family_id: PANTHER:PTHR12480
family_name: ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD
preferred_name: JMJD4/JMJD6/JMJD8-related JmjC proteins
summary: This family includes JMJD4, JMJD6, JMJD8 and plant JMJ20/JMJ22-like proteins. JmjC architecture
  unites the group but does not establish a common substrate, chromatin role or developmental pathway.
functional_coherence: HETEROGENEOUS
coherence_reason: The wheat target and Arabidopsis JMJ22 share an F-box/JmjC architecture and an assigned
  subfamily, supporting a focused comparison. Plant light and gibberellin phenotypes require orthology
  and regulatory-context evidence; they do not apply to animal JMJD4/JMJD6/JMJD8. Histone arginine demethylation
  must be distinguished from other oxygenase activities.
subfamilies:
- subfamily_id: PANTHER:PTHR12480:SF21
  label: JMJC DOMAIN-CONTAINING PROTEIN 8
  description: Recorded placement of A0A3B6RKV1. The wheat target and Arabidopsis JMJ22 share an F-box/JmjC
    architecture and an assigned subfamily, supporting a focused comparison. Plant light and gibberellin
    phenotypes require orthology and regulatory-context evidence; they do not apply to animal JMJD4/JMJD6/JMJD8.
    Histone arginine demethylation must be distinguished from other oxygenase activities.
  representative_members:
  - id: UniProtKB:A0A3B6RKV1
    gene_symbol: A0A3B6RKV1
    organism: Triticum aestivum
    gene_review: genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-ai-review.yaml
term_assessments:
- assessed_term:
    id: GO:0010099
    label: regulation of photomorphogenesis
  scope: UNRESOLVED
  scope_reason: Arabidopsis JMJ20/JMJ22 act downstream of light-activated PHYB in the cited germination
    experiments. The wheat F-box/JmjC architecture makes this plant branch a relevant comparison, while
    JMJD4/6/8 and other JmjC proteins are not thereby assigned a photomorphogenesis role. Conservation
    of the PHYB-regulated circuit and the complete positive plant branch boundary remain unresolved.
  supported_by:
  - reference_id: PMID:22483719
    supporting_text: "histone arginine demethylases, JMJ20 and \nJMJ22"
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR003347; JmjC_dom.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT   DOMAIN          89..135
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT                   /note="F-box"
  - reference_id: PMID:22483719
    supporting_text: "JMJ20 and \nJMJ22, act redundantly as positive regulators of seed germination."
- assessed_term:
    id: GO:0010476
    label: gibberellin mediated signaling pathway
  scope: UNRESOLVED
  scope_reason: The JMJ20/JMJ22 study links these proteins to increased gibberellic acid through GA3ox1/GA3ox2
    regulation. That establishes a hormone-metabolism connection; it does not automatically identify every
    homolog as a component of the gibberellin signal-transduction pathway. Resolve biosynthesis versus
    signal reception/transduction and conserved plant regulatory context before transfer.
  supported_by:
  - reference_id: PMID:22483719
    supporting_text: "histone arginine demethylases, JMJ20 and \nJMJ22"
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR003347; JmjC_dom.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT   DOMAIN          89..135
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT                   /note="F-box"
  - reference_id: PMID:22483719
    supporting_text: "JMJ20 and \nJMJ22, act redundantly as positive regulators of seed germination."
- assessed_term:
    id: GO:0040029
    label: epigenetic regulation of gene expression
  scope: UNRESOLVED
  scope_reason: The cited plant study reports removal of repressive histone arginine methylation at GA3ox
    loci, providing a specific chromatin-regulatory example. JmjC fold conservation alone does not establish
    histone substrate choice or an epigenetic mechanism in the wheat target or the animal JMJD branches.
    The biochemical substrate and locus-specific regulation delimit this hypothesis.
  supported_by:
  - reference_id: PMID:22483719
    supporting_text: "histone arginine demethylases, JMJ20 and \nJMJ22"
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR003347; JmjC_dom.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT   DOMAIN          89..135
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT                   /note="F-box"
  - reference_id: PMID:22483719
    supporting_text: "JMJ20 and \nJMJ22, act redundantly as positive regulators of seed germination."
- assessed_term:
    id: GO:0010114
    label: response to red light
  scope: UNRESOLVED
  scope_reason: PHYB activation supplies a direct red-light pathway context for Arabidopsis JMJ20/JMJ22.
    It is an organism-level upstream input, not a shared light-sensing property of a JmjC catalytic domain.
    A red-light response cannot be granted across nonplant branches or untested plant paralogs.
  supported_by:
  - reference_id: PMID:22483719
    supporting_text: "histone arginine demethylases, JMJ20 and \nJMJ22"
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR003347; JmjC_dom.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT   DOMAIN          89..135
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT                   /note="F-box"
  - reference_id: PMID:22483719
    supporting_text: "JMJ20 and \nJMJ22, act redundantly as positive regulators of seed germination."
- assessed_term:
    id: GO:0010030
    label: positive regulation of seed germination
  scope: UNRESOLVED
  scope_reason: The Arabidopsis paper directly identifies redundant positive effects of JMJ20 and JMJ22
    on seed germination. That is stronger than a generic JmjC analogy but remains a plant regulatory-branch
    result. The wheat comparison requires orthology and preservation of seed expression and the GA3ox/PHYB
    context; no exhaustive germination-positive subfamily set is established.
  supported_by:
  - reference_id: PMID:22483719
    supporting_text: "histone arginine demethylases, JMJ20 and \nJMJ22"
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR003347; JmjC_dom.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: DR   InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox.
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT   DOMAIN          89..135
  - reference_id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
    supporting_text: FT                   /note="F-box"
  - reference_id: PMID:22483719
    supporting_text: "JMJ20 and \nJMJ22, act redundantly as positive regulators of seed germination."
references:
- id: PMID:22483719
  title: Control of seed germination by light-induced histone arginine demethylation activity.
- id: file:genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt
- id: file:interpro/panther/PTHR12480/PTHR12480-entries.csv
- id: file:interpro/panther/PTHR12480/PTHR12480-paint.tsv
review_status: COMPLETE
reviewed_by: codex
review_date: '2026-09-10'
notes: 'WHEAT/A0A3B6RKV1: requested accession A0A3B6RKV1; current record A0A3B6RKV1; sequence length 511;
  source cohort ARGO50. Family boundaries were assessed using the fetched member set and the cited domain,
  literature and analytical evidence. Gene-review verdicts and ARBA assertions are not independent validation.
  PANTHER subfamily labels and membership are recorded from the frozen UniProt records and panther.obo;
  they do not by themselves prove functional uniformity within a subfamily. PAINT rows were inspected
  as ancestral assertions, but node placement is not adjudicated without the relevant descendant tree/alignment.
  No residue requirement is encoded without a verified sequence-version anchor. A target-level refutation
  is not a family-wide NOT_APPLICABLE judgment. Exact protein-name-only predictions are treated as family-identification
  hypotheses rather than invented GO predictions.'