ROT1

UniProt ID: Q03691
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for ROT1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005789 endoplasmic reticulum membrane
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006458 'de novo' protein folding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: 'de novo' protein folding is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0007118 budding cell apical bud growth
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: budding cell apical bud growth is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IBA
GO_REF:0000033 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for ROT1.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0005783 endoplasmic reticulum
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006458 'de novo' protein folding
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: 'de novo' protein folding is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
HDA
PMID:26928762
One library to make them all: streamlining the creation of y... 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
HDA
PMID:14562095
Global analysis of protein localization in budding yeast. 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IGI
PMID:16874095
Causal links between protein folding in the ER and events al... 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034975 protein folding in endoplasmic reticulum
IGI
PMID:16874095
Causal links between protein folding in the ER and events al... 		ACCEPT
Summary: Manual review: protein folding in endoplasmic reticulum is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005789 endoplasmic reticulum membrane
IDA
PMID:16567426
Saccharomyces cerevisiae Rot1p is an ER-localized membrane p... 		ACCEPT
Summary: Manual review: endoplasmic reticulum membrane is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006458 'de novo' protein folding
IMP
PMID:18508919
Saccharomyces cerevisiae Rot1 is an essential molecular chap... 		ACCEPT
Summary: Manual review: 'de novo' protein folding is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006458 'de novo' protein folding
IPI
PMID:18508919
Saccharomyces cerevisiae Rot1 is an essential molecular chap... 		ACCEPT
Summary: Manual review: 'de novo' protein folding is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006487 protein N-linked glycosylation
IGI
PMID:22492205
The essential endoplasmic reticulum chaperone Rot1 is requir... 		ACCEPT
Summary: Manual review: protein N-linked glycosylation is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006487 protein N-linked glycosylation
IPI
PMID:22492205
The essential endoplasmic reticulum chaperone Rot1 is requir... 		ACCEPT
Summary: Manual review: protein N-linked glycosylation is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0007118 budding cell apical bud growth
IMP
PMID:17606994
Rot1 plays an antagonistic role to Clb2 in actin cytoskeleto... 		ACCEPT
Summary: Manual review: budding cell apical bud growth is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0007118 budding cell apical bud growth
IGI
PMID:17606994
Rot1 plays an antagonistic role to Clb2 in actin cytoskeleto... 		ACCEPT
Summary: Manual review: budding cell apical bud growth is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0009272 fungal-type cell wall biogenesis
IMP
PMID:9545237
Cell wall integrity modulates RHO1 activity via the exchange... 		ACCEPT
Summary: Manual review: fungal-type cell wall biogenesis is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0030950 establishment or maintenance of actin cytoskeleton polarity
IMP
PMID:17606994
Rot1 plays an antagonistic role to Clb2 in actin cytoskeleto... 		ACCEPT
Summary: Manual review: establishment or maintenance of actin cytoskeleton polarity is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0035269 protein O-linked glycosylation via mannose
IGI
PMID:22492205
The essential endoplasmic reticulum chaperone Rot1 is requir... 		ACCEPT
Summary: Manual review: protein O-linked glycosylation via mannose is consistent with known biology of ROT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:18508919
Saccharomyces cerevisiae Rot1 is an essential molecular chap... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for ROT1.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0051082 unfolded protein binding
IMP
PMID:18508919
Saccharomyces cerevisiae Rot1 is an essential molecular chap... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for ROT1.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PMID:14562095
Global analysis of protein localization in budding yeast.
PMID:16567426
Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding.
PMID:16874095
Causal links between protein folding in the ER and events along the secretory pathway.
PMID:17606994
Rot1 plays an antagonistic role to Clb2 in actin cytoskeleton dynamics throughout the cell cycle.
PMID:18508919
Saccharomyces cerevisiae Rot1 is an essential molecular chaperone in the endoplasmic reticulum.
PMID:22492205
The essential endoplasmic reticulum chaperone Rot1 is required for protein N- and O-glycosylation in yeast.
PMID:26928762
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
PMID:9545237
Cell wall integrity modulates RHO1 activity via the exchange factor ROM2.

