associated immunoph... 		ACCEPT
Summary: Manual review: peptidyl-prolyl cis-trans isomerase activity is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding
IDA
PMID:10942767
Cpr6 and Cpr7, two closely related Hsp90-associated immunoph... 		ACCEPT
Summary: Manual review: protein refolding is consistent with known biology of CPR7.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:10942767
Cpr6 and Cpr7, two closely related Hsp90-associated immunoph... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for CPR7.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10942767
Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties.
PMID:15766533
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.
PMID:16554755
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.
PMID:23396352
Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle.
PMID:8873448
Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth.
PMID:9819421
CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.
PMID:9819422
Cns1 is an essential protein associated with the hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Delta cells.

📄 View Raw YAML

 
id: P47103
gene_symbol: CPR7
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for CPR7'
existing_annotations:
- term:
    id: GO:0003755
    label: peptidyl-prolyl cis-trans isomerase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: peptidyl-prolyl cis-trans isomerase activity is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016018
    label: cyclosporin A binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cyclosporin A binding is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytosol is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003755
    label: peptidyl-prolyl cis-trans isomerase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: peptidyl-prolyl cis-trans isomerase activity is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: protein folding is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016853
    label: isomerase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: isomerase activity is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15766533
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19536198
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23396352
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8873448
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9819421
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9819422
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IPI
  original_reference_id: PMID:10942767
  review:
    summary: 'Manual review: cytosol is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003755
    label: peptidyl-prolyl cis-trans isomerase activity
  evidence_type: IDA
  original_reference_id: PMID:10942767
  review:
    summary: 'Manual review: peptidyl-prolyl cis-trans isomerase activity is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IDA
  original_reference_id: PMID:10942767
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of CPR7.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:10942767
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for CPR7.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10942767
  title: Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties.
  findings: []
- id: PMID:15766533
  title: 'Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.'
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:19536198
  title: 'An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.'
  findings: []
- id: PMID:23396352
  title: Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle.
  findings: []
- id: PMID:8873448
  title: Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth.
  findings: []
- id: PMID:9819421
  title: CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.
  findings: []
- id: PMID:9819422
  title: Cns1 is an essential protein associated with the hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Delta cells.
  findings: []