TSA1

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005829 cytosol	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: cytosol is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006979 response to oxidative stress	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Manual review: response to oxidative stress may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0008379 thioredoxin peroxidase activity	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042744 hydrogen peroxide catabolic process	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: hydrogen peroxide catabolic process is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0045454 cell redox homeostasis	IBA GO_REF:0000033	ACCEPT	Summary: Manual review: cell redox homeostasis is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0098869 cellular oxidant detoxification	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: Manual review: cellular oxidant detoxification may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0004601 peroxidase activity	IEA GO_REF:0000043	ACCEPT	Summary: Manual review: peroxidase activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm	IEA GO_REF:0000120	ACCEPT	Summary: Manual review: cytoplasm is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008379 thioredoxin peroxidase activity	IEA GO_REF:0000117	ACCEPT	Summary: Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016209 antioxidant activity	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: Manual review: antioxidant activity may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016491 oxidoreductase activity	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: Manual review: oxidoreductase activity may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0034599 cellular response to oxidative stress	IEA GO_REF:0000117	ACCEPT	Summary: Manual review: cellular response to oxidative stress is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034605 cellular response to heat	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: Manual review: cellular response to heat may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0045454 cell redox homeostasis	IEA GO_REF:0000117	ACCEPT	Summary: Manual review: cell redox homeostasis is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0050821 protein stabilization	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: Manual review: protein stabilization may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051920 peroxiredoxin activity	IEA GO_REF:0000002	ACCEPT	Summary: Manual review: peroxiredoxin activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0140824 thioredoxin-dependent peroxiredoxin activity	IEA GO_REF:0000120	ACCEPT	Summary: Manual review: thioredoxin-dependent peroxiredoxin activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding	IPI PMID:16272220 A yeast two-hybrid knockout strain to explore thioredoxin-in...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for TSA1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:16554755 Global landscape of protein complexes in the yeast Saccharom...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for TSA1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:18719252 High-quality binary protein interaction map of the yeast int...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for TSA1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding	IPI PMID:37968396 The social and structural architecture of the yeast protein ...	MARK AS OVER ANNOTATED	Summary: Manual review: protein binding is too generic or over-extended for TSA1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0019207 kinase regulator activity	IMP PMID:27634403 Redox-dependent Regulation of Gluconeogenesis by a Novel Mec...	KEEP AS NON CORE	Summary: Manual review: kinase regulator activity may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm	HDA PMID:22842922 Dissecting DNA damage response pathways by analysing protein...	ACCEPT	Summary: Manual review: cytoplasm is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006111 regulation of gluconeogenesis	IMP PMID:27634403 Redox-dependent Regulation of Gluconeogenesis by a Novel Mec...	KEEP AS NON CORE	Summary: Manual review: regulation of gluconeogenesis may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006457 protein folding	IDA PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding	IMP PMID:16251355 The thioredoxin system protects ribosomes against stress-ind...	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034599 cellular response to oxidative stress	IDA PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	ACCEPT	Summary: Manual review: cellular response to oxidative stress is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034605 cellular response to heat	IDA PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	KEEP AS NON CORE	Summary: Manual review: cellular response to heat may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051082 unfolded protein binding	IDA PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for TSA1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0072721 cellular response to dithiothreitol	IMP PMID:16251355 The thioredoxin system protects ribosomes against stress-ind...	KEEP AS NON CORE	Summary: Manual review: cellular response to dithiothreitol may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006457 protein folding	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008379 thioredoxin peroxidase activity	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	ACCEPT	Summary: Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034605 cellular response to heat	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	KEEP AS NON CORE	Summary: Manual review: cellular response to heat may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0042802 identical protein binding	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	MARK AS OVER ANNOTATED	Summary: Manual review: identical protein binding is too generic or over-extended for TSA1. Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0045454 cell redox homeostasis	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	ACCEPT	Summary: Manual review: cell redox homeostasis is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0050821 protein stabilization	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	KEEP AS NON CORE	Summary: Manual review: protein stabilization may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051082 unfolded protein binding	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for TSA1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0051258 protein polymerization	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	KEEP AS NON CORE	Summary: Manual review: protein polymerization may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0071447 cellular response to hydroperoxide	IMP PMID:15163410 Two enzymes in one; two yeast peroxiredoxins display oxidati...	KEEP AS NON CORE	Summary: Manual review: cellular response to hydroperoxide may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0006457 protein folding	IMP PMID:24022485 Peroxiredoxin chaperone activity is critical for protein hom...	ACCEPT	Summary: Manual review: protein folding is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000077 DNA damage checkpoint signaling	IGI PMID:19851444 Loss of yeast peroxiredoxin Tsa1p induces genome instability...	KEEP AS NON CORE	Summary: Manual review: DNA damage checkpoint signaling may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm	IDA PMID:10681558 Distinct physiological functions of thiol peroxidase isoenzy...	ACCEPT	Summary: Manual review: cytoplasm is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm	IDA PMID:8344960 Cloning, sequencing, and mutation of thiol-specific antioxid...	ACCEPT	Summary: Manual review: cytoplasm is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol	IDA PMID:18271751 The yeast Tsa1 peroxiredoxin is a ribosome-associated antiox...	ACCEPT	Summary: Manual review: cytosol is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008379 thioredoxin peroxidase activity	IDA PMID:7961686 Thioredoxin-dependent peroxide reductase from yeast.	ACCEPT	Summary: Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008379 thioredoxin peroxidase activity	IMP PMID:7961686 Thioredoxin-dependent peroxide reductase from yeast.	ACCEPT	Summary: Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008379 thioredoxin peroxidase activity	IDA PMID:9799566 Thermosensitive phenotype of yeast mutant lacking thioredoxi...	ACCEPT	Summary: Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0008379 thioredoxin peroxidase activity	IMP PMID:9799566 Thermosensitive phenotype of yeast mutant lacking thioredoxi...	ACCEPT	Summary: Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0033194 response to hydroperoxide	IMP PMID:15210711 Cytosolic thioredoxin peroxidase I and II are important defe...	KEEP AS NON CORE	Summary: Manual review: response to hydroperoxide may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0034599 cellular response to oxidative stress	IGI PMID:15051715 Peroxiredoxin-null yeast cells are hypersensitive to oxidati...	ACCEPT	Summary: Manual review: cellular response to oxidative stress is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034599 cellular response to oxidative stress	IMP PMID:18271751 The yeast Tsa1 peroxiredoxin is a ribosome-associated antiox...	ACCEPT	Summary: Manual review: cellular response to oxidative stress is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034599 cellular response to oxidative stress	IDA PMID:8344960 Cloning, sequencing, and mutation of thiol-specific antioxid...	ACCEPT	Summary: Manual review: cellular response to oxidative stress is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034599 cellular response to oxidative stress	IMP PMID:8344960 Cloning, sequencing, and mutation of thiol-specific antioxid...	ACCEPT	Summary: Manual review: cellular response to oxidative stress is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042262 DNA protection	IMP PMID:19543365 Peroxiredoxin Tsa1 is the key peroxidase suppressing genome ...	KEEP AS NON CORE	Summary: Manual review: DNA protection may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0043022 ribosome binding	IDA PMID:18271751 The yeast Tsa1 peroxiredoxin is a ribosome-associated antiox...	KEEP AS NON CORE	Summary: Manual review: ribosome binding may be context-dependent or peripheral for TSA1. Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0045454 cell redox homeostasis	IDA PMID:8344960 Cloning, sequencing, and mutation of thiol-specific antioxid...	ACCEPT	Summary: Manual review: cell redox homeostasis is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0045454 cell redox homeostasis	IMP PMID:8344960 Cloning, sequencing, and mutation of thiol-specific antioxid...	ACCEPT	Summary: Manual review: cell redox homeostasis is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0045454 cell redox homeostasis	IMP PMID:9799566 Thermosensitive phenotype of yeast mutant lacking thioredoxi...	ACCEPT	Summary: Manual review: cell redox homeostasis is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding	IMP PMID:16251355 The thioredoxin system protects ribosomes against stress-ind...	MODIFY	Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for TSA1. Reason: Modified to align with current curation guidance and improve term specificity. Proposed replacements: protein folding chaperone
GO:0051920 peroxiredoxin activity	IDA PMID:17210445 Reactions of yeast thioredoxin peroxidases I and II with hyd...	ACCEPT	Summary: Manual review: peroxiredoxin activity is consistent with known biology of TSA1. Reason: Retained as supported or plausible for this gene and evidence context.

