NAP1

UniProt ID: P25293
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

NAP1 encodes a conserved histone chaperone with roles in chromatin assembly, ribosome biogenesis, and cell cycle regulation. Nap1p functions primarily as an H2A-H2B chaperone, cooperating with the karyopherin Kap114 to transport histone H2A-H2B dimers into the nucleus for deposition into nucleosomes; binding of Ran-GTP (Gsp1) to this complex promotes accurate nucleosome assembly. Nap1p also participates in histone exchange, facilitating replacement of canonical H2A-H2B dimers with variant dimers. Beyond chromatin, Nap1p serves as an assembly chaperone for the small ribosomal subunit protein eS6 (Rps6a/Rps6b), promoting its solubility and contributing to 40S subunit biogenesis. During mitosis, Nap1p regulates septin organization at the bud neck and modulates B-type cyclin (Clb2p) function, linking chromatin dynamics to cell cycle progression. Orthologous to human NAP1L1-4.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0000785 chromatin
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: chromatin is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005634 nucleus
IBA
GO_REF:0000033 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006334 nucleosome assembly
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: nucleosome assembly is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042393 histone binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: histone binding is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003682 chromatin binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: chromatin binding is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003677 DNA binding
IEA
GO_REF:0000043 		KEEP AS NON CORE
Summary: Manual review: DNA binding may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005634 nucleus
IEA
GO_REF:0000120 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: Manual review: cytoplasm may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005935 cellular bud neck
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: Manual review: cellular bud neck may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005940 septin ring
IEA
GO_REF:0000117 		KEEP AS NON CORE
Summary: Manual review: septin ring may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006334 nucleosome assembly
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: nucleosome assembly is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:10688190
A comprehensive analysis of protein-protein interactions in ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:11805837
Systematic identification of protein complexes in Saccharomy... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:12058072
Cell cycle-dependent assembly of a Gin4-septin complex. 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:14645854
ATP-driven exchange of histone H2AZ variant catalyzed by SWR... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:14759368
High-definition macromolecular composition of yeast RNA-proc... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:15045029
A protein complex containing the conserved Swi2/Snf2-related... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16299494
A phosphatase complex that dephosphorylates gammaH2AX regula... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16429126
Proteome survey reveals modularity of the yeast cell machine... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16554755
Global landscape of protein complexes in the yeast Saccharom... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:18467557
An in vivo map of the yeast protein interactome. 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:18719252
High-quality binary protein interaction map of the yeast int... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:19172749
Histone chaperone specificity in Rtt109 activation. 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:20489023
A global protein kinase and phosphatase interaction network ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:21179020
Defining the budding yeast chromatin-associated interactome. 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:23468594
A safeguard mechanism regulates Rho GTPases to coordinate cy... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:25416945
A memory system of negative polarity cues prevents replicati... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:9214386
Control of mitotic events by Nap1 and the Gin4 kinase. 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:9813092
The septins are required for the mitosis-specific activation... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:16432217
The structure of nucleosome assembly protein 1. 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:18467557
An in vivo map of the yeast protein interactome. 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:18719252
High-quality binary protein interaction map of the yeast int... 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0042802 identical protein binding
IPI
PMID:21179020
Defining the budding yeast chromatin-associated interactome. 		MARK AS OVER ANNOTATED
Summary: Manual review: identical protein binding is too generic or over-extended for NAP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0140597 protein carrier chaperone
IDA
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein ch... 		ACCEPT
Summary: Manual review: protein carrier chaperone is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000511 H2A-H2B histone complex chaperone activity
IDA
PMID:39601790
Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted... 		ACCEPT
Summary: Manual review: H2A-H2B histone complex chaperone activity is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006334 nucleosome assembly
IDA
PMID:39601790
Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted... 		ACCEPT
Summary: Manual review: nucleosome assembly is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000511 H2A-H2B histone complex chaperone activity
IDA
PMID:27225933
Structural evidence for Nap1-dependent H2A-H2B deposition an... 		ACCEPT
Summary: Manual review: H2A-H2B histone complex chaperone activity is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006334 nucleosome assembly
IDA
PMID:27225933
Structural evidence for Nap1-dependent H2A-H2B deposition an... 		ACCEPT
Summary: Manual review: nucleosome assembly is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000920 septum digestion after cytokinesis
NAS
PMID:12058072
Cell cycle-dependent assembly of a Gin4-septin complex. 		KEEP AS NON CORE
Summary: Manual review: septum digestion after cytokinesis may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0000921 septin ring assembly
NAS
PMID:12058072
Cell cycle-dependent assembly of a Gin4-septin complex. 		KEEP AS NON CORE
Summary: Manual review: septin ring assembly may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006607 NLS-bearing protein import into nucleus
IMP
PMID:12456659
A role for nucleosome assembly protein 1 in the nuclear tran... 		KEEP AS NON CORE
Summary: Manual review: NLS-bearing protein import into nucleus may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0042274 ribosomal small subunit biogenesis
IGI
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein ch... 		KEEP AS NON CORE
Summary: Manual review: ribosomal small subunit biogenesis may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051082 unfolded protein binding
IDA
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein ch... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for NAP1.
