VPS45 encodes a Sec1/Munc18 (SM) family protein essential for vacuolar protein sorting and membrane traffic between the late Golgi and the prevacuolar compartment. Vps45p binds and regulates the SNARE proteins Pep12p (a prevacuolar t-SNARE) and Tlg2p (a late Golgi/early endosome t-SNARE), promoting their proper function in SNARE complex assembly and membrane fusion. It is required for fusion of Golgi-derived transport vesicles with the prevacuolar compartment and also contributes to vacuole inheritance. Mutations in human VPS45 cause severe congenital neutropenia, underscoring the conserved importance of this trafficking regulator. Orthologous to human VPS45.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
|
GO:0016192
vesicle-mediated transport
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: Manual review: vesicle-mediated transport is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0000139
Golgi membrane
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: Manual review: Golgi membrane is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0006886
intracellular protein transport
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: Manual review: intracellular protein transport is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005737
cytoplasm
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: Manual review: cytoplasm is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005774
vacuolar membrane
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: Manual review: vacuolar membrane is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005794
Golgi apparatus
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: Manual review: Golgi apparatus is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0006886
intracellular protein transport
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: Manual review: intracellular protein transport is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0015031
protein transport
|
IEA
GO_REF:0000043 |
ACCEPT |
Summary: Manual review: protein transport is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0016192
vesicle-mediated transport
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: Manual review: vesicle-mediated transport is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0031201
SNARE complex
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: Manual review: SNARE complex is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0031338
regulation of vesicle fusion
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: Manual review: regulation of vesicle fusion is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0098588
bounding membrane of organelle
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: Manual review: bounding membrane of organelle is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005515
protein binding
|
IPI
PMID:10397773 A role for Tlg1p in the transport of proteins within the Gol... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:10978279 Pep3p/Pep5p complex: a putative docking factor at multiple s... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:12553664 A novel phospholipid-binding protein from the yeast Saccharo... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:16429126 Proteome survey reveals modularity of the yeast cell machine... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:18719252 High-quality binary protein interaction map of the yeast int... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:19667197 The N-terminal peptide of the syntaxin Tlg2p modulates bindi... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:27107014 An inter-species protein-protein interaction network across ... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0005515
protein binding
|
IPI
PMID:37968396 The social and structural architecture of the yeast protein ... |
MARK AS OVER ANNOTATED |
Summary: Manual review: protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0000011
vacuole inheritance
|
IMP
PMID:1493335 Morphological classification of the yeast vacuolar protein s... |
ACCEPT |
Summary: Manual review: vacuole inheritance is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0000139
Golgi membrane
|
IDA
PMID:7720726 Yeast Vps45p is a Sec1p-like protein required for the consum... |
ACCEPT |
Summary: Manual review: Golgi membrane is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0000149
SNARE binding
|
IPI
PMID:16769821 The Sec1p/Munc18 protein Vps45p binds its cognate SNARE prot... |
ACCEPT |
Summary: Manual review: SNARE binding is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0005829
cytosol
|
IDA
PMID:9624182 The vesicle transport protein Vps33p is an ATP-binding prote... |
ACCEPT |
Summary: Manual review: cytosol is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0006623
protein targeting to vacuole
|
IMP
PMID:7628704 STT10, a novel class-D VPS yeast gene required for osmotic i... |
ACCEPT |
Summary: Manual review: protein targeting to vacuole is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0006895
Golgi to endosome transport
|
IGI
PMID:9335586 Genetic interactions between a pep7 mutation and the PEP12 a... |
ACCEPT |
Summary: Manual review: Golgi to endosome transport is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0006896
Golgi to vacuole transport
|
IMP
PMID:7720726 Yeast Vps45p is a Sec1p-like protein required for the consum... |
ACCEPT |
Summary: Manual review: Golgi to vacuole transport is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0007033
vacuole organization
|
IMP
PMID:9650782 Traffic into the prevacuolar/endosomal compartment of Saccha... |
ACCEPT |
Summary: Manual review: vacuole organization is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0007035
vacuolar acidification
|
IMP
PMID:7628704 STT10, a novel class-D VPS yeast gene required for osmotic i... |
ACCEPT |
Summary: Manual review: vacuolar acidification is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0031201
SNARE complex
|
IPI
PMID:10397773 A role for Tlg1p in the transport of proteins within the Gol... |
ACCEPT |
Summary: Manual review: SNARE complex is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0032258
cytoplasm to vacuole targeting by the Cvt pathway
|
IMP
PMID:10545112 Cytoplasm to vacuole trafficking of aminopeptidase I require... |
ACCEPT |
Summary: Manual review: cytoplasm to vacuole targeting by the Cvt pathway is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0035543
positive regulation of SNARE complex assembly
|
IMP
PMID:11432826 Vps45p stabilizes the syntaxin homologue Tlg2p and positivel... |
ACCEPT |
Summary: Manual review: positive regulation of SNARE complex assembly is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0048210
Golgi vesicle fusion to target membrane
|
IMP
PMID:9650782 Traffic into the prevacuolar/endosomal compartment of Saccha... |
ACCEPT |
Summary: Manual review: Golgi vesicle fusion to target membrane is consistent with known biology of VPS45.
