GSF2

id: Q04697
gene_symbol: GSF2
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for GSF2'
existing_annotations:
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of GSF2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IDA
  original_reference_id: PMID:10377429
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of GSF2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:26928762
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of GSF2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: HDA
  original_reference_id: PMID:11914276
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of GSF2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005741
    label: mitochondrial outer membrane
  evidence_type: HDA
  original_reference_id: PMID:16407407
  review:
    summary: 'Manual review: mitochondrial outer membrane is consistent with known biology of GSF2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IMP
  original_reference_id: PMID:15623581
  review:
    summary: 'Manual review: protein folding is consistent with known biology of GSF2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034394
    label: protein localization to cell surface
  evidence_type: IMP
  original_reference_id: PMID:10377429
  review:
    summary: 'Manual review: protein localization to cell surface is consistent with known biology of GSF2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034394
    label: protein localization to cell surface
  evidence_type: IGI
  original_reference_id: PMID:10377429
  review:
    summary: 'Manual review: protein localization to cell surface is consistent with known biology of GSF2.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:15623581
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for GSF2.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
references:
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:10377429
  title: Efficient export of the glucose transporter Hxt1p from the endoplasmic reticulum requires Gsf2p.
  findings: []
- id: PMID:11914276
  title: Subcellular localization of the yeast proteome.
  findings: []
- id: PMID:15623581
  title: Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER.
  findings: []
- id: PMID:16407407
  title: Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.
  findings: []
- id: PMID:26928762
  title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
  findings: []