Reason: Modified to align with current curation guidance and improve term specificity.
GO:0005737 cytoplasm
IDA
PMID:30341817
Septin-associated proteins Aim44 and Nis1 traffic between th... 		KEEP AS NON CORE
Summary: Manual review: cytoplasm may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0032174 cellular bud neck septin collar
IDA
PMID:30341817
Septin-associated proteins Aim44 and Nis1 traffic between th... 		KEEP AS NON CORE
Summary: Manual review: cellular bud neck septin collar may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0032153 cell division site
IDA
PMID:25416945
A memory system of negative polarity cues prevents replicati... 		KEEP AS NON CORE
Summary: Manual review: cell division site may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0098841 protein localization to cell division site after cytokinesis
IMP
PMID:25416945
A memory system of negative polarity cues prevents replicati... 		KEEP AS NON CORE
Summary: Manual review: protein localization to cell division site after cytokinesis may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006334 nucleosome assembly
IDA
PMID:1400414
Functional analysis of nucleosome assembly protein, NAP-1. T... 		ACCEPT
Summary: Manual review: nucleosome assembly is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008047 enzyme activator activity
IDA
PMID:22308335
Histone density is maintained during transcription mediated ... 		KEEP AS NON CORE
Summary: Manual review: enzyme activator activity may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0031116 positive regulation of microtubule polymerization
IMP
PMID:7622567
NAP1 acts with Clb1 to perform mitotic functions and to supp... 		KEEP AS NON CORE
Summary: Manual review: positive regulation of microtubule polymerization may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm
IDA
PMID:7622566
Members of the NAP/SET family of proteins interact specifica... 		KEEP AS NON CORE
Summary: Manual review: cytoplasm may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006334 nucleosome assembly
IDA
PMID:2016313
Identification and molecular cloning of yeast homolog of nuc... 		ACCEPT
Summary: Manual review: nucleosome assembly is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006337 nucleosome disassembly
IDA
PMID:16492771
Chromatin remodeling by nucleosome disassembly in vitro. 		ACCEPT
Summary: Manual review: nucleosome disassembly is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0007117 budding cell bud growth
IMP
PMID:13680156
Saccharomyces cerevisiae Ats1p interacts with Nap1p, a cytop... 		KEEP AS NON CORE
Summary: Manual review: budding cell bud growth may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0030332 cyclin binding
IPI
PMID:7622566
Members of the NAP/SET family of proteins interact specifica... 		KEEP AS NON CORE
Summary: Manual review: cyclin binding may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
IDA
PMID:22308335
Histone density is maintained during transcription mediated ... 		KEEP AS NON CORE
Summary: Manual review: positive regulation of transcription elongation by RNA polymerase II may be context-dependent or peripheral for NAP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0042393 histone binding
IDA
PMID:17289584
Chz1, a nuclear chaperone for histone H2AZ. 		ACCEPT
Summary: Manual review: histone binding is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042393 histone binding
IDA
PMID:21348863
Assembly states of the nucleosome assembly protein 1 (NAP-1)... 		ACCEPT
Summary: Manual review: histone binding is consistent with known biology of NAP1.
