HSP10

UniProt ID: P38910
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for HSP10

Existing Annotations Review

GO Term Evidence Action Reason
GO:0006457 protein folding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005759 mitochondrial matrix
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrial matrix is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051087 protein-folding chaperone binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein-folding chaperone binding is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0046872 metal ion binding
IBA
GO_REF:0000033 		KEEP AS NON CORE
Summary: Manual review: metal ion binding may be context-dependent or peripheral for HSP10.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051082 unfolded protein binding
IBA
GO_REF:0000033 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for HSP10.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005524 ATP binding
IEA
GO_REF:0000002 		KEEP AS NON CORE
Summary: Manual review: ATP binding may be context-dependent or peripheral for HSP10.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005739 mitochondrion
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005759 mitochondrial matrix
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: mitochondrial matrix is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0044183 protein folding chaperone
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: protein folding chaperone is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
HDA
PMID:24769239
Quantitative variations of the mitochondrial proteome and ph... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
HDA
PMID:16823961
Toward the complete yeast mitochondrial proteome: multidimen... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0045041 protein import into mitochondrial intermembrane space
IMP
PMID:7913473
Role of the chaperonin cofactor Hsp10 in protein folding and... 		ACCEPT
Summary: Manual review: protein import into mitochondrial intermembrane space is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051131 chaperone-mediated protein complex assembly
IMP
PMID:7913473
Role of the chaperonin cofactor Hsp10 in protein folding and... 		ACCEPT
Summary: Manual review: chaperone-mediated protein complex assembly is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005759 mitochondrial matrix
IDA
PMID:7903252
Cloning and disruption of the gene encoding yeast mitochondr... 		ACCEPT
Summary: Manual review: mitochondrial matrix is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IDA
PMID:7902576
Identification and functional analysis of chaperonin 10, the... 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding
IDA
PMID:9256426
Significance of chaperonin 10-mediated inhibition of ATP hyd... 		ACCEPT
Summary: Manual review: protein refolding is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding
IMP
PMID:9256426
Significance of chaperonin 10-mediated inhibition of ATP hyd... 		ACCEPT
Summary: Manual review: protein refolding is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:7902576
Identification and functional analysis of chaperonin 10, the... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for HSP10.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0051087 protein-folding chaperone binding
IPI
PMID:9256426
Significance of chaperonin 10-mediated inhibition of ATP hyd... 		ACCEPT
Summary: Manual review: protein-folding chaperone binding is consistent with known biology of HSP10.
Reason: Retained as supported or plausible for this gene and evidence context.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:16823961
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
PMID:24769239
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
PMID:7902576
Identification and functional analysis of chaperonin 10, the groES homolog from yeast mitochondria.
PMID:7903252
Cloning and disruption of the gene encoding yeast mitochondrial chaperonin 10, the homolog of E. coli groES.
PMID:7913473
Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria.
PMID:9256426
Significance of chaperonin 10-mediated inhibition of ATP hydrolysis by chaperonin 60.

📄 View Raw YAML

 
id: P38910
gene_symbol: HSP10
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for HSP10'
existing_annotations:
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005759
    label: mitochondrial matrix
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrial matrix is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051087
    label: protein-folding chaperone binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein-folding chaperone binding is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0046872
    label: metal ion binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: metal ion binding may be context-dependent or peripheral for HSP10.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for HSP10.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: ATP binding may be context-dependent or peripheral for HSP10.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005759
    label: mitochondrial matrix
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: mitochondrial matrix is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: protein folding is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0044183
    label: protein folding chaperone
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: protein folding chaperone is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:24769239
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:16823961
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0045041
    label: protein import into mitochondrial intermembrane space
  evidence_type: IMP
  original_reference_id: PMID:7913473
  review:
    summary: 'Manual review: protein import into mitochondrial intermembrane space is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051131
    label: chaperone-mediated protein complex assembly
  evidence_type: IMP
  original_reference_id: PMID:7913473
  review:
    summary: 'Manual review: chaperone-mediated protein complex assembly is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005759
    label: mitochondrial matrix
  evidence_type: IDA
  original_reference_id: PMID:7903252
  review:
    summary: 'Manual review: mitochondrial matrix is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IDA
  original_reference_id: PMID:7902576
  review:
    summary: 'Manual review: protein folding is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IDA
  original_reference_id: PMID:9256426
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IMP
  original_reference_id: PMID:9256426
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:7902576
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for HSP10.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0051087
    label: protein-folding chaperone binding
  evidence_type: IPI
  original_reference_id: PMID:9256426
  review:
    summary: 'Manual review: protein-folding chaperone binding is consistent with known biology of HSP10.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: PMID:16823961
  title: 'Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.'
  findings: []
- id: PMID:24769239
  title: Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
  findings: []
- id: PMID:7902576
  title: Identification and functional analysis of chaperonin 10, the groES homolog from yeast mitochondria.
  findings: []
- id: PMID:7903252
  title: Cloning and disruption of the gene encoding yeast mitochondrial chaperonin 10, the homolog of E. coli groES.
  findings: []
- id: PMID:7913473
  title: Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria.
  findings: []
- id: PMID:9256426
  title: Significance of chaperonin 10-mediated inhibition of ATP hydrolysis by chaperonin 60.
  findings: []