SSA3

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005634 nucleus	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: nucleus may be context-dependent or peripheral for SSA3. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: cytoplasm is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005886 plasma membrane	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: plasma membrane may be context-dependent or peripheral for SSA3. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: ATP hydrolysis activity is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0031072 heat shock protein binding	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: heat shock protein binding is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0044183 protein folding chaperone	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: protein folding chaperone is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: cytosol is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: protein refolding is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000166 nucleotide binding	IEA GO_REF:0000043	ACCEPT	Summary: Manual review: nucleotide binding is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005524 ATP binding	IEA GO_REF:0000120	ACCEPT	Summary: Manual review: ATP binding is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm	IEA GO_REF:0000120	ACCEPT	Summary: Manual review: cytoplasm is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding	IEA GO_REF:0000117	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: Manual review: SRP-dependent cotranslational protein targeting to membrane, translocation may be context-dependent or peripheral for SSA3. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity	IEA GO_REF:0000120	ACCEPT	Summary: Manual review: ATP hydrolysis activity is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IEA GO_REF:0000117	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for SSA3. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0005515 protein binding	IPI PMID:11805837 Systematic identification of protein complexes in Saccharomy...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSA3. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:16554755 Global landscape of protein complexes in the yeast Saccharom...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSA3. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:19536198 An atlas of chaperone-protein interactions in Saccharomyces ...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSA3. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:27107014 An inter-species protein-protein interaction network across ...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSA3. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:31454312 The role of structural pleiotropy and regulatory evolution i...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSA3. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins	IMP PMID:24855027 Life-span extension by a metacaspase in the yeast Saccharomy...	KEEP AS NON CORE	Summary: Manual review: protein quality control for misfolded or incompletely synthesized proteins may be context-dependent or peripheral for SSA3. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005829 cytosol	IDA PMID:10745074 Cytosolic Hsp70s are involved in the transport of aminopepti...	ACCEPT	Summary: Manual review: cytosol is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding	IGI PMID:9789005 Folding in vivo of a newly translated yeast cytosolic enzyme...	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation	IMP PMID:8754838 Functional interaction of cytosolic hsp70 and a DnaJ-related...	KEEP AS NON CORE	Summary: Manual review: SRP-dependent cotranslational protein targeting to membrane, translocation may be context-dependent or peripheral for SSA3. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity	IGI PMID:3302682 Complex interactions among members of an essential subfamily...	ACCEPT	Summary: Manual review: ATP hydrolysis activity is consistent with known biology of SSA3. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IGI PMID:9789005 Folding in vivo of a newly translated yeast cytosolic enzyme...	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for SSA3. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone

📄 View Raw YAML

id: P09435
gene_symbol: SSA3
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for SSA3'
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for SSA3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: plasma membrane may be context-dependent or peripheral for SSA3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0031072
    label: heat shock protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: heat shock protein binding is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0044183
    label: protein folding chaperone
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding chaperone is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytosol is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000166
    label: nucleotide binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: nucleotide binding is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: protein folding is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006616
    label: SRP-dependent cotranslational protein targeting to membrane, translocation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: SRP-dependent cotranslational protein targeting to membrane, translocation may be context-dependent or peripheral for SSA3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for SSA3.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11805837
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19536198
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107014
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31454312
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA3.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0006515
    label: protein quality control for misfolded or incompletely synthesized proteins
  evidence_type: IMP
  original_reference_id: PMID:24855027
  review:
    summary: 'Manual review: protein quality control for misfolded or incompletely synthesized proteins may be context-dependent or peripheral for SSA3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:10745074
  review:
    summary: 'Manual review: cytosol is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IGI
  original_reference_id: PMID:9789005
  review:
    summary: 'Manual review: protein folding is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006616
    label: SRP-dependent cotranslational protein targeting to membrane, translocation
  evidence_type: IMP
  original_reference_id: PMID:8754838
  review:
    summary: 'Manual review: SRP-dependent cotranslational protein targeting to membrane, translocation may be context-dependent or peripheral for SSA3.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IGI
  original_reference_id: PMID:3302682
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of SSA3.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IGI
  original_reference_id: PMID:9789005
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for SSA3.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10745074
  title: Cytosolic Hsp70s are involved in the transport of aminopeptidase 1 from the cytoplasm into the vacuole.
  findings: []
- id: PMID:11805837
  title: Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:19536198
  title: 'An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.'
  findings: []
- id: PMID:24855027
  title: Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:27107014
  title: An inter-species protein-protein interaction network across vast evolutionary distance.
  findings: []
- id: PMID:31454312
  title: The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs.
  findings: []
- id: PMID:3302682
  title: Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae.
  findings: []
- id: PMID:8754838
  title: Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo.
  findings: []
- id: PMID:9789005
  title: Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins.
  findings: []

Gene Description

Existing Annotations Review

References

📄 View Raw YAML