Reason: Retained as supported or plausible for this gene and evidence context.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10688190
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.
PMID:11805837
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
PMID:12058072
Cell cycle-dependent assembly of a Gin4-septin complex.
PMID:12456659
A role for nucleosome assembly protein 1 in the nuclear transport of histones H2A and H2B.
PMID:13680156
Saccharomyces cerevisiae Ats1p interacts with Nap1p, a cytoplasmic protein that controls bud morphogenesis.
PMID:1400414
Functional analysis of nucleosome assembly protein, NAP-1. The negatively charged COOH-terminal region is not necessary for the intrinsic assembly activity.
PMID:14645854
ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.
PMID:14759368
High-definition macromolecular composition of yeast RNA-processing complexes.
PMID:15045029
A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
PMID:16299494
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
PMID:16429126
Proteome survey reveals modularity of the yeast cell machinery.
PMID:16432217
The structure of nucleosome assembly protein 1.
PMID:16492771
Chromatin remodeling by nucleosome disassembly in vitro.
PMID:16554755
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
PMID:17289584
Chz1, a nuclear chaperone for histone H2AZ.
PMID:18467557
An in vivo map of the yeast protein interactome.
PMID:18719252
High-quality binary protein interaction map of the yeast interactome network.
PMID:19172749
Histone chaperone specificity in Rtt109 activation.
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.
PMID:2016313
Identification and molecular cloning of yeast homolog of nucleosome assembly protein I which facilitates nucleosome assembly in vitro.
PMID:20489023
A global protein kinase and phosphatase interaction network in yeast.
PMID:21179020
Defining the budding yeast chromatin-associated interactome.
PMID:21348863
Assembly states of the nucleosome assembly protein 1 (NAP-1) revealed by sedimentation velocity and non-denaturing MS.
PMID:22308335
Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro.
PMID:23468594
A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity.
PMID:25416945
A memory system of negative polarity cues prevents replicative aging.
PMID:27225933
Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly.
PMID:30341817
Septin-associated proteins Aim44 and Nis1 traffic between the bud neck and the nucleus in the yeast Saccharomyces cerevisiae.
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein chaperOME.
PMID:37968396
The social and structural architecture of the yeast protein interactome.
PMID:39601790
Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.
PMID:7622566
Members of the NAP/SET family of proteins interact specifically with B-type cyclins.
PMID:7622567
NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast.
PMID:9214386
Control of mitotic events by Nap1 and the Gin4 kinase.
PMID:9813092
The septins are required for the mitosis-specific activation of the Gin4 kinase.

📄 View Raw YAML

 
id: P25293
gene_symbol: NAP1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: >-
  NAP1 encodes a conserved histone chaperone with roles in chromatin assembly,
  ribosome biogenesis, and cell cycle regulation. Nap1p functions primarily as
  an H2A-H2B chaperone, cooperating with the karyopherin Kap114 to transport
  histone H2A-H2B dimers into the nucleus for deposition into nucleosomes;
  binding of Ran-GTP (Gsp1) to this complex promotes accurate nucleosome
  assembly. Nap1p also participates in histone exchange, facilitating
  replacement of canonical H2A-H2B dimers with variant dimers. Beyond
  chromatin, Nap1p serves as an assembly chaperone for the small ribosomal
  subunit protein eS6 (Rps6a/Rps6b), promoting its solubility and
  contributing to 40S subunit biogenesis. During mitosis, Nap1p regulates
  septin organization at the bud neck and modulates B-type cyclin (Clb2p)
  function, linking chromatin dynamics to cell cycle progression. Orthologous
  to human NAP1L1-4.