Reason: Retained as supported or plausible for this gene and evidence context.
|
|
GO:0051082
unfolded protein binding
|
IMP
PMID:11432826 Vps45p stabilizes the syntaxin homologue Tlg2p and positivel... |
MARK AS OVER ANNOTATED |
Summary: Manual review: unfolded protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
|
GO:0051082
unfolded protein binding
|
IPI
PMID:11432826 Vps45p stabilizes the syntaxin homologue Tlg2p and positivel... |
MARK AS OVER ANNOTATED |
Summary: Manual review: unfolded protein binding is too generic or over-extended for VPS45.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
|
id: P38932
gene_symbol: VPS45
product_type: PROTEIN
status: DRAFT
taxon:
id: NCBITaxon:559292
label: Saccharomyces cerevisiae
description: >-
VPS45 encodes a Sec1/Munc18 (SM) family protein essential for vacuolar
protein sorting and membrane traffic between the late Golgi and the
prevacuolar compartment. Vps45p binds and regulates the SNARE proteins
Pep12p (a prevacuolar t-SNARE) and Tlg2p (a late Golgi/early endosome
t-SNARE), promoting their proper function in SNARE complex assembly and
membrane fusion. It is required for fusion of Golgi-derived transport
vesicles with the prevacuolar compartment and also contributes to vacuole
inheritance. Mutations in human VPS45 cause severe congenital neutropenia,
underscoring the conserved importance of this trafficking regulator.
Orthologous to human VPS45.
existing_annotations:
- term:
id: GO:0016192
label: vesicle-mediated transport
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: vesicle-mediated transport is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0000139
label: Golgi membrane
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: Golgi membrane is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0006886
label: intracellular protein transport
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'Manual review: intracellular protein transport is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'Manual review: cytoplasm is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005774
label: vacuolar membrane
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'Manual review: vacuolar membrane is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005794
label: Golgi apparatus
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'Manual review: Golgi apparatus is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0006886
label: intracellular protein transport
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'Manual review: intracellular protein transport is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0015031
label: protein transport
evidence_type: IEA
original_reference_id: GO_REF:0000043
review:
summary: 'Manual review: protein transport is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0016192
label: vesicle-mediated transport
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'Manual review: vesicle-mediated transport is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0031201
label: SNARE complex
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'Manual review: SNARE complex is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0031338
label: regulation of vesicle fusion
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'Manual review: regulation of vesicle fusion is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0098588
label: bounding membrane of organelle
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'Manual review: bounding membrane of organelle is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10397773
review:
summary: 'Manual review: protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10978279
review:
summary: 'Manual review: protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12553664
review:
summary: 'Manual review: protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16429126
review:
summary: 'Manual review: protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18719252
review:
summary: 'Manual review: protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19667197
review:
summary: 'Manual review: protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:27107014
review:
summary: 'Manual review: protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:37968396
review:
summary: 'Manual review: protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0000011
label: vacuole inheritance
evidence_type: IMP
original_reference_id: PMID:1493335
review:
summary: 'Manual review: vacuole inheritance is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0000139
label: Golgi membrane
evidence_type: IDA
original_reference_id: PMID:7720726
review:
summary: 'Manual review: Golgi membrane is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0000149
label: SNARE binding
evidence_type: IPI
original_reference_id: PMID:16769821
review:
summary: 'Manual review: SNARE binding is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0005829
label: cytosol
evidence_type: IDA
original_reference_id: PMID:9624182
review:
summary: 'Manual review: cytosol is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0006623
label: protein targeting to vacuole
evidence_type: IMP
original_reference_id: PMID:7628704
review:
summary: 'Manual review: protein targeting to vacuole is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0006895
label: Golgi to endosome transport
evidence_type: IGI
original_reference_id: PMID:9335586
review:
summary: 'Manual review: Golgi to endosome transport is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0006896
label: Golgi to vacuole transport
evidence_type: IMP
original_reference_id: PMID:7720726
review:
summary: 'Manual review: Golgi to vacuole transport is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0007033
label: vacuole organization
evidence_type: IMP
original_reference_id: PMID:9650782
review:
summary: 'Manual review: vacuole organization is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0007035
label: vacuolar acidification
evidence_type: IMP
original_reference_id: PMID:7628704
review:
summary: 'Manual review: vacuolar acidification is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0031201
label: SNARE complex
evidence_type: IPI
original_reference_id: PMID:10397773
review:
summary: 'Manual review: SNARE complex is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0032258
label: cytoplasm to vacuole targeting by the Cvt pathway
evidence_type: IMP
original_reference_id: PMID:10545112
review:
summary: 'Manual review: cytoplasm to vacuole targeting by the Cvt pathway is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0035543
label: positive regulation of SNARE complex assembly
evidence_type: IMP
original_reference_id: PMID:11432826
review:
summary: 'Manual review: positive regulation of SNARE complex assembly is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0048210
label: Golgi vesicle fusion to target membrane
evidence_type: IMP
original_reference_id: PMID:9650782
review:
summary: 'Manual review: Golgi vesicle fusion to target membrane is consistent with known biology of VPS45.'
