TODO: Add description for SSB1
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
|
GO:0003729
mRNA binding
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: Manual review: mRNA binding is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005634
nucleus
|
IBA
GO_REF:0000033 |
KEEP AS NON CORE |
Summary: Manual review: nucleus may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0005737
cytoplasm
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: Manual review: cytoplasm is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:1990904
ribonucleoprotein complex
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: Manual review: ribonucleoprotein complex is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0000932
P-body
|
IEA
GO_REF:0000044 |
KEEP AS NON CORE |
Summary: Manual review: P-body may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0003676
nucleic acid binding
|
IEA
GO_REF:0000002 |
ACCEPT |
Summary: Manual review: nucleic acid binding is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0003723
RNA binding
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: Manual review: RNA binding is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005730
nucleolus
|
IEA
GO_REF:0000044 |
KEEP AS NON CORE |
Summary: Manual review: nucleolus may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0005737
cytoplasm
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: Manual review: cytoplasm is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0010494
cytoplasmic stress granule
|
IEA
GO_REF:0000044 |
KEEP AS NON CORE |
Summary: Manual review: cytoplasmic stress granule may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0005515
protein binding
|
IPI
PMID:16429126 Proteome survey reveals modularity of the yeast cell machine... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for SSB1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:16554755 Global landscape of protein complexes in the yeast Saccharom... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for SSB1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:37968396 The social and structural architecture of the yeast protein ... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for SSB1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0045947
negative regulation of translational initiation
|
IDA
PMID:28986506 Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- an... |
KEEP AS NON CORE |
Summary: Manual review: negative regulation of translational initiation may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0045947
negative regulation of translational initiation
|
IMP
PMID:28986506 Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- an... |
KEEP AS NON CORE |
Summary: Manual review: negative regulation of translational initiation may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0045947
negative regulation of translational initiation
|
IDA
PMID:39617253 An Intrinsically Disordered RNA Binding Protein Modulates mR... |
KEEP AS NON CORE |
Summary: Manual review: negative regulation of translational initiation may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0045947
negative regulation of translational initiation
|
IMP
PMID:39617253 An Intrinsically Disordered RNA Binding Protein Modulates mR... |
KEEP AS NON CORE |
Summary: Manual review: negative regulation of translational initiation may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0048027
mRNA 5'-UTR binding
|
IDA
PMID:28986506 Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- an... |
ACCEPT |
Summary: Manual review: mRNA 5'-UTR binding is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0048027
mRNA 5'-UTR binding
|
IDA
PMID:39617253 An Intrinsically Disordered RNA Binding Protein Modulates mR... |
ACCEPT |
Summary: Manual review: mRNA 5'-UTR binding is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0035617
stress granule disassembly
|
IDA
PMID:35440550 Low complexity RGG-motif sequence is required for Processing... |
KEEP AS NON CORE |
Summary: Manual review: stress granule disassembly may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0000932
P-body
|
IDA
PMID:23222640 Global analysis of yeast mRNPs. |
KEEP AS NON CORE |
Summary: Manual review: P-body may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0010494
cytoplasmic stress granule
|
IDA
PMID:23222640 Global analysis of yeast mRNPs. |
KEEP AS NON CORE |
Summary: Manual review: cytoplasmic stress granule may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0010494
cytoplasmic stress granule
|
HDA
PMID:26777405 ATPase-Modulated Stress Granules Contain a Diverse Proteome ... |
KEEP AS NON CORE |
Summary: Manual review: cytoplasmic stress granule may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0003729
mRNA binding
|
HDA
PMID:23222640 Global analysis of yeast mRNPs. |
ACCEPT |
Summary: Manual review: mRNA binding is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0003729
mRNA binding
|
IDA
PMID:23222640 Global analysis of yeast mRNPs. |
ACCEPT |
Summary: Manual review: mRNA binding is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0000932
P-body
|
IDA
PMID:16782896 Sbp1p affects translational repression and decapping in Sacc... |
KEEP AS NON CORE |
Summary: Manual review: P-body may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0005730
nucleolus
|
IDA
PMID:2121740 SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-s... |
KEEP AS NON CORE |
Summary: Manual review: nucleolus may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0005730
nucleolus
|
IDA
PMID:2823109 Saccharomyces cerevisiae SSB1 protein and its relationship t... |
KEEP AS NON CORE |
Summary: Manual review: nucleolus may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:16782896 Sbp1p affects translational repression and decapping in Sacc... |
ACCEPT |
Summary: Manual review: cytoplasm is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0017148
negative regulation of translation
|
IDA
PMID:22284680 Scd6 targets eIF4G to repress translation: RGG motif protein... |
KEEP AS NON CORE |
Summary: Manual review: negative regulation of translation may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
|
GO:0031370
eukaryotic initiation factor 4G binding
|
IDA
PMID:22284680 Scd6 targets eIF4G to repress translation: RGG motif protein... |
ACCEPT |
Summary: Manual review: eukaryotic initiation factor 4G binding is consistent with known biology of SSB1.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0032055
negative regulation of translation in response to stress
|
IMP
PMID:16782896 Sbp1p affects translational repression and decapping in Sacc... |
KEEP AS NON CORE |
Summary: Manual review: negative regulation of translation in response to stress may be context-dependent or peripheral for SSB1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
|
id: P10080
gene_symbol: SSB1
product_type: PROTEIN
status: DRAFT
taxon:
id: NCBITaxon:559292
label: Saccharomyces cerevisiae
description: 'TODO: Add description for SSB1'
existing_annotations:
- term:
id: GO:0003729
label: mRNA binding
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: mRNA binding is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005634
label: nucleus
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: nucleus may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: cytoplasm is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:1990904