existing_annotations:
- term:
    id: GO:0000785
    label: chromatin
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: chromatin is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006334
    label: nucleosome assembly
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nucleosome assembly is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042393
    label: histone binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: histone binding is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003682
    label: chromatin binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: chromatin binding is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003677
    label: DNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: DNA binding may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005935
    label: cellular bud neck
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cellular bud neck may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005940
    label: septin ring
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: septin ring may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006334
    label: nucleosome assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: nucleosome assembly is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10688190
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11805837
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12058072
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14645854
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14759368
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15045029
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16299494
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16429126
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18467557
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18719252
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19172749
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19536198
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20489023
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21179020
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23468594
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25416945
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9214386
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9813092
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:16432217
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:18467557
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:18719252
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:21179020
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for NAP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0140597
    label: protein carrier chaperone
  evidence_type: IDA
  original_reference_id: PMID:31062022
  review:
    summary: 'Manual review: protein carrier chaperone is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000511
    label: H2A-H2B histone complex chaperone activity
  evidence_type: IDA
  original_reference_id: PMID:39601790
  review:
    summary: 'Manual review: H2A-H2B histone complex chaperone activity is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006334
    label: nucleosome assembly
  evidence_type: IDA
  original_reference_id: PMID:39601790
  review:
    summary: 'Manual review: nucleosome assembly is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000511
    label: H2A-H2B histone complex chaperone activity
  evidence_type: IDA
  original_reference_id: PMID:27225933
  review:
    summary: 'Manual review: H2A-H2B histone complex chaperone activity is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006334
    label: nucleosome assembly
  evidence_type: IDA
  original_reference_id: PMID:27225933
  review:
    summary: 'Manual review: nucleosome assembly is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000920
    label: septum digestion after cytokinesis
  evidence_type: NAS
  original_reference_id: PMID:12058072
  review:
    summary: 'Manual review: septum digestion after cytokinesis may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0000921
    label: septin ring assembly
  evidence_type: NAS
  original_reference_id: PMID:12058072
  review:
    summary: 'Manual review: septin ring assembly may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006607
    label: NLS-bearing protein import into nucleus
  evidence_type: IMP
  original_reference_id: PMID:12456659
  review:
    summary: 'Manual review: NLS-bearing protein import into nucleus may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0042274
    label: ribosomal small subunit biogenesis
  evidence_type: IGI
  original_reference_id: PMID:31062022
  review:
    summary: 'Manual review: ribosomal small subunit biogenesis may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:31062022
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for NAP1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0000511
      label: H2A-H2B histone complex chaperone activity
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:30341817
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0032174
    label: cellular bud neck septin collar
  evidence_type: IDA
  original_reference_id: PMID:30341817
  review:
    summary: 'Manual review: cellular bud neck septin collar may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0032153
    label: cell division site
  evidence_type: IDA
  original_reference_id: PMID:25416945
  review:
    summary: 'Manual review: cell division site may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0098841
    label: protein localization to cell division site after cytokinesis
  evidence_type: IMP
  original_reference_id: PMID:25416945
  review:
    summary: 'Manual review: protein localization to cell division site after cytokinesis may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006334
    label: nucleosome assembly
  evidence_type: IDA
  original_reference_id: PMID:1400414
  review:
    summary: 'Manual review: nucleosome assembly is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008047
    label: enzyme activator activity
  evidence_type: IDA
  original_reference_id: PMID:22308335
  review:
    summary: 'Manual review: enzyme activator activity may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0031116
    label: positive regulation of microtubule polymerization
  evidence_type: IMP
  original_reference_id: PMID:7622567
  review:
    summary: 'Manual review: positive regulation of microtubule polymerization may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:7622566
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006334
    label: nucleosome assembly
  evidence_type: IDA
  original_reference_id: PMID:2016313
  review:
    summary: 'Manual review: nucleosome assembly is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006337
    label: nucleosome disassembly
  evidence_type: IDA
  original_reference_id: PMID:16492771
  review:
    summary: 'Manual review: nucleosome disassembly is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0007117
    label: budding cell bud growth
  evidence_type: IMP
  original_reference_id: PMID:13680156
  review:
    summary: 'Manual review: budding cell bud growth may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0030332
    label: cyclin binding
  evidence_type: IPI
  original_reference_id: PMID:7622566
  review:
    summary: 'Manual review: cyclin binding may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0032968
    label: positive regulation of transcription elongation by RNA polymerase II
  evidence_type: IDA
  original_reference_id: PMID:22308335
  review:
    summary: 'Manual review: positive regulation of transcription elongation by RNA polymerase II may be context-dependent or peripheral for NAP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0042393
    label: histone binding
  evidence_type: IDA
  original_reference_id: PMID:17289584
  review:
    summary: 'Manual review: histone binding is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042393
    label: histone binding
  evidence_type: IDA
  original_reference_id: PMID:21348863
  review:
    summary: 'Manual review: histone binding is consistent with known biology of NAP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10688190
  title: A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.
