SHY1

UniProt ID: P53266
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for SHY1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0033617 mitochondrial respiratory chain complex IV assembly
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of SHY1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of SHY1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005743 mitochondrial inner membrane
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: mitochondrial inner membrane is consistent with known biology of SHY1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016020 membrane
IEA
GO_REF:0000002 		KEEP AS NON CORE
Summary: Manual review: membrane may be context-dependent or peripheral for SHY1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005515 protein binding
IPI
PMID:17882259
Shy1 couples Cox1 translational regulation to cytochrome c o... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SHY1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:17882260
Coa1 links the Mss51 post-translational function to Cox1 cof... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SHY1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0016020 membrane
IDA
PMID:15306853
Mss51p and Cox14p jointly regulate mitochondrial Cox1p expre... 		KEEP AS NON CORE
Summary: Manual review: membrane may be context-dependent or peripheral for SHY1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005777 peroxisome
HDA
PMID:35563734
Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulati... 		KEEP AS NON CORE
Summary: Manual review: peroxisome may be context-dependent or peripheral for SHY1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005739 mitochondrion
HDA
PMID:24769239
Quantitative variations of the mitochondrial proteome and ph... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of SHY1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005739 mitochondrion
HDA
PMID:16823961
Toward the complete yeast mitochondrial proteome: multidimen... 		ACCEPT
Summary: Manual review: mitochondrion is consistent with known biology of SHY1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005743 mitochondrial inner membrane
IDA
PMID:15306853
Mss51p and Cox14p jointly regulate mitochondrial Cox1p expre... 		ACCEPT
Summary: Manual review: mitochondrial inner membrane is consistent with known biology of SHY1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005743 mitochondrial inner membrane
IDA
PMID:9162072
SHY1, the yeast homolog of the mammalian SURF-1 gene, encode... 		ACCEPT
Summary: Manual review: mitochondrial inner membrane is consistent with known biology of SHY1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0033617 mitochondrial respiratory chain complex IV assembly
IMP
PMID:17882259
Shy1 couples Cox1 translational regulation to cytochrome c o... 		ACCEPT
Summary: Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of SHY1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IMP
PMID:11389896
Shy1p occurs in a high molecular weight complex and is requi... 		MARK AS OVER ANNOTATED
Summary: Manual review: unfolded protein binding is too generic or over-extended for SHY1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PMID:11389896
Shy1p occurs in a high molecular weight complex and is required for efficient assembly of cytochrome c oxidase in yeast.
PMID:15306853
Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae.
PMID:16823961
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
PMID:17882259
Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.
PMID:17882260
Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
PMID:24769239
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
PMID:35563734
Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis.
PMID:9162072
SHY1, the yeast homolog of the mammalian SURF-1 gene, encodes a mitochondrial protein required for respiration.

📄 View Raw YAML

 
id: P53266
gene_symbol: SHY1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for SHY1'
existing_annotations:
- term:
    id: GO:0033617
    label: mitochondrial respiratory chain complex IV assembly
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of SHY1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of SHY1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: mitochondrial inner membrane is consistent with known biology of SHY1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016020
    label: membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: membrane may be context-dependent or peripheral for SHY1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17882259
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SHY1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17882260
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SHY1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0016020
    label: membrane
  evidence_type: IDA
  original_reference_id: PMID:15306853
  review:
    summary: 'Manual review: membrane may be context-dependent or peripheral for SHY1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005777
    label: peroxisome
  evidence_type: HDA
  original_reference_id: PMID:35563734
  review:
    summary: 'Manual review: peroxisome may be context-dependent or peripheral for SHY1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:24769239
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of SHY1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: HDA
  original_reference_id: PMID:16823961
  review:
    summary: 'Manual review: mitochondrion is consistent with known biology of SHY1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IDA
  original_reference_id: PMID:15306853
  review:
    summary: 'Manual review: mitochondrial inner membrane is consistent with known biology of SHY1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IDA
  original_reference_id: PMID:9162072
  review:
    summary: 'Manual review: mitochondrial inner membrane is consistent with known biology of SHY1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0033617
    label: mitochondrial respiratory chain complex IV assembly
  evidence_type: IMP
  original_reference_id: PMID:17882259
  review:
    summary: 'Manual review: mitochondrial respiratory chain complex IV assembly is consistent with known biology of SHY1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:11389896
  review:
    summary: 'Manual review: unfolded protein binding is too generic or over-extended for SHY1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:11389896
  title: Shy1p occurs in a high molecular weight complex and is required for efficient assembly of cytochrome c oxidase in yeast.
  findings: []
- id: PMID:15306853
  title: Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae.
  findings: []
- id: PMID:16823961
  title: 'Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.'
  findings: []
- id: PMID:17882259
  title: Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.
  findings: []
- id: PMID:17882260
  title: Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
  findings: []
- id: PMID:24769239
  title: Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
  findings: []
- id: PMID:35563734
  title: Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis.
  findings: []
- id: PMID:9162072
  title: SHY1, the yeast homolog of the mammalian SURF-1 gene, encodes a mitochondrial protein required for respiration.
  findings: []