SSZ1

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005634 nucleus	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: nucleus may be context-dependent or peripheral for SSZ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: cytoplasm may be context-dependent or peripheral for SSZ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005886 plasma membrane	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: plasma membrane may be context-dependent or peripheral for SSZ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: ATP hydrolysis activity is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0031072 heat shock protein binding	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: heat shock protein binding is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0044183 protein folding chaperone	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: protein folding chaperone is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: cytosol may be context-dependent or peripheral for SSZ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0042026 protein refolding	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: protein refolding is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000166 nucleotide binding	IEA GO_REF:0000043	ACCEPT	Summary: Manual review: nucleotide binding is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005524 ATP binding	IEA GO_REF:0000120	ACCEPT	Summary: Manual review: ATP binding is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Manual review: cytoplasm may be context-dependent or peripheral for SSZ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016887 ATP hydrolysis activity	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: ATP hydrolysis activity is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding	IPI PMID:11274393 RAC, a stable ribosome-associated complex in yeast formed by...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSZ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:15766533 Navigating the chaperone network: an integrative map of phys...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSZ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:16429126 Proteome survey reveals modularity of the yeast cell machine...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSZ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:16554755 Global landscape of protein complexes in the yeast Saccharom...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSZ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:19536198 An atlas of chaperone-protein interactions in Saccharomyces ...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSZ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:23202586 Structural characterization of a eukaryotic chaperone--the r...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSZ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:37070168 RNA-dependent interactome allows network-based assignment of...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSZ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:37968396 The social and structural architecture of the yeast protein ...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for SSZ1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0006450 regulation of translational fidelity	IDA PMID:15456889 The ribosome-bound chaperones RAC and Ssb1/2p are required f...	ACCEPT	Summary: Manual review: regulation of translational fidelity is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding	NAS PMID:11274393 RAC, a stable ribosome-associated complex in yeast formed by...	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051083 'de novo' cotranslational protein folding	IDA PMID:11274393 RAC, a stable ribosome-associated complex in yeast formed by...	ACCEPT	Summary: Manual review: 'de novo' cotranslational protein folding is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IMP PMID:11054575 Yeast Pdr13p and Zuo1p molecular chaperones are new function...	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for SSZ1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0051083 'de novo' cotranslational protein folding	IMP PMID:11274393 RAC, a stable ribosome-associated complex in yeast formed by...	ACCEPT	Summary: Manual review: 'de novo' cotranslational protein folding is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006452 translational frameshifting	IMP PMID:16607023 Specific effects of ribosome-tethered molecular chaperones o...	ACCEPT	Summary: Manual review: translational frameshifting is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0002181 cytoplasmic translation	IMP PMID:11929994 A functional chaperone triad on the yeast ribosome.	ACCEPT	Summary: Manual review: cytoplasmic translation is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm	IDA PMID:10792726 Hyperactive forms of the Pdr1p transcription factor fail to ...	KEEP AS NON CORE	Summary: Manual review: cytoplasm may be context-dependent or peripheral for SSZ1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006364 rRNA processing	IMP PMID:20368619 A ribosome-anchored chaperone network that facilitates eukar...	ACCEPT	Summary: Manual review: rRNA processing is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006450 regulation of translational fidelity	IMP PMID:15456889 The ribosome-bound chaperones RAC and Ssb1/2p are required f...	ACCEPT	Summary: Manual review: regulation of translational fidelity is consistent with known biology of SSZ1. Reason: Retained as supported or plausible for this gene and evidence context.

📄 View Raw YAML

id: P38788
gene_symbol: SSZ1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for SSZ1'
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for SSZ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for SSZ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: plasma membrane may be context-dependent or peripheral for SSZ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0031072
    label: heat shock protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: heat shock protein binding is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0044183
    label: protein folding chaperone
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein folding chaperone is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytosol may be context-dependent or peripheral for SSZ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0042026
    label: protein refolding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein refolding is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000166
    label: nucleotide binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: nucleotide binding is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: ATP binding is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for SSZ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016887
    label: ATP hydrolysis activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: ATP hydrolysis activity is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11274393
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSZ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15766533
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSZ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16429126
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSZ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSZ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19536198
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSZ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23202586
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSZ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37070168
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSZ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for SSZ1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0006450
    label: regulation of translational fidelity
  evidence_type: IDA
  original_reference_id: PMID:15456889
  review:
    summary: 'Manual review: regulation of translational fidelity is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: NAS
  original_reference_id: PMID:11274393
  review:
    summary: 'Manual review: protein folding is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051083
    label: '''de novo'' cotranslational protein folding'
  evidence_type: IDA
  original_reference_id: PMID:11274393
  review:
    summary: 'Manual review: ''de novo'' cotranslational protein folding is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:11054575
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for SSZ1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0051083
    label: '''de novo'' cotranslational protein folding'
  evidence_type: IMP
  original_reference_id: PMID:11274393
  review:
    summary: 'Manual review: ''de novo'' cotranslational protein folding is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006452
    label: translational frameshifting
  evidence_type: IMP
  original_reference_id: PMID:16607023
  review:
    summary: 'Manual review: translational frameshifting is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0002181
    label: cytoplasmic translation
  evidence_type: IMP
  original_reference_id: PMID:11929994
  review:
    summary: 'Manual review: cytoplasmic translation is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:10792726
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for SSZ1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006364
    label: rRNA processing
  evidence_type: IMP
  original_reference_id: PMID:20368619
  review:
    summary: 'Manual review: rRNA processing is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006450
    label: regulation of translational fidelity
  evidence_type: IMP
  original_reference_id: PMID:15456889
  review:
    summary: 'Manual review: regulation of translational fidelity is consistent with known biology of SSZ1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10792726
  title: Hyperactive forms of the Pdr1p transcription factor fail to respond to positive regulation by the hsp70 protein Pdr13p.
  findings: []
- id: PMID:11054575
  title: Yeast Pdr13p and Zuo1p molecular chaperones are new functional Hsp70 and Hsp40 partners.
  findings: []
- id: PMID:11274393
  title: RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin.
  findings: []
- id: PMID:11929994
  title: A functional chaperone triad on the yeast ribosome.
  findings: []
- id: PMID:15456889
  title: The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae.
  findings: []
- id: PMID:15766533
  title: 'Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.'
  findings: []
- id: PMID:16429126
  title: Proteome survey reveals modularity of the yeast cell machinery.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:16607023
  title: Specific effects of ribosome-tethered molecular chaperones on programmed -1 ribosomal frameshifting.
  findings: []
- id: PMID:19536198
  title: 'An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.'
  findings: []
- id: PMID:20368619
  title: A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis.
  findings: []
- id: PMID:23202586
  title: Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.
  findings: []
- id: PMID:37070168
  title: RNA-dependent interactome allows network-based assignment of RNA-binding protein function.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []

Gene Description

Existing Annotations Review

References

📄 View Raw YAML