SQT1

UniProt ID: P35184
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for SQT1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005515 protein binding
IPI
PMID:16429126
Proteome survey reveals modularity of the yeast cell machine... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SQT1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:16554755
Global landscape of protein complexes in the yeast Saccharom... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SQT1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:27107014
An inter-species protein-protein interaction network across ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SQT1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SQT1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0051082 unfolded protein binding
IDA
PMID:26112308
Co-translational capturing of nascent ribosomal proteins by ... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for SQT1.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein carrier chaperone
GO:0005737 cytoplasm
HDA
PMID:11914276
Subcellular localization of the yeast proteome. 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of SQT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042273 ribosomal large subunit biogenesis
IMP
PMID:26112308
Co-translational capturing of nascent ribosomal proteins by ... 		ACCEPT
Summary: Manual review: ribosomal large subunit biogenesis is consistent with known biology of SQT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000027 ribosomal large subunit assembly
IMP
PMID:9271392
SQT1, which encodes an essential WD domain protein of Saccha... 		ACCEPT
Summary: Manual review: ribosomal large subunit assembly is consistent with known biology of SQT1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
IDA
PMID:9271392
SQT1, which encodes an essential WD domain protein of Saccha... 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of SQT1.
Reason: Retained as supported or plausible for this gene and evidence context.

References

PMID:11914276
Subcellular localization of the yeast proteome.
PMID:16429126
Proteome survey reveals modularity of the yeast cell machinery.
PMID:16554755
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
PMID:26112308
Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.
PMID:27107014
An inter-species protein-protein interaction network across vast evolutionary distance.
PMID:37968396
The social and structural architecture of the yeast protein interactome.
PMID:9271392
SQT1, which encodes an essential WD domain protein of Saccharomyces cerevisiae, suppresses dominant-negative mutations of the ribosomal protein gene QSR1.

📄 View Raw YAML

 
id: P35184
gene_symbol: SQT1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for SQT1'
existing_annotations:
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16429126
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SQT1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SQT1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107014
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SQT1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SQT1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:26112308
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for SQT1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0140597
      label: protein carrier chaperone
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: HDA
  original_reference_id: PMID:11914276
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of SQT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042273
    label: ribosomal large subunit biogenesis
  evidence_type: IMP
  original_reference_id: PMID:26112308
  review:
    summary: 'Manual review: ribosomal large subunit biogenesis is consistent with known biology of SQT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000027
    label: ribosomal large subunit assembly
  evidence_type: IMP
  original_reference_id: PMID:9271392
  review:
    summary: 'Manual review: ribosomal large subunit assembly is consistent with known biology of SQT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:9271392
  review:
    summary: 'Manual review: cytosol is consistent with known biology of SQT1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: PMID:11914276
  title: Subcellular localization of the yeast proteome.
  findings: []
- id: PMID:16429126
  title: Proteome survey reveals modularity of the yeast cell machinery.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:26112308
  title: Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.
  findings: []
- id: PMID:27107014
  title: An inter-species protein-protein interaction network across vast evolutionary distance.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []
- id: PMID:9271392
  title: SQT1, which encodes an essential WD domain protein of Saccharomyces cerevisiae, suppresses dominant-negative mutations of the ribosomal protein gene QSR1.
  findings: []