TODO: Add description for NSG2
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
|
GO:0005783
endoplasmic reticulum
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: Manual review: endoplasmic reticulum is consistent with known biology of NSG2.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0016126
sterol biosynthetic process
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: Manual review: sterol biosynthetic process is consistent with known biology of NSG2.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005789
endoplasmic reticulum membrane
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of NSG2.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0071561
nucleus-vacuole junction
|
IDA
PMID:41132095 Role of Pex31 in metabolic adaptation of the nucleus-vacuole... |
KEEP AS NON CORE |
Summary: Manual review: nucleus-vacuole junction may be context-dependent or peripheral for NSG2.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0005783
endoplasmic reticulum
|
HDA
PMID:26928762 One library to make them all: streamlining the creation of y... |
ACCEPT |
Summary: Manual review: endoplasmic reticulum is consistent with known biology of NSG2.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005783
endoplasmic reticulum
|
HDA
PMID:14562095 Global analysis of protein localization in budding yeast. |
ACCEPT |
Summary: Manual review: endoplasmic reticulum is consistent with known biology of NSG2.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0016126
sterol biosynthetic process
|
IGI
PMID:16270032 INSIG: a broadly conserved transmembrane chaperone for stero... |
ACCEPT |
Summary: Manual review: sterol biosynthetic process is consistent with known biology of NSG2.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0051082
unfolded protein binding
|
IMP
PMID:16270032 INSIG: a broadly conserved transmembrane chaperone for stero... |
MARK AS OVER ANNOTATED |
Summary: Manual review: unfolded protein binding is too generic or over-extended for NSG2.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
id: P53898
gene_symbol: NSG2
product_type: PROTEIN
status: DRAFT
taxon:
id: NCBITaxon:559292
label: Saccharomyces cerevisiae
description: 'TODO: Add description for NSG2'
existing_annotations:
- term:
id: GO:0005783
label: endoplasmic reticulum
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: endoplasmic reticulum is consistent with known biology of NSG2.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0016126
label: sterol biosynthetic process
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: sterol biosynthetic process is consistent with known biology of NSG2.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005789
label: endoplasmic reticulum membrane
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of NSG2.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0071561
label: nucleus-vacuole junction
evidence_type: IDA
original_reference_id: PMID:41132095
review:
summary: 'Manual review: nucleus-vacuole junction may be context-dependent or peripheral for NSG2.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0005783
label: endoplasmic reticulum
evidence_type: HDA
original_reference_id: PMID:26928762
review:
summary: 'Manual review: endoplasmic reticulum is consistent with known biology of NSG2.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005783
label: endoplasmic reticulum
evidence_type: HDA
original_reference_id: PMID:14562095
review:
summary: 'Manual review: endoplasmic reticulum is consistent with known biology of NSG2.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0016126
label: sterol biosynthetic process
evidence_type: IGI
original_reference_id: PMID:16270032
review:
summary: 'Manual review: sterol biosynthetic process is consistent with known biology of NSG2.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0051082
label: unfolded protein binding
evidence_type: IMP
original_reference_id: PMID:16270032
review:
summary: 'Manual review: unfolded protein binding is too generic or over-extended for NSG2.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000033
title: Annotation inferences using phylogenetic trees
findings: []
- id: GO_REF:0000044
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
findings: []
- id: PMID:14562095
title: Global analysis of protein localization in budding yeast.
findings: []
- id: PMID:16270032
title: 'INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.'
findings: []
- id: PMID:26928762
title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
findings: []
- id: PMID:41132095
title: Role of Pex31 in metabolic adaptation of the nucleus-vacuole junction.
findings: []