GET3

UniProt ID: Q12154
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

GET3 encodes an ATPase that is the central targeting factor in the GET (Guided Entry of Tail-anchored proteins) pathway. As a homodimer, Get3p recognizes and binds the transmembrane domain of newly synthesized tail-anchored (TA) membrane proteins in the cytosol, shielding the hydrophobic segment from aqueous solvent. ATP binding drives a closed dimer conformation that facilitates TA substrate capture, and the Get3p-substrate complex is then delivered to the ER membrane via the Get1p/Get2p receptor, where ATP hydrolysis triggers substrate release and membrane insertion. Get3p also cooperates with the HDEL receptor Erd2p in ATP-dependent retrograde retrieval of ER-resident proteins from the Golgi, and functions as a guanine nucleotide exchange factor for Gpa1p in pheromone signaling. Under oxidative stress with ATP depletion, Get3p undergoes a conformational switch to act as a holdase chaperone. Orthologous to human GET3/TRC40.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0043529 GET complex
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: GET complex is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016887 ATP hydrolysis activity
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: ATP hydrolysis activity is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0071816 tail-anchored membrane protein insertion into ER membrane
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: tail-anchored membrane protein insertion into ER membrane is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IEA
GO_REF:0000108 		KEEP AS NON CORE
Summary: Manual review: protein folding may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0000166 nucleotide binding
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: nucleotide binding is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005524 ATP binding
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: ATP binding is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005794 Golgi apparatus
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: Manual review: Golgi apparatus may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016192 vesicle-mediated transport
IEA
GO_REF:0000043 		KEEP AS NON CORE
Summary: Manual review: vesicle-mediated transport may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016787 hydrolase activity
IEA
GO_REF:0000043 		KEEP AS NON CORE
Summary: Manual review: hydrolase activity may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: ATP hydrolysis activity is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0043529 GET complex
IEA
GO_REF:0000104 		ACCEPT
Summary: Manual review: GET complex is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0045048 protein insertion into ER membrane
IEA
GO_REF:0000104 		ACCEPT
Summary: Manual review: protein insertion into ER membrane is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0046685 response to arsenic-containing substance
IEA
GO_REF:0000043 		KEEP AS NON CORE
Summary: Manual review: response to arsenic-containing substance may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0046872 metal ion binding
IEA
GO_REF:0000043 		KEEP AS NON CORE
Summary: Manual review: metal ion binding may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005515 protein binding
IPI
PMID:11283351
A comprehensive two-hybrid analysis to explore the yeast pro... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:11805837
Systematic identification of protein complexes in Saccharomy... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16260785
The yeast Arr4p ATPase binds the chloride transporter Gef1p ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16269340
Exploration of the function and organization of the yeast ea... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16429126
Proteome survey reveals modularity of the yeast cell machine... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16554755
Global landscape of protein complexes in the yeast Saccharom... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16816426
The conserved ATPase Get3/Arr4 modulates the activity of mem... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:18467557
An in vivo map of the yeast protein interactome. 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:18719252
High-quality binary protein interaction map of the yeast int... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:18724936
The GET complex mediates insertion of tail-anchored proteins... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:19675567
The structural basis of tail-anchored membrane protein recog... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:20106980
Crystal structure of Get4-Get5 complex and its interactions ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:20850366
A chaperone cascade sorts proteins for posttranslational mem... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:21866104
The mechanism of membrane-associated steps in tail-anchored ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:24727835
Crystal structure of ATP-bound Get3-Get4-Get5 complex reveal... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:25745174
Protein targeting. Structure of the Get3 targeting factor in... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:27107014
An inter-species protein-protein interaction network across ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:16260785
The yeast Arr4p ATPase binds the chloride transporter Gef1p ... 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:19675567
The structural basis of tail-anchored membrane protein recog... 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:19706470
Model for eukaryotic tail-anchored protein binding based on ... 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:22124326
Tail-anchor targeting by a Get3 tetramer: the structure of a... 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:24727835
Crystal structure of ATP-bound Get3-Get4-Get5 complex reveal... 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:25745174
Protein targeting. Structure of the Get3 targeting factor in... 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005789 endoplasmic reticulum membrane
NAS
PMID:32910895
Structural Basis of Tail-Anchored Membrane Protein Biogenesi... 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0045048 protein insertion into ER membrane
