NSG1

UniProt ID: P38837
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for NSG1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005783 endoplasmic reticulum
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of NSG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016126 sterol biosynthetic process
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: sterol biosynthetic process is consistent with known biology of NSG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of NSG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:18467557
An in vivo map of the yeast protein interactome. 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NSG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:27107014
An inter-species protein-protein interaction network across ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NSG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for NSG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0071561 nucleus-vacuole junction
IDA
PMID:41132095
Role of Pex31 in metabolic adaptation of the nucleus-vacuole... 		KEEP AS NON CORE
Summary: Manual review: nucleus-vacuole junction may be context-dependent or peripheral for NSG1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005783 endoplasmic reticulum
HDA
PMID:26928762
One library to make them all: streamlining the creation of y... 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of NSG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034399 nuclear periphery
HDA
PMID:22842922
Dissecting DNA damage response pathways by analysing protein... 		KEEP AS NON CORE
Summary: Manual review: nuclear periphery may be context-dependent or peripheral for NSG1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005829 cytosol
IDA
PMID:22932476
The nuclear localization of SWI/SNF proteins is subjected to... 		KEEP AS NON CORE
Summary: Manual review: cytosol may be context-dependent or peripheral for NSG1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005634 nucleus
IDA
PMID:22932476
The nuclear localization of SWI/SNF proteins is subjected to... 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for NSG1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005783 endoplasmic reticulum
IDA
PMID:16270032
INSIG: a broadly conserved transmembrane chaperone for stero... 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of NSG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016126 sterol biosynthetic process
IMP
PMID:16270032
INSIG: a broadly conserved transmembrane chaperone for stero... 		ACCEPT
Summary: Manual review: sterol biosynthetic process is consistent with known biology of NSG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016126 sterol biosynthetic process
IPI
PMID:16270032
INSIG: a broadly conserved transmembrane chaperone for stero... 		ACCEPT
Summary: Manual review: sterol biosynthetic process is consistent with known biology of NSG1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IMP
PMID:16270032
INSIG: a broadly conserved transmembrane chaperone for stero... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for NSG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0051082 unfolded protein binding
IPI
PMID:16270032
INSIG: a broadly conserved transmembrane chaperone for stero... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for NSG1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PMID:16270032
INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.
PMID:18467557
An in vivo map of the yeast protein interactome.
PMID:22842922
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
PMID:22932476
The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation.
PMID:26928762
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
PMID:27107014
An inter-species protein-protein interaction network across vast evolutionary distance.
PMID:37968396
The social and structural architecture of the yeast protein interactome.
PMID:41132095
Role of Pex31 in metabolic adaptation of the nucleus-vacuole junction.

📄 View Raw YAML

 
id: P38837
gene_symbol: NSG1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for NSG1'
existing_annotations:
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of NSG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016126
    label: sterol biosynthetic process
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: sterol biosynthetic process is consistent with known biology of NSG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of NSG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18467557
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NSG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107014
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NSG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for NSG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0071561
    label: nucleus-vacuole junction
  evidence_type: IDA
  original_reference_id: PMID:41132095
  review:
    summary: 'Manual review: nucleus-vacuole junction may be context-dependent or peripheral for NSG1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:26928762
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of NSG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034399
    label: nuclear periphery
  evidence_type: HDA
  original_reference_id: PMID:22842922
  review:
    summary: 'Manual review: nuclear periphery may be context-dependent or peripheral for NSG1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:22932476
  review:
    summary: 'Manual review: cytosol may be context-dependent or peripheral for NSG1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:22932476
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for NSG1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IDA
  original_reference_id: PMID:16270032
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of NSG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016126
    label: sterol biosynthetic process
  evidence_type: IMP
  original_reference_id: PMID:16270032
  review:
    summary: 'Manual review: sterol biosynthetic process is consistent with known biology of NSG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016126
    label: sterol biosynthetic process
  evidence_type: IPI
  original_reference_id: PMID:16270032
  review:
    summary: 'Manual review: sterol biosynthetic process is consistent with known biology of NSG1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:16270032
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for NSG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IPI
  original_reference_id: PMID:16270032
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for NSG1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:16270032
  title: 'INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.'
  findings: []
- id: PMID:18467557
  title: An in vivo map of the yeast protein interactome.
  findings: []
- id: PMID:22842922
  title: Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
  findings: []
- id: PMID:22932476
  title: The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation.
  findings: []
- id: PMID:26928762
  title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
  findings: []
- id: PMID:27107014
  title: An inter-species protein-protein interaction network across vast evolutionary distance.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []
- id: PMID:41132095
  title: Role of Pex31 in metabolic adaptation of the nucleus-vacuole junction.
  findings: []