SSA4

UniProt ID: P22202
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for SSA4

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005634 nucleus
IBA
GO_REF:0000033 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for SSA4.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005886 plasma membrane
IBA
GO_REF:0000033 		KEEP AS NON CORE
Summary: Manual review: plasma membrane may be context-dependent or peripheral for SSA4.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: ATP hydrolysis activity is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0031072 heat shock protein binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: heat shock protein binding is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0044183 protein folding chaperone
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein folding chaperone is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042026 protein refolding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein refolding is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000166 nucleotide binding
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: nucleotide binding is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005524 ATP binding
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: ATP binding is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IEA
GO_REF:0000117 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
IEA
GO_REF:0000117 		KEEP AS NON CORE
Summary: Manual review: SRP-dependent cotranslational protein targeting to membrane, translocation may be context-dependent or peripheral for SSA4.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: ATP hydrolysis activity is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IEA
GO_REF:0000117 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for SSA4.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0005515 protein binding
IPI
PMID:16429126
Proteome survey reveals modularity of the yeast cell machine... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SSA4.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:17892321
Structure-templated predictions of novel protein interaction... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SSA4.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SSA4.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:31454312
The role of structural pleiotropy and regulatory evolution i... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SSA4.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:37968396
The social and structural architecture of the yeast protein ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for SSA4.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005634 nucleus
IDA
PMID:11279056
Starvation promotes nuclear accumulation of the hsp70 Ssa4p ... 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for SSA4.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm
IDA
PMID:11279056
Starvation promotes nuclear accumulation of the hsp70 Ssa4p ... 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IGI
PMID:9789005
Folding in vivo of a newly translated yeast cytosolic enzyme... 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of SSA4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
IMP
PMID:8754838
Functional interaction of cytosolic hsp70 and a DnaJ-related... 		KEEP AS NON CORE
Summary: Manual review: SRP-dependent cotranslational protein targeting to membrane, translocation may be context-dependent or peripheral for SSA4.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051082 unfolded protein binding
IGI
PMID:9789005
Folding in vivo of a newly translated yeast cytosolic enzyme... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for SSA4.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:11279056
Starvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells.
PMID:16429126
Proteome survey reveals modularity of the yeast cell machinery.
PMID:17892321
Structure-templated predictions of novel protein interactions from sequence information.
PMID:19536198
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.
PMID:31454312
The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs.
PMID:37968396
The social and structural architecture of the yeast protein interactome.
PMID:8754838
Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo.
PMID:9789005
Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins.

📄 View Raw YAML

 
id: P22202
gene_symbol: SSA4
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for SSA4'
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for SSA4.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: plasma membrane may be context-dependent or peripheral for SSA4.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0031072
    label: heat shock protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: heat shock protein binding is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0044183
    label: protein folding chaperone
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding chaperone is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytosol is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000166
    label: nucleotide binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: nucleotide binding is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: protein folding is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006616
    label: SRP-dependent cotranslational protein targeting to membrane, translocation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: SRP-dependent cotranslational protein targeting to membrane, translocation may be context-dependent or peripheral for SSA4.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for SSA4.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16429126
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA4.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17892321
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA4.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19536198
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA4.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31454312
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA4.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSA4.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:11279056
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for SSA4.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:11279056
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IGI
  original_reference_id: PMID:9789005
  review:
    summary: 'Manual review: protein folding is consistent with known biology of SSA4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006616
    label: SRP-dependent cotranslational protein targeting to membrane, translocation
  evidence_type: IMP
  original_reference_id: PMID:8754838
  review:
    summary: 'Manual review: SRP-dependent cotranslational protein targeting to membrane, translocation may be context-dependent or peripheral for SSA4.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IGI
  original_reference_id: PMID:9789005
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for SSA4.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:11279056
  title: Starvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells.
  findings: []
- id: PMID:16429126
  title: Proteome survey reveals modularity of the yeast cell machinery.
  findings: []
- id: PMID:17892321
  title: Structure-templated predictions of novel protein interactions from sequence information.
  findings: []
- id: PMID:19536198
  title: 'An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.'
  findings: []
- id: PMID:31454312
  title: The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []
- id: PMID:8754838
  title: Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo.
  findings: []
- id: PMID:9789005
  title: Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins.
  findings: []