IDA
PMID:21866104
The mechanism of membrane-associated steps in tail-anchored ... 		ACCEPT
Summary: Manual review: protein insertion into ER membrane is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016887 ATP hydrolysis activity
TAS
Reactome:R-SCE-9628646 		ACCEPT
Summary: Manual review: ATP hydrolysis activity is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0071816 tail-anchored membrane protein insertion into ER membrane
IMP
PMID:18724936
The GET complex mediates insertion of tail-anchored proteins... 		ACCEPT
Summary: Manual review: tail-anchored membrane protein insertion into ER membrane is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008270 zinc ion binding
RCA
PMID:30358795
The cellular economy of the Saccharomyces cerevisiae zinc pr... 		KEEP AS NON CORE
Summary: Manual review: zinc ion binding may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0044183 protein folding chaperone
IDA
PMID:25242142
The protein targeting factor Get3 functions as ATP-independe... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein folding chaperone is too generic or over-extended for GET3.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0043529 GET complex
IDA
PMID:32910895
Structural Basis of Tail-Anchored Membrane Protein Biogenesi... 		ACCEPT
Summary: Manual review: GET complex is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
HDA
PMID:26928762
One library to make them all: streamlining the creation of y... 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
HDA
PMID:14562095
Global analysis of protein localization in budding yeast. 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
TAS
Reactome:R-SCE-9628640 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
TAS
Reactome:R-SCE-9628646 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
TAS
Reactome:R-SCE-9629050 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034599 cellular response to oxidative stress
IDA
PMID:25242142
The protein targeting factor Get3 functions as ATP-independe... 		KEEP AS NON CORE
Summary: Manual review: cellular response to oxidative stress may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051082 unfolded protein binding
IDA
PMID:25242142
The protein targeting factor Get3 functions as ATP-independe... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for GET3.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein carrier chaperone
GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion
IMP
PMID:18261907
Coactivation of G protein signaling by cell-surface receptor... 		KEEP AS NON CORE
Summary: Manual review: pheromone-dependent signal transduction involved in conjugation with cellular fusion may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005085 guanyl-nucleotide exchange factor activity
IDA
PMID:18261907
Coactivation of G protein signaling by cell-surface receptor... 		KEEP AS NON CORE
Summary: Manual review: guanyl-nucleotide exchange factor activity may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
IDA
PMID:20850366
A chaperone cascade sorts proteins for posttranslational mem... 		ACCEPT
Summary: Manual review: post-translational protein targeting to endoplasmic reticulum membrane is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
IDA
PMID:16269340
Exploration of the function and organization of the yeast ea... 		KEEP AS NON CORE
Summary: Manual review: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
IMP
PMID:16269340
Exploration of the function and organization of the yeast ea... 		KEEP AS NON CORE
Summary: Manual review: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
IGI
PMID:16269340
Exploration of the function and organization of the yeast ea... 		KEEP AS NON CORE
Summary: Manual review: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0009408 response to heat
IMP
PMID:12680698
The Saccharomyces cerevisiae Arr4p is involved in metal and ... 		KEEP AS NON CORE
Summary: Manual review: response to heat may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0010038 response to metal ion
IMP
PMID:12680698
The Saccharomyces cerevisiae Arr4p is involved in metal and ... 		KEEP AS NON CORE
Summary: Manual review: response to metal ion may be context-dependent or peripheral for GET3.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity
IDA
PMID:12680698
The Saccharomyces cerevisiae Arr4p is involved in metal and ... 		ACCEPT
Summary: Manual review: ATP hydrolysis activity is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0043529 GET complex
IPI
PMID:16269340
Exploration of the function and organization of the yeast ea... 		ACCEPT
Summary: Manual review: GET complex is consistent with known biology of GET3.
Reason: Retained as supported or plausible for this gene and evidence context.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000104
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
GO_REF:0000108
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:11283351
A comprehensive two-hybrid analysis to explore the yeast protein interactome.
PMID:11805837
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
PMID:12680698
The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance.
PMID:14562095
Global analysis of protein localization in budding yeast.
PMID:16260785
The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol.
PMID:16269340
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.
PMID:16429126
Proteome survey reveals modularity of the yeast cell machinery.
PMID:16554755
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
PMID:16816426
The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.
PMID:18261907
Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor.
PMID:18467557
An in vivo map of the yeast protein interactome.
PMID:18719252
High-quality binary protein interaction map of the yeast interactome network.
PMID:18724936
The GET complex mediates insertion of tail-anchored proteins into the ER membrane.
PMID:19675567
The structural basis of tail-anchored membrane protein recognition by Get3.
PMID:19706470
Model for eukaryotic tail-anchored protein binding based on the structure of Get3.
PMID:20106980
Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1.
PMID:20850366
A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.
PMID:21866104
The mechanism of membrane-associated steps in tail-anchored protein insertion.
