TSR4

UniProt ID: P25040
Organism: Saccharomyces cerevisiae
Review Status: DRAFT
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Gene Description

TODO: Add description for TSR4

Existing Annotations Review

GO Term Evidence Action Reason
GO:0030490 maturation of SSU-rRNA
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: maturation of SSU-rRNA is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042254 ribosome biogenesis
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: ribosome biogenesis is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
IDA
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein ch... 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0140597 protein carrier chaperone
IDA
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein ch... 		ACCEPT
Summary: Manual review: protein carrier chaperone is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042274 ribosomal small subunit biogenesis
IMP
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein ch... 		ACCEPT
Summary: Manual review: ribosomal small subunit biogenesis is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0042274 ribosomal small subunit biogenesis
IGI
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein ch... 		ACCEPT
Summary: Manual review: ribosomal small subunit biogenesis is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein ch... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for TSR4.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein carrier chaperone
GO:0042274 ribosomal small subunit biogenesis
IMP
PMID:31182640
Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rp... 		ACCEPT
Summary: Manual review: ribosomal small subunit biogenesis is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IDA
PMID:31182640
Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rp... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for TSR4.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein carrier chaperone
GO:0051082 unfolded protein binding
IPI
PMID:31182640
Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rp... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for TSR4.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein carrier chaperone
GO:0005737 cytoplasm
IDA
PMID:31182640
Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rp... 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005737 cytoplasm
HDA
PMID:14562095
Global analysis of protein localization in budding yeast. 		ACCEPT
Summary: Manual review: cytoplasm is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0030490 maturation of SSU-rRNA
IMP
PMID:19806183
Rational extension of the ribosome biogenesis pathway using ... 		ACCEPT
Summary: Manual review: maturation of SSU-rRNA is consistent with known biology of TSR4.
Reason: Retained as supported or plausible for this gene and evidence context.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PMID:14562095
Global analysis of protein localization in budding yeast.
PMID:19806183
Rational extension of the ribosome biogenesis pathway using network-guided genetics.
PMID:31062022
Tsr4 and Nap1, two novel members of the ribosomal protein chaperOME.
PMID:31182640
Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rps2 in Saccharomyces cerevisiae.

📄 View Raw YAML

 
id: P25040
gene_symbol: TSR4
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:559292
  label: Saccharomyces cerevisiae
description: 'TODO: Add description for TSR4'
existing_annotations:
- term:
    id: GO:0030490
    label: maturation of SSU-rRNA
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: maturation of SSU-rRNA is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: cytosol is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042254
    label: ribosome biogenesis
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: ribosome biogenesis is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:31062022
  review:
    summary: 'Manual review: cytosol is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0140597
    label: protein carrier chaperone
  evidence_type: IDA
  original_reference_id: PMID:31062022
  review:
    summary: 'Manual review: protein carrier chaperone is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042274
    label: ribosomal small subunit biogenesis
  evidence_type: IMP
  original_reference_id: PMID:31062022
  review:
    summary: 'Manual review: ribosomal small subunit biogenesis is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0042274
    label: ribosomal small subunit biogenesis
  evidence_type: IGI
  original_reference_id: PMID:31062022
  review:
    summary: 'Manual review: ribosomal small subunit biogenesis is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:31062022
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for TSR4.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0140597
      label: protein carrier chaperone
- term:
    id: GO:0042274
    label: ribosomal small subunit biogenesis
  evidence_type: IMP
  original_reference_id: PMID:31182640
  review:
    summary: 'Manual review: ribosomal small subunit biogenesis is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:31182640
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for TSR4.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0140597
      label: protein carrier chaperone
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IPI
  original_reference_id: PMID:31182640
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for TSR4.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0140597
      label: protein carrier chaperone
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:31182640
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: HDA
  original_reference_id: PMID:14562095
  review:
    summary: 'Manual review: cytoplasm is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0030490
    label: maturation of SSU-rRNA
  evidence_type: IMP
  original_reference_id: PMID:19806183
  review:
    summary: 'Manual review: maturation of SSU-rRNA is consistent with known biology of TSR4.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: PMID:14562095
  title: Global analysis of protein localization in budding yeast.
  findings: []
- id: PMID:19806183
  title: Rational extension of the ribosome biogenesis pathway using network-guided genetics.
  findings: []
- id: PMID:31062022
  title: Tsr4 and Nap1, two novel members of the ribosomal protein chaperOME.
  findings: []
- id: PMID:31182640
  title: Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rps2 in Saccharomyces cerevisiae.
  findings: []