action: ACCEPT
reason: Retained as supported or plausible for this gene and evidence context.
- term:
id: GO:0051082
label: unfolded protein binding
evidence_type: IMP
original_reference_id: PMID:11432826
review:
summary: 'Manual review: unfolded protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
id: GO:0051082
label: unfolded protein binding
evidence_type: IPI
original_reference_id: PMID:11432826
review:
summary: 'Manual review: unfolded protein binding is too generic or over-extended for VPS45.'
action: MARK_AS_OVER_ANNOTATED
reason: Marked over-annotated because more specific terms capture the biology more accurately.
references:
- id: GO_REF:0000033
title: Annotation inferences using phylogenetic trees
findings: []
- id: GO_REF:0000043
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
findings: []
- id: GO_REF:0000044
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
findings: []
- id: GO_REF:0000117
title: Electronic Gene Ontology annotations created by ARBA machine learning models
findings: []
- id: GO_REF:0000120
title: Combined Automated Annotation using Multiple IEA Methods
findings: []
- id: PMID:10397773
title: A role for Tlg1p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae.
findings: []
- id: PMID:10545112
title: Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p.
findings: []
- id: PMID:10978279
title: 'Pep3p/Pep5p complex: a putative docking factor at multiple steps of vesicular transport to the vacuole of Saccharomyces cerevisiae.'
findings: []
- id: PMID:11432826
title: Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation.
findings: []
- id: PMID:12553664
title: A novel phospholipid-binding protein from the yeast Saccharomyces cerevisiae with dual binding specificities for the transport GTPase Ypt7p and the Sec1-related Vps33p.
findings: []
- id: PMID:1493335
title: 'Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.'
findings: []
- id: PMID:16429126
title: Proteome survey reveals modularity of the yeast cell machinery.
findings: []
- id: PMID:16769821
title: The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes.
findings: []
- id: PMID:18719252
title: High-quality binary protein interaction map of the yeast interactome network.
findings: []
- id: PMID:19667197
title: The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p.
findings: []
- id: PMID:27107014
title: An inter-species protein-protein interaction network across vast evolutionary distance.
findings: []
- id: PMID:37968396
title: The social and structural architecture of the yeast protein interactome.
findings: []
- id: PMID:7628704
title: STT10, a novel class-D VPS yeast gene required for osmotic integrity related to the PKC1/STT1 protein kinase pathway.
findings: []
- id: PMID:7720726
title: Yeast Vps45p is a Sec1p-like protein required for the consumption of vacuole-targeted, post-Golgi transport vesicles.
findings: []
- id: PMID:9335586
title: 'Genetic interactions between a pep7 mutation and the PEP12 and VPS45 genes: evidence for a novel SNARE component in transport between the Saccharomyces cerevisiae Golgi complex and endosome.'
findings: []
- id: PMID:9624182
title: The vesicle transport protein Vps33p is an ATP-binding protein that localizes to the cytosol in an energy-dependent manner.
findings: []
- id: PMID:9650782
title: 'Traffic into the prevacuolar/endosomal compartment of Saccharomyces cerevisiae: a VPS45-dependent intracellular route and a VPS45-independent, endocytic route.'
findings: []