PMID:22124326
Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue.
PMID:24727835
Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.
PMID:25242142
The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions.
PMID:25745174
Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
PMID:26928762
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
PMID:27107014
An inter-species protein-protein interaction network across vast evolutionary distance.
PMID:30358795
The cellular economy of the Saccharomyces cerevisiae zinc proteome.
PMID:32910895
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.
PMID:37968396
The social and structural architecture of the yeast protein interactome.
Reactome:R-SCE-9628640
SBH1:GET3:ADP:GET1:GET2 dissociates yielding SBH1 in the endoplasmic reticulum membrane
Reactome:R-SCE-9628646
SBH1:GET3:ADP binds GET1:GET2
Reactome:R-SCE-9629050
SBH1:GET3:ATP:GET4:MDY2:SGT2 dissociates and GET3 hydrolyzes ATP yielding SBH1:GET3:ADP

📄 View Raw YAML

 
id: Q12154
gene_symbol: GET3
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: >-
  GET3 encodes an ATPase that is the central targeting factor in the GET
  (Guided Entry of Tail-anchored proteins) pathway. As a homodimer, Get3p
  recognizes and binds the transmembrane domain of newly synthesized
  tail-anchored (TA) membrane proteins in the cytosol, shielding the
  hydrophobic segment from aqueous solvent. ATP binding drives a closed dimer
  conformation that facilitates TA substrate capture, and the Get3p-substrate
  complex is then delivered to the ER membrane via the Get1p/Get2p receptor,
  where ATP hydrolysis triggers substrate release and membrane insertion. Get3p
  also cooperates with the HDEL receptor Erd2p in ATP-dependent retrograde
  retrieval of ER-resident proteins from the Golgi, and functions as a
  guanine nucleotide exchange factor for Gpa1p in pheromone signaling. Under
  oxidative stress with ATP depletion, Get3p undergoes a conformational switch
  to act as a holdase chaperone. Orthologous to human GET3/TRC40.
existing_annotations:
- term:
    id: GO:0043529
    label: GET complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: GET complex is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0071816
    label: tail-anchored membrane protein insertion into ER membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: tail-anchored membrane protein insertion into ER membrane is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  review:
    summary: 'Manual review: protein folding may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0000166
    label: nucleotide binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: nucleotide binding is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: Golgi apparatus may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016192
    label: vesicle-mediated transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: vesicle-mediated transport may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016787
    label: hydrolase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: hydrolase activity may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0043529
    label: GET complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000104
  review:
    summary: 'Manual review: GET complex is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0045048
    label: protein insertion into ER membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000104
  review:
    summary: 'Manual review: protein insertion into ER membrane is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0046685
    label: response to arsenic-containing substance
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: response to arsenic-containing substance may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0046872
    label: metal ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: metal ion binding may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11283351
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11805837
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16260785
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16269340
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16429126
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16816426
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18467557
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18719252
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18724936
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19675567
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20106980
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20850366
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21866104
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24727835
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25745174
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107014
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:16260785
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:19675567
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:19706470
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:22124326
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:24727835
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:25745174
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: NAS
  original_reference_id: PMID:32910895
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0045048
    label: protein insertion into ER membrane
  evidence_type: IDA
  original_reference_id: PMID:21866104
  review:
    summary: 'Manual review: protein insertion into ER membrane is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: TAS
  original_reference_id: Reactome:R-SCE-9628646
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0071816
    label: tail-anchored membrane protein insertion into ER membrane
  evidence_type: IMP
  original_reference_id: PMID:18724936
  review:
    summary: 'Manual review: tail-anchored membrane protein insertion into ER membrane is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008270
    label: zinc ion binding
  evidence_type: RCA
  original_reference_id: PMID:30358795
  review:
    summary: 'Manual review: zinc ion binding may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0044183
    label: protein folding chaperone
  evidence_type: IDA
  original_reference_id: PMID:25242142
  review:
    summary: 'Manual review: protein folding chaperone is too generic or over-extended for GET3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0043529
    label: GET complex
  evidence_type: IDA
  original_reference_id: PMID:32910895
  review:
