family_id: PANTHER:PTHR10194
family_name: RAS GTPASE-ACTIVATING PROTEINS
preferred_name: Ras and Rap GTPase-activating proteins
summary: RasGAP-related proteins accelerate GTP hydrolysis by small GTPases rather than hydrolyzing free
  GTP as the principal catalyst themselves. Ras versus Rap preference and regulatory localization vary
  across the group.
functional_coherence: MOSTLY_COHERENT
coherence_reason: The mosquito target carries a RasGAP domain and conserved-site signature. General GTPase-activator
  activity is mechanistically consistent, while a specific GTPase substrate or signaling pathway needs
  branch-specific evidence. A conserved domain does not dispense with checking the catalytic interface
  in divergent members.
subfamilies:
- subfamily_id: PANTHER:PTHR10194:SF60
  label: RAS GTPASE-ACTIVATING PROTEIN RASKOL
  description: Recorded placement of A0A6I8TLE4. The mosquito target carries a RasGAP domain and conserved-site
    signature. General GTPase-activator activity is mechanistically consistent, while a specific GTPase
    substrate or signaling pathway needs branch-specific evidence. A conserved domain does not dispense
    with checking the catalytic interface in divergent members.
  representative_members:
  - id: UniProtKB:A0A6I8TLE4
    gene_symbol: A0A6I8TLE4
    organism: Aedes aegypti
    gene_review: genes/AEDAE/A0A6I8TLE4/A0A6I8TLE4-ai-review.yaml
term_assessments:
- assessed_term:
    id: GO:0005096
    label: GTPase activator activity
  scope: UNRESOLVED
  scope_reason: Neurofibromin and p120GAP mutagenesis directly establish Ras GTPase activation through
    a catalytic interface that positions the arginine-finger region. The mosquito RasGAP domain and conserved-site
    signature support a comparable GAP mechanism. Ras versus Rap preference and inactive interface variants
    require branch-specific analysis; the complete functional set is not restricted to the benchmark Raskol
    subfamily.
  supported_by:
  - reference_id: PMID:12787671
    supporting_text: 'The finger loop is crucial

      for the stabilization of the transition state'
  - reference_id: file:genes/AEDAE/A0A6I8TLE4/A0A6I8TLE4-uniprot.txt
    supporting_text: DR   InterPro; IPR023152; RasGAP_CS.
  - reference_id: file:genes/AEDAE/A0A6I8TLE4/A0A6I8TLE4-uniprot.txt
    supporting_text: DR   InterPro; IPR001936; RasGAP_dom.
  - reference_id: file:genes/human/NF1/NF1-uniprot.txt
    supporting_text: 'CC   -!- FUNCTION: Stimulates the GTPase activity of Ras.'
references:
- id: PMID:12787671
  title: Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.
- id: file:genes/AEDAE/A0A6I8TLE4/A0A6I8TLE4-uniprot.txt
- id: file:interpro/panther/PTHR10194/PTHR10194-entries.csv
- id: file:interpro/panther/PTHR10194/PTHR10194-paint.tsv
- id: file:genes/human/NF1/NF1-uniprot.txt
review_status: COMPLETE
reviewed_by: codex
review_date: '2026-09-10'
notes: 'AEDAE/A0A6I8TLE4: requested accession A0A6I8TLE4; current record A0A6I8TLE4; sequence length 1442;
  source cohort ARGO50. Family boundaries were assessed using the fetched member set and the cited domain,
  literature and analytical evidence. Gene-review verdicts and ARBA assertions are not independent validation.
  PANTHER subfamily labels and membership are recorded from the frozen UniProt records and panther.obo;
  they do not by themselves prove functional uniformity within a subfamily. PAINT rows were inspected
  as ancestral assertions, but node placement is not adjudicated without the relevant descendant tree/alignment.
  No residue requirement is encoded without a verified sequence-version anchor. A target-level refutation
  is not a family-wide NOT_APPLICABLE judgment. Exact protein-name-only predictions are treated as family-identification
  hypotheses rather than invented GO predictions.'