EPS1

UniProt ID: P40557
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for EPS1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0003756 protein disulfide isomerase activity
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003756 protein disulfide isomerase activity
IEA
GO_REF:0000003 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0012505 endomembrane system
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: endomembrane system is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016853 isomerase activity
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: isomerase activity is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0036503 ERAD pathway
IMP
PMID:12881414
Substrate recognition in ER-associated degradation mediated ... 		ACCEPT
Summary: Manual review: ERAD pathway is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EPS1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0019153 protein-disulfide reductase (glutathione) activity
IDA
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		ACCEPT
Summary: Manual review: protein-disulfide reductase (glutathione) activity is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003756 protein disulfide isomerase activity
IMP
PMID:11157982
Functional differences in yeast protein disulfide isomerases... 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IDA
PMID:10545109
Eps1, a novel PDI-related protein involved in ER quality con... 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006621 protein retention in ER lumen
IMP
PMID:10545109
Eps1, a novel PDI-related protein involved in ER quality con... 		ACCEPT
Summary: Manual review: protein retention in ER lumen is consistent with known biology of EPS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for EPS1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.

References

GO_REF:0000003
Gene Ontology annotation based on Enzyme Commission mapping
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:10545109
Eps1, a novel PDI-related protein involved in ER quality control in yeast.
PMID:11157982
Functional differences in yeast protein disulfide isomerases.
PMID:12881414
Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family.
PMID:16002399
Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.

📄 View Raw YAML

 
id: P40557
gene_symbol: EPS1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for EPS1'
existing_annotations:
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000003
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0012505
    label: endomembrane system
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: endomembrane system is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016853
    label: isomerase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: isomerase activity is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0036503
    label: ERAD pathway
  evidence_type: IMP
  original_reference_id: PMID:12881414
  review:
    summary: 'Manual review: ERAD pathway is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EPS1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0019153
    label: protein-disulfide reductase (glutathione) activity
  evidence_type: IDA
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: protein-disulfide reductase (glutathione) activity is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: IMP
  original_reference_id: PMID:11157982
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IDA
  original_reference_id: PMID:10545109
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006621
    label: protein retention in ER lumen
  evidence_type: IMP
  original_reference_id: PMID:10545109
  review:
    summary: 'Manual review: protein retention in ER lumen is consistent with known biology of EPS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for EPS1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000003
  title: Gene Ontology annotation based on Enzyme Commission mapping
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: PMID:10545109
  title: Eps1, a novel PDI-related protein involved in ER quality control in yeast.
  findings: []
- id: PMID:11157982
  title: Functional differences in yeast protein disulfide isomerases.
  findings: []
- id: PMID:12881414
  title: Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family.
  findings: []
- id: PMID:16002399
  title: Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.
  findings: []