    summary: 'Manual review: GET complex is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: HDA
  original_reference_id: PMID:26928762
  review:
    summary: 'Manual review: cytosol is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:14562095
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-SCE-9628640
  review:
    summary: 'Manual review: cytosol is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-SCE-9628646
  review:
    summary: 'Manual review: cytosol is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-SCE-9629050
  review:
    summary: 'Manual review: cytosol is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034599
    label: cellular response to oxidative stress
  evidence_type: IDA
  original_reference_id: PMID:25242142
  review:
    summary: 'Manual review: cellular response to oxidative stress may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:25242142
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for GET3.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0140597
      label: protein carrier chaperone
- term:
    id: GO:0000750
    label: pheromone-dependent signal transduction involved in conjugation with cellular fusion
  evidence_type: IMP
  original_reference_id: PMID:18261907
  review:
    summary: 'Manual review: pheromone-dependent signal transduction involved in conjugation with cellular fusion may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005085
    label: guanyl-nucleotide exchange factor activity
  evidence_type: IDA
  original_reference_id: PMID:18261907
  review:
    summary: 'Manual review: guanyl-nucleotide exchange factor activity may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006620
    label: post-translational protein targeting to endoplasmic reticulum membrane
  evidence_type: IDA
  original_reference_id: PMID:20850366
  review:
    summary: 'Manual review: post-translational protein targeting to endoplasmic reticulum membrane is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006890
    label: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  evidence_type: IDA
  original_reference_id: PMID:16269340
  review:
    summary: 'Manual review: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006890
    label: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  evidence_type: IMP
  original_reference_id: PMID:16269340
  review:
    summary: 'Manual review: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006890
    label: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  evidence_type: IGI
  original_reference_id: PMID:16269340
  review:
    summary: 'Manual review: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0009408
    label: response to heat
  evidence_type: IMP
  original_reference_id: PMID:12680698
  review:
    summary: 'Manual review: response to heat may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0010038
    label: response to metal ion
  evidence_type: IMP
  original_reference_id: PMID:12680698
  review:
    summary: 'Manual review: response to metal ion may be context-dependent or peripheral for GET3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IDA
  original_reference_id: PMID:12680698
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0043529
    label: GET complex
  evidence_type: IPI
  original_reference_id: PMID:16269340
  review:
    summary: 'Manual review: GET complex is consistent with known biology of GET3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000104
  title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
  findings: []
- id: GO_REF:0000108
  title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:11283351
  title: A comprehensive two-hybrid analysis to explore the yeast protein interactome.
  findings: []
- id: PMID:11805837
  title: Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
  findings: []
- id: PMID:12680698
  title: The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance.
  findings: []
- id: PMID:14562095
  title: Global analysis of protein localization in budding yeast.
  findings: []
- id: PMID:16260785
  title: The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol.
  findings: []
- id: PMID:16269340
  title: Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.
  findings: []
- id: PMID:16429126
  title: Proteome survey reveals modularity of the yeast cell machinery.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:16816426
  title: The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.
  findings: []
- id: PMID:18261907
  title: Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor.
  findings: []
- id: PMID:18467557
  title: An in vivo map of the yeast protein interactome.
  findings: []
- id: PMID:18719252
  title: High-quality binary protein interaction map of the yeast interactome network.
  findings: []
- id: PMID:18724936
  title: The GET complex mediates insertion of tail-anchored proteins into the ER membrane.
  findings: []
- id: PMID:19675567
  title: The structural basis of tail-anchored membrane protein recognition by Get3.
  findings: []
- id: PMID:19706470
  title: Model for eukaryotic tail-anchored protein binding based on the structure of Get3.
  findings: []
- id: PMID:20106980
  title: Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1.
  findings: []
- id: PMID:20850366
  title: A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.
  findings: []
- id: PMID:21866104
  title: The mechanism of membrane-associated steps in tail-anchored protein insertion.
  findings: []
- id: PMID:22124326
  title: 'Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue.'
  findings: []
- id: PMID:24727835
  title: Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.
  findings: []
- id: PMID:25242142
  title: The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions.
  findings: []
- id: PMID:25745174
  title: Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
  findings: []
- id: PMID:26928762
  title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
  findings: []
- id: PMID:27107014
  title: An inter-species protein-protein interaction network across vast evolutionary distance.
  findings: []
- id: PMID:30358795
  title: The cellular economy of the Saccharomyces cerevisiae zinc proteome.
  findings: []
- id: PMID:32910895
  title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []
- id: Reactome:R-SCE-9628640
  title: SBH1:GET3:ADP:GET1:GET2 dissociates yielding SBH1 in the endoplasmic reticulum membrane
  findings: []
- id: Reactome:R-SCE-9628646
  title: SBH1:GET3:ADP binds GET1:GET2
  findings: []
- id: Reactome:R-SCE-9629050
  title: SBH1:GET3:ATP:GET4:MDY2:SGT2 dissociates and GET3 hydrolyzes ATP yielding SBH1:GET3:ADP
  findings: []