SHQ1

id: P40486
gene_symbol: SHQ1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for SHQ1'
existing_annotations:
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nucleoplasm is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000493
    label: box H/ACA snoRNP assembly
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: box H/ACA snoRNP assembly is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for SHQ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0140597
      label: protein carrier chaperone
- term:
    id: GO:0000493
    label: box H/ACA snoRNP assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: box H/ACA snoRNP assembly is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: nucleus is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:22932476
  review:
    summary: 'Manual review: cytosol is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000493
    label: box H/ACA snoRNP assembly
  evidence_type: IMP
  original_reference_id: PMID:12228251
  review:
    summary: 'Manual review: box H/ACA snoRNP assembly is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000493
    label: box H/ACA snoRNP assembly
  evidence_type: IPI
  original_reference_id: PMID:12228251
  review:
    summary: 'Manual review: box H/ACA snoRNP assembly is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:22932476
  review:
    summary: 'Manual review: nucleus is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IDA
  original_reference_id: PMID:12228251
  review:
    summary: 'Manual review: nucleoplasm is consistent with known biology of SHQ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:19426738
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for SHQ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0140597
      label: protein carrier chaperone
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:12228251
  title: The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis.
  findings: []
- id: PMID:19426738
  title: The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.
  findings: []
- id: PMID:22932476
  title: The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation.
  findings: []