EGD2

UniProt ID: P38879
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for EGD2

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006612 protein targeting to membrane
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein targeting to membrane is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IBA
GO_REF:0000033 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for EGD2.
Reason: Modified to align with current curation guidance and improve term specificity.
GO:0005634 nucleus
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for EGD2.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005854 nascent polypeptide-associated complex
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: nascent polypeptide-associated complex is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0015031 protein transport
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: protein transport is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:16429126
Proteome survey reveals modularity of the yeast cell machine... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EGD2.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16554755
Global landscape of protein complexes in the yeast Saccharom... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EGD2.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16926149
The yeast Ccr4-Not complex controls ubiquitination of the na... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EGD2.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:18719252
High-quality binary protein interaction map of the yeast int... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EGD2.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:27107014
An inter-species protein-protein interaction network across ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EGD2.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EGD2.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005737 cytoplasm
IDA
PMID:10219998
Initial characterization of the nascent polypeptide-associat... 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051083 'de novo' cotranslational protein folding
NAS
PMID:26618777
Functional Dissection of the Nascent Polypeptide-Associated ... 		ACCEPT
Summary: Manual review: 'de novo' cotranslational protein folding is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006613 cotranslational protein targeting to membrane
IGI
PMID:10518932
The nascent polypeptide-associated complex (NAC) of yeast fu... 		ACCEPT
Summary: Manual review: cotranslational protein targeting to membrane is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005854 nascent polypeptide-associated complex
IDA
PMID:10219998
Initial characterization of the nascent polypeptide-associat... 		ACCEPT
Summary: Manual review: nascent polypeptide-associated complex is consistent with known biology of EGD2.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0032266 phosphatidylinositol-3-phosphate binding
IDA
PMID:16343487
Identification of novel phospholipid binding proteins in Sac... 		KEEP AS NON CORE
Summary: Manual review: phosphatidylinositol-3-phosphate binding may be context-dependent or peripheral for EGD2.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051082 unfolded protein binding
IMP
PMID:9482879
The yeast nascent polypeptide-associated complex initiates p... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for EGD2.
Reason: Modified to align with current curation guidance and improve term specificity.
GO:0070273 phosphatidylinositol-4-phosphate binding
IDA
PMID:16343487
Identification of novel phospholipid binding proteins in Sac... 		KEEP AS NON CORE
Summary: Manual review: phosphatidylinositol-4-phosphate binding may be context-dependent or peripheral for EGD2.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0070300 phosphatidic acid binding
IDA
PMID:16343487
Identification of novel phospholipid binding proteins in Sac... 		KEEP AS NON CORE
Summary: Manual review: phosphatidic acid binding may be context-dependent or peripheral for EGD2.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
IDA
PMID:16343487
Identification of novel phospholipid binding proteins in Sac... 		KEEP AS NON CORE
Summary: Manual review: phosphatidylinositol-3,5-bisphosphate binding may be context-dependent or peripheral for EGD2.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PMID:10219998
Initial characterization of the nascent polypeptide-associated complex in yeast.
PMID:10518932
The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane.
PMID:16343487
Identification of novel phospholipid binding proteins in Saccharomyces cerevisiae.
PMID:16429126
Proteome survey reveals modularity of the yeast cell machinery.
PMID:16554755
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
PMID:16926149
The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex.
PMID:18719252
High-quality binary protein interaction map of the yeast interactome network.
PMID:26618777
Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae.
PMID:27107014
An inter-species protein-protein interaction network across vast evolutionary distance.
PMID:37968396
The social and structural architecture of the yeast protein interactome.
PMID:9482879
The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo.

📄 View Raw YAML

 
id: P38879
gene_symbol: EGD2
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for EGD2'
existing_annotations:
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006612
    label: protein targeting to membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein targeting to membrane is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for EGD2.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0051083
      label: "'de novo' cotranslational protein folding"
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for EGD2.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005854
    label: nascent polypeptide-associated complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: nascent polypeptide-associated complex is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0015031
    label: protein transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: protein transport is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16429126
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EGD2.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EGD2.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16926149
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EGD2.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18719252
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EGD2.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107014
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EGD2.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EGD2.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:10219998
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051083
    label: '''de novo'' cotranslational protein folding'
  evidence_type: NAS
  original_reference_id: PMID:26618777
  review:
    summary: 'Manual review: ''de novo'' cotranslational protein folding is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006613
    label: cotranslational protein targeting to membrane
  evidence_type: IGI
  original_reference_id: PMID:10518932
  review:
    summary: 'Manual review: cotranslational protein targeting to membrane is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005854
    label: nascent polypeptide-associated complex
  evidence_type: IDA
  original_reference_id: PMID:10219998
  review:
    summary: 'Manual review: nascent polypeptide-associated complex is consistent with known biology of EGD2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0032266
    label: phosphatidylinositol-3-phosphate binding
  evidence_type: IDA
  original_reference_id: PMID:16343487
  review:
    summary: 'Manual review: phosphatidylinositol-3-phosphate binding may be context-dependent or peripheral for EGD2.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:9482879
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for EGD2.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0051083
      label: "'de novo' cotranslational protein folding"
- term:
    id: GO:0070273
    label: phosphatidylinositol-4-phosphate binding
  evidence_type: IDA
  original_reference_id: PMID:16343487
  review:
    summary: 'Manual review: phosphatidylinositol-4-phosphate binding may be context-dependent or peripheral for EGD2.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0070300
    label: phosphatidic acid binding
  evidence_type: IDA
  original_reference_id: PMID:16343487
  review:
    summary: 'Manual review: phosphatidic acid binding may be context-dependent or peripheral for EGD2.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0080025
    label: phosphatidylinositol-3,5-bisphosphate binding
  evidence_type: IDA
  original_reference_id: PMID:16343487
  review:
    summary: 'Manual review: phosphatidylinositol-3,5-bisphosphate binding may be context-dependent or peripheral for EGD2.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:10219998
  title: Initial characterization of the nascent polypeptide-associated complex in yeast.
  findings: []
- id: PMID:10518932
  title: The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane.
  findings: []
- id: PMID:16343487
  title: Identification of novel phospholipid binding proteins in Saccharomyces cerevisiae.
  findings: []
- id: PMID:16429126
  title: Proteome survey reveals modularity of the yeast cell machinery.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:16926149
  title: The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex.
  findings: []
- id: PMID:18719252
  title: High-quality binary protein interaction map of the yeast interactome network.
  findings: []
- id: PMID:26618777
  title: Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae.
  findings: []
- id: PMID:27107014
  title: An inter-species protein-protein interaction network across vast evolutionary distance.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []
- id: PMID:9482879
  title: The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo.
  findings: []