LHS1

UniProt ID: P36016
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for LHS1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0000774 adenyl-nucleotide exchange factor activity
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: adenyl-nucleotide exchange factor activity is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034663 endoplasmic reticulum chaperone complex
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: endoplasmic reticulum chaperone complex is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000166 nucleotide binding
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: nucleotide binding is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005524 ATP binding
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: ATP binding is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005788 endoplasmic reticulum lumen
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum lumen is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016787 hydrolase activity
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: hydrolase activity is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016887 ATP hydrolysis activity
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: ATP hydrolysis activity is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for LHS1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:23217712
CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abund... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for LHS1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005783 endoplasmic reticulum
HDA
PMID:26928762
One library to make them all: streamlining the creation of y... 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000774 adenyl-nucleotide exchange factor activity
IDA
PMID:14704430
Coordinated activation of Hsp70 chaperones. 		ACCEPT
Summary: Manual review: adenyl-nucleotide exchange factor activity is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005524 ATP binding
IDA
PMID:19759005
Nucleotide binding by Lhs1p is essential for its nucleotide ... 		ACCEPT
Summary: Manual review: ATP binding is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005524 ATP binding
IMP
PMID:19759005
Nucleotide binding by Lhs1p is essential for its nucleotide ... 		ACCEPT
Summary: Manual review: ATP binding is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005788 endoplasmic reticulum lumen
IDA
PMID:8654361
A novel Hsp70 of the yeast ER lumen is required for the effi... 		ACCEPT
Summary: Manual review: endoplasmic reticulum lumen is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005788 endoplasmic reticulum lumen
IDA
PMID:8887673
SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae e... 		ACCEPT
Summary: Manual review: endoplasmic reticulum lumen is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006986 response to unfolded protein
IMP
PMID:8654361
A novel Hsp70 of the yeast ER lumen is required for the effi... 		ACCEPT
Summary: Manual review: response to unfolded protein is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006986 response to unfolded protein
IMP
PMID:8887673
SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae e... 		ACCEPT
Summary: Manual review: response to unfolded protein is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0031204 post-translational protein targeting to membrane, translocation
IMP
PMID:8654361
A novel Hsp70 of the yeast ER lumen is required for the effi... 		ACCEPT
Summary: Manual review: post-translational protein targeting to membrane, translocation is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0031204 post-translational protein targeting to membrane, translocation
IMP
PMID:8887673
SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae e... 		ACCEPT
Summary: Manual review: post-translational protein targeting to membrane, translocation is consistent with known biology of LHS1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IMP
PMID:10409721
Cer1p functions as a molecular chaperone in the endoplasmic ... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for LHS1.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0051082 unfolded protein binding
IMP
PMID:8654361
A novel Hsp70 of the yeast ER lumen is required for the effi... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for LHS1.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0051082 unfolded protein binding
IMP
PMID:8887673
SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae e... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for LHS1.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10409721
Cer1p functions as a molecular chaperone in the endoplasmic reticulum of Saccharomyces cerevisiae.
PMID:14704430
Coordinated activation of Hsp70 chaperones.
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.
PMID:19759005
Nucleotide binding by Lhs1p is essential for its nucleotide exchange activity and for function in vivo.
PMID:23217712
CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.
PMID:26928762
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
PMID:8654361
A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors.
PMID:8887673
SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae endoplasmic reticulum.

📄 View Raw YAML

 
id: P36016
gene_symbol: LHS1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for LHS1'
existing_annotations:
- term:
    id: GO:0000774
    label: adenyl-nucleotide exchange factor activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: adenyl-nucleotide exchange factor activity is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034663
    label: endoplasmic reticulum chaperone complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: endoplasmic reticulum chaperone complex is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000166
    label: nucleotide binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: nucleotide binding is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005788
    label: endoplasmic reticulum lumen
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum lumen is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016787
    label: hydrolase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: hydrolase activity is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19536198
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for LHS1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23217712
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for LHS1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:26928762
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000774
    label: adenyl-nucleotide exchange factor activity
  evidence_type: IDA
  original_reference_id: PMID:14704430
  review:
    summary: 'Manual review: adenyl-nucleotide exchange factor activity is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IDA
  original_reference_id: PMID:19759005
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IMP
  original_reference_id: PMID:19759005
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005788
    label: endoplasmic reticulum lumen
  evidence_type: IDA
  original_reference_id: PMID:8654361
  review:
    summary: 'Manual review: endoplasmic reticulum lumen is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005788
    label: endoplasmic reticulum lumen
  evidence_type: IDA
  original_reference_id: PMID:8887673
  review:
    summary: 'Manual review: endoplasmic reticulum lumen is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006986
    label: response to unfolded protein
  evidence_type: IMP
  original_reference_id: PMID:8654361
  review:
    summary: 'Manual review: response to unfolded protein is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006986
    label: response to unfolded protein
  evidence_type: IMP
  original_reference_id: PMID:8887673
  review:
    summary: 'Manual review: response to unfolded protein is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0031204
    label: post-translational protein targeting to membrane, translocation
  evidence_type: IMP
  original_reference_id: PMID:8654361
  review:
    summary: 'Manual review: post-translational protein targeting to membrane, translocation is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0031204
    label: post-translational protein targeting to membrane, translocation
  evidence_type: IMP
  original_reference_id: PMID:8887673
  review:
    summary: 'Manual review: post-translational protein targeting to membrane, translocation is consistent with known biology of LHS1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:10409721
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for LHS1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:8654361
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for LHS1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:8887673
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for LHS1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10409721
  title: Cer1p functions as a molecular chaperone in the endoplasmic reticulum of Saccharomyces cerevisiae.
  findings: []
- id: PMID:14704430
  title: Coordinated activation of Hsp70 chaperones.
  findings: []
- id: PMID:19536198
  title: 'An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.'
  findings: []
- id: PMID:19759005
  title: Nucleotide binding by Lhs1p is essential for its nucleotide exchange activity and for function in vivo.
  findings: []
- id: PMID:23217712
  title: CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.
  findings: []
- id: PMID:26928762
  title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
  findings: []
- id: PMID:8654361
  title: A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors.
  findings: []
- id: PMID:8887673
  title: SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae endoplasmic reticulum.
  findings: []