EUG1

UniProt ID: P32474
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for EUG1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005783 endoplasmic reticulum
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034976 response to endoplasmic reticulum stress
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: response to endoplasmic reticulum stress is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003756 protein disulfide isomerase activity
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003756 protein disulfide isomerase activity
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005788 endoplasmic reticulum lumen
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum lumen is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0015035 protein-disulfide reductase activity
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: protein-disulfide reductase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016853 isomerase activity
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: isomerase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IEA
GO_REF:0000117 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for EUG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:27107014
An inter-species protein-protein interaction network across ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EUG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005783 endoplasmic reticulum
HDA
PMID:26928762
One library to make them all: streamlining the creation of y... 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
HDA
PMID:11914276
Subcellular localization of the yeast proteome. 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003756 protein disulfide isomerase activity
ISS
PMID:11157982
Functional differences in yeast protein disulfide isomerases... 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0015035 protein-disulfide reductase activity
ISS
PMID:11157982
Functional differences in yeast protein disulfide isomerases... 		ACCEPT
Summary: Manual review: protein-disulfide reductase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for EUG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0019153 protein-disulfide reductase (glutathione) activity
IDA
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		ACCEPT
Summary: Manual review: protein-disulfide reductase (glutathione) activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for EUG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0003756 protein disulfide isomerase activity
IMP
PMID:11157982
Functional differences in yeast protein disulfide isomerases... 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003756 protein disulfide isomerase activity
IGI
PMID:11157982
Functional differences in yeast protein disulfide isomerases... 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003756 protein disulfide isomerase activity
IDA
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		ACCEPT
Summary: Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IGI
PMID:11157982
Functional differences in yeast protein disulfide isomerases... 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0015035 protein-disulfide reductase activity
IGI
PMID:11157982
Functional differences in yeast protein disulfide isomerases... 		ACCEPT
Summary: Manual review: protein-disulfide reductase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0015035 protein-disulfide reductase activity
IDA
PMID:16002399
Interactions among yeast protein-disulfide isomerase protein... 		ACCEPT
Summary: Manual review: protein-disulfide reductase activity is consistent with known biology of EUG1.
Reason: Retained as supported or plausible for this gene and evidence context.

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:11157982
Functional differences in yeast protein disulfide isomerases.
PMID:11914276
Subcellular localization of the yeast proteome.
PMID:16002399
Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.
PMID:26928762
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
PMID:27107014
An inter-species protein-protein interaction network across vast evolutionary distance.

📄 View Raw YAML

 
id: P32474
gene_symbol: EUG1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for EUG1'
existing_annotations:
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034976
    label: response to endoplasmic reticulum stress
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: response to endoplasmic reticulum stress is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005788
    label: endoplasmic reticulum lumen
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum lumen is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: protein folding is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0015035
    label: protein-disulfide reductase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: protein-disulfide reductase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016853
    label: isomerase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: isomerase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for EUG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107014
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EUG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:26928762
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:11914276
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: ISS
  original_reference_id: PMID:11157982
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0015035
    label: protein-disulfide reductase activity
  evidence_type: ISS
  original_reference_id: PMID:11157982
  review:
    summary: 'Manual review: protein-disulfide reductase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for EUG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0019153
    label: protein-disulfide reductase (glutathione) activity
  evidence_type: IDA
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: protein-disulfide reductase (glutathione) activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for EUG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: IMP
  original_reference_id: PMID:11157982
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: IGI
  original_reference_id: PMID:11157982
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003756
    label: protein disulfide isomerase activity
  evidence_type: IDA
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: protein disulfide isomerase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IGI
  original_reference_id: PMID:11157982
  review:
    summary: 'Manual review: protein folding is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0015035
    label: protein-disulfide reductase activity
  evidence_type: IGI
  original_reference_id: PMID:11157982
  review:
    summary: 'Manual review: protein-disulfide reductase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0015035
    label: protein-disulfide reductase activity
  evidence_type: IDA
  original_reference_id: PMID:16002399
  review:
    summary: 'Manual review: protein-disulfide reductase activity is consistent with known biology of EUG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:11157982
  title: Functional differences in yeast protein disulfide isomerases.
  findings: []
- id: PMID:11914276
  title: Subcellular localization of the yeast proteome.
  findings: []
- id: PMID:16002399
  title: Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.
  findings: []
- id: PMID:26928762
  title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
  findings: []
- id: PMID:27107014
  title: An inter-species protein-protein interaction network across vast evolutionary distance.
  findings: []