📄 View Raw YAML

 
id: Q03691
gene_symbol: ROT1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for ROT1'
existing_annotations:
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006458
    label: '''de novo'' protein folding'
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: ''de novo'' protein folding is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0007118
    label: budding cell apical bud growth
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: budding cell apical bud growth is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for ROT1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006458
    label: '''de novo'' protein folding'
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: ''de novo'' protein folding is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:26928762
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: HDA
  original_reference_id: PMID:14562095
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IGI
  original_reference_id: PMID:16874095
  review:
    summary: 'Manual review: protein folding is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034975
    label: protein folding in endoplasmic reticulum
  evidence_type: IGI
  original_reference_id: PMID:16874095
  review:
    summary: 'Manual review: protein folding in endoplasmic reticulum is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IDA
  original_reference_id: PMID:16567426
  review:
    summary: 'Manual review: endoplasmic reticulum membrane is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006458
    label: '''de novo'' protein folding'
  evidence_type: IMP
  original_reference_id: PMID:18508919
  review:
    summary: 'Manual review: ''de novo'' protein folding is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006458
    label: '''de novo'' protein folding'
  evidence_type: IPI
  original_reference_id: PMID:18508919
  review:
    summary: 'Manual review: ''de novo'' protein folding is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006487
    label: protein N-linked glycosylation
  evidence_type: IGI
  original_reference_id: PMID:22492205
  review:
    summary: 'Manual review: protein N-linked glycosylation is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006487
    label: protein N-linked glycosylation
  evidence_type: IPI
  original_reference_id: PMID:22492205
  review:
    summary: 'Manual review: protein N-linked glycosylation is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0007118
    label: budding cell apical bud growth
  evidence_type: IMP
  original_reference_id: PMID:17606994
  review:
    summary: 'Manual review: budding cell apical bud growth is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0007118
    label: budding cell apical bud growth
  evidence_type: IGI
  original_reference_id: PMID:17606994
  review:
    summary: 'Manual review: budding cell apical bud growth is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0009272
    label: fungal-type cell wall biogenesis
  evidence_type: IMP
  original_reference_id: PMID:9545237
  review:
    summary: 'Manual review: fungal-type cell wall biogenesis is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0030950
    label: establishment or maintenance of actin cytoskeleton polarity
  evidence_type: IMP
  original_reference_id: PMID:17606994
  review:
    summary: 'Manual review: establishment or maintenance of actin cytoskeleton polarity is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0035269
    label: protein O-linked glycosylation via mannose
  evidence_type: IGI
  original_reference_id: PMID:22492205
  review:
    summary: 'Manual review: protein O-linked glycosylation via mannose is consistent with known biology of ROT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:18508919
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for ROT1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:18508919
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for ROT1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:14562095
  title: Global analysis of protein localization in budding yeast.
  findings: []
- id: PMID:16567426
  title: Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding.
  findings: []
- id: PMID:16874095
  title: Causal links between protein folding in the ER and events along the secretory pathway.
  findings: []
- id: PMID:17606994
  title: Rot1 plays an antagonistic role to Clb2 in actin cytoskeleton dynamics throughout the cell cycle.
  findings: []
- id: PMID:18508919
  title: Saccharomyces cerevisiae Rot1 is an essential molecular chaperone in the endoplasmic reticulum.
  findings: []
- id: PMID:22492205
  title: The essential endoplasmic reticulum chaperone Rot1 is required for protein N- and O-glycosylation in yeast.
  findings: []
- id: PMID:26928762
  title: 'One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.'
  findings: []
- id: PMID:9545237
  title: Cell wall integrity modulates RHO1 activity via the exchange factor ROM2.
  findings: []