PNO1

UniProt ID: Q99216
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for PNO1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005634 nucleus
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: nucleus is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0003723 RNA binding
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: RNA binding is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005730 nucleolus
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: nucleolus is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042254 ribosome biogenesis
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: ribosome biogenesis is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005730 nucleolus
IDA
PMID:27980088
Architecture of the yeast small subunit processome. 		ACCEPT
Summary: Manual review: nucleolus is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0030490 maturation of SSU-rRNA
NAS
PMID:15489292
RNA polymerase I transcription and pre-rRNA processing are l... 		ACCEPT
Summary: Manual review: maturation of SSU-rRNA is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000056 ribosomal small subunit export from nucleus
IMP
PMID:18755838
TOR regulates the subcellular distribution of DIM2, a KH dom... 		ACCEPT
Summary: Manual review: ribosomal small subunit export from nucleus is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042134 rRNA primary transcript binding
IDA
PMID:18755838
TOR regulates the subcellular distribution of DIM2, a KH dom... 		ACCEPT
Summary: Manual review: rRNA primary transcript binding is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042255 ribosome assembly
IMP
PMID:18755838
TOR regulates the subcellular distribution of DIM2, a KH dom... 		ACCEPT
Summary: Manual review: ribosome assembly is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0030686 90S preribosome
HDA
PMID:12150911
90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, a... 		ACCEPT
Summary: Manual review: 90S preribosome is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0043248 proteasome assembly
IMP
PMID:12502737
Nob1p is required for biogenesis of the 26S proteasome and d... 		KEEP AS NON CORE
Summary: Manual review: proteasome assembly may be context-dependent or peripheral for PNO1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0043248 proteasome assembly
IPI
PMID:12502737
Nob1p is required for biogenesis of the 26S proteasome and d... 		KEEP AS NON CORE
Summary: Manual review: proteasome assembly may be context-dependent or peripheral for PNO1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IMP
PMID:12736301
RRP20, a component of the 90S preribosome, is required for p... 		ACCEPT
Summary: Manual review: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IMP
PMID:12736301
RRP20, a component of the 90S preribosome, is required for p... 		ACCEPT
Summary: Manual review: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005634 nucleus
IDA
PMID:12502737
Nob1p is required for biogenesis of the 26S proteasome and d... 		ACCEPT
Summary: Manual review: nucleus is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005730 nucleolus
IDA
PMID:10923024
Functional analysis of six genes from chromosomes XIV and XV... 		ACCEPT
Summary: Manual review: nucleolus is consistent with known biology of PNO1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:12502737
Nob1p is required for biogenesis of the 26S proteasome and d... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for PNO1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10923024
Functional analysis of six genes from chromosomes XIV and XV of Saccharomyces cerevisiae reveals YOR145c as an essential gene and YNL059c/ARP5 as a strain-dependent essential gene encoding nuclear proteins.
PMID:12150911
90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors.
PMID:12502737
Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae.
PMID:12736301
RRP20, a component of the 90S preribosome, is required for pre-18S rRNA processing in Saccharomyces cerevisiae.
PMID:15489292
RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components.
PMID:18755838
TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export.
PMID:27980088
Architecture of the yeast small subunit processome.

📄 View Raw YAML

 
id: Q99216
gene_symbol: PNO1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for PNO1'
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nucleus is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: RNA binding is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: nucleolus is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042254
    label: ribosome biogenesis
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ribosome biogenesis is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: IDA
  original_reference_id: PMID:27980088
  review:
    summary: 'Manual review: nucleolus is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0030490
    label: maturation of SSU-rRNA
  evidence_type: NAS
  original_reference_id: PMID:15489292
  review:
    summary: 'Manual review: maturation of SSU-rRNA is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000056
    label: ribosomal small subunit export from nucleus
  evidence_type: IMP
  original_reference_id: PMID:18755838
  review:
    summary: 'Manual review: ribosomal small subunit export from nucleus is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042134
    label: rRNA primary transcript binding
  evidence_type: IDA
  original_reference_id: PMID:18755838
  review:
    summary: 'Manual review: rRNA primary transcript binding is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042255
    label: ribosome assembly
  evidence_type: IMP
  original_reference_id: PMID:18755838
  review:
    summary: 'Manual review: ribosome assembly is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0030686
    label: 90S preribosome
  evidence_type: HDA
  original_reference_id: PMID:12150911
  review:
    summary: 'Manual review: 90S preribosome is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0043248
    label: proteasome assembly
  evidence_type: IMP
  original_reference_id: PMID:12502737
  review:
    summary: 'Manual review: proteasome assembly may be context-dependent or peripheral for PNO1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0043248
    label: proteasome assembly
  evidence_type: IPI
  original_reference_id: PMID:12502737
  review:
    summary: 'Manual review: proteasome assembly may be context-dependent or peripheral for PNO1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0000447
    label: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  evidence_type: IMP
  original_reference_id: PMID:12736301
  review:
    summary: 'Manual review: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000472
    label: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  evidence_type: IMP
  original_reference_id: PMID:12736301
  review:
    summary: 'Manual review: endonucleolytic cleavage to generate mature 5''-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:12502737
  review:
    summary: 'Manual review: nucleus is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: IDA
  original_reference_id: PMID:10923024
  review:
    summary: 'Manual review: nucleolus is consistent with known biology of PNO1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:12502737
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for PNO1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10923024
  title: Functional analysis of six genes from chromosomes XIV and XV of Saccharomyces cerevisiae reveals YOR145c as an essential gene and YNL059c/ARP5 as a strain-dependent essential gene encoding nuclear proteins.
  findings: []
- id: PMID:12150911
  title: 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors.
  findings: []
- id: PMID:12502737
  title: Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae.
  findings: []
- id: PMID:12736301
  title: RRP20, a component of the 90S preribosome, is required for pre-18S rRNA processing in Saccharomyces cerevisiae.
  findings: []
- id: PMID:15489292
  title: RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components.
  findings: []
- id: PMID:18755838
  title: TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export.
  findings: []
- id: PMID:27980088
  title: Architecture of the yeast small subunit processome.
  findings: []