label: ribonucleoprotein complex
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: ribonucleoprotein complex is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0000932
label: P-body
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'Manual review: P-body may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0003676
label: nucleic acid binding
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'Manual review: nucleic acid binding is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0003723
label: RNA binding
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'Manual review: RNA binding is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005730
label: nucleolus
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'Manual review: nucleolus may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'Manual review: cytoplasm is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0010494
label: cytoplasmic stress granule
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'Manual review: cytoplasmic stress granule may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16429126
review:
summary: 'Manual review: protein binding is too generic or over-extended for SSB1.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16554755
review:
summary: 'Manual review: protein binding is too generic or over-extended for SSB1.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:37968396
review:
summary: 'Manual review: protein binding is too generic or over-extended for SSB1.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0045947
label: negative regulation of translational initiation
evidence_type: IDA
original_reference_id: PMID:28986506
review:
summary: 'Manual review: negative regulation of translational initiation may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0045947
label: negative regulation of translational initiation
evidence_type: IMP
original_reference_id: PMID:28986506
review:
summary: 'Manual review: negative regulation of translational initiation may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0045947
label: negative regulation of translational initiation
evidence_type: IDA
original_reference_id: PMID:39617253
review:
summary: 'Manual review: negative regulation of translational initiation may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0045947
label: negative regulation of translational initiation
evidence_type: IMP
original_reference_id: PMID:39617253
review:
summary: 'Manual review: negative regulation of translational initiation may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0048027
label: mRNA 5'-UTR binding
evidence_type: IDA
original_reference_id: PMID:28986506
review:
summary: 'Manual review: mRNA 5''-UTR binding is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0048027
label: mRNA 5'-UTR binding
evidence_type: IDA
original_reference_id: PMID:39617253
review:
summary: 'Manual review: mRNA 5''-UTR binding is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0035617
label: stress granule disassembly
evidence_type: IDA
original_reference_id: PMID:35440550
review:
summary: 'Manual review: stress granule disassembly may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0000932
label: P-body
evidence_type: IDA
original_reference_id: PMID:23222640
review:
summary: 'Manual review: P-body may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0010494
label: cytoplasmic stress granule
evidence_type: IDA
original_reference_id: PMID:23222640
review:
summary: 'Manual review: cytoplasmic stress granule may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0010494
label: cytoplasmic stress granule
evidence_type: HDA
original_reference_id: PMID:26777405
review:
summary: 'Manual review: cytoplasmic stress granule may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0003729
label: mRNA binding
evidence_type: HDA
original_reference_id: PMID:23222640
review:
summary: 'Manual review: mRNA binding is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0003729
label: mRNA binding
evidence_type: IDA
original_reference_id: PMID:23222640
review:
summary: 'Manual review: mRNA binding is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0000932
label: P-body
evidence_type: IDA
original_reference_id: PMID:16782896
review:
summary: 'Manual review: P-body may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0005730
label: nucleolus
evidence_type: IDA
original_reference_id: PMID:2121740
review:
summary: 'Manual review: nucleolus may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0005730
label: nucleolus
evidence_type: IDA
original_reference_id: PMID:2823109
review:
summary: 'Manual review: nucleolus may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:16782896
review:
summary: 'Manual review: cytoplasm is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0017148
label: negative regulation of translation
evidence_type: IDA
original_reference_id: PMID:22284680
review:
summary: 'Manual review: negative regulation of translation may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
id: GO:0031370
label: eukaryotic initiation factor 4G binding
evidence_type: IDA
original_reference_id: PMID:22284680
review:
summary: 'Manual review: eukaryotic initiation factor 4G binding is consistent with known biology of SSB1.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0032055
label: negative regulation of translation in response to stress
evidence_type: IMP
original_reference_id: PMID:16782896
review:
summary: 'Manual review: negative regulation of translation in response to stress may be context-dependent or peripheral for SSB1.'
action: KEEP_AS_NON_CORE
reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
references:
- id: GO_REF:0000002
title: Gene Ontology annotation through association of InterPro records with GO terms
findings: []
- id: GO_REF:0000033
title: Annotation inferences using phylogenetic trees
findings: []
- id: GO_REF:0000044
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
findings: []
- id: GO_REF:0000120
title: Combined Automated Annotation using Multiple IEA Methods
findings: []
- id: PMID:16429126
title: Proteome survey reveals modularity of the yeast cell machinery.
findings: []
- id: PMID:16554755
title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
findings: []
- id: PMID:16782896
title: Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae.
findings: []
- id: PMID:2121740
title: SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs.
findings: []
- id: PMID:22284680
title: 'Scd6 targets eIF4G to repress translation: RGG motif proteins as a class of eIF4G-binding proteins.'
findings: []
- id: PMID:23222640
title: Global analysis of yeast mRNPs.
findings: []
- id: PMID:26777405
title: ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.
findings: []
- id: PMID:2823109
title: Saccharomyces cerevisiae SSB1 protein and its relationship to nucleolar RNA-binding proteins.
findings: []
- id: PMID:28986506
title: Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner.
findings: []
- id: PMID:35440550
title: Low complexity RGG-motif sequence is required for Processing body (P-body) disassembly.
findings: []
- id: PMID:37968396
title: The social and structural architecture of the yeast protein interactome.
findings: []
- id: PMID:39617253
title: An Intrinsically Disordered RNA Binding Protein Modulates mRNA Translation and Storage.
findings: []