MDJ1

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005737 cytoplasm	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: cytoplasm may be context-dependent or peripheral for MDJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0042026 protein refolding	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: protein refolding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IBA GO_REF:0000033	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for MDJ1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0005524 ATP binding	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: ATP binding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Manual review: mitochondrion may be context-dependent or peripheral for MDJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006457 protein folding	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008270 zinc ion binding	IEA GO_REF:0000043	ACCEPT	Summary: Manual review: zinc ion binding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0009408 response to heat	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: response to heat is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0031072 heat shock protein binding	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: heat shock protein binding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0046872 metal ion binding	IEA GO_REF:0000043	ACCEPT	Summary: Manual review: metal ion binding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IEA GO_REF:0000002	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for MDJ1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0005515 protein binding	IPI PMID:16554755 Global landscape of protein complexes in the yeast Saccharom...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for MDJ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:19536198 An atlas of chaperone-protein interactions in Saccharomyces ...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for MDJ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:27107014 An inter-species protein-protein interaction network across ...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for MDJ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0008270 zinc ion binding	RCA PMID:30358795 The cellular economy of the Saccharomyces cerevisiae zinc pr...	ACCEPT	Summary: Manual review: zinc ion binding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion	HDA PMID:24769239 Quantitative variations of the mitochondrial proteome and ph...	KEEP AS NON CORE	Summary: Manual review: mitochondrion may be context-dependent or peripheral for MDJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005739 mitochondrion	HDA PMID:16823961 Toward the complete yeast mitochondrial proteome: multidimen...	KEEP AS NON CORE	Summary: Manual review: mitochondrion may be context-dependent or peripheral for MDJ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0001671 ATPase activator activity	IDA PMID:9973563 Two distinct mechanisms operate in the reactivation of heat-...	ACCEPT	Summary: Manual review: ATPase activator activity is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005759 mitochondrial matrix	IDA PMID:15383543 Zim17, a novel zinc finger protein essential for protein imp...	ACCEPT	Summary: Manual review: mitochondrial matrix is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006458 'de novo' protein folding	IMP PMID:8168133 Mdj1p, a novel chaperone of the DnaJ family, is involved in ...	ACCEPT	Summary: Manual review: 'de novo' protein folding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins	IMP PMID:7957078 Molecular chaperones cooperate with PIM1 protease in the deg...	ACCEPT	Summary: Manual review: protein quality control for misfolded or incompletely synthesized proteins is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0009408 response to heat	IMP PMID:8603724 Role of the mitochondrial DnaJ homologue, Mdj1p, in the prev...	ACCEPT	Summary: Manual review: response to heat is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding	IMP PMID:8168133 Mdj1p, a novel chaperone of the DnaJ family, is involved in ...	ACCEPT	Summary: Manual review: protein refolding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding	IDA PMID:9973563 Two distinct mechanisms operate in the reactivation of heat-...	ACCEPT	Summary: Manual review: protein refolding is consistent with known biology of MDJ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IMP PMID:8943361 Role of the mitochondrial DnaJ homolog Mdj1p as a chaperone ...	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for MDJ1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone

📄 View Raw YAML

id: P35191
gene_symbol: MDJ1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for MDJ1'
existing_annotations:
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for MDJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for MDJ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: mitochondrion may be context-dependent or peripheral for MDJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: protein folding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008270
    label: zinc ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: zinc ion binding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0009408
    label: response to heat
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: response to heat is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0031072
    label: heat shock protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: heat shock protein binding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0046872
    label: metal ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: metal ion binding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for MDJ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for MDJ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19536198
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for MDJ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107014
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for MDJ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0008270
    label: zinc ion binding
  evidence_type: RCA
  original_reference_id: PMID:30358795
  review:
    summary: 'Manual review: zinc ion binding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:24769239
  review:
    summary: 'Manual review: mitochondrion may be context-dependent or peripheral for MDJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:16823961
  review:
    summary: 'Manual review: mitochondrion may be context-dependent or peripheral for MDJ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0001671
    label: ATPase activator activity
  evidence_type: IDA
  original_reference_id: PMID:9973563
  review:
    summary: 'Manual review: ATPase activator activity is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005759
    label: mitochondrial matrix
  evidence_type: IDA
  original_reference_id: PMID:15383543
  review:
    summary: 'Manual review: mitochondrial matrix is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006458
    label: '''de novo'' protein folding'
  evidence_type: IMP
  original_reference_id: PMID:8168133
  review:
    summary: 'Manual review: ''de novo'' protein folding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006515
    label: protein quality control for misfolded or incompletely synthesized proteins
  evidence_type: IMP
  original_reference_id: PMID:7957078
  review:
    summary: 'Manual review: protein quality control for misfolded or incompletely synthesized proteins is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0009408
    label: response to heat
  evidence_type: IMP
  original_reference_id: PMID:8603724
  review:
    summary: 'Manual review: response to heat is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IMP
  original_reference_id: PMID:8168133
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IDA
  original_reference_id: PMID:9973563
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of MDJ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:8943361
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for MDJ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:15383543
  title: Zim17, a novel zinc finger protein essential for protein import into mitochondria.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:16823961
  title: 'Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.'
  findings: []
- id: PMID:19536198
  title: 'An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.'
  findings: []
- id: PMID:24769239
  title: Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
  findings: []
- id: PMID:27107014
  title: An inter-species protein-protein interaction network across vast evolutionary distance.
  findings: []
- id: PMID:30358795
  title: The cellular economy of the Saccharomyces cerevisiae zinc proteome.
  findings: []
- id: PMID:7957078
  title: Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria.
  findings: []
- id: PMID:8168133
  title: Mdj1p, a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding.
  findings: []
- id: PMID:8603724
  title: Role of the mitochondrial DnaJ homologue, Mdj1p, in the prevention of heat-induced protein aggregation.
  findings: []
- id: PMID:8943361
  title: Role of the mitochondrial DnaJ homolog Mdj1p as a chaperone for mitochondrially synthesized and imported proteins.
  findings: []
- id: PMID:9973563
  title: Two distinct mechanisms operate in the reactivation of heat-denatured proteins by the mitochondrial Hsp70/Mdj1p/Yge1p chaperone system.
  findings: []

Gene Description

Existing Annotations Review

References

📄 View Raw YAML