  findings: []
- id: PMID:11805837
  title: Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
  findings: []
- id: PMID:12058072
  title: Cell cycle-dependent assembly of a Gin4-septin complex.
  findings: []
- id: PMID:12456659
  title: A role for nucleosome assembly protein 1 in the nuclear transport of histones H2A and H2B.
  findings: []
- id: PMID:13680156
  title: Saccharomyces cerevisiae Ats1p interacts with Nap1p, a cytoplasmic protein that controls bud morphogenesis.
  findings: []
- id: PMID:1400414
  title: Functional analysis of nucleosome assembly protein, NAP-1. The negatively charged COOH-terminal region is not necessary for the intrinsic assembly activity.
  findings: []
- id: PMID:14645854
  title: ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.
  findings: []
- id: PMID:14759368
  title: High-definition macromolecular composition of yeast RNA-processing complexes.
  findings: []
- id: PMID:15045029
  title: A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
  findings: []
- id: PMID:16299494
  title: A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
  findings: []
- id: PMID:16429126
  title: Proteome survey reveals modularity of the yeast cell machinery.
  findings: []
- id: PMID:16432217
  title: The structure of nucleosome assembly protein 1.
  findings: []
- id: PMID:16492771
  title: Chromatin remodeling by nucleosome disassembly in vitro.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:17289584
  title: Chz1, a nuclear chaperone for histone H2AZ.
  findings: []
- id: PMID:18467557
  title: An in vivo map of the yeast protein interactome.
  findings: []
- id: PMID:18719252
  title: High-quality binary protein interaction map of the yeast interactome network.
  findings: []
- id: PMID:19172749
  title: Histone chaperone specificity in Rtt109 activation.
  findings: []
- id: PMID:19536198
  title: 'An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.'
  findings: []
- id: PMID:2016313
  title: Identification and molecular cloning of yeast homolog of nucleosome assembly protein I which facilitates nucleosome assembly in vitro.
  findings: []
- id: PMID:20489023
  title: A global protein kinase and phosphatase interaction network in yeast.
  findings: []
- id: PMID:21179020
  title: Defining the budding yeast chromatin-associated interactome.
  findings: []
- id: PMID:21348863
  title: Assembly states of the nucleosome assembly protein 1 (NAP-1) revealed by sedimentation velocity and non-denaturing MS.
  findings: []
- id: PMID:22308335
  title: Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro.
  findings: []
- id: PMID:23468594
  title: A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity.
  findings: []
- id: PMID:25416945
  title: A memory system of negative polarity cues prevents replicative aging.
  findings: []
- id: PMID:27225933
  title: Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly.
  findings: []
- id: PMID:30341817
  title: Septin-associated proteins Aim44 and Nis1 traffic between the bud neck and the nucleus in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:31062022
  title: Tsr4 and Nap1, two novel members of the ribosomal protein chaperOME.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []
- id: PMID:39601790
  title: Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.
  findings: []
- id: PMID:7622566
  title: Members of the NAP/SET family of proteins interact specifically with B-type cyclins.
  findings: []
- id: PMID:7622567
  title: NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast.
  findings: []
- id: PMID:9214386
  title: Control of mitotic events by Nap1 and the Gin4 kinase.
  findings: []
- id: PMID:9813092
  title: The septins are required for the mitosis-specific activation of the Gin4 kinase.
  findings: []