📄 View Raw YAML

id: P34760
gene_symbol: TSA1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: >-
  TSA1 encodes the major cytoplasmic thioredoxin peroxidase (peroxiredoxin),
  a dual-function protein that acts as both an antioxidant enzyme and a
  molecular chaperone. As a peroxidase, Tsa1p catalyzes the
  thioredoxin-dependent reduction of hydrogen peroxide and organic
  hydroperoxides, protecting cells against oxidative damage. It also serves
  as a hydrogen peroxide sensor and signal transducer, relaying the H2O2
  signal to the transcription factor Yap1p by inducing intramolecular
  disulfide bond formation that triggers Yap1p nuclear accumulation and
  activation. Under oxidative stress or heat shock, Tsa1p undergoes a
  reversible structural switch from low-molecular-weight peroxidase species to
  high-molecular-weight oligomeric complexes with chaperone holdase activity,
  enhancing resistance to proteotoxic stress. Tsa1p also associates with
  ribosomes as an antioxidant, protects against oxidative damage caused by
  nascent-protein misfolding, and is required for telomere length maintenance.
  Orthologous to human PRDX1/PRDX2.
existing_annotations:
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytosol is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006979
    label: response to oxidative stress
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: response to oxidative stress may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0008379
    label: thioredoxin peroxidase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042744
    label: hydrogen peroxide catabolic process
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: hydrogen peroxide catabolic process is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0045454
    label: cell redox homeostasis
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cell redox homeostasis is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0098869
    label: cellular oxidant detoxification
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: cellular oxidant detoxification may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0004601
    label: peroxidase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: peroxidase activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008379
    label: thioredoxin peroxidase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016209
    label: antioxidant activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: antioxidant activity may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016491
    label: oxidoreductase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: oxidoreductase activity may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0034599
    label: cellular response to oxidative stress
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: cellular response to oxidative stress is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034605
    label: cellular response to heat
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: cellular response to heat may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0045454
    label: cell redox homeostasis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: cell redox homeostasis is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0050821
    label: protein stabilization
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'Manual review: protein stabilization may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051920
    label: peroxiredoxin activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: peroxiredoxin activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0140824
    label: thioredoxin-dependent peroxiredoxin activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: thioredoxin-dependent peroxiredoxin activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16272220
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for TSA1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16554755
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for TSA1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18719252
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for TSA1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37968396
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for TSA1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0019207
    label: kinase regulator activity
  evidence_type: IMP
  original_reference_id: PMID:27634403
  review:
    summary: 'Manual review: kinase regulator activity may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: HDA
  original_reference_id: PMID:22842922
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006111
    label: regulation of gluconeogenesis
  evidence_type: IMP
  original_reference_id: PMID:27634403
  review:
    summary: 'Manual review: regulation of gluconeogenesis may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IDA
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: protein folding is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IMP
  original_reference_id: PMID:16251355
  review:
    summary: 'Manual review: protein folding is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034599
    label: cellular response to oxidative stress
  evidence_type: IDA
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: cellular response to oxidative stress is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034605
    label: cellular response to heat
  evidence_type: IDA
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: cellular response to heat may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for TSA1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0072721
    label: cellular response to dithiothreitol
  evidence_type: IMP
  original_reference_id: PMID:16251355
  review:
    summary: 'Manual review: cellular response to dithiothreitol may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: protein folding is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008379
    label: thioredoxin peroxidase activity
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034605
    label: cellular response to heat
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: cellular response to heat may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: identical protein binding is too generic or over-extended for TSA1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0045454
    label: cell redox homeostasis
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: cell redox homeostasis is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0050821
    label: protein stabilization
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: protein stabilization may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for TSA1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0051258
    label: protein polymerization
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: protein polymerization may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0071447
    label: cellular response to hydroperoxide
  evidence_type: IMP
  original_reference_id: PMID:15163410
  review:
    summary: 'Manual review: cellular response to hydroperoxide may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IMP
  original_reference_id: PMID:24022485
  review:
    summary: 'Manual review: protein folding is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000077
    label: DNA damage checkpoint signaling
  evidence_type: IGI
  original_reference_id: PMID:19851444
  review:
    summary: 'Manual review: DNA damage checkpoint signaling may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:10681558
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:8344960
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:18271751
  review:
    summary: 'Manual review: cytosol is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008379
    label: thioredoxin peroxidase activity
  evidence_type: IDA
  original_reference_id: PMID:7961686
  review:
    summary: 'Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008379
    label: thioredoxin peroxidase activity
  evidence_type: IMP
  original_reference_id: PMID:7961686
  review:
    summary: 'Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008379
    label: thioredoxin peroxidase activity
  evidence_type: IDA
  original_reference_id: PMID:9799566
  review:
    summary: 'Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0008379
    label: thioredoxin peroxidase activity
  evidence_type: IMP
  original_reference_id: PMID:9799566
  review:
    summary: 'Manual review: thioredoxin peroxidase activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0033194
    label: response to hydroperoxide
  evidence_type: IMP
  original_reference_id: PMID:15210711
  review:
    summary: 'Manual review: response to hydroperoxide may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0034599
    label: cellular response to oxidative stress
  evidence_type: IGI
  original_reference_id: PMID:15051715
  review:
    summary: 'Manual review: cellular response to oxidative stress is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034599
    label: cellular response to oxidative stress
  evidence_type: IMP
  original_reference_id: PMID:18271751
  review:
    summary: 'Manual review: cellular response to oxidative stress is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034599
    label: cellular response to oxidative stress
  evidence_type: IDA
  original_reference_id: PMID:8344960
  review:
    summary: 'Manual review: cellular response to oxidative stress is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034599
    label: cellular response to oxidative stress
  evidence_type: IMP
  original_reference_id: PMID:8344960
  review:
    summary: 'Manual review: cellular response to oxidative stress is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042262
    label: DNA protection
  evidence_type: IMP
  original_reference_id: PMID:19543365
  review:
    summary: 'Manual review: DNA protection may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0043022
    label: ribosome binding
  evidence_type: IDA
  original_reference_id: PMID:18271751
  review:
    summary: 'Manual review: ribosome binding may be context-dependent or peripheral for TSA1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0045454
    label: cell redox homeostasis
  evidence_type: IDA
  original_reference_id: PMID:8344960
  review:
    summary: 'Manual review: cell redox homeostasis is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0045454
    label: cell redox homeostasis
  evidence_type: IMP
  original_reference_id: PMID:8344960
  review:
    summary: 'Manual review: cell redox homeostasis is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0045454
    label: cell redox homeostasis
  evidence_type: IMP
  original_reference_id: PMID:9799566
  review:
    summary: 'Manual review: cell redox homeostasis is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IMP
  original_reference_id: PMID:16251355
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for TSA1.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0051920
    label: peroxiredoxin activity
  evidence_type: IDA
  original_reference_id: PMID:17210445
  review:
    summary: 'Manual review: peroxiredoxin activity is consistent with known biology of TSA1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10681558
  title: Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae.
  findings: []
- id: PMID:15051715
  title: Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable.
  findings: []
- id: PMID:15163410
  title: Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function.
  findings: []
- id: PMID:15210711
  title: 'Cytosolic thioredoxin peroxidase I and II are important defenses of yeast against organic hydroperoxide insult: catalases and peroxiredoxins cooperate in the decomposition of H2O2 by yeast.'
  findings: []
- id: PMID:16251355
  title: The thioredoxin system protects ribosomes against stress-induced aggregation.
  findings: []
- id: PMID:16272220
  title: A yeast two-hybrid knockout strain to explore thioredoxin-interacting proteins in vivo.
  findings: []
- id: PMID:16554755
  title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  findings: []
- id: PMID:17210445
  title: 'Reactions of yeast thioredoxin peroxidases I and II with hydrogen peroxide and peroxynitrite: rate constants by competitive kinetics.'
  findings: []
- id: PMID:18271751
  title: The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant.
  findings: []
- id: PMID:18719252
  title: High-quality binary protein interaction map of the yeast interactome network.
  findings: []
- id: PMID:19543365
  title: Peroxiredoxin Tsa1 is the key peroxidase suppressing genome instability and protecting against cell death in Saccharomyces cerevisiae.
  findings: []
- id: PMID:19851444
  title: Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels.
  findings: []
- id: PMID:22842922
  title: Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
  findings: []
- id: PMID:24022485
  title: Peroxiredoxin chaperone activity is critical for protein homeostasis in zinc-deficient yeast.
  findings: []
- id: PMID:27634403
  title: Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin.
  findings: []
- id: PMID:37968396
  title: The social and structural architecture of the yeast protein interactome.
  findings: []
- id: PMID:7961686
  title: Thioredoxin-dependent peroxide reductase from yeast.
  findings: []
- id: PMID:8344960
  title: Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae.
  findings: []
- id: PMID:9799566
  title: Thermosensitive phenotype of yeast mutant lacking thioredoxin peroxidase.
  findings: []

Gene Description

Existing